Angioflux 600 imawonetsa antithrombotic, angioprotective ndi anticoagulant zotsatira. Dzinali likuwonetsa kuchuluka kwa wogwira ntchito - 600 PISCES. Mankhwala amadziwika ndi chilengedwe ponseponse - amagwiritsidwa ntchito matenda osiyanasiyana limodzi ndi kuwonjezeka kwa mamasukidwe amwazi, kuchuluka kwa thrombosis.
ATX
B01AB11.
Angioflux 600 imagwiritsidwa ntchito pamatenda osiyanasiyana omwe amaphatikizidwa ndi kuchuluka kwamitsempha yamagazi, thrombosis wambiri.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amaperekedwa m'njira ziwiri: makapisozi ndi yankho la jakisoni wamkati ndi mtsempha. Amasiyana muyezo wa zomwe zimagwira, zomwe ndi sulodexide. Mankhwala mu mawonekedwe amadzimadzi amapezeka mu ampoules a 2 ml. Kuphatikizika kwa sulodexide pamenepa ndi magawo 600. Poyerekeza, 1 kapisozi muli magawo 250 a zinthu. Zomwe zili mu yankho limaphatikizapo zigawo zothandiza:
- sodium kolorayidi;
- madzi a jakisoni.
Mutha kugula mankhwalawa monga njira yankho mumapaketi a 5 ndi 10 ampoules.
Zotsatira za pharmacological
Chipangizocho chikuimira anticoagulants ogwirira ntchito mwachindunji. Ntchito yayikulu ya Angioflux ndi kuthekera kolimbikitsa mphamvu yamagazi. Mothandizidwa ndi iye, kuchepa kwamphamvu kwa mapangidwe a magazi kumadziwika. Izi zimachitika chifukwa cha kuchepa kwa magazi m'maso.
Mphamvu ya antithrombotic imaperekedwa chifukwa cha zochita za zigawo za sulodexide. Chifukwa chake, ili ndi kachigawo kakang'ono ngati heparin kogwira ntchito mwachangu. Mphamvu yogwira ya Angioflux ndi 80% yopangidwa ndi chinthuchi. Kuphatikiza apo, sulodexide imakhala ndi 20% dermatan sulfate, yomwe ili pafupi ndi heparin cofactor mu katundu.
Chifukwa cha kukhalapo kwa zigawozi, zotsatira za profibrinolytic zimaperekedwanso. Zotsatira zake, sikuti magazi amachepetsa magazi okha, komanso kuthekera kwa mankhwalawa kuti awononge mapangidwe omwe amapangika kale kumadziwikanso. Chifukwa cha malowa, mankhwalawa amatha kugwiritsidwa ntchito pa gawo lililonse la chitukuko cha matenda omwe amaphatikizidwa ndi kwambiri thrombosis kapena kuwonjezeka kwamitsempha yamagazi.
Mothandizidwa ndi Angioflux, pali kuchepa kwamphamvu kwa dongosolo la magazi kupanga.
Kuphwanya mapangidwe magazi kuundana chifukwa chopinga cha adayambitsa Xa ndi Pa zinthu zomwe zimakhudza magazi. Zifukwa zina: kuchulukitsa kwa kupanga komanso kutulutsa kwa prostacyclin, komanso kuchepa kwa zinthu za plasma fibrinogen. Katundu wina (profibrinolytic) amawonekera chifukwa cha kuletsa kwa ntchito ya zoletsa za minofu ya plasminogen activator. Nthawi yomweyo, mlingo wa minofu wa plasminogen activate ukuwonjezeka.
Chifukwa cha njirazi, mosemphana ndi limagwirira, magazi amaphatikizika. Chuma china cha mankhwalawa (angioprotective) chimawonetsedwa chifukwa chodziwikirana ndi maselo amkati mwamitsempha yamagazi. Pa nthawi yomweyo, kusintha kwamunthu kumadziwika kuti: kukhulupirika kumabwezeretsedwa, kupweteka kwa pore kwamphamvu yamagetsi yam'mimba ya basement imakhala yofanana. Zotsatira zake, kuvomerezedwa kumachepetsedwa, chifukwa chomwe zotsatira zabwino komanso zoperewera za analgesic zimaperekedwa. Kuphatikiza apo, microcirculation imakhala yofanana.
Pamodzi ndi zotsatirazi, kubwezeretsa magazi kumadziwika. Chifukwa chake, ndende ya triglycerides imakhala yofanana. Izi ndi zida zopanga ma membrane am'magazi, amazindikiranso ntchito yamphamvu. Kuwonjezeka kwa kuponderezedwa kwawo kumachitika chifukwa cha kukondoweza kwa enzyme yomwe imakhudzidwa ndi lipolysis. Ntchito yake yayikulu ndikuyambitsa kupanga kwa triglyceride. Kuphatikiza apo, kutsika kwapang'onopang'ono pakukula kwa maselo a mesangium kumadziwika. Komabe, makulidwe amtundu wapansi amachepa.
Mukamagwiritsa ntchito yankho la jakisoni, kuthekera kwa kuwonongeka kwa zigawo zokhala ngati heparin sikumayikidwa.
Pharmacokinetics
Makhalidwe abwino a mankhwalawa amaphatikiza kufalikira kokwanira m'thupi lonse. Ambiri (90%) a mankhwalawa amakwiridwa ndi makhoma amkati a ziwiya. Chifukwa cha kuyambitsa yankho intramuscularly kapena kudzera m'mitsempha, ntchito yapamwamba ya chinthu chachikulu cha Angioflux imafikiridwa mphindi 15 pambuyo pa jekeseni, nthawi zina kale - pambuyo pa mphindi 5. Kuchuluka kwa mayamwidwe ndikugawa kwa mankhwalawa zimatengera momwe thupi liliri, gawo la matendawa komanso kuchuluka kwa magazi panthawi ya mankhwalawa.
Mukamagwiritsa ntchito yankho la jakisoni, kuthekera kwa kuwonongeka kwa zigawo zokhala ngati heparin sikumayikidwa. Zoyipa izi zimapezeka mu heparin yotsika kwambiri. Zotsatira zake, kuchuluka kwa anticoagulant zochita kumachepa. Chiwindi ndi impso zimagwira nawo gawo la kusintha ndikutulutsa sodeodeide m'thupi.
Kuchulukitsa kwa chinthu chachikulu ndikokwera: njirayi imayamba pambuyo pa jakisoni maola 4. Kuchuluka kwina kwa sulodexide kumachotsedwa tsiku loyamba, gawo lotsalira patsiku lachiwiri.
Zizindikiro zogwiritsidwa ntchito
Zochitika m'masiku omwe Angioflux angagwiritsidwe ntchito:
- matenda osiyanasiyana limodzi ndi kuwonjezeka kwa thrombosis, kuchuluka kwamitsempha yamagazi, kusintha kwazinthu zake zamatsenga;
- kuchepa kwa minyewa yam'mimba, yomwe imayambitsa kupsinjika kwa miyendo;
- ma pathologies okuta ziwalo zam'mimba za retina zamankhwala am'maso (retinopathy) osiyanasiyana etiologies;
- ngozi yamitsempha;
- encephalopathy;
- njira zowonongeka m'matumbo amitsempha yamagazi;
- atherosulinotic mtima matenda;
- aimpso kuwonongeka, kuwonetseredwa kuwonongeka kwa mafupa a chiuno ndi ma glomerular zida (nephropathy), zomwe zimayambitsa zifukwa zosiyanasiyana;
- matenda ashuga nephropathy, retinopathy, komanso matenda a shuga.
Contraindication
Mankhwala sagwiritsidwa ntchito ngati:
- diathesis yotsatana ndi kukha magazi, komwe kumawonetsedwa ndi kumasulidwa kwa magazi kudzera m'makoma amitsempha yamagazi;
- zilizonse zamatenda zomwe hypocoagulation imayamba;
- Zotsatira zoyipa za Angioflux;
- hypersensitivity heparin, chifukwa yogwira pophika mankhwala amakhala ndi ofanana maselo dongosolo;
- chizolowezi cha thupi kutaya magazi, chifukwa mankhwala amatha kukhudza magazi.
Zokhudza contraindication zimadziwikanso. Pankhaniyi, mankhwalawa amaloledwa kugwiritsidwa ntchito, koma moyang'aniridwa ndi dokotala. Chifukwa chake, Angioflux angagwiritsidwe ntchito ngati vuto lopanda mchere limalimbikitsidwa kwa wodwala, koma mosamala. Izi ndichifukwa choti mapangidwe a chida ichi akuphatikizanso ndi sodium.
Momwe angatenge
Kuchuluka kwa masiku onse a Angioflux 600 mwa njira yothetsera vutoli ndi 2 ml, yomwe ikufanana ndi zomwe zili mum'mapapo ambiri. Mankhwalawa amatha kuperekedwa kudzera m'mitsempha yayikulu: kuti mulingo wambiri uthandizidwe nthawi yomweyo, mankhwala a sodexide amaperekedwa m'magazi pang'onopang'ono, omwe amapewa kuwoneka pamavuto angapo. Kuphatikiza apo, yankho limagwiritsidwa ntchito intramuscularly. Malangizo ogwiritsira ntchito:
- ngati akukonzekera kuperekera Angioflux ndi dontho, zomwe zili m'mapulogalamuwa zimaphatikizidwa ndi yankho la 0.9% sodium chloride muyeso: 2 ml ya mankhwala pa 150-200 ml ya NaCl;
- Mankhwala nthawi zambiri amayamba ndi kholo makonzedwe a mankhwala, pambuyo masabata 2-3 tikulimbikitsidwa kusinthira kwa makapisozi (1 pc. 2 kawiri pa tsiku), njira ya utsogoleri pamenepa kumatenga masiku 30-40.
Mankhwalawa amagwiritsidwa ntchito kawiri pachaka. Kuchulukana kwa kuchuluka kwa mankhwalawa, komanso nthawi yayitali ya chithandizo, nthawi zambiri zimatsimikiziridwa payekhapayekha, zomwe zimatha kukhudzidwa ndi momwe wodwalayo alili, zotsatira za kuyezetsa magazi, komanso kupezeka kwa ma pathologies ena.
Kumwa mankhwala a shuga
Poganizira kuti pakati pa zomwe zikugwiritsidwa ntchito ndi mankhwalawa, matendawa amadziwikanso, palibe chifukwa chowerengera. Odwala omwe ali ndi matenda opatsirana a shuga amapatsidwa mtundu wanthawi zonse, koma ngati zinthu zovuta zikuchitika, maphunzirowo akhoza kusokonezedwa. Pankhaniyi, nthawi yamankhwala imatsimikiziridwa payekhapayekha, popeza ma pathologies ena amapezeka nthawi zambiri omwe amathandizira kufupikitsa / kukulitsa nthawi yayitali ya chithandizo.
Zotsatira zoyipa
Mawonetsero olakwika otsatirawa adadziwika:
- kupweteka m'dera la singano pa jekeseni;
- kumverera koyaka, hematoma pamalo opumira.
Matumbo
Pambuyo pakusintha kwa makulidwe a makasitomala kupita pakamwa, kuwoneka kupweteka m'mimba, nseru ndi kusanza kumachitika.
Matupi omaliza
Mukamagwiritsa ntchito mankhwalawa (mu mtundu uliwonse wa mankhwalawa), matupi awo amatha kuyambika, zizindikiro zake ndi: zotupa, kutupa, kuyabwa, khungu redness.
Malangizo apadera
Chipangizocho sichimakhudzanso kuyendetsa galimoto, chifukwa sichimayambitsa vuto la ziwalo zofunika (zamkati pamtima, chapakati chamanjenje, ziwalo zamawonedwe ndi kumva, kupuma kwamphamvu).
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amatha kuikidwa mu 2nd ndi 3 trimesters. Chenjezo liyenera kuchitidwa panthawi ya mankhwala. M'miyezi itatu yoyambirira ya mimba, Angioflux sagwiritsidwa ntchito.
Zambiri pazokhudzana ndi mankhwalawa mthupi la mwana nthawi yoyamwitsa sizokwanira, chifukwa mankhwalawa ayenera kugwiritsidwa ntchito mosamala.
Gwiritsani ntchito mu ukalamba
Mankhwalawa adapangidwa, chifukwa odwala a gululi nthawi zambiri amapezeka ndi matenda amitsempha, kuphatikizapo omwe amathandizidwa ndi kuchepa kwa minyewa yachilengedwe. Kuchulukitsa kwa mankhwalawa sikofunikira ngati palibe kuwonetsa koipa pamankhwala.
Mlingo wa Angioflux kwa ana 600
Mankhwalawa sagwiritsidwa ntchito, chifukwa palibe chidziwitso chokwanira chokhudza momwe odwala amsinkhu uno alili.
Bongo
Ngati kuchuluka kwa sulodexide kumachulukirachulukira, kuchuluka kwake kwa plasma kumawonjezeka, chifukwa theka la moyo wa chinthuchi ndi masiku 1-2. Mankhwala osokoneza bongo amayamba kutuluka magazi. Pankhaniyi, nthawi yomweyo musokoneze njira ya mankhwalawa komanso kuchitira monga othandizira.
Kuchita ndi mankhwala ena
Angioflux imawonjezera mphamvu ya mankhwala ambiri: anticoagulants, ma antiplatelet othandizira, heparin. Ndi munthawi yomweyo makonzedwe, mlingo recalculation nthawi zina amafunikira, ndi ulamuliro wamagazi amafunikanso.
Angioflux sangathe kugwiritsidwa ntchito limodzi ndi ma hemostatic othandizira. Pankhaniyi, zotsutsana zimatheka.
Mankhwala ambiri (mankhwala antiviral, maantibayotiki, ndi ena otero) samawakhudza mankhwalawo.
Analogs a Angioflux 600
Ngati chifukwa cha hypersensitivity sikutheka kugwiritsa ntchito mankhwalawa, m'malo ena mumagwiritsidwa ntchito:
- Wessel Douai F;
- Clexane;
- Fraxiparin;
- Fragmin.
Yoyamba mwa zosankhazi ndi analogue yachindunji ya Angioflux, chifukwa ndiwofanana mu kapangidwe ndi mawonekedwe a kumasulidwa. Amadziwika ndi zomwezi ndimapangidwe ake, motero mutha kugwiritsa ntchito izi osanenanso muyeso.
Clexane imakhala ndi sodium ya enoxaparin yosiyanasiyana mosiyanasiyana monga chinthu chogwira ntchito. Itha kugulidwa ngati mawonekedwe a jakisoni. Mankhwala ndi a gulu la mankhwalawa potengera mphamvu yochepa ya heparin.
Fraxiparin ili ndi calcium nadroparin. Iyi ndi heparin yotsika kwambiri. Njira za gululi ndizotsika pang'ono ku Angioflux pogwira ntchito, chifukwa amasunga katundu kwakanthawi kochepa.
Fragmin ndiwotsogolera. Muli dalteparin sodium. Pankhani ya mtengo komanso kugwira ntchito kwake, mankhwalawa ndi ofanana ndi Angioflux, koma amasiyanitsidwa ndi kuchuluka kwa ma contraindication ndi zotsatira zoyipa.
Kupita kwina mankhwala
Kodi ndingagule popanda kulandira mankhwala?
Mankhwala omwe mumalandira.
Mtengo
Mtengo wapakati ndi ma ruble 1720.
Malo osungirako a Angioflux 600
Kufikira kwa ana kwa mankhwalawa kuyenera kutsekedwa. Zosungirako: kutentha kwa mpweya - mpaka + 30 ° ะก.
Tsiku lotha ntchito
Mankhwalawa amasunga katundu wawo kwa zaka zitatu kuyambira tsiku lomwe amatulutsa.
Ndemanga za Angioflux 600
Madokotala
Veremeev I. L., wothandizira, wazaka 39, Krasnoyarsk
Chidacho chimapereka kuyendetsa bwino kwambiri. Pokayikira kocheperako kuti mwayamba kutaya magazi, ndibwino osagwiritsa ntchito. Ndikupangira ndikuwonjezera magazi.
Amirov O. O., wazachipatala, wazaka 45, St. Petersburg
Imafulumira kukhala yamitsempha yamagazi. Matenda a gynecology komanso nthawi ya pakati, sindingavomerezenso kuti mugwiritse ntchito - pali kuthekera kwakukulu kwa magazi a chiberekero.
Odwala
Galina, wazaka 38, Perm
Poyamba ndimaganiza kuti mavitamini komanso zakudya zina zofunika zimapangidwa kuti magazi akhale ofanana, koma atapita kukaonana ndi adotolo chifukwa chakuwoneka bwino, funso ili lidadziwika kuti: mankhwala apadera amakhudzanso magazi. Zowonda, zimalepheretsa kuwoneka kwa magazi. Poganiza kuti ndinapezeka kuti ndili ndi vuto la mtima (ndi thrombosis), sindingathe popanda Angioflux tsopano. Ndimatenga maphunziro kawiri pachaka. Ngakhale zovuta sizinakhalepo, matendawa amatha kukhala abwinobwino.
Anna, wazaka 42, Belgorod
Chida chabwino, koma chodula. Pachifukwa ichi, ndidapempha adotolo kuti atole analogue. Ndapeza zotupa za ziwiya za khosi chifukwa cha osteochondrosis. Izi zikutanthauza kuti nthawi ndi nthawi mumayenera kulandira chithandizo chamankhwala omwe amakonzanso magazi kupita ku ubongo. Othandizira kupatulira magazi ndizofunikiranso, chifukwa mamvekedwe amwazi amawonjezeka pang'ono. Kudya pafupipafupi mankhwala osokoneza bongo sikokwanira kwa ine.
