Liprimar 10 ndi mankhwala opangira omwe ali ndi lipid-yotsitsa. Mankhwala ndikofunikira kuti muchepetse cholesterol mokwanira komanso lipoprotein yotsika. Zotsatira zake, kuthekera kwa kupangika kwa mapangidwe a atherosulinotic pamakoma amitsempha yamagazi kumachepa, mulingo wa triglycerides umachepa ndipo mafuta a metabolism m'thupi amayamba bwino. Maziko a zochita za atorvastatin, omwe amafunikira kuti athetse hypercholesterolemia.
Dzinalo Losayenerana
Atorvastatin.
Liprimar 10 ndiyofunikira kuti muchepetse cholesterol mokwanira komanso lipoproteins yotsika.
ATX
C10AA05.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka m'mapiritsi otsekemera olimbitsa thupi. Mlingo wa magawo uli ndi 10 mg ya calcium wa atorvastatin ngati pawiri yogwira. Pakuthamanga kwa mayamwidwe ndi kuchuluka kwa bioavailability, piritsi ili ndi zinthu zina:
- ma cellcose a microcrystalline;
- magnesium wakuba;
- shuga mkaka;
- hyprolose;
- croscarmellose sodium;
- calcium carbonate.
Zomwe zimapangidwira mapiritsiwa zimaphatikizapo microcrystalline cellulose, magnesium stearate, mkaka wa shuga, hyprolose, croscarmellose sodium, calcium carbonate.
Nembanemba wa filimuyo uli ndi sera wa candelilla, hypromellose, polyethylene glycol, talc, emulsion simethicone, titanium dioxide. Pamiyala yoyera ya mawonekedwe a elliptical, cholembedwa "PD 155" ndi muyeso wa zinthu zomwe zimayikidwa zimayikidwa.
Zotsatira za pharmacological
Liprimar ndi m'gulu lamankhwala ochepetsa lipid. The yogwira mankhwala atorvastatin ndi blocker yosankha ya HMG-CoA reductase, puloteni yofunika yofunikira pakusintha kwa 3-hydroxy-3-methylglutaryl coenzyme kukhala mevalonate.
Pamaso pa cholowa cha hypercholesterolemia (cholesterol yowonjezera), dyslipidemia wosakanikirana, ntchito yogwira Liprimara ithandiza kuchepetsa kuchuluka kwa cholesterol (Ch), apolipoprotein B, VLDL ndi LDL (lowensens lipoproteins) ndi kuchuluka kwa triglycerides. Atorvastatin imayambitsa kuwonjezeka kwa osachulukitsa lipoprotein (HDL).
Limagwirira ntchito ndi chifukwa kupsinjika kwa ntchito ya HMG-CoA reductase komanso kuletsa mapangidwe a cholesterol mu hepatocytes.
Atorvastatin imatha kuwonjezera kuchuluka kwa zolimba kwambiri za lipoprotein receptors kunja kwa chiwindi cell membrane, zomwe zimatsogolera pakuwonjezeka ndikuwonongeka kwa LDL.
Mankhwala amatha kuwonjezera kuchuluka kwa otsika osalimba lipoprotein zolandilira kunja kwa chiwindi cell nembanemba.
Pulogalamu yogwira imachepetsa kapangidwe ka cholesterol ya LDL ndi kuchuluka kwa lipoproteins, chifukwa chomwe pali kuwonjezeka kwa ntchito ya LDL receptors. Odwala omwe ali ndi homozygous cholowa hypercholesterolemia osagwirizana ndi mankhwala a lipid-kutsitsa, mayunitsi a LDL amachepa. The achire zotsatira zimawonedwa pakatha masabata awiri atayamba kugwiritsa ntchito mankhwala. Kuchuluka kwake kunalembedwa patatha mwezi umodzi chithandizo ndi Liprimar.
Pharmacokinetics
Pambuyo pakamwa, mapiritsi sasungunuka pansi pa hydrochloric acid m'mimba, kugwera mu projimalum ya jejunum. Mu gawo ili la chakudya chamagaya, nembanemba wa filimuyi umadutsa hydrolysis.
Piritsi imasweka, michere ndi mankhwala amayamba kumizidwa kudzera mwa microvilli yapadera.
Atorvastatin amalowa m'magazi kuchokera kukhoma lamatumbo, pomwe amafikira kuchuluka kwa plasma mkati mwa maola 1-2. Mwa akazi, kugwiritsidwa ntchito komwe kumakhala ndi 20% ndizokwera kuposa amuna.
Bioavailability ukufika 14-30%. Mitengo yotsika imayamba chifukwa cha parietal metabolism ya atorvastatin mu mucous membrane yamatumbo ndi kusintha kwa maselo a chiwindi ndi isoenzyme ya cytochrome CYP3A4. Zinthu zomwe zimagwira ntchito zimangokhala ndi albumin ndi 98%, chifukwa chake hemodialysis siyothandiza. Kutha kwa theka moyo kumafika maola 14. Achire zotsatira amapitilira kwa 20-30 maola. Atorvastatin amasiya thupi pang'onopang'ono kudzera mu mkodzo - 2% yokha ya mankhwalawa imapezeka mkodzo patatha gawo limodzi.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amagwiritsidwa ntchito kuzipatala:
- chachikulu hypercholesterolemia cha chibadwa komanso osakhala cholowa;
- okwera amkati mwa triglycerides kugonjetsedwa ndi zakudya mankhwala;
- cholowa homozygous hypercholesterolemia ndi mphamvu yochepa ya zakudya ndi zina zosagwiritsa ntchito mankhwala;
- kuphatikiza kwa Hyperlipidemia.
Mankhwala amatchulidwa ngati muyezo wa kupewa matenda a mtima kwa odwala pakalibe zizindikiro za matenda a mtima, koma ndi zoopsa: ukalamba, zizolowezi zoyipa, kuthamanga kwa magazi, matenda a shuga. Gulu lowopsa limaphatikizapo anthu omwe ali ndi vuto la hypercholesterolemia komanso otsika HDL.
Mankhwala amatchulidwa ngati njira yolepheretsa matenda a mtima.
Mankhwala amagwiritsidwa ntchito ngati adjunct kudya mankhwala akumwa dysbetalipoproteinemia. Liprimar imagwiritsidwa ntchito ngati njira yolepheretsa kukula kwa zovuta kwa odwala omwe ali ndi myocardial ischemia kuti achepetse kufa, vuto la mtima, sitiroko komanso kuchipatala kwa angina pectoris.
Contraindication
Mankhwala sinafotokozeredwe kuchuluka kwa chiwopsezo cha minofu ya zigawo zikuluzikulu za Liprimar, komanso pamilandu yotsatirayi:
- matenda oopsa a chiwindi;
- ana ochepera zaka 18;
- kuchuluka plasma ntchito kwa hepatic transaminases zoposa 3 zina.
Chenjezo liyenera kuchitika mukamamwa mowa kwambiri.
Momwe mungatenge Liprimar 10
Mapiritsi amayikidwa kukonzekera pakamwa, mosasamala nthawi yatsiku kapena chakudya. Mankhwala osokoneza bongo amachitika pokhapokha ngati ntchito ya hypocholesterolemic idatha, kuchepetsa thupi motsutsana ndi maziko a kunenepa kwambiri, zolimbitsa thupi. Ngati kuchuluka kwa cholesterol kumayambitsidwa ndi matenda oyamba, musanagwiritse ntchito Liprimar, muyenera kuyesa kuthetsa njira yayikulu ya pathological. Munthawi yonse ya mankhwalawa, muyenera kutsatira zakudya zapadera.
Mankhwala osokoneza bongo omwe ali ndi Liprimar 10 amachitika pokhapokha pogwiritsa ntchito mphamvu ya hypocholesterolemic.
Mlingo watsiku ndi tsiku ndi 10-80 mg pakugwiritsidwa ntchito kamodzi ndipo umasinthidwa malinga ndi momwe LDL-C ikuthandizira komanso pakuwaniritsa njira yothandizira.
Mlingo woyenera wovomerezeka ndi 80 mg.
Mankhwalawa ndi Liprimar, ndikofunikira kuyang'anira kuchuluka kwa ma lipids masabata onse a 2-4, pambuyo pake muyenera kufunsa dokotala za kusintha kwa mankhwalawa.
Kuthetsa njira yosakanikirana ya hyperlipidemia, m`pofunika kutenga 10 mg kamodzi patsiku, pomwe homozygous cholowa hypercholesterolemia imafuna mlingo wokwanira wa 80 mg. Potsirizira pake, kuchuluka kwa cholesterol kumachepetsedwa ndi 20-45%.
Kumwa mankhwala a shuga
Odwala omwe ali ndi matenda ashuga ayenera kusamala pamene hypercholesterolemia ipezeka. Anthu oterewa ali pachiwopsezo chotenga matenda a mtima. Liprimar imagwiritsidwa ntchito ngati njira yolepheretsa kulowetsedwa kwa myocardial. Mlingo umatsimikiziridwa ndi dotolo woyenera kutengera mlingo wa cholesterol.
Odwala omwe ali ndi matenda ashuga ayenera kusamala pamene hypercholesterolemia ipezeka.
Kodi ndizotheka kugawa pakati
Palibe chiopsezo pamapiritsi, zomwe zikutanthauza kuti sangathe kugawa mawonekedwe.
Zotsatira zoyipa za Liprimara 10
Ndi kugwiritsa ntchito mosayenera mankhwalawa, mavuto amabwera omwe amatha mosiyanasiyana kutanthauzira.
Matumbo
Mwina kuwoneka kusanza, kutsegula m'mimba, kupweteka m'dera la epigastric, kudzimbidwa komanso kugona. Nthawi zina, kuthandizidwa ndi Liprimar kumatha kupangitsa kuti munthu azidwala matenda osokoneza bongo, kupweteka kwa kapamba, hepatitis ndi jaundice.
Hematopoietic ziwalo
Nthawi zina, kupsinjika kwa mafupa kumachitika, limodzi ndi thrombocytopenia.
Liprimar 10 ingayambitse kusowa tulo.
Pakati mantha dongosolo
Zotsatira zoyipa ndi kuwonongeka kwa dongosolo lamanjenje zimawonekera monga:
- kusowa tulo
- general malaise;
- asthenic syndrome;
- mutu ndi chizungulire;
- kuchepa ndi kutaya kwathunthu kwa zomverera;
- zotumphukira mantha dongosolo;
- amnesia.
Kuchokera kwamikodzo
Mwa amuna, kukanika kwa erectile komanso kusungika kwamikodzo kumachitika.
Kuchokera ku kupuma
Dyspnea ikhoza kuchitika.
Matupi omaliza
Ndi chizolowezi chowonetsa anaphylactic zimachitika, zotupa pakhungu, redness, kuyabwa, exryative erythema, necrosis wa subcutaneous mafuta wosanjikiza zingaoneke. M'mavuto akulu, edema ya Quincke ndi anaphylactic zimayamba.
Kudya kwa mankhwala omwe amafunsidwa kumatha kupangitsa kuti khungu lizioneka ngati lakuda.
Zokhudza mphamvu pakuwongolera njira
Mankhwala samasokoneza zochitika zomwe zimafuna kuyankhidwa mwachangu ndi kusamala. Mukamalandira mankhwalawa, kuyendetsa galimoto ndikuwongolera zida zovuta kuzinthu zamaloledwa.
Malangizo apadera
Pochita ndi Liprimar masabata asanu ndi limodzi aliwonse, ndikofunikira kuchititsa kuwunika kwa chiwindi ndi zizindikiro za ALT, AST. Ngati ntchito ya aminotransferases pamwambamwamba yopitilira muyeso imakhala yoposa katatu, ndikofunikira kufunsa dokotala pakuchepetsa.
Chifukwa cha hypocholesterolemic therapy, nthawi zina, mawonekedwe a kupweteka kwa minofu motsutsana ndi maziko a myopathy amawonetsedwa. Nthawi yomweyo, kafukufuku wa zasayansi adawonetsa kuwonjezeka kwa 10 kwa ntchito ya creatine phosphokinase poyerekeza ndi chizolowezi.
Ngati wodwala ali ndi kufooka komanso kupweteka m'misempha ya mafupa, muyenera kusiya kumwa mankhwalawo.
Nthawi zina, rhabdomyolysis imapangika - kuwonongeka kwa necrotic minofu minofu, limodzi ndi kulephera kwaimpso.
Kugwiritsa ntchito mankhwalawa kuyenera kuyimitsidwa ndi kuchepa kwa kuthamanga kwa magazi.
Kuchepetsa kwamkati ndi zotsatira za myoglobinuria. Kuti muchepetse vuto la rhabdomyolysis, muyenera kusiya kumwa mankhwala otsatirawa:
- pa opareshoni ndi malo ambiri;
- kuvulala kwambiri kwa impso;
- kuchepa kwamphamvu kwa kuthamanga kwa magazi;
- zoopsa zamakina;
- minofu kukokana.
Wodwala ayenera kudziwitsidwa za chiopsezo cha rhabdomyolysis. Ndi chilolezo chamankhwala, wodwalayo amakakamizidwa kufunafuna chithandizo chamankhwala ndi kufooka kwa minofu ndi mawonekedwe a ululu wosaneneka, wothandizidwa ndi kutentha ndi kutopa.
Kulemba Liprimar kwa ana 10
Mankhwala saloledwa kugwiritsa ntchito ana.
Kuyenderana ndi mowa
Mankhwala sayenera kusakanikirana ndi zinthu zopangidwa ndi chidakwa. Mowa wa Ethyl umalepheretsa dongosolo lamkati, kuchepa kwa magazi ndi magazi, motero mphamvu ya hypocholesterolemic yogwiritsira ntchito Liprimar imachepetsedwa. Kutheka kwa mapangidwe a atherosselotic plaques pamakoma amitsempha yamagazi kumawonjezeka.
Mankhwala sayenera kusakanikirana ndi zinthu zopangidwa ndi chidakwa.
Mankhwala ochulukirapo a Liprimar 10
Mankhwala osokoneza bongo akachitika, mavuto amakula. Katundu wotsutsa sakhala kuti wapangidwa, motero, pakubwera kuchipatala, chithandizo chamankhwala chimachitika.
Kuchita ndi mankhwala ena
Cimetidine, Phenazone, Azithromycin, maantacid, Terfenadine, Warfarin, Amlodipine sizikhudza magawo a pharmacokinetic a Liprimar ndipo samayanjana ndi atorvastatin.
Kuphatikiza sikofunikira
Chifukwa cha chiopsezo cha ma neuromuscular pathologies, kayendedwe ka Liprimar sikulimbikitsidwa:
- mankhwala a cyclosporin;
- nicotinic acid zotumphukira;
- Erythromycin;
- mankhwala a antifungal;
- mafupa.
Makonzedwe a Liprimar ndi Erythromycin osavomerezeka.
Kuphatikiza kwamankhwala kotereku kumatha kubweretsa myopathy.
Ndi chisamaliro
Ndikulimbikitsidwa kusamala mukamagwiritsa ntchito Liprimar ndi mankhwala ena:
- Atorvastatin amatha kuwonjezera AUC ya kulera kwapakamwa ndi 20-30%, kutengera mahomoni omwe ali pakukonzekera.
- Atorvastatin ndi mlingo wa 40 mg wophatikizidwa ndi 240 mg wa Diltiazem kumabweretsa kuwonjezeka kwa plasma ndende ya atorvastatin m'magazi. Mukatenga 200 mg ya Itraconazole ndi 20-40 mg wa Liprimar, kuwonjezeka kwa AUC ya atorvastatin kunawonedwa.
- Rifampicin amachepetsa plasma kuchuluka kwa atorvastatin.
- Colestipol imayambitsa kuchepa kwa plasma cholesterol-kupunguza mankhwala.
- Ndi kuphatikiza mankhwala ndi digoxin, kuchuluka kwa otsiriza kumawonjezeka ndi 20%.
Madzi a mphesa amachepetsa zochita za cytochrome isoenzyme CYP3A4, ndichifukwa chake mukamamwa madzi okwanira malita 1.2 patsiku, kuchuluka kwa plasma kwa atorvastatin kumawonjezeka. Zofananazo zimawonedwa mutatenga CYP3A4 inhibitors (Ritonavir, Ketoconazole).
Liprimar ndi oletsedwa kugwiritsa ntchito kwa amayi 10 oyembekezera.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Kuletsedwa kugwiritsa ntchito mankhwalawa kwa amayi apakati, chifukwa pali chiopsezo chophwanya kuyika koyenera kwa minofu ndi ziwalo pa nthawi ya kakulidwe ka mazira. Palibe deta pa kuthekera kwa Liprimar kudutsa chotchinga cha hematoplacental.
Panthawi ya mankhwala, kuyamwitsa kuyenera kusiyidwa.
Analogi
Magawo a mankhwala omwe ali ndi vuto lofananalo akuphatikizapo:
- Atoris;
- Tulip;
- Vazator;
- Atorakord;
- Atorvastatin-SZ.
Kusinthanitsa kumachitika pambuyo pothandizidwa ndi madokotala.
Kupita kwina mankhwala
Mankhwala amagulitsidwa mosamala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo wa Liprimar 10
Mtengo wapakati wa mapiritsi a 10 mg ndi ma ruble 750-1000.
Zosungidwa zamankhwala
Ndikofunikira kuti mankhwalawa asungidwe m'malo mwake ndi chinyezi chochepa kutentha kwa + 15 ... + 25 ° C.
Tsiku lotha ntchito
Zaka zitatu
Wopanga
Gedecke GmbH, Germany.
Analog ya Liprimar - mankhwala a Atoris amagulitsidwa m'mafakisoni mosiyanasiyana malinga ndi mankhwala.
Ndemanga pa Liprimar 10
Elvira Ignatieva, wazaka 76, Lipetsk
Miyezi 6 yapitayo, pamene kuyezetsa magazi konse kunatengedwa, cholesterol yokwezeka ya 7.5 mmol idawululidwa. Ndili ndi matenda a mtima, chifukwa chake, kupewa misempha, cholesterol iyenera kuchepetsedwa nthawi yochepa. Dokotala adakhazikitsa Liprimar 40 mg tsiku lililonse. Mtengo ndiwokwera, koma wolungamitsidwa mwa kuchita bwino. Kuwunikira kwaposachedwa kukuwonetsa kuchepa kwa cholesterol mpaka 6 mmol.
Kristina Molchanova, wazaka 24, Yaroslavl
Agogo ali ndi atherosulinosis a ziwiya zamagawo am'munsi ndipo cholesterol yake ndi LDL zimachulukitsidwa. Choyamba adasankha Rosuvastatin, yemwe sanali woyenera. Panalibe zosintha zabwino. Pambuyo pa Rosuvastatin, Liprimar adalembedwa.Chifukwa cha mankhwalawa, mbiri ya lipid yomaliza idawonetsa kusinthika: cholesterol ndi kuchepa kwa thupi, kuchuluka kwa lipoproteins okwera kumawonjezeka.
