Dalacin C ndi wothandizira antimicrobial yemwe amagwiritsidwa ntchito pochotsa njira yotupa kumayendedwe kachilombo ka tizilombo toyambitsa matenda. Maantibayotiki amathandizira kulimbana ndi mabakiteriya okhala ndi mphamvu ya aerobic. Mankhwalawa amatha kuphatikiza zonse za bacteriostatic ndi bactericidal pa ma virus. Mphamvu ya mankhwalawa imakhazikika pa clindamycin, yomwe imapezeka ndi lincosamide. Wothandizira antibacterial samapangidwira kuti azigwiritsa ntchito amayi apakati.
Dzinalo Losayenerana
Clindamycin.
Ma Antibiotic Dalacin C amathandiza kulimbana ndi tizilombo toyambitsa matenda a grob-aerobic bacteria.
ATX
J01FF01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa m'mitundu iwiri yokha.
Njira Zothetsera
Yankho la jakisoni limagawidwa m'magalasi awiri a galasi 2, 4 kapena 6 ml. Mbale zanyamula zonyamula makatoni a 1 kapena 10 ma PC. 1 ml ya mawonekedwe amadzimadzi ali ndi 150 mg yogwira pophika - clindamycin phosphate. Zinthu zina zomwe zimapanga izi zimaphatikizapo mowa wa benzyl, mchere wopanda mchere ndi madzi osabala a jakisoni.
Makapisozi
Chomwe chimagwiritsidwa ntchito ndi ufa woyera wa clindamycin hydrochloride wokhala ndi mlingo wa 150 kapena 300 mg, womwe umatidwa m'chigoba cholimba cha makapisozi.
Dalacin C wogwira ntchito ndi ufa woyera wa clindamycin hydrochloride, womwe umatidwa m'chigoba cholimba cha makapisozi.
Pamodzi ndi kulumikizana kwapano kuli ndi zina zowonjezera:
- shuga mkaka;
- wowuma chimanga;
- magnesium wakuba;
- titanium dioxide ndi gelatin kupanga chipolopolo chakunja.
Makapisozi adapangidwa oyera, adalembedwa pamtunda ndi "P&U 395". Magawo a mankhwalawa adatsekedwa m'matumba a blister a 8 ma PC. Phukusi la makatoni lili ndi matuza 2 (makapu 16).
Mtundu wosapezeka
Mankhwalawa sapezeka monga zonona ndi mapiritsi.
Zotsatira za pharmacological
Mankhwala olimbana ndi mankhwalawo ali m'gulu la antimicrobials a lincosamide. The mankhwala yaying'ono Mlingo amachita bacteriostically, kusokoneza mitotic magawo pathogenic microflora. Ndi kuwonjezeka kwa mulingo woyenera kugwiritsidwa ntchito kamodzi, clindamycin imayamba kuchita bactericidal: sikuti amangosokoneza njira yoberekera maselo, komanso amawononga mapuloteni omwe amapanga ma cell a membrane.
Dalacin C amasokoneza njira yoberekera maselo, ndipo amawonongeranso mapuloteni omwe amapanga ma cell a cellorganism.
Ndi kutaya mphamvu kwa chipolopolo chakunja, kupanikizika kwa osmotic kumaphwanya bacterium.
Pharmacokinetics
Chidacho chogulitsidwa ndimakoma mpaka m'matumbo. Pambuyo pakukonzekera pakamwa, pazambiri seramu yozungulira ya clindamycin imakhazikika pambuyo pa mphindi 45. Kudya kumachepetsa mayamwidwe amomwe mankhwalawo amapangidwira, koma samakhudza kuperewera kwa mayamwidwe ndi bioavailability.
Ndi makina a v / m, clindamycin phosphate imafika pachimake patatha maola 1-3, ndi kulowetsedwa kwa mphindi 18-20.
M'matumbo, mankhwalawo amamangidwa ndi mapuloteni ndi 40-90%. Pankhaniyi, mankhwalawa sadziunjikira minyewa ya thupi, yogawidwanso chimodzimodzi pakuyang'ana kwa njira ya pathological. Clindamycin pafupifupi imasinthika mu hepatocytes a chiwindi. Kutha kwa theka-moyo kumapangitsa mphindi 90-210. 10%% ya mankhwalawa imachoka m'thupi momwe imadutsa mu mkodzo, 4% amachotsera ndowe. Zotsalazo zimapukusidwa mu ndulu kapena kudzera m'matumbo mwa mawonekedwe osagwira.
Mankhwala omwe akufunsidwa amakhala atasinthika kwathunthu mu chiwindi cha chiwindi.
Kodi limayikidwa kuti?
Clindamycin imagwira ntchito pothana ndi matenda opatsirana komanso otupa omwe amayambitsidwa ndi bakiteriya omwe amagwiritsa ntchito:
- kugonjetsedwa kwa m'munsi (bakiteriya matenda opatsirana, kuphatikizika kwa mphamvu, kuphatikizira kwa purulent m'mapapu, chibayo) ndi kumtunda (kutupa kwa tinthu tomwe timatulutsa minyewa, matenda amkati a pakati, kutentha thupi);
- mabala omwe ali ndi kachilomboka komanso kuwonongeka kwa minofu yofewa, matenda amkhungu, kuphatikiza furunculosis, ziphuphu za streptococcal, impetigo, abscesses mu subcutaneous mafuta wosanjikiza, erysipelas, paronychia;
- kutupa kwa peritoneum ndi kugaya chakudya thirakiti, peritonitis (clindamycin imaphatikizidwa ndi mankhwala othandizira anaerobes);
- matenda opatsirana a musculoskeletal system: osteomyelitis, nyamakazi;
- endocarditis, periodontitis;
- encephalitis yoyambitsidwa ndi toxoplasma, ndi chibayo chifukwa cha kachilombo ka HIV.
Clindamycin amagwira ntchito yolimbana ndi tizilombo toyambitsa matenda a matenda a m'mimba (kuchulukitsa kwa puritive exudate m'matumbo a mazira, ma fallopian machubu, njira zotupa m'matumbo a ziwalo zamkati, zotupa za kumaliseche kwa cuff). Pa kuwonongeka kwa khomo lachiberekero ndi chlamydia panthawi yoyesedwa, kupezeka kuti mankhwala osokoneza bongo omwe ali ndi clindamycin amatha kuthetseratu microflora ya bakiteriya.
Contraindication
Mankhwala ndi contraindicated pamaso pa kuchuluka chiwopsezo cha zimakhala ndi zinthu zomwe amapanga mankhwala.
Ndi chisamaliro
Mankhwala tikulimbikitsidwa kuti azigwiritsidwa ntchito moyang'aniridwa ndi achipatala kwa anthu omwe ali ndi zilonda zam'mimba komanso zotupa zam'mimba, myasthenia gravis ndi chiwindi kwambiri.
Momwe mungatenge Dalacin C?
Mankhwala olimbana ndi mankhwalawa amapangidwira jakisoni wamkati kapena kulowetsedwa kwamkati. Akuluakulu odwala mankhwalawa matenda opweteka kwambiri pamimba, ziwalo za m'chiuno mwa akazi kapena zovuta zimayikidwa tsiku lililonse la 2400-2700 mg wa mankhwala. Mlingo umagawidwa majekeseni a 2-4. Ndi njira yofatsa komanso yolimbitsa thupi ya pathological process, 1.2-1.8 g patsiku, yogawidwa pawiri jakisoni, ndikokwanira kukwaniritsa zochizira.
Mlingo woyenera kwambiri ndi 4.8 g patsiku.
Ndi mawu oyambitsa / m, mlingo umodzi sayenera kupitirira 600 mg.
Ndi kutukusira kwa mafupa a m'chiuno, mankhwalawa amathandizidwa ndi 900 mg ndi yopuma pakati Mlingo wa maola 8.
Dokotala wokhayo ndiye ali ndi ufulu kusintha mtundu wa mankhwalawo, kutengera momwe mankhwalawo amathandizira, chithunzi cha matenda opatsirana, ndi machitidwe a wodwala:
| Njira yachilengedwe | Chithandizo cha mankhwala |
| Matenda a Beta Hemolytic Streptococcus | Njira ya chithandizo ndi masiku 10. 1200-1800 mg ndi mankhwala patsiku, logawidwa m'magulu atatu. |
| Ziphuphu za chibayo za chibayo mwa odwala Edzi | I / O 0.6-0.9 g aliyense maola 6 kapena 900 mg ndi gawo la maola 8 kwa masiku 21. |
| Kutupa kwa Pelvic | 900 mg iv ndi nthawi pakati Mlingo wa maola 8. Ndikulimbikitsidwa kuphatikiza mankhwala a antibacterial ndi mankhwala omwe amatsutsana ndi gram-aerobes yoyipa. Clindamycin imayang'aniridwa iv m'masiku 4 ndi masiku awiri pambuyo pa kusintha kwa zomwe wodwala amakhala nazo. Pambuyo jekeseni, amasinthana kukamwa makapisozi a Dalacin C ndi 450-600 mg wa pakadutsa maola 6. Njira yochizira imatenga masiku 10 mpaka 14. |
| Kupewa kumatenda opaleshoni pamutu ndi m'khosi | 900 mg ya mankhwalawa imapukusidwa mu 1000 ml ya isotonic 0,9% sodium kolorayidi ndi kuthiriridwa panthawi ya opaleshoni, mabala otseguka a mutu ndi khosi musanayambe kupindika. |
| Toxoplasma encephalitis chifukwa cha kachilombo ka HIV | Mu / pakukhazikitsa 0.6-1.2 g maola 6 aliwonse kwa masabata awiri, kenako ndikutsatira pakamwa kwa makapisozi a 300 mg a 300 mg maola 6 aliwonse. Mankhwala olimbana ndi mankhwalawa amaphatikizidwa ndi pyrimethamine mlingo wa 25-75 mg. Ndi kukhazikitsidwa kwa mlingo waukulu, folic acid ndi mankhwala 10-25 mg. |
| Kupewa kwa endocarditis pamaso pa hypersensitivity ku gulu la penicillin | IV 600 mg ola limodzi isanakwane penicillin. |
Ndi matenda ashuga
Odwala omwe ali ndi matenda ashuga amalimbikitsidwa kuti apatsidwe mankhwala ena onse.
Odwala omwe ali ndi matenda ashuga amalimbikitsidwa kuti apatsidwe mankhwala ena onse.
Zotsatira zoyipa za Dalacin Ts
Zotsatira zoyipa zimachitika ndi mlingo woyenera wa mankhwalawa kapenanso mlingo umodzi wapamwamba.
Matumbo
Ndi chitukuko cha zoyipa m'mimbamo ya m'mimba, zotsatirazi zingachitike:
- kupweteka kwa epigastric;
- kuthawa;
- dysbiosis yamatumbo;
- kamwa yowuma
- esophagitis;
- cholestatic jaundice;
- matenda a chiwindi;
- pseudomembranous enterocolitis.
Pakati mantha dongosolo
Palibe zoyipa zomwe zimachitika chifukwa cha mankhwalawa pazomwe zimachitika m'magazi amanjenje.
Kuchokera kwamikodzo
Pali mwayi wa vaginitis.
Chimodzi mwazotsatira zoyipa za Dalacin C ndikutheka kwa vaginitis.
Kuchokera ku kupuma
Mu makanda asanakonzekere, chifukwa cha kupezeka kwa mowa wa benzyl popanga yankho la Dalacin C, kuyambika kwa vuto la kufalikira kumatha.
Pa khungu
Mothandizidwa ndi intramuscularly, khungu limapweteka, ndipo zilonda zam'mimba zimatha kuwoneka. Nthawi zina, thrombophlebitis imawonedwa.
Matupi omaliza
Odwala omwe amakonda kuwonetseredwa kwa thupi lawo siligwirizana, nthawi zambiri, zotupa za kachitidwe zimawonedwa pakhungu lowonda komanso loletsa. Chotupa chake ndi chofanana ndi chikuku.
Madokotala anati mawonekedwe a chotupa cha maculopapular, kuyabwa, urticaria.
Nthawi zina, multifocal Stevens-Johnson erythema, anaphylactic mantha, angioedema ndi exfoliative dermatitis amapangidwa.
Odwala amakonda thupi lawo siligwirizana, mutamwa Dalacin C, zotupa za pakhungu zimawonedwa pakhungu.
Zokhudza mphamvu pakuwongolera njira
Mankhwala samalepheretsa magwiridwe antchito a ziwalo zamkati zamanjenje ndipo samayambitsa matenda a psychomotor. Chifukwa chake, mukamalandira mankhwalawa ndi clindamycin, kuyendetsa kumaloledwa, mutha kuchita masewera olimbitsa thupi ndikuwongolera zida zovuta zomwe zimafuna kuyang'aniridwa komanso kuthamanga kwambiri panthawi ya ntchito.
Malangizo apadera
Kapangidwe ka mankhwala ndimaphatikizidwe ndi benzyl mowa. Gawo lothandiza limatha kuyambitsa mpweya-kulavulira kapena kupweteka kwa dyspnea, komwe kumatha kubweretsa kuphedwa kwa akhanda.
Nthawi yotsatsa itatha, milandu yokhala ngati ma pseudomembranous colitis motsutsana ndi matenda otsegula m'mimba idalembedwa, chifukwa cha mawonekedwe a zotupa zotayirira, ndikofunikira kupatula chiopsezo cha matendawa.
Ngati pali zokayikitsa za chitukuko cha pseudomembranous enterocolitis, ndikofunikira kuyimitsa kudya kapena jakisoni wa Dalacin C.
Akazindikira kuti amatsimikizira kuti ali ndi vutoli, mankhwalawo amathetsedwa. Kuchepa kwa matenda akuchulukirachulukira ngati magaziwo akupezeka ndowe.
Ndikofunika kukumbukira kuti ma antimicrobials amalepheretsa microflora yachilengedwe m'matumbo.
Ndikofunika kukumbukira kuti ma antimicrobials amalepheretsa microflora yachilengedwe m'matumbo. Izi zimatha kupangitsa kukula kwa clostridia komanso kulepheretsa kaphatikizidwe ka vitamini K. Clostridium Hardile kungayambitse matenda a pseudomembranous colitis, njira yoopsa yomwe imafunanso kubwezeretsanso kwa zamagetsi zamagetsi. Poizoni wa Clostridium amathandizira kuthetsa kudya kwa 150-500 mg wa vancomycin.
Gwiritsani ntchito mu ukalamba
Anthu azaka zopitilira 65 azilandira mlingo woyenera.
Kupangira Dalacin Ts kwa ana
Muubwana, kuyambira mwezi umodzi, mlingo wa tsiku ndi tsiku umatsimikiziridwa pamlingo wa 20-40 mg pa 1 kg ya kulemera kwa thupi. Mlingo umagawidwa majekeseni atatu. Kwa akhanda mpaka masiku 30 amoyo, tikulimbikitsidwa kuti mupereke mankhwalawa kanayi pa tsiku ndi mlingo wa 15-20 mg pa 1 makilogalamu.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Clindamycin imatha kudutsa chopinga. Pakupanga kwa mwana wosabadwayo mothandizidwa ndi mankhwala osokoneza bongo, kuyika kwa cartilage ndi minofu minofu kumatha kusokonekera.
Kwa azimayi oyembekezera, mankhwalawa amalembedwa pokhapokha pazovuta.
Kwa azimayi oyembekezera, mankhwalawa amangolembedwa pokhapokha povuta, pamene kuthekera kwa intrauterine pathology komwe kumachitika mu mluza kumakhala kocheperako poyerekeza ndi chiopsezo ku moyo wa mayi.
Pa mankhwala, ndikofunikira kuyimitsa kuyamwitsa.
Mankhwala ochulukirapo a Dalacin Ts
Panalibe milandu ya bongo. Odwala omwe akuwonetsedweratu, zimachitika kuti anaphylactoid angayambike, ndikuwonetsa mawonekedwe a angioedema ndi kukula kwa anaphylactic. Pankhaniyi, kuyambitsidwa kwa adrenaline kapena GCS (glucocorticosteroids) ndikofunikira.
Kuchita ndi mankhwala ena
Panthawi yophunzira zamankhwala, ndikulowerera pamodzi kwa clindamycin ndi erythromycin kulowa mu khungu, zotsatira zoyipa zimawonedwa. Mankhwala alibe zochizira. Pazinthu zotere, kuwopsa kwa maselo kumawonjezeka, chifukwa chake mankhwalawa sakuphatikizidwa ndi zovuta.
Pali kupangika kwa mankhwala a Dalacin C okhala ndi minyewa yopuma chifukwa choletsa kufalitsa kwa chikondwerero cha neuromuscular ndi clindamycin.
Kuphatikiza kumeneku kumagwiritsidwa ntchito pazowopsa zokha. Popereka mankhwala onse, kuyang'anira wodwala ndikofunikira.
Mtundu wa yankho la Dalacin C yankho silimagwirizana ndi ciprofloxacin.
Mlingo wothetsera vutoli sugwirizana ndi Ampicillin, barbiturates, sodium bicarbonate, Ciprofloxacin.
Kuyenderana ndi mowa
Mankhwala ndi Dalacin C, mowa sayenera kuledzera. Mowa wa Ethyl umawononga mphamvu yogwira ntchito kwamkati wamanjenje, ziwalo zamagazi ndi chiwindi. Ethanol ikhoza kuyambitsa kufooka kwa zochizira, zimachulukitsa zovuta.
Analogi
Gulu la zomwe zimachitika m'malo omwe ali ndi mankhwala ofanana ndi mankhwala
- Dalmatia
- Clindamycin;
- Makapisozi a Clindacil;
- Clindacin.
Dokotala wopezekapo ali ndi ufulu wogwirizira makapisozi kapena yankho la Dalacin C pakadalibe njira zochizira kapena zotsatira zoyipa.
Kupita kwina mankhwala
Wopanga mankhwala sangagulitse mankhwala popanda mankhwala.
Mtengo wa Dalacin Ts
Mtengo wapakati wa makapisozi ndi ma ruble 700, yankho la jakisoni - 1789 rubles.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kuti mankhwalawa asungidwe m'malo okhala ndi chinyezi chochepa kwambiri, otetezedwa ndi dzuwa, kutentha mpaka + 25 ° C.
Tsiku lotha ntchito
Zaka 2
Wopanga
Kupanga Pfizer, Belgium.
Analogue ya Dalacin C - mankhwala Clindacin akulimbikitsidwa kuti azisungidwa m'malo okhala ndi chinyezi chochepa chinyezi.
Ndemanga za Dalacin Ts
Antonina Efimova, wazaka 27, Ryazan.
Makapisozi olembedwa Dalacin C gynecologist. Ndakhala ndikusokonezeka msambo chifukwa cha kukula kwa microflora yama bakiteriya. Pambuyo pa mankhwala a 2 milungu, kutupa kumapita, kukula kwina kwama bakiteriya kunayima. Mankhwalawa adapirira bwino ndi ntchito yake. Kumbukirani kuti maantibayotiki ndi ovuta kugaya.Mankhwala ayenera kumwedwa nthawi yayitali monga momwe dokotala wakunenera.
Lidia Fedotova, wazaka 34, Krasnodar.
Nditenga makapisozi monga adanenera dotolo wamano. Mankhwala othandizira amafunikira kupewa matenda pakachitika opaleshoni yovuta. Sindinazindikire zovuta zilizonse, panalibe zovuta pambuyo pakuchita opareshoni. Koma panali vuto matumbo. Dysbacteriosis inayamba, chifukwa chake kunali kofunikira kutenga ma proiotic.
