Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin. Zimayambitsidwa m'thupi kokha mothandizidwa ndi jakisoni. Imayendetsa moyenera Zizindikiro za glycemic.
Dzinalo Losayenerana
INN - Apidra.
Insulin glulisin ndi mankhwala othandizira odwala matenda a shuga omwe amadalira insulin kapena osadalira insulin.
ATX
Kusunga kwa ATX - A10AV06.
Dzina la malonda
Ipezeka pansi pa mayina amalonda Apidra ndi Apidra SoloStar.
Zotsatira za pharmacological
Mankhwalawa ndi njira yofananirananso ya insulin ya munthu. Mphamvu yakuchitapo kanthu ndi yofanana ndi imelo yomwe imapangidwa ndi kapamba wathanzi. Glulisin amachita zinthu mwachangu komanso amakhala ndi mphamvu yayitali.
Pambuyo kukhazikitsidwa m'thupi (mosadukiza), timadzi timene timayambira kugwiritsira ntchito kagayidwe kazakudya.
Thupi limachepetsa kuchuluka kwa shuga m'magazi, limalimbikitsa mayamwidwe ake ndi minyewa, makamaka minofu yamatumbo ndi minofu ya adipose. Amalepheretsa mapangidwe a glucose mu zimakhala za chiwindi. Kuchulukitsa mapuloteni.
Kafukufuku wachipatala akuwonetsa kuti glulisin, womwe umaperekedwa kwa mphindi ziwiri asanadye, umaperekanso kuchuluka kwa shuga m'magazi momwe munthu amasungunulira insulin, yoyendetsedwa ndi theka la ola asanadye.
Zochita za insulin sizisintha mwa anthu amitundu yosiyanasiyana.
Pharmacokinetics
Pambuyo subcutaneous makonzedwe a mankhwala, pazenera ambiri mu magazi amafika pambuyo mphindi 55. Nthawi yayitali yakukhala mankhwala omwe ali m'magazi ndi mphindi 161. Ndi subcutaneous makonzedwe a mankhwalawa m'dera lakhomopo khoma kapena phewa, mayamwidwe mwachangu kuposa kukhazikitsa kwa mankhwala mu ntchafu. Bioavailability pafupifupi 70%. Kuchotsa theka-moyo pafupifupi mphindi 18.
Pambuyo pakuyendetsa pang'onopang'ono, glulisin imachotsedwako mwachangu kuposa insulin yamunthu yomweyo. Ndi kuwonongeka kwa impso, kuthamanga kwa kuyambira kwa zomwe zimafunikira kumakhazikika. Zambiri pazakusintha kwamatenda a insulin mwa okalamba sizinaphunzitsidwe mokwanira.
Zizindikiro zogwiritsidwa ntchito
Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.
Glulisin akuwonetsedwa ngati ali ndi matenda ashuga omwe amafuna insulin ndi matenda a shuga a 2.
Contraindication
Mankhwala ndi contraindicated vuto la hypoglycemia ndi hypersensitivity kwa Apidra.
Kodi kumwa insulini glulisin?
Imaperekedwa pang'onopang'ono 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo jakisoni, malo a jakisoni sayenera kutenthedwa. Simungathe kusakaniza mitundu ingapo ya insulini mu syringe yomweyo, ngakhale kuti wodwalayo akhoza kupatsidwa ma insulin osiyanasiyana. Kubwezeretsanso yankho lisanayambike makonzedwe ake.
Musanagwiritse ntchito, muyenera kuyang'ana botolo. Ndikothekanso kusungitsa yankho mu syringe pokhapokha ngati yankho likuwonekera komanso lilibe tinthu tambiri.
Malangizo ogwiritsa ntchito cholembera
Khola lomweli liyenera kugwiritsidwa ntchito ndi wodwala m'modzi. Ngati yawonongeka, siyololedwa kuigwiritsa ntchito. Musanagwiritse ntchito cholembera, fufuzani mosamala cartridge. Itha kugwiritsidwa ntchito pokhapokha yankho likakhala lomveka komanso lopanda zosayera. Cholembera chopanda kanthu ziyenera kutayidwa ngati zinyalala za pabanja.
Mankhwalawa kutumikiridwa subcutaneously 0-15 mphindi asanadye. Jakisoni amapangidwa m'mimba, ntchafu, phewa. Pambuyo jakisoni, malo a jakisoni sayenera kutenthedwa.
Pambuyo pochotsa kapu, tikulimbikitsidwa kuti mulembe mayendedwe ndi yankho. Kenako ikani singano mosamala ndi cholembera. Mu chipangizo chatsopano, chizindikiro cha mlingo chikuwonetsa "8". Ntchito zina, ziyenera kuyikidwa pambali pa chizindikiro "2". Kanikizani batani la dispenser njira yonse.
Kugwira chiwongoladzanja, chotsani thovu lamkati podina. Ngati zonse zachitika molondola, dontho laling'ono la insulini limawonekera pamphumi ya singano. Chipangizocho chimakuthandizani kuti muyike mlingo kuchokera pa 2 mpaka 40 mayunitsi. Izi zitha kuchitika ndikutembenuza chotumiza. Kulipiritsa, batani la dispenser likulimbikitsidwa kuti lizikokedwa momwe lingathere.
Ikani singano m'matumba a subcutaneous. Kenako dinani batani njira yonse. Asanachotsere singano, iyenera kuchitidwa kwa masekondi 10. Pambuyo pa jakisoni, chotsani ndikuchotsa singano. Sikelo akuwonetsa kuchuluka kwa insulini yomwe imatsala mu syringe.
Ngati cholembera sichingagwire bwino ntchito, ndiye kuti yankho limatha kutengedwa kuchokera ku cartridge kupita ku syringe.
Zotsatira zoyipa za insulin glulisin
Zotsatira zoyipa kwambiri za insulin ndi hypoglycemia. Itha kuchitika chifukwa chogwiritsa ntchito mankhwala ochuluka. Zizindikiro zakuchepa kwa shuga m'magazi zimayamba pang'onopang'ono:
- thukuta lozizira;
- khungu komanso kuzizira kwa khungu;
- kumva mwamphamvu kutopa;
- wokongola
- zosokoneza zowoneka;
- kugwedezeka
- nkhawa kwambiri;
- chisokonezo, zovuta kuyang'ana;
- kumva kwamphamvu m'mutu;
- kuchuluka kwa mtima.
Hypoglycemia ikhoza kuchuluka. Uku ndikuwopseza moyo, chifukwa kumayambitsa kusokonezeka kwa ubongo, ndipo m'malo ovuta kwambiri - imfa.
Pa khungu
Pa malo a jakisoni, kuyabwa ndi kutupa kumachitika. Izi ndizosakhalitsa, ndipo simuyenera kumwa mankhwala kuti muthane nawo. Mwina chitukuko cha lipodystrophy mwa akazi omwe amapezeka jakisoni. Izi zimachitika ngati zalembedwa pamalo amodzi. Kuti izi zisachitike, tsamba la jakisalo liyenera kusinthidwa.
Matupi omaliza
Ndizachilendo kwambiri kuti mankhwala amatha kuyambitsa ziwopsezo.
Zokhudza mphamvu pakuwongolera njira
Ndi hypoglycemia, ndizoletsedwa kuyendetsa galimoto kapena kuyendetsa zinthu zovuta kuchita.
Malangizo apadera
Kusamutsa wodwala ku mtundu watsopano wa insulin kumachitika kokha moyang'aniridwa ndi achipatala. Nthawi zina, chithandizo cha hypoglycemic chingafunikire. Mukamasintha zolimbitsa thupi, muyenera kusintha mlingo wake.
Gwiritsani ntchito mu ukalamba
Mankhwalawa amatha kugwiritsidwa ntchito mukalamba. Mankhwala osokoneza bongo safunikira.
Kupatsa ana
Insulin yamtunduwu imatha kuperekedwa kwa ana azaka zopitilira zisanu ndi chimodzi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Pali umboni wochepa wokhudza kugwiritsa ntchito mankhwalawa panthawi ya bere komanso poyamwitsa. Kafukufuku wazinyama wa mankhwalawa sanawonetse zotsatira zam'mimba.
Popereka mankhwala awa kwa amayi apakati, muyenera kusamala kwambiri. Ndikofunikira kuyeza shuga m'magazi.
Odwala omwe ali ndi matenda osokoneza bongo amafunika kuwunika kuchuluka kwa shuga m'magazi. Pa trimester yoyamba, zofunika za insulin zimatha kuchepera pang'ono. Kaya insulin idutsa mkaka wa m'mawere sichikudziwika.
The ntchito aimpso kuwonongeka
Osasintha kuchuluka kwa mankhwalawa omwe amaperekedwa ndi mankhwalawo othandizira kuwonongeka kwa impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kafukufuku wachipatala kwa odwala omwe ali ndi vuto la chiwindi ntchito sanachitepo.
Glulisin insulin kwambiri
Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo mlingo wake umatha kukhala wosiyana - kuchokera wofatsa mpaka wovuta.
Magawo a hypoglycemia ofatsa amaletsedwa kugwiritsa ntchito shuga kapena shuga. Ndikulimbikitsidwa kuti odwala nthawi zonse amakhala ndi maswiti, ma cookie, msuzi wokoma, kapena zidutswa za shuga woyengedwa nawo limodzi.
Pogwiritsa ntchito mlingo wambiri, hypoglycemia imakula msanga, ndipo mlingo wake umatha kukhala wosiyana - kuchokera wofatsa mpaka wovuta.
Ndi kuchuluka kwambiri kwa hypoglycemia, munthu amasiya kuzindikira. Glucagon kapena dextrose amaperekedwa ngati thandizo loyamba. Ngati palibe chochitika pakayendetsedwe ka glucagon, ndiye kuti jakisoni yemweyo imabwerezedwa. Pambuyo podzikanso, muyenera kupatsa wodwalayo tiyi wokoma.
Kuchita ndi mankhwala ena
Mankhwala ena amatha kuthana ndi kagayidwe ka glucose. Izi zimafunikira kusintha kwa insulin. Mankhwala otsatirawa amalimbikitsa hypoglycemic zotsatira za Apidra:
- shuga yochepetsera mankhwala omwe amamwa;
- ACE zoletsa;
- Disopyramids;
- mafupa;
- Fluoxetine;
- monoamine oxidase zoletsa zinthu;
- Pentoxifylline;
- Propoxyphene;
- salicylic acid ndi zotumphukira zake;
- sulfonamides.
Mankhwala oterewa amachepetsa ntchito ya insulin:
- GCS;
- Danazole;
- Diazoxide;
- mankhwala okodzetsa;
- Isoniazid;
- kukonzekera - zochokera phenothiazine;
- Kukula kwa mahomoni;
- chithokomiro cha chithokomiro;
- mahomoni ogonana achikazi omwe amapezeka mu mankhwala oletsa kubereka;
- zinthu zomwe zimalepheretsa mapuloteni.
Beta-adrenergic blocking agents, clonidine hydrochloride, kukonzekera kwa lifiyamu kumatha kupititsa patsogolo, kapena, kungafooketse ntchito ya insulin. Kugwiritsa ntchito Pentamidine koyamba kumayambitsa hypoglycemia, kenako kuwonjezeka kowopsa kwa kuchuluka kwa shuga m'magazi.
Insulin sikuyenera kusakanikirana ndi mitundu ina ya mahomoni awa mu syringe yomweyo. Zomwezo zimagwiranso ntchito ndi mapampu a kulowetsedwa.
Kuyenderana ndi mowa
Kumwa mowa kumatha kuyambitsa hypoglycemia.
Analogi
Ma fanizo a Glulisin ndi awa:
- Apidra
- Novorapid Flekspen;
- Epidera;
- insulin isophane.
Kupita kwina mankhwala
Apidra amapezeka pamankhwala. Anthu odwala matenda ashuga amapeza mankhwalawo kwaulere.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo
Mtengo wa cholembera sichikhala pafupifupi ma ruble 2,000.
Zosungidwa zamankhwala
Makatoni ndi mbale osatsegulidwa ziyenera kusungidwa mufiriji yokha. Kuzizira kwa insulin sikuloledwa. Mbale ndi ma cartridge otseguka amasungidwa pa kutentha osaposa + 25ºC.
Tsiku lotha ntchito
Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu 4, pambuyo pake uyenera kutayidwa.
Mankhwalawa ndi oyenera kwa zaka ziwiri. Moyo wa alumali mu botolo lotseguka kapena makatoni ndi milungu inayi, pambuyo pake uyenera kutayidwa.
Wopanga
Amapangidwa ku bizinesi Sanofi-Aventis Deutschland GmbH, Germany.
Ndemanga
Madokotala
Ivan, wazaka 50, endocrinologist, ku Moscow: "Mothandizidwa ndi Apidra, ndizotheka kuyendetsa zizindikiro za glycemia mwa odwala omwe ali ndi matenda ashuga a 1. Ndikupangira kuti mupeze insulini musanadye.
Svetlana, wazaka 49, wodwala matenda ashuga, Izhevsk: "Glulisin ndi imodzi mwazitsulo zabwino kwambiri. Odwala amaleza bwino, koma malinga ndi mankhwala ndi mitundu yokhazikitsidwa. Hypoglycemia ndiyosowa kwambiri."
Odwala
A Andrei, wazaka 45, ku St. Petersburg: "Glulusin sachititsa kuti shuga achepetse, motero ndikofunika kwa ine ngati ndimadwala matenda ashuga". "
Olga, wazaka 50, Tula: "Ma insulini akale ankandipangitsa kumva kuwawa, ndipo tsamba la jakisoni linali lopweteka nthawi zonse. Glulizin sizimayambitsa matendawa. Ndiosavuta kugwiritsa ntchito cholembera ndipo, koposa zonse, ndizothandiza."
Lydia, wazaka 58, Rostov-on-Don: "Chifukwa cha Glulizin, ndimakhala ndi shuga nthawi zonse nditatha kudya. Ndimatsatila kadyedwe kake komanso kuonetsetsa kuti mankhwalawo ndi otani. Palibe zolemba za hypoglycemia."
