Metformin 500 ikuwonetsedwa pakuwongolera odwala matenda ashuga. Matendawa amasiyana ndi matenda ena pakufalikira komanso chiwopsezo cha kufa. Chithandizo cha matenda a shuga ndichimodzi mwazinthu zofunika kwambiri zomwe madokotala amapanga padziko lonse lapansi.
Dzinalo Losayenerana
Dzinali ndi Metformin.
ATX
A10BA02.
Kutulutsa mafomu ndi kapangidwe kake
Amapangidwa ngati mapiritsi. Kuphatikizikako kumakhala ndi mankhwala a metformin hydrochloride ndi zigawo zina zothandizira: silicon dioxide, mchere wa magnesium stearic, Copovidone, selulosi, Opadry II. Mankhwalawa samatulutsa.
Amapangidwa monga mapiritsi, mapangidwewo ali ndi mankhwala a metformin hydrochloride ndi zigawo zothandiza.
Zotsatira za pharmacological
Metformin (dimethylbiguanide) ali ndi mphamvu yogwira matendawa. Mphamvu yake yokhala ndi bioactive imalumikizidwa ndi kuthekera kwoletsa kayendedwe ka gluconeogenesis mthupi. Poterepa, kuchuluka kwa ATP m'maselo kumachepa, komwe kumapangitsa kutsekemera kwa shuga. Mankhwalawa amachulukitsa kuchuluka kwa glucose omwe amalowa kuchokera kunja kwa gawo kulowa mu cell. Pali kuwonjezeka kwa kuchuluka kwa lactate ndi pyruvate mu zimakhala.
Mankhwalawa amachepetsa mphamvu yakuwonongeka kwamafuta, amalepheretsa mapangidwe a mafuta osasinthika.
Mukamagwiritsa ntchito ma biguanides, kusintha kwa insulin kumawonedwa, zomwe zimapangitsa kutsika pang'ono kwa kuchuluka kwa shuga m'magazi. Simalimbikitsa kupangika kwa insulin ndi maselo a beta, omwe amathandizira kupumula kwa hyperinsulinemia (kuchuluka kwa insulin m'magazi).
Mwa odwala wathanzi, kutenga Metformin sikumabweretsa kutsika kwa shuga m'magazi. Mwakutero, imatengedwa kuti athane ndi kunenepa kwambiri chifukwa cha kuletsa kudya, kuchepetsa mphamvu ya kuyamwa kwa shuga m'matumbo am'magazi kulowa m'magazi.
Ilinso ndi katundu wa hypolipidemic, ndiko kuti, imachepetsa kuchuluka kwa lipoproteins yotsika yomwe imayambitsa mapangidwe a atherosranceotic. Imakhala ndi phindu pa kachitidwe ka mitsempha yamagazi ndi mtima, imalepheretsa mawonekedwe a angiopathy (kuwonongeka kwa mitsempha ndi mitsempha ya shuga).
Pharmacokinetics
Pambuyo pakukonzekera kwa piritsi, kuchuluka kwa dimethylbiguanide kumachitika pambuyo pa maola 2,5. Maola 6 atagwiritsidwa ntchito yamkati, njira yoyamwa kuchokera m'matumbo am'mimba inatha, ndipo pambuyo pake panali kuchepa kwapang'onopang'ono mu kuchuluka kwa Metformin m'madzi a m'magazi.
Kulandila mu Mlingo wothandizirana kumathandizira kusungunuka kwa mankhwalawa mu plasma mkati mwa 1-2 μg mu 1 lita.
Kugwiritsa ntchito mankhwalawa ndi chakudya kumachepetsa kuyamwa kwa yogwira plasma. Kukopa kwa mankhwalawa kumachitika m'matumbo, m'mimba, m'mimba mwake. The bioavailability wa mankhwala mpaka 60%. Mapuloteni a Plasma samamanga mokwanira.
Amayamwa ndi impso ndi 30% osasinthika. Kuchuluka kwa piritsi kumachotsedwa ndi chiwindi.
Kulandila mu Mlingo wothandizirana kumathandizira kusungunuka kwa mankhwalawa mu plasma mkati mwa 1-2 μg mu 1 lita.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amalembera mtundu wa 1 kapena matenda ashuga 2. Ndikuphatikizira kwa chithandizo chachikulu cha matenda ashuga (pogwiritsa ntchito mankhwala a insulin kapena shuga). Pankhani ya shuga wodalira insulin, amangoyikidwa limodzi ndi insulin. Mtundu wachiwiri wa matenda ashuga, monotherapy akhoza kutumikiridwa.
Ndikulimbikitsidwanso chithandizo cha kunenepa kwambiri, makamaka ngati matenda amtunduwu amafunikira kuwunika kwamtundu wamagazi.
Contraindication
Ogwirizana zotsatirazi:
- wodwala mpaka zaka 15;
- Hypersensitivity kuti metformin ndi gawo lina lililonse la mapiritsi;
- chikhazikitso;
- kukanika kwa aimpso ndi kulephera (komwe kunayankhidwa ndi creatinine chilolezo);
- ketoacidosis;
- minofu necrosis;
- kuchepa thupi chifukwa chakusanza kapena kutsekula m'mimba;
- matenda ashuga a m'mitsempha;
- matenda opatsirana opatsirana;
- mantha wodwala;
- kugunda kwamtima kwambiri;
- kuperewera kwa adrenal;
- chakudya chopatsa mphamvu m'munsimu 1000 kcal;
- kulephera kwa chiwindi;
- lactic acidosis (kuphatikiza ndi mu anamnesis);
- kusiya mowa;
- pachimake ndi matenda opatsirana omwe amayambitsa kufa kwa minofu ya mpweya mwa anthu;
- malungo
- kuvulala kwakukulu, kulowererapo kwa opaleshoni, nthawi ya postoperative;
- kugwiritsa ntchito mitundu iliyonse ya zinthu za radiopaque zokhala ndi ayodini;
- kuledzera pachimake ndi Mowa;
- mimba
- kuyamwa.
Odwala omwe ali ndi chidakwa samaloledwa kutenga Metformin 500.
Ndi chisamaliro
Chenjezo liyenera kuchitika mukamamwa zinthu zochepetsa shuga poyerekeza ndi vuto lomwe lingachitike. Odwala ayenera kutsatira malamulo azakudya zopatsa thanzi, kutsatira zakudya zomwe zimagwiritsidwa ntchito tsiku lonse. Ndi kuchuluka kwamphamvu kwa thupi, kuchuluka kochepa kuyenera kugwiritsidwa ntchito.
Momwe mungatenge Metformin 500
Mapiritsi amatengedwa pakamwa, popanda kutafuna, ndimadzi ambiri. Ngati wodwala akuvutika kumeza, ndiye kuti amaloledwa kugawanitsa piritsi mu magawo awiri. Komanso, theka lachiwiri la piritsi liyenera kuledzera nthawi yoyamba yoyamba.
Asanadye kapena pambuyo chakudya
Phwando limachitika pokhapokha chakudya.
Kumwa mankhwala a shuga
Mu matenda a shuga, mlingo woyamba umafotokozedwa m'mapiritsi awiri a 500 mg. Sizingagawidwe mu 2 kapena 3 Mlingo: izi zimathandizira kufooketsa kukula kwa mavuto. Pambuyo pa masabata awiri, kuchuluka kumakhala kosangalatsa - mapiritsi atatu a 0,5 g aliyense. Mulingo wambiri wa metformin tsiku lililonse ndi 3 g.
Metformin 500 imangotengedwa mukatha kudya.
Pankhani yogwiritsira ntchito Metformin ndi insulin, mlingo wake sasintha. Pambuyo pake, kuchepa kwina kwa kuchuluka kwa insulin yomwe imatengedwa kumachitika. Ngati wodwala amadya zoposa 40 mayunitsi. insulin, ndiye kuchepa kwa kuchuluka kwake ndizovomerezeka pokhapokha kuchipatala.
Momwe mungatengere kuti muchepetse kunenepa
Kuti muchepetse kunenepa, mankhwalawa amayatsidwa 0,5 g 2 pa tsiku, onetsetsani kuti mwadya. Ngati kuchepa kwa thupi sikokwanira, ndiye kuti mukumwedwa mlingo wina wa 0,5 G. Nthawi yayitali ya mankhwalawa sayenera kupitilira masabata atatu. Sukulu yotsatira iyenera kuzibwereza kokha mwezi umodzi.
Pokonza kuchepa thupi muyenera kuchita masewera.
Nthawi yopumula
Hafu ya moyo wa dimethylbiguanide ndi maola 6.5.
Zotsatira zoyipa za Metformin 500
Kukula kwa mavuto kumachitika nthawi zambiri.
Matumbo
Zotsatira zake zoyipa ndizambiri: nseru, kusanza, kutsegula m'mimba, kuchepa kwakudya, kupweteka m'mimba ndi matumbo. Nthawi zambiri odwala amatha kumva kutsekemera kwachitsulo mkamwa.
Zotsatira zoyipa kwambiri ndiz kupweteka pamimba ndi matumbo.
Zizindikirozi zimangowoneka kumayambiriro kogwiritsa ntchito mankhwalawo kenako ndikuzimiririka. Chithandizo chapadera sichofunikira kuti muchepetse zizindikirozi.
Kuchokera kumbali ya kagayidwe
Ndikosowa kwambiri kuti wodwala apange lactic acidosis. Vutoli likufunika kuthetsedwa.
Pa khungu
Ngati hypersensitivity odwala, zimachitika khungu mu mawonekedwe a redness wa khungu ndi kuyabwa kungachitike.
Dongosolo la Endocrine
Nthawi zambiri, odwala omwe ali ndi vuto la chithokomiro kapena adrenal gland amagwira ntchito amatha kuwonedwa.
Matupi omaliza
Thupi lawo siligwirizana zimachitika pokhapokha ngati munthu akumva chidwi kwambiri ndi phula. Munthu amatha kupanga: erythema, kuyabwa, khungu rede ndi mtundu wa urticaria.
Ngati hypersensitivity odwala, zimachitika khungu mu mawonekedwe a redness wa khungu ndi kuyabwa kungachitike.
Zokhudza mphamvu pakuwongolera njira
Palibe zoyipa pakutha kuyendetsa magwiridwe antchito ndi kuyendetsa galimoto. Kusamala kwakukulu kuyenera kugwiritsidwa ntchito popereka Metformin limodzi ndi mankhwala ena ochepetsa shuga, chifukwa amatha kuchepetsa kwambiri shuga. Kuyendetsa pamenepa sikuti ndikulimbikitsidwa kuti mupewe ngozi.
Malangizo apadera
Kugwiritsa ntchito mankhwalawa kumalumikizidwa ndi mawonekedwe ena. Chenjezo liyenera kuchitika pakukhudza kulephera kwa mtima, kuperewera kwaimpso, komanso chiwindi. Mankhwala, amafunika kuwunika glucometer.
Mankhwalawa adathetsedwa masiku awiri m'mbuyomu komanso masiku awiri atatha fluoroscopy pogwiritsa ntchito ma radiopaque othandizira. Zomwezi ziyenera kuchitika pamene wodwala wayika opaleshoni yopanga opaleshoni wamba kapena yam'nyumba.
Ndi chitukuko cha matenda amkodzo ndi ziwalo, muyenera kufunsa dokotala.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Sizoletsedwa kutenga mwana ndikamamuyamwitsa.
Kupangira Metformin kwa ana 500
Kwa ana ochepera zaka 15, mankhwalawa saikidwa.
Gwiritsani ntchito mu ukalamba
Kwa anthu achikulire, kusintha kwa mankhwalawa ndikofunikira. Sindikulimbikitsidwa kuti odwala atenge mankhwala oyenera. Malingaliro othandizira othandizira ayenera kugwiritsidwa ntchito kuchepetsa mavuto. Nthawi zina zotchulidwa Metformin 400.
The ntchito aimpso kuwonongeka
Ngati vuto la impso, mankhwalawa ayenera kugwiritsidwa ntchito mosamala. Ngati matenda ashuga a nephropathy ayamba, ndiye kuti mankhwalawo amathetsedwa, chifukwa kugwiritsa ntchito kwake kumayambitsa kuwonongeka kwa impso. Chimodzi mwa zolinga zakuchiritsa matenda a shuga ndikuletsa kukula kwa vuto la impso ndi kuwonongeka kwa khungu.
Pazovuta za impso, mankhwalawa amayenera kugwiritsidwa ntchito mosamala, ngati matenda a shuga apezeka, ndiye kuti mankhwalawo amatha.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi zovuta za chiwindi, mankhwalawa aledzera mosamala. Osiyanasiyana kuwonongeka kwa chiwindi minofu amathandizira kusintha kagayidwe. Zizindikiro za Creatinine clearance ndi magawo ena a biochemical ayenera kuyang'aniridwa mosamala.
Mankhwala ochulukirapo a Metformin 500
Mankhwala osokoneza bongo amatha kuyambitsa lactic acidosis, koma osayamba hypoglycemia. Zizindikiro za lactic acidosis:
- kusanza
- kutsegula m'mimba
- kusasangalala m'mimba;
- kuchuluka kwambiri kutentha;
- kupweteka kwa minofu
- kupweteka m'mimba.
Pakakhala chisamaliro chamankhwala panthawiyi chizungulire, chizungulire chimayamba. Mtsogolomo, chikomokere chimachitika.
Gwiritsani ntchito kutha ndi chitukuko cha acidosis. Wodwalayo amalizidwa kuchipatala mwachangu. Njira yothandiza kwambiri yochotsera thupi ndi hemodialysis.
Pakakhala chithandizo chamankhwala osokoneza bongo, chizungulire, chizungulire chimayamba.
Kuchita ndi mankhwala ena
Chisamaliro chiyenera kuthandizidwa pakakhala munthawi yomweyo sulfonyl-urea ndi insulin. Pali chiopsezo chachikulu cha kutsika kwamphamvu kwa shuga mumagazi. Hypoglycemic zotsatira za biguanides zimachepetsedwa ndi mankhwala otsatirawa:
- glucocorticosteroid wothandizila zochitika zonse ndi wamba;
- sympathomimetic zinthu;
- glucagon;
- kukonzekera kwa adrenaline;
- progestogens ndi estrogens;
- Kukonzekera kwa zinthu zotulutsidwa ndi chithokomiro;
- mankhwala a nikotini acid;
- thiazide okodzetsa;
- phenothiazines;
- Cimetidine.
Sinthani zotsatira za hypoglycemic:
- ACE zoletsa;
- beta-2 adrenergic antagonists;
- Mao zoletsa;
- Cyclophosphamide ndi mawonekedwe ake;
- onse omwe si a steroidal PVP;
- Oxytetracycline.
Chisamaliro chiyenera kuthandizidwa pakakhala munthawi yomweyo sulfonyl-urea ndi insulin.
Kutenga mankhwala okhala ndi ayodini m'maphunziro a X-ray amasintha kagayidwe ka Metformin, ndichifukwa chake imayamba kuwonetsa. Amatha kuyambitsa matenda a impso.
Chlorpromazine ikuletsa kutulutsa insulin. Izi zingafune kuwonjezeka kwa metformin.
Kudya kwa Biguanides kumawonjezera kuchuluka kwa Amilorid, Quinine, Vancomycin, Quinidine, Cimetidine, Triamteren, Ranitidine, Procainamide, Nifedipine.
Kuyenderana ndi mowa
Mowa umawonjezera chiopsezo cha lactic acidosis. Pa chithandizo, muyenera kupewa zakumwa zoledzeretsa ndi mankhwala onse okhala ndi ethanol ndi zinthu, chifukwa alibe mgwirizano ndi Metformin.
Analogi
Ma Analogs ndi:
- Fomu;
- Glucophage;
- Siofor;
- Metformin Siofor;
- Metformin Kutalika;
- Metformin Canon;
- Metformin Zentiva;
- Bagomet;
- Metfogamm;
- Langerine;
- Glycomet.
Formmetin imatha kukhala ngati fanizo la mankhwala a Metformin 500.
Kupita kwina mankhwala
Dokotala amafunikira kulandira. Dzinalo liyenera kulembedwa m'Chilatini.
Kodi ndingagule popanda kulandira mankhwala?
Sizoletsedwa kugulitsa mankhwalawo mu mankhwala popanda mankhwala.
Kudzipatsa tokha kungasinthe kwambiri mkhalidwe wa munthu ndikuyambitsa matenda oopsa a hypoglycemia.
Mtengo wa Metformin 500
Mtengo wa mankhwalawa ku Russia ndi pafupifupi ma ruble 155. pa paketi 60 yamapiritsi.
Zosungidwa zamankhwala
Ziyenera kusungidwa m'chipinda chouma m'malo owuma.
Tsiku lotha ntchito
Mankhwalawa ndi oyenera kugwiritsidwa ntchito kwa zaka zitatu.
Wopanga
Mankhwalawa amapangidwa m'mabizinesi a Indoco remixies ltd, L-14, Verna Industrial Area, Verna, Salcete, Goa - 403 722, India, Teva Pharmaceutical Enterprises Ltd. Ku Russia, munthu akhoza kupeza mankhwala opangidwa ku Gedeon Richter bizinesi.
Ndemanga za Metformin 500
Pa intaneti mutha kuwerengera za akatswiri ndi odwala omwe adamwa mankhwalawa.
Madokotala
Irina, wazaka 50, endocrinologist, ku Moscow: "Metformin ndi ofanana - Glucofage ndi Siofor - amathandizira kuwongolera moyenera matendawa ndikuchepetsa kuchuluka kwa shuga. Mankhwalawa amaloledwa bwino ndi odwala, pokhapokha nthawi zambiri pomwe chiwonetsero cha m'mimba chinayamba m'masiku oyamba a chithandizo. Mlingo wokhazikitsidwa moyenera umachepetsa kufunikira kwa matenda a shuga. "
Svetlana, wazaka 52, wodwala matenda am'madzi, a smolensk: "Ntchito yothandizira odwala matenda ashuga ndikusungabe kuchuluka kwa shuga mkati mwa nthawi zonse komanso kupewa kuteteza zovuta zowopsa. Metformin imagwirizana bwino ndi ntchitozi. Odwala omwe amamwa mankhwalawa, index ya glycemic ili pafupi kwambiri."
Odwala
Anatoly, wazaka 50, St. Petersburg: "Metformin inathandizira kupewa kuyambika kwa hyperglycemia. Shuga tsopano samachulukanso kuposa 8 mmol / L. Ndikumva bwino. Ndimatenga Metformin 1000 molingana ndi malangizo."
Irina, wazaka 48, Penza: "Kumwa mankhwalawa, kunachepetsa kumwa kwa insulin.Zinali zotheka kusunga zisonyezo za glycemia mkati mwa malire omwe adokotala adawalimbikitsa. Mapiritsiwa atatha, kupweteka kwa minofu kunatha, ndipo kuona kunasintha. "
Kuchepetsa thupi
Olga, wazaka 28, Ryazan: "Mothandizidwa ndi Metformin 850, zinali zotheka kuchepetsa kulemera ndi makilogalamu 8 pophatikiza ndi zakudya zama calorie ochepa komanso thupi lochepera. Ndikumva bwino, sindimva chizungulire kapena kukomoka. Pambuyo pa chithandizo ndimayesetsa kutsatira zakudya kuchokera kunenepa kwambiri."
