Momwe mungagwiritsire ntchito Metglib 400?

Metglib 400 ndiwothandiza kutsegula m'mibadwo yatsopano ya hypoglycemic pochiza odwala matenda akuluakulu a shuga. Sichimayambitsa hypoglycemia, sichikhudzanso kubisika kwa insulin mthupi. Kumwa mankhwalawa kumabweretsa zotsatira zabwino pakuwongolera komanso kuwongolera matenda ashuga.

Dzinalo Losayenerana

INN - Glibenclamide + Metformin.

ATX

Khodi malinga ndi gulu la ATX ndi A10BD02.

Kutulutsa mafomu ndi kapangidwe kake

Piritsi limodzi limaphatikizapo 400 mg ya metformin hydrochloride ndi glibenclamide 2,5 mg. Mapiritsiwa amaphatikizidwa ndi filimu yosungunuka m'matumbo. Zowonjezera zili ndi calcium hydrogenphosphate dihydrate, sodium stearyl fumarate, povidone, microcrystalline cellulose.

Metglib 400 ndiwothandiza kutsegula m'mibadwo yatsopano ya hypoglycemic pochiza odwala matenda akuluakulu a shuga.

Zotsatira za pharmacological

Chidacho chili ndi kuphatikiza kwa mankhwala a hypoglycemic a magulu osiyanasiyana a mankhwala - metformin, glibenclamide. Poyerekeza ndi biguanides, Metformin imachepetsa kuchuluka kwa shuga. Ili ndi njira zotsatirazi zomwe zizichitika mthupi:

• kuchepa kwa mphamvu ya kupanga shuga m'magazi a chiwindi;
• kuchuluka kwa cell receptors kwa insulin;
• kuonjezera njira zakumwa ndi pokonza shuga mu minofu maselo;
• Kuchedwa kuyamwa kwa glucose m'mimba;
• kukhazikika kapena kuchepa thupi mwa anthu odwala matenda ashuga.

Metformin imathandizira mulingo wamagazi lipids. Amachepetsa kuchuluka kwa mafuta m'thupi, makamaka chifukwa cha kupsinjika kwa lipoproteins. Lowers triglycerides.

Glibenclamide ndi gulu lochokera ku gulu lachiwiri la sulfonylurea.

Ndi kagwiritsidwe ntchito, kuchuluka kwa shuga m'magazi kumatsika, chifukwa kumapangitsa kuti insulin iphatikizidwe ndi maselo a beta. Izi zimakwaniritsa kutsitsa shuga kwa Metformin. Chifukwa chake, kutsika kwamphamvu kwa shuga m'magazi kumachitika, komwe kumalepheretsa kukula kwa zochitika za hyperglycemia ndikulepheretsa kukula kwa mikhalidwe yovuta kwambiri ya hyperglycemic.

Metformin imathandizira mulingo wamagazi lipids.

Pharmacokinetics

Pambuyo pakugwiritsira ntchito kwamkati, glibenclamide imalowetsedwa kwathunthu kuchokera m'mimba. Kuyika kwake kwakukulu kumatsimikiziridwa pambuyo maola 4. Pafupifupi zimagwirira kwathunthu mapuloteni mu madzi a m'magazi. Amapangidwa ndi kupukutidwa ndi ndulu, ndowe.

Metformin sikugwirizana ndi mapuloteni a plasma. Zofooka pang'ono, zimayamba kuwola, zotulutsidwa mkodzo. Gawo lamankhwala limatuluka ndi ndowe.

Ndi a impso pathologies, kuchuluka kwa metformin m'magazi kumakweza mwanjira ina, chifukwa impso zilibe nthawi yoti zimveke. Kudya sikukhudza kupezeka kwa mankhwalawa kuchokera ku ma Biguanides angapo.

Zizindikiro zogwiritsidwa ntchito

Ndikulimbikitsidwa kuti mugwiritse ntchito ngati mukudwala matenda ashuga a 2 omwe samatengera insulin, malinga ngati chithandizo cha zakudya komanso maphunziro akuthupi sizithandiza kapena mukatha kugwiritsa ntchito zinthu zina za sulfonylurea. Itha kuyikidwanso m'malo mwa chithandizo cham'mbuyomu ndi Metformin ndi zotumphukira za sulfonylurea, bola ngati wodwala matenda a shuga amawongolera bwino ndipo sipanakhalepo ndimavuto owopsa a hyperglycemic.

Chalangizidwa kuti mugwiritse ntchito matenda a shuga osadalira insulin.

Contraindication

Mankhwalawa ali ndi zotsutsana ndi izi:

1. Mtundu woyamba wa shuga.
2. Kukhudzika kwambiri kwa thupi mpaka metformin, glibenclamide ndi zinthu zina zokhudzana ndi sulfonylcarbamides.
3. Zambiri zomwe zimathandizira kusintha kwa impso: kuchepa magazi, matenda akulu, mantha.
4. Ketoacidosis, precoma ndi chikomokere.
5. Hypersensitivity pazinthu zina zomwe zimapanga Metglib.
6. Kulephera kwamkati ndi mavuto ena amakono omwe amachititsa kuchepa kwa chilolezo cha creatinine pansi pa 60 ml / min.
7. Intravenous makonzedwe a x-ray okhala ndi ayodini.
8. Zomwe zimayendetsedwa ndi kukhudzidwa ndi mpweya wa minofu ya minofu: kusakwanira kwa mtima, mapapu, kugunda kwamtima.
9. Kulephera kwa chiwindi, kuphatikizapo hepatitis.
10. Porphyria (kuphwanya njira za pigment metabolism, limodzi ndi kuchuluka kwa magazi m'matumbo a porphyrins, owonetsedwa ndi kukhudzika kwa khungu kufikira kuwala kwa dzuwa, komanso matenda amanjenje kapena amisala).
11. Kutenga Miconazole.
12. Opaleshoni, kuvulala komanso kuwotcha kwakukulu.
13. Zofunikira zofuna insulin.
14. Poizoni wambiri.
15. Lactic acidosis (kuphatikizapo mbiri).
16. Kuthana ndi wodwala ochepa calorie zakudya ndi malire a tsiku ndi tsiku caloric kudya zosakwana 1000 kcal.
17. Wodwala wosakwana zaka 18.

Ndi kulephera kwa chiwindi, chiwindi chimaletsedwa.

Kugwiritsa yotupa matenda a genitourinary gawo.

Poizoni wakumwa wambiri, mankhwalawa saikidwa mankhwala.

Kutsatira kwa x-ray zamagulu okhala ndi ayodini ndi njira yotsutsa kugwiritsa ntchito Metglib 400.

Metglib 400 siyikusonyezedwa pakuchitapo kanthu pochita opaleshoni.

Ngati wodwala amatsatira zakudya zochepa zama calorie, kumwa mankhwalawa ndi otsutsana.

Ndi chisamaliro

Mankhwala ndi mankhwala mosamala milandu:

• malungo;
• uchidakwa;
• kuperewera kwa adrenal;
• kusagwira bwino ntchito kwa anterior pituitary gland;
• zotupa za chithokomiro;
• zaka zopitilira 70 (pali vuto la hypoglycemia).

Momwe mungatenge Metglib 400?

Malangizowo akuwonetsa kuti mankhwalawo amamwa pakamwa. Phaleli silingathe kutafunidwa, kutafunidwa, kuphwanyidwa kukhala ufa kapena kuyimitsidwa. Iyenera kumezedwa yonse ndikutsukidwa ndi madzi okwanira komanso madzi. Kugwiritsa ntchito zakumwa zina pazolinga izi sikuloledwa chifukwa chosintha mu hypoglycemic zochita za Metglib.

Malangizowo akuwonetsa kuti mankhwalawo amatengedwa pakamwa, piritsi silingathe kutafunidwa, kutafunidwa, kuphwanyidwa kukhala ufa kapena kupangidwa mwa kuyimitsidwa.

Ndi matenda ashuga

Mlingo wa mankhwala a shuga umatsimikiziridwa ndi dokotala, kutengera mtundu wa wodwala, kagayidwe kazakudya. Pakuyika kwa mlingo, chizindikiro cha glycemia ndichofunikira.

Nthawi zambiri mlingo woyamba ndi mapiritsi 1 kapena 2 patsiku. Ayenera kumwedwa ndi chakudya chachikulu. Mtsogolomo, mlingo ungakulitse kuchuluka kwa shuga.

Mlingo waukulu ndi mapiritsi 6. Poterepa, adagawidwa pazigawo zitatu.

Zotsatira zoyipa za Metglib 400

Zotsatira zotsatirazi zimatha kuchitika pakumwa:

1. Pali kusintha pamagulu amwazi ndi mkhalidwe wamitsempha yamagazi, yowonetsedwa mu agranulocytosis, leukopenia ndi thrombocytopenia. Mavutowa ndi osowa komanso amatha pambuyo posiya mankhwala. Hemolytic anemia, mafupa apasidiya (kusakwanira kwa ziwalo), pancytopenia (kuchepa kwa zinthu zonse zopangidwa m'magazi) ndizosowa kwambiri.
2. Nthawi zina mantha a anaphylactic amatha. Pali zimachitika lakuthwa kudziwa kwa zotumphukira sulfonylurea.
3. Pa gawo la metabolism, hypoglycemia, porphyria, kuchepa kwa mayamwidwe a Vitamini B12, limodzi ndi kugwiritsa ntchito mankhwala a Metformin kwa nthawi yayitali. Pali chiopsezo cha megaloblastic anemia.
4. Kulawa kosasangalatsa pamkamwa wamkamwa ndikotheka. Kumayambiriro kwa chithandizo, kukomoka kwakanthawi kachipangizidwe ka masomphenya kumachitika chifukwa cha kuchepa kwa ndende ya glucose.
5. Nthawi zambiri pamakhala nseru, kutsegula m'mimba, kusanza, kupweteka pamimba komanso kuchepa (nthawi zina kusowa kwathunthu) chilakolako cha kugona. Izi zimawonekera kumayambiriro kwa chithandizo chamankhwala ndipo zimadutsa mwachangu. Kugwiritsa ntchito mankhwalawa mosiyanasiyana Mlingo komanso kuwonjezeka pang'onopang'ono kwa mankhwalawa kumachepetsa mwayi wokhala ndi zizindikiro.
6. Nthawi zambiri, vuto la chiwindi komanso kuchuluka kwa michere ya chiwindi kumatha kuchitika. Pankhaniyi, muyenera kusiya kutenga.
7. Dermatological zimachitika kawirikawiri sizimawoneka - kuyabwa, zidzolo, urticaria. Allergic vasculitis, erythema, ndi dermatitis nthawi zina amatha. Pakhala pali zochitika zowonjezera khungu pakulowa dzuwa.
8. Nthawi zina zimakhala zotheka kuwonjezera kuchuluka kwa urea ndi creatinine mu seramu.
9. Osati kawirikawiri, zigawo za kuchepa kwa magazi a sodium zimachitika.

Zokhudza mphamvu pakuwongolera njira

Chifukwa cha chiwopsezo cha kuyambitsa hypoglycemia koyambira koyambirira kwa chithandizo, ndikofunikira kukana kugwira ntchito zokhudzana ndi kuyendetsa ndi kuwongolera makina. Pamodzi ndi chiopsezo cha hypoglycemia, chikumbumtima chitha kuperewera.

Zotsatira zoyenera kumwa mankhwalawa zimachitika mseru, kusanza.

Mukamamwa Metglib 400, kutsegula m'mimba kumatha kuchitika.

Ngakhale mukumwa mankhwalawa, mantha a anaphylactic nthawi zina amatha.

Pakhoza kukhala kukoma kosasangalatsa pamlomo wamkati pamankhwala a Metglib 400.

Pafupipafupi, pamene mukumwa Metglib 400, zimachitika pakhungu zimayambitsa - kuyabwa, zotupa, urticaria.

Malangizo apadera

Kuchiza kuyenera kuchitika kokha moyang'aniridwa ndi katswiri. Munthawi ya zochizira, upangiri wonse wa dokotala uyenera kuyang'aniridwa mosamalitsa: kudya bwino, kuwunika pafupipafupi magazi a glucose komanso mukatha kudya.

Sizoletsedwa kumwa zakudya zochepetsa shuga.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Nthawi ya bere, kuikidwa kwake kumatsutsana. Wodwala ayenera kudziwitsa adotolo kuti akukonzekera kutenga pakati kapena kuti wabwera. Mimba ikachitika pamene mukumwa mankhwalawo, mankhwalawo amayenera kuperekedwa nthawi yomweyo. Pambuyo pakuchotsedwa kwa Metglib, wodwalayo adalandira mankhwala a insulin (kuyambitsa jakisoni wa insulin kuti achepetse kuchuluka kwa shuga).

Amasungidwa motsutsana kupatsa Metglib nthawi yoyamwitsa. Ichi ndichifukwa chosowa deta pakukwaniritsidwa kwa zigawo za mankhwala zomwe zingalowe mkaka wa m'mawere. Ngati pakufunika kugwiritsa ntchito mankhwalawa pakadwala, wodwala amamuika jakisoni wa insulin kapena mwana amusamutsa njira yodyetsa.

Chithandizo cha Metglib cha ana 400

Sanapatsidwe.

Gwiritsani ntchito mu ukalamba

Chisamaliro chapadera chikuyenera kutengedwa ndi okalamba. Pali chiopsezo cha hypoglycemia yoopsa.

The ntchito aimpso kuwonongeka

Ndi kukanika kwa impso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala, chifukwa kuwonjezeka kwa milingo yamagazi ake omwe amagwira ntchito ndizotheka. Kulephera kwa aimpso sikugwiritsidwa ntchito.

Ndi kukanika kwa impso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Singathe kutumizidwa pakuwonongeka kwa chiwindi.

Mankhwala ochulukirapo a Metglib 400

Ndi mankhwala osokoneza bongo, hypoglycemia imayamba. Wofatsa kwambiri wokhala ndi hypoglycemia amasiya kugwiritsa ntchito maswiti. Muyenera kusintha kuchuluka kwa mankhwalawa ndikusintha zakudya.

Mu hypoglycemia yayikulu, kusazindikira kumachitika, paroxysm, matenda amitsempha omwe amafunikira chithandizo chamankhwala mwadzidzidzi. Mpumulo wovuta kwambiri umafuna kukhazikitsidwa kwa Dextrose mthupi.

Hyperglycemia wokayikitsa ndi chidziwitso chakuchipatala komwe munthu amapanga. Popewa kuyambiranso, munthu amafunika kupatsidwa chakudya chopezeka m'zakudya zopatsa mphamvu zambiri.

Mu matenda a chiwindi mu odwala matenda ashuga, mlingo wa glibenclamide chilolezo ukuwonjezeka. Chifukwa chake, odwala oterowo ayenera kuwunika mosamala mlingo wa mankhwalawa. Mukamagwiritsa ntchito Mlingo wa Metglib wapamwamba, dialysis ndi yopanda tanthauzo.

Popeza Metformin ili mgawoli, kugwiritsa ntchito Metglib mosalekeza kungapangitse lactic acidosis. Ichi ndi chiopsezo chofunikira kuchipatala. Lactate ndi metformin imatha kuthetsedwa ndi dialysis.

Lactate ndi metformin imatha kuthetsedwa ndi dialysis.

Kuchita ndi mankhwala ena

Mankhwala, munthawi yomweyo kugwiritsa ntchito phenylbutazone amaletsedwa. Zimawonjezera ntchito ya hypoglycemic ya Metglib. Ndikofunika kugwiritsa ntchito mankhwala ena osapweteka a anti-yotupa pochiza ululu ndi kutupa.

Osagwiritsa ntchito zinthu zina ndi sulfonylurea ngati wodwala akutenga kale Metglib. Kupanda kutero, hypoglycemia imayamba.

Kugwiritsidwa ntchito kwa Bosentan kumachulukitsa chiopsezo cha zovuta za mankhwala a chiwindi. Zotsatira za glibenclamide zitha kuchepetsedwa kwambiri.

Kuyenderana ndi mowa

Mankhwala, kugwiritsidwa ntchito ngati disulfiram ndikotheka (kofanana ndi zomwe zimachitika ndi ethanol ndi Antabus). Mankhwalawa sagwirizana ndi ethanol.

Mowa ungakulitse mwayi wokhala ndi vuto lalikulu la hypoglycemia ndi hypoglycemic coma. Chifukwa chake, ndi chithandizo cha Metglib, ma tinctures omwe ali ndi mowa amaletsedwa.

Analogi

Zowunikira za chida ndi:

• Glibenfage;
• Glibomet;
• Glucovans;
• Gluconorm;
• Gluconorm Plus;
• Mphamvu ya Metglib.

Kupita kwina mankhwala

Yoperekedwa ndi mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Mankhwala ena amalola kugulitsa Metglib popanda mankhwala a dokotala. Odwala omwe amagula mankhwala popanda kuikidwa ndi katswiri ali pachiwopsezo chifukwa amatha kudwala kwambiri hypoglycemia.

M'malo mwa Metglib, mutha kugwiritsa ntchito Glibomet.

M'malo mwake, Metglib nthawi zina amaikidwa ngati Glucovans.

Gluconorm imawerengedwa kuti ndi mankhwala analogue.

Gluconorm kuphatikizanso ili ndi mankhwala ofanana ndi Metglib 400.

Wogwirizana kwathunthu ndi Metglib ndi Metglib Force.

Mtengo wa Metglib 400

Mtengo wapakatikati wa maphukusi (40 mapiritsi) ndi ma ruble 300.

Zosungidwa zamankhwala

Sungani pamalo owuma, owuma komanso osawoneka bwino ndi dzuwa. Kutentha kosungiramo mankhwalawa sikuyenera kupitirira + 25 ° C.

Tsiku lotha ntchito

Mankhwalawa amatha kusungidwa kwa zaka 3 kuyambira tsiku lopangidwa.

Wopanga

Yopangidwa ku Canonfarm Production, Russia.

Ndemanga za Metglib 400

Madokotala

Irina, wazaka 38, endocrinologist, Obninsk: "Ndimapatsa Metglib odwala omwe ali ndi mtundu wofupika wa matenda amtundu wa II. M'masabata oyamba, odwala amatenga mapiritsi awiri patsiku, ndiye kuti mlingo umawonjezereka kukhala mapiritsi a 3-4. Chifukwa cha izi, ndizotheka kusunga shuga yamagazi nthawi zonse ndipo osaziposa. "

Svetlana, wazaka 45, endocrinologist, ku Moscow: "Metglib ndi chida chothandiza kuthana ndi matenda ashuga komanso kupewa matenda a hyperglycemia. Amalekeredwa bwino ndi odwala, milandu ya hypoglycemia ndi zotsatira zina zoyipa sizinawoneke kawirikawiri."

Odwala

Ivan, wazaka 50, Peterzavodsk: "Njira yothandiza ya matenda ashuga yomwe siyambitsa chizungulire, kusakhala ndi thanzi labwino komanso nthawi yomweyo imakupatsani mwayi wokhala ndi shuga m'magazi ena. Mankhwala ena sanakhale ndi izi.

Olga, wazaka 42, Vologda: "Nditamwa Metglib, thanzi langa linakhala bwino.

Polina, wazaka 39, Kirov: "Mankhwala otsika mtengo komanso othandiza amakhala bwino, amachepetsa shuga. Zotsatira zake zimabwera mofulumira kuposa mankhwala ena. Palibe zotsatira zoyipa atangoyamba kumene chithandizo chamankhwala."