Mankhwala Rosuvastin ndi Atorvastatin ndi othandizira a hypolipidemic. Kuphatikiza pa kuthekera kutsitsa cholesterol yamagazi, ali ndi antioxidant katundu ndipo amalepheretsa kukula ndi kugawikana kwa zotupa maselo. Kupangidwa ndi makampani osiyanasiyana opanga mankhwala ku Russia ndipo ali m'gulu la mankhwala omwe mumalandira.
Makhalidwe a rosuvastatin
Mankhwala ndi piritsi yoyera ya biconvex yokhala ndi yogwira mankhwala rosuvastatin, pazotsatirazi:
- 5 mg;
- 10 mg;
- 20 mg;
- 40 mg
Mankhwala Rosuvastin ndi Atorvastatin m'munsi mafuta m'thupi, ali ndi antioxidant katundu ndipo akuletsa kukula kwa zotupa maselo.
Mapiritsi amagulitsidwa m'makatoni. Kuchuluka kwazomwe zili phukusili ndi ma 7 ma PC., Pazowonjezera ndi 300 ma PC.
The bioavailability wa mankhwala pafupifupi 20%. Pazitali kwambiri mumagazi mumafika maola 5 pambuyo pa kuperekedwa. Kutha kwa theka-moyo ndi maola 19.
Mlingo wovomerezeka wa mankhwalawa ndi 10 mg (kwa odwala a mtundu wa Mongoloid - 5 mg), omwe amatengedwa kamodzi patsiku. Ngati ndi kotheka, ikhoza kuwonjezeka mpaka 20 mg kamodzi patsiku, koma osapitirira kuposa mwezi wokhazikitsidwa. Kugwiritsa ntchito Mlingo wa 40 mg ndikotheka mwa mitundu yayikulu yokha ya matenda ndikuyang'aniridwa ndi dokotala.
Khalidwe la Atorvastatin
Gawo lomwe limagwira ntchito ndi mankhwala omwewo omwe amatha kupezeka piritsi zotsatirazi:
- 10 mg;
- 20 mg;
- 40 mg;
- 80 mg
Kutengera ndi wopanga, mapiritsiwo amatha kukhala ozungulira kapena ozungulira, kukhala ndi cholembedwa kumbali imodzi ya mbali. Mankhwalawa amagulitsidwa m'makatoni. Chiwerengero chochepa cha mapiritsi omwe ali phukusi ndi 10 zidutswa, pazitali ndizingwe 300.
Atorvastatin iyenera kutengedwa pamimba yopanda kanthu, chifukwa kuphatikiza ndi chakudya kumalepheretsa kuyamwa kwa chinthu.
Mankhwala amadziwika ndi otsika bioavailability (12%). Kuzindikira kwakukulu kumakwaniritsidwa patatha maola awiri atatha kukhazikitsa. Hafu ya moyo ndi maola 13.
Mlingo wa mankhwalawa zimatengera kukhudzana koyambirira kwa cholesterol ndipo amayenera kusankhidwa payekhapayekha kwa wodwala aliyense. Njira yoyamba yolimbikitsidwa ndi 10 mg kamodzi patsiku. Mlingo wololedwa wambiri patsiku ndi 80 mg. Mankhwala ayenera kumwedwa pamimba yopanda kanthu. Kuphatikiza ndi chakudya kumalepheretsa kuyamwa kwa zinthu zomwe zimagwira.
Kuyerekezera Mankhwala
Mankhwala onse omwe amawaganizira ndi a gulu la zopangidwa ma statins. Poyerekeza ndi zinthu zina za gululi, zimadziwika ndi kuchepa kwamtundu wa TG. Komabe, zosakaniza zawo zogwira ntchito sizofanana.
Kufanana
Mankhwalawa ali ndi cholinga chomwecho chotenga - kutsitsa cholesterol. Awo mankhwalawa amatha kuchepa kwa chopinga cha HMG-CoA reductase. Zotsatira za izi ndizakuchepa kwa cholesterol m'maselo ndi activation ya LDL cholesterol catabolism. Kuchuluka kwake komwe kumapangitsa kutsekemera kwake kumadalira mlingo wa mankhwalawo.
Zotsatira zina zabwino mukutenga Rosuvastatin kapena Atorvastatin ndi:
- kusintha kwa endothelium ndi kukanika;
- matenda a rheological magazi;
- kusintha kwa boma la makoma a mtima ndi atheroma.
Zizindikiro zamagwiritsidwe ntchito awa ndi matenda otsatirawa:
- hypercholesterolemia zosiyanasiyana, kuphatikizapo homozygous mabanja hypercholesterolemia;
- Hyperlipidemia mtundu IIa ndi IIb;
- Mtundu wa III wa dysbetalipoproteinemia;
- endo native hypertriglyceridemia (mtundu IV).
Kuphatikiza apo, mankhwalawa amagwiritsidwa ntchito ngati prophylaxis ndi odwala omwe ali ndi zifukwa zingapo zothandizira matenda a mtima, monga:
- zaka zopitilira 55;
- kusuta
- matenda a shuga;
- matenda oopsa
- cholesterol yotsika (HDL) m'magazi;
- chizolowezi cha chibadwa.
Amawalembera anthu omwe adapezeka ndi ischemia, kuti achepetse mwayi wokhala ndi angina pectoris, kugunda kwa mtima kapena sitiroko.
Mankhwala ali ndi zotsutsana zomwezi. Rosuvastatin kapena Atorvastatin sanalembedwe:
- matenda a chiwindi mu gawo yogwira;
- pa mimba ndi mkaka wa m`mawere;
- ana ndi achinyamata.
Mosamala, mankhwalawa ayenera kugwiritsidwa ntchito ndi:
- uchidakwa;
- kukonzekera kwa myopathy;
- kulephera kwambiri kwaimpso.
Mawonekedwe ake amachititsa thupi kusintha mankhwala ndi mankhwalawa ndi ofanana. Akatengedwa, amakula monga zovuta monga:
- kusowa tulo ndi chizungulire, komanso zochitika zina kuchokera kumanjenje yayikulu;
- kukhumudwa kwamalingaliro, monga kuchepa kwa kakomedwe kapena tinnitus;
- kupweteka pachifuwa, arrhythmia, angina pectoris;
- kuchepa magazi, kusokonezeka kwa magazi;
- bronchitis, chibayo, mphumu, mphuno;
- nseru ndi zina zam'mimba zimachitikira;
- nyamakazi, kuchuluka kwa gout;
- kutupa
- chitukuko cha matenda a urogenital;
- kukhudzana kwa khungu;
- Kusintha kwa kuchuluka kwa magazi;
- kulemera;
- kukula kwa bere;
- mawonetseredwe a ziwengo.
Kwambiri achire zotsatira zimatheka pambuyo 4 milungu mankhwala ndi mankhwalawa.
Mukamamwa mankhwalawa, amayi omwe ali ndi zaka zobereka ayenera kugwiritsa ntchito njira zodalirika zakulera.
Kodi pali kusiyana kotani?
Ngakhale ndizofanana, mankhwalawa ndi amibadwo yosiyanasiyana yama statins. Rosuvastatin ndikutukuka kwatsopano komwe kumakupatsani mwayi wochepetsa ndi mulingo woyenerera wa chinthu chomwe chikugwirika chifukwa chogwira ntchito kwambiri.
Mankhwala omwe afunsidwa ali ndi njira zosiyanasiyana zothetsera:
- atorvastatin amuchotsa kuchokera mu thupi ndi bile mu mawonekedwe a metabolites momwe amasinthidwa ndi michere ya chiwindi;
- rosuvastatin - wosasinthika ndi ndowe.
Rosuvastatin ndi chinthu cha hydrophilic, ndipo Atorvastatin imasungunuka m'mafuta.
Mtundu wachiwiri wa matenda a shuga a shuga, ndikofunikira kusankha rosuvastatin, chifukwa umakhala ndi mphamvu zochepa pakukula kwa chakudya.
Zomwe zili bwino
Kafukufuku akuwonetsa kuti zomwe zimachitika potsatira zovuta ndizofanana kwa mankhwalawa.
Zidadziwika kuti ndi mtundu wachiwiri wa matenda ashuga, ndikofunikira kusankha ma hydrophilic statins, omwe akuphatikizapo Rosuvastatin, chifukwa zinthu zotere zimakhudza kagayidwe kazakudya.
Zomwe zimakhala zotsika mtengo
Mitengo ya Rosuvastatin ndi Atorvastatin zimatengera zinthu zingapo:
- kuchuluka kwa mapiritsi pa paketi iliyonse;
- wopanga mankhwala;
- ndondomeko yamitengo yamapulogalamu;
- dera yogulira mankhwalawo.
Mankhwala odziwika pa intaneti amakonda kugula Rosuvastatin pamitengo yotsatirayi:
- Mapiritsi 30 a 10 mg opangidwa ndi Izvarino Pharma - ma ruble 545.7;
- Mapiritsi 30 a 10 mg opangidwa ndi Vertex - 349.3 rubles;
- Mapiritsi 60 a 20 mg, opangidwa ndi Canonpharm Production LLC, - 830.5 rubles.;
- Mapiritsi 90 a 20 mg opangidwa ndi kampani "North Star" - ma ruble 1010.8.
Atorvastatin itha kugulidwa pamtengo wotsatirawu:
- Mapiritsi 30 a 10 mg opangidwa ndi kampani ya North Star - 138 rubles;
- Mapiritsi 30 a 10 mg opangidwa ndi Ozone LLC - ma ruble 65.4;
- Mapiritsi 60 a 40 mg opangidwa ndi kampani ya North Star - ma ruble 361.4;
- Mapiritsi 90 a 20 mg a Vertex mtundu - 799 ma ruble.
Kuchokera pamitengo yomwe tafotokozayi, zikuwonekeratu kuti Atorvastatin ndi mankhwala otsika mtengo kuposa Rosuvastatin.
Ndibwino - rosuvastatin kapena atorvastatin?
Zambiri zomwe zikupezeka poyerekeza kugwira bwino kwa mankhwalawa zimawonetsa kuti chithandizo cha rosuvastatin chimathandizanso kuchepetsa kutsika kwa cholesterol. Kuphatikiza apo, mankhwalawa ndi amtundu wa mibadwo 4 ndipo akuwonetsa kugwirira ntchito kwakukulu ngati prophylactic kwa matenda a m'mitsempha.
Komabe, kusankha kwa mankhwala kuyenera kupangidwa ndi dokotala yemwe akupita kwa wodwala aliyense, poganizira za momwe alili, matenda omwe ali kale komanso kuchuluka kwachuma.
Kodi rosuvastatin akhoza m'malo mwa atorvastatin?
Ngakhale kuti kufananizira kwa nyimbo kumawonetsa kuti zomwe zimagwiritsidwa ntchito ku Rosuvastatin ndi Atorvastatin sizinthu zomwezo, ndizofananira komanso zosinthika. Komabe, musanachoke ku mankhwala amzake kupita ku wina, muyenera kufunsa dokotala nthawi zonse, chifukwa ma pharmacokinetics a mankhwalawa ndi osiyana, chifukwa chomwe mankhwalawa amakhudza maselo a chiwindi ndi ubongo mosiyanasiyana, komanso njira zosiyanasiyana zoperekera miyala.
Madokotala amafufuza
Grigory, wazaka 46, ku Moscow: "Chinthu chachikulu chomwe wodwala ayenera kudziwa akamamwa mankhwalawa ndikuti cholinga chawo sichimachotsa kufunika kotsatira zakudya zomwe wapatsidwa. Choyamba, ndimavomereza Rosuvastatin, chifukwa kuyesedwa kwake kwakukulu kumatsimikiziridwa ku chipatala. .
Valentina, wazaka 34, Novosibirsk: "Ndimaona kuti kumwa mankhwalawa ndi njira yabwino kwambiri yothandizira matenda a mtima ndi matenda a mtima. Ndimpereka kwa odwala onse omwe ali ndi cholesterol yayikulu."
Ndemanga za Odwala a Rosuvastatin ndi Atorvastatin
Nikolai: wa zaka 52, Kazan: "Ubwino wokha wa Atorvastatin ndi mtengo wotsika. Kwa ine, kayendetsedwe kake kanaphatikizidwa ndi zovuta zingapo: nseru ndi mutu zimasokonekera nthawi zonse. Nthawi yomweyo, kuchuluka kwa cholesterol ya magazi kumakhalabe kokwezeka."
Svetlana, wazaka 45, Murmansk: "Upangiri wa dokotala, ndinasiya kumwa Atorvastatin kupita ku Rosuvastatin, chifukwa chinkandisokoneza pafupipafupi. Nditha kunena kuti mankhwalawa sadzetsa vuto lotere, komanso amakhudzanso mafuta a cholesterol."
