Kuthamanga kwa magazi, kupangitsa matenda oopsa, kumakhudza anthu 20-30%. Ziwerengerozi zimatha kukwera mpaka 70% ndi kukula msinkhu. Mankhwala Lozap ndi Concor ali m'magulu osiyanasiyana a pharmacological, koma nthawi zambiri amadziwikanso pamodzi kuti achepetse kuthamanga kwa magazi ndikusunga zochitika za mtima. Kuphatikizikako kumapereka zotsatira zoyenera pamavuto amtima, kumapangitsa kuti ischemic isokonekere komanso kugunda kwa mtima.
Khalidwe Lozap
Mankhwalawa amachokera ku gulu la pharmacological la angiotensin II receptor blockers ndi okodzetsa. Kusankhidwa kwake koyamba ndikuchotsa matenda oopsa. Chofunikira pa Lozap ndi losartan potaziyamu:
- relieves zotumphukira mtima;
- amayang'anira kukakamiza;
- amathandizira diuretic zotsatira;
- Imachepetsa ntchito ya adrenaline ndi aldosterone, yowonjezera pamodzi ndi madzi;
- amachepetsa katundu pa myocardium, amalepheretsa hypertrophy yake.
Lozap ndi mankhwala ochizira matenda oopsa.
Zotsatira zabwino zokhazikika pakukhazikika kwa mankhwalawa zimawonedwa pambuyo pa masabata 2-6, ndipo zochizira zimakhalapo kwanthawi yayitali ngakhale kumapeto kwa maphunzirowo. Kamodzi m'matumbo am'mimba, ziwalo za Lozap zimatha kutengeka mosavuta, zimapangidwa m'maselo a chiwindi, zotulutsidwa m'matumbo (mu voliyumu yayikulu) komanso mkodzo. Gawo lochita ntchito silidutsa mu mawonekedwe a ubongo-wamagazi kuchokera m'magazi kupita ku minyewa yaubongo, kuteteza maselo awo azinsinsi kuti asatenge poizoni ndi zinthu zotayidwa.
Lozap imapangidwa m'mapiritsi (12,5, 50 ndi 100 mg aliyense), imayikidwa nthawi imodzi patsiku, mosasamala kanthu za kudya.
Malondawa akuphatikiza, kuwonjezera pa potaziyamu wa losartan:
- silicon dioxide (sorbent);
- cellulose (fiber fiber);
- crospovidone (chosungunulira chomwe chimagwiritsa ntchito bwino kutulutsa zomwe zimagwira piritsi);
- magnesium stearate (emulsifier);
- hypromellose (plasticizer);
- macrogol (mankhwala ofewetsa thukuta);
- titanium dioxide (utoto woyera chakudya, zowonjezera E171);
- mannitol (diuretic);
- talcum ufa.
Mankhwala wolembedwa:
- Kuchepetsa kupanikizika ndikupatula mavuto a mtima;
- mu zovuta chithandizo cha matenda osachiritsika myocardial;
- ndi nephropathy (matenda ashuga);
- ndi kumanzere kwamitsempha yamagazi.
Zoyipa:
- Kuchepetsa ziwiya za aimpso (stenosis);
- tsankho kwa zigawo zikuluzikulu;
- mimba ndi mkaka wa m`mawere;
- wazaka 18.
Mukazindikira kukanika kwa hepatic ndi aimpso, chithandizo chimayang'aniridwa ndi dokotala, ndikuyamba kumwa mapiritsi okhala ndi waukulu. Asanakhazikitsidwe kwa Lozap, zizindikiritso zamagetsi amagetsi am'madzi zimasinthidwa. Pa mankhwala, tikulimbikitsidwa kuyang'ana zomwe zili K (potaziyamu) m'thupi la odwala okalamba.
Mbali Yabwino
Mankhwalawa ndi am'gulu lachipatala la osankha beta1-blockers omwe amathandizanso kukula kwa minofu ya mtima (inotropic athari). Chosakaniza chopangira cha Concor ndi bisoprolol fumarate:
- amachepetsa ntchito ya sypatadrenal system yomwe imayendetsa kufalitsa kwa kukhudzidwa kwa mitsempha mu hypothalamus;
- imaletsa mtima adrenoreceptors omwe amamanga adrenaline, norepinephrine, catecholamines, amawongolera zochitika zawo za pharmacological ndi zokhudza thupi;
- imatenga nawo gawo pobisalira ndi kagayidwe kachakudya.
Concor - mankhwala omwe ali ndi mphamvu pa kukula kwa minofu ya mtima.
Kuchuluka kwa mankhwalawa kumatsimikiziridwa mu minofu itatha maola atatu, njira yothandizira achire imasungidwa tsiku lonse. Pambuyo polowa m'matumbo am'mimba, bisoprolol imatengedwa ndi ma cell oposa 90% ndipo imagawidwa kwa ziwalo zonse ndi minyewa. Amayamwa osasinthika mumkodzo patatha maola 11-14. Kutsika kwamphamvu kwa kuthamanga kwa magazi kumawonedwa pambuyo pa mwezi umodzi wakudya. Mukamagwiritsa ntchito piritsi limodzi lokha patsiku, odwala amati:
- kuchepa kwa zotumphukira mtima kukana;
- Kuchotsa kwa kuchuluka kwa ntchito ya polypeptide renin (mahomoni amomwe amayambitsa vasoconstrictor element angiotensin);
- matenda a mtima;
- kubwezeretsa magazi.
Mapiritsi a Concor, kuwonjezera pa chinthu chachikulu (bisoprolol fumarate), akuphatikiza:
- silika;
- cellulose;
- crospovidone;
- magnesium wakuba;
- hypromellose;
- macrogol;
- titanium dioxide;
- iron oxide (utoto wachikasu, chakudya chowonjezera cha E172);
- dimethicone (mafuta a silicone);
- calcium hydrogen phosphate (gwero la Ca);
- kukhuthala.
Concor imalembedwa ngati prophylactic motsutsana ndi vuto la mtima, kuthana ndi kulephera kwa mtima popanda kuchulukitsa komanso pazinthu monga:
- matenda oopsa;
- ischemia;
- angina pectoris.
Concor imayikidwa ngati prophylactic motsutsana ndi vuto la mtima, kuthana ndi kulephera kwa mtima.
Mankhwalawa ali ndi zotsutsana zotsatirazi:
- kulephera kwa mtima;
- Cardiogenic mantha;
- bradycardia (mpaka 60 kumenyedwa pamphindi);
- kuthamanga kwa systolic (mpaka 100 mmHg)
- mphumu ya bronchial yomwe ikupita patsogolo;
- matenda oopsa a m'mapapo;
- Matenda a Raynaud (kufalikira kwamitsempha yamagazi m'mitsempha yamapazi);
- chotupa mu thumbo ta adrenal ya medulla (pheochromocytoma);
- kuphwanya acid ndi alkaline bwino;
- thupi lawo siligwirizana zigawo zikuluzikulu za mankhwala;
- wazaka 18.
Kukhazikitsidwa kwa Concor pa nthawi ya pakati kumawonetsedwa pokhapokha ngati zabwino za chithandizo chotere kwa mkazi zimaposa zovuta zoyipa zomwe zingachitike pakukula kwa mwana wosabadwayo. Mukamayamwitsa, ndikulimbikitsidwa kuletsa mankhwalawa. Ndipo Concor imagwiritsidwa ntchito mosamala pamene:
- matenda a shuga;
- hyperthyroidism (kukanika kwa chithokomiro);
- kwambiri aimpso ndi kwa chiwindi kuwonongeka;
- ndi psoriasis;
- matenda obadwa nawo a mtima.
Mankhwalawa ndi a nthawi yayitali. Amayamba ndi milingo yaying'ono, ndikukulitsa kuchuluka kwake pamene wodwalayo asinthana ndi zochitika za bisoprolol.
Mapiritsiwo akupezeka mu 2,5, 5 ndi 10 mg Mlingo ndipo amadzipatsa ndi theka la mlingo wocheperako, kupitilira mlingo wotsatira (wokulirapo) osapitilira masabata awiri pambuyo pake. Mankhwalawa amachitika pansi pa kayendetsedwe ka magazi tsiku ndi tsiku, pamaso pa zizindikiro zam'magazi, mlingo umachepetsedwa mpaka voliyumu yapitayo, kuchepa kwake pang'onopang'ono kapena kusiya kwathunthu kwa mankhwalawo.
Kuyerekeza kwa Lozap ndi Concor
Mankhwalawa ali ndi njira zosiyanasiyana zochizira. Kuchita kwa zigawo za Concor kumayeneranso kusintha ntchito ya mtima, ndipo Lozap amawongolera kuthinikizidwa m'matumba. Koma ntchito yawo wamba ndikuchepetsa kuthamanga mu ziwiya ndi mitsempha. Kuphatikiza kophatikizira kumawonjezera luso la mankhwalawa, koma mankhwalawa amayenera kumwedwa motsogozedwa ndi katswiri.
Kufanana
Mankhwala onse awiriwa ndi mankhwala a mtima ndipo ali ndi mawonekedwe ofanana:
- mankhwalawa ali ndi mitundu yofanana yotulutsira (mwa mapiritsi);
- amasulidwa malinga ndi mankhwala;
- Chisonyezo chogwiritsira ntchito - nkhondo yolimbana ndi matenda oopsa;
- momwe zimasonyezedwera pafupipafupi makonzedwe - nthawi imodzi patsiku;
- kulimbikitsana wina ndi mnzake;
- olembedwa movutikira pomwe njira imodzi yathandizira siyothandiza;
- amafuna yaitali maphunziro;
- amafunika kuyang'anira kuchuluka kwa kuchuluka kwa magazi;
- osagawiridwa kwa ana.
Ndikofunikira kutenga Lozap ndi Concor monga momwe akuwongolera komanso kuyang'aniridwa ndi katswiri.
Kodi pali kusiyana kotani?
Zovuta:
- opanga Lozap - Czech Republic; Concor imapanga Germany;
- monga gawo la zinthu zingapo zoyambira (lazortan ndi bisoprolol), kupereka njira zawo (zawo);
- mndandanda wazinthu zothandizira ku Concor ndiwofalikira, ndipo, mwakutero, ukatengedwa, mwayi wokhudzana ndi zovuta zonse umakhala wapamwamba;
- pali kusiyana kotsimikizika mu contraindication (musanagwiritse ntchito mankhwala aliwonse, muyenera kuphunzira zonunkhira zomwe zaphatikizidwa ndi phukusi);
- amasiyanasiyana kukula kwa piritsi (kulemera kwa chinthu chachikulu ndi zinthu zowonjezera).
Zomwe zimakhala zotsika mtengo
Mtengo wapakati pamapiritsi a Lozap:
- 12.5 mg No. 30 - ma ruble 120;
- 50 mg No. 30 - 253 rubles.;
- 50 mg No. 60 - 460 ma ruble;
- 100 mg No. 30 - 346 ma ruble .;
- 100 mg No. 60 - 570 rubles.;
- 100 mg No. 90 - 722 rubles.
Mtengo wapakati wamapiritsi a Concor:
- 2,5 mg No. 30 - ma ruble 150;
- 5 mg No. 30 - 172 ma ruble .;
- 5 mg No. 50 - 259 ma ruble .;
- 10 mg No. 30 - 289 ma ruble .;
- 10 mg No. 50 - 430 rubles.
Zomwe zili bwino: Lozap kapena Concor
Ndi iti mwa mankhwalawa omwe ndi abwino kumwa, omwe adokotala amapanga. Ndalama zonse ziwiri zimagulitsidwa ndi mankhwala, kugwiritsa ntchito kwawo kwaulere sikuloledwa. Kusankha kwa mankhwala kumayendetsedwa ndi:
- Zizindikiro payekha;
- matenda ophatikizika;
- zochita ndi zosakaniza;
- zaka wodwala.
Bisoprolol imalowanso kuchuluka kwa zotulutsa zamtima, ndipo lazortan imakulitsa kukula kwa arterioles (nthambi zamitsempha yayikulu), chifukwa chomwe kuthamanga kwa zotumphukira kumachepa. Njira zoterezi zosiyanasiyana za mankhwala osiyanasiyana zimapulumutsa minofu ya mtima. Chifukwa chake, njira yabwino kwambiri yoperekera chithandizo chambiri ndi kuchuluka kwa myocardium ndi mankhwala othandizira awiriwa omwe ali ndi mphamvu yotsimikiziridwa.
Ndemanga za Odwala
Kristina, wazaka 41, Krasnodar
Ndakhala ndikutenga Lozap kwa mwezi wopitilira kuchuluka kwa matenda oopsa. Palibe zotsatira, ndipo panali zovuta zonse zomwe zimatheka malinga ndi malangizo (arrhythmia, kupweteka kumbuyo ndi kumbuyo kwa sternum kunawonjezeredwa). Kupanikizika kwa systolic kumakwezedwa nthawi zonse. Ngakhale adotolo adanena kuti zoyipa za mankhwalawa ndizochepa. Chifukwa chake zonse ndi za payekha.
Valentina, wazaka 60, Kursk
Ndimamwa Concor zaka 10 Mlingo wochepera. Mtima suuma, koma nthawi zambiri pamakhala kuthamanga kwa magazi (160/100). Wochiritsirayo adatumiza Lozap, ndipo kenako adasinthidwa kukhala Dalneva, popeza ma contraindication adawonekera.
Sergey, wazaka 45, Pskov
Panali kugunda kwakukulu komanso kugunda kwamtima kwachangu. Zovuta za Losartan ndi Concor zidayikidwa ndi dokotala. Zinthu zinayamba kuyenda bwino, koma chifukwa cha izi ndinayenera kumwa mankhwala opitilira mwezi (tsiku lililonse piritsi 1 m'mawa). Panalibe mavuto.
Lozap ndi Concor amagulitsidwa ndi mankhwala, kugwiritsa ntchito kwawo kwaulere sikuloledwa.
Ndemanga za madotolo za Lozap ndi Concor
Sergeeva S.N., katswiri wamkulu, Perm
Kugwiritsira ntchito pamodzi kwa mankhwalawa antihypertensive ndikotheka. Mankhwalawa ndi abwino chifukwa mutha kuwamwa kamodzi patsiku, koma maphunzirowa ndiwotalikirapo ndipo osavomerezeka kuti musokoneze.
Moskvin P.K., katswiri wamtima, Oryol
Momwe kupanikizika kudakhala kwacibwinobwino - Ndimapereka malangizo kuti nditenge Lozap ndi Concor limodzi. Mankhwalawa amatha kugwirizanitsidwa bwino, kukulitsa othandizira wina ndi mnzake. Ndikofunika kuyang'anitsitsa osati kukakamiza komanso kutsika, komanso zimachitika. Zoyipa zamankhwala: osati mtengo wotsika kwambiri (phukusi limodzi lokhala ndi zotsatira zabwino silikhala lokwanira) komanso contraindication oopsa. Ngati palibe zoyipa, ndiye kuti kupangika koteroko kumabwezeretsa mtima m'miyezi iwiri.
Kirsanova T.M., wothandizira, Korolev
Tiyenera kudziwa kuti othandizira onsewa ndi okodzetsa. Kulandilidwa kumalimbikitsidwa m'mawa, chifukwa usiku kukopa kukodza kumayambitsa zovuta. Kuphatikiza kwabwino, ndikulimbikitsa.
