Janumet 850 adalembedwa kuti abwezeretse shuga m'magazi. Ubwino wa mankhwalawa ndi kupezeka kwa kuphatikiza kwa zinthu zomwe zimawonetsa kutchulidwa kwa hypoglycemic.
Dzinalo Losayenerana
Metformin + sitagliptin
Janumet 850 adalembedwa kuti abwezeretse shuga m'magazi.
ATX
A10BD07
Kutulutsa mafomu ndi kapangidwe kake
Pali mtundu umodzi wokha wa mankhwalawa - mapiritsi. Zigawo zazikulu ndi: metformin hydrochloride, sitagliptin phosphate monohydrate. Kuphatikizika kwa mankhwala awa ndi kosiyana kwambiri. Piritsi limodzi lili ndi mlingo wa metformin - 850 mg, sitagliptin - 50 mg.
Pali mitundu ina ya Yanumet. Amasiyana mu gawo la metformin. Kuchuluka kwa zinthuzi kumatha kukhala 500 kapena 1000 mg. Kuzunzidwa kwa sitagliptin nthawi zonse kumakhala 50 mg. Mutha kugula mankhwalawa m'mapaketi am'melo. Chiwerengero chawo chonyamula makatoni amasiyana: 1, 2, 4, 6, 7 ma PC.
Pali mtundu umodzi wa mapiritsi a Yanumet.
Zotsatira za pharmacological
Magawo onsewa omwe amapangidwa ndi Yanumet ali m'gulu la othandizira a hypoglycemic. Amagwiritsidwa ntchito pophatikiza, chifukwa amadziwika ndi zotsatira zowonjezera. Njira, metformin imathandizira mphamvu ya sitaglipin m'thupi ndi mosemphanitsa. Mukamagwiritsa ntchito zinthu zonsezi payekhapayekha, zotsatira zake zimapezeka mosavomerezeka. Mankhwala osakanikirana a Yanumet nthawi zambiri amapatsidwa mankhwala a metformin, pomwe sizotheka kukwaniritsa kusintha kwa wodwala.
Chilichonse mwazinthu zomwe zimachitika mosiyanasiyana, chifukwa zonse ziwiri ndi zamagulu osiyanasiyana amankhwala. Mwachitsanzo, metformin ndi woimira gulu lalikulu la Biguanide. Sizikhudza kupanga insulin. Makina a zochita za metformin amatengera njira zina. Komabe, ndi mankhwala omwe ali ndi chinthu ichi, kuwonjezeka kwa chidwi cha thupi pokoka insulin kumadziwika. Izi zimachitika chifukwa cha kuchepa kwa chiwerengero cha insulin chomasuka. Komabe, chiŵerengero cha insulin kwa proinsulin chikuwonjezeka.
Metformin ili ndi mwayi wambiri pazinthu zina zomwe zimakhala ndi hypoglycemic. Chifukwa chake, izi zimakhudza kagayidwe ka lipid: zimachepetsa kaphatikizidwe ka mafuta aulere acid, pamene makutidwe ndi okosijeni amatsalira, omwe amalepheretsa kuyamwa kwawo. Chifukwa chake, limodzi ndi matenda a shuga, pali kuchepa kwamphamvu kwa mapangidwe a mafuta. Izi zimakhazikitsa kulemera.
Ntchito ina ya metformin ndi kuponderezedwa kwa kaphatikizidwe ka shuga m'magazi. Nthawi yomweyo, pali kuchepa kwamphamvu kwa mayamwidwe a shuga m'matumbo. Metformin imasiyana ndi ma analogues (zotchedwa sulfonylurea zotumphukira) mwakuti sizimayambitsa chitukuko cha hypoglycemia. Popeza kuti gawo ili silikukhudzana ndi kapangidwe ka insulin, kufunikira kwa zizindikiro za hyperinsulinemia kumakhala kotsika kwambiri.
Magawo onsewa omwe amapangidwa ndi Yanumet ali m'gulu la othandizira a hypoglycemic. Amagwiritsidwa ntchito pophatikiza, metformin imathandizira zotsatira za sitaglipin ndi mosemphanitsa.
Katundu wachiwiri (sitagliptin) ndi choletsa wa enzyme DPP-4. Ikatengedwa, njira ya syntretin synthesis imayambitsa. Ichi ndi mahomoni omwe amathandizira kudzilamulira pakudzipanga shuga. Zotsatira zabwino zimaperekedwa chifukwa cha kuyambitsa kwa kaphatikizidwe ka insulin ndi kutenga kwa kapamba. Komabe, kuchuluka kwa kupanga glucagon kumachepa. Zotsatira zake zakupangira izi, kuletsa kwa kaphatikizidwe ka glucose kumadziwika.
Pharmacokinetics
Zambiri zomwe zimapezeka mu metformin zimatha pambuyo pa mphindi 120 mutamwa mankhwalawa. Ma pharmacokinetics a chinthu ichi amakula msanga. Pambuyo maola 6, kuchuluka kwa metformin kumayamba kuchepa. Chimodzi mwazinthu izi ndi kuperewera kwamphamvu mapuloteni a plasma. Amasiyanitsidwa ndikutha kudziunjikira pang'onopang'ono mu zimakhala za chiwindi, impso, komanso kuphatikizira gland. Kuthetsa theka-moyo kumasiyanasiyana patatha maola angapo. Metformin imachotsedwa m'thupi ndikugawana impso.
Pankhani ya bioavailability, sitagliptin imaposa zomwe takambirana pamwambapa. Kuchita kwa paramuyi ndi 87 ndi 60%, motsatana. Sitagliptin alibe bwino. Poterepa, gawo lalikulu la mankhwalawo limachotsedwa m'thupi momwe limalowetsanso ziwalo zam'mimba. Hafu ya moyo wa chinthu ichi ndi yayitali ndipo ndi maola 12.
Zizindikiro zogwiritsidwa ntchito
Mankhwala ndi mtundu wa II matenda a shuga. Yanumet ndi othandiza kwambiri kuposa mankhwala amodzi amodzi omwe amapangidwa ndi metformin kapena zinthu zina zomwe zimalepheretsa kaphatikizidwe ka glucose. Pachifukwa ichi, chimagwiritsidwa ntchito pomwe sizinali zotheka kukwaniritsa zotsatira zabwino pa chithandizo cha matenda a shuga II mellitus.
Janumet amalembera mtundu wachiwiri wa shuga.
Janumet ikhoza kutumikiridwa panthawi yovuta ya mankhwala limodzi ndi mankhwala a gulu la sulfonamide. Chidachi chimagwiritsidwa ntchito pokana kudya kwa hypocaloric ndi masewera olimbitsa thupi.
Contraindication
Mankhwalawa sangathe kugwiritsidwa ntchito ngati vuto lililonse la munthu likupanga. Zotsutsa zina:
- ovuta a wodwalayo, akukhudza impso: kugwedezeka, matenda akulu;
- matenda limodzi ndi kuwonongeka kwa mtima, hypoxia;
- mtundu I matenda ashuga mellitus;
- uchidakwa;
- kuchuluka acidity m'magazi (lactic acidosis).
Janumet adayikidwa kuti adye zakudya. Musapitirire muyeso wa tsiku ndi tsiku wa sitagliptin (100 mg).
Ndi chisamaliro
Odwala a zaka zopitilira 80 ayenera kugwiritsa ntchito mankhwalawa mosamala.
Mungamutenge bwanji Janumet 850?
Mapiritsi amayikidwa kuti agwiritsidwe ntchito ndi zakudya. Musapitirire muyeso wa tsiku ndi tsiku wa sitagliptin (100 mg). Pafupipafupi kumwa mankhwalawa ndi 2 pa tsiku.
Ndi matenda ashuga
Muyenera kuyambitsa maphunziro a mankhwalawa osagwira ntchito pang'ono (sitagliptin, metformin): 50 ndi 500 mg, motero. Nthawi zambiri kuvomerezeka kumakhala kosasinthika munthawi yonse ya chithandizo (2 kawiri pa tsiku). Komabe, mlingo wa metformin ukuwonjezeka pang'onopang'ono. Pambuyo pa 500 mg, adotolo amatipatsa 850, ndiye 1000 mg. Pomwe kuwonjezeka kwa mlingo wa mankhwalawa kumatsimikiziridwa payekhapayekha, chifukwa zimatengera momwe thupi lilili, kupezeka kwa matenda ena.
Zotsatira zoyipa za Yanumet 850
Zizindikiro zamanjenje: kugona, kupweteka mutu, chizungulire.
Kuchokera ku minculoskeletal system: kupweteka kumbuyo, kupweteka kwa minofu.
Muyenera kuyambitsa maphunziro a mankhwalawa osagwira ntchito pang'ono (sitagliptin, metformin): 50 ndi 500 mg, motero. Pambuyo pa 500 mg, adotolo amatipatsa 850, ndiye 1000 mg.
Matumbo
Khansa ya m'mimba, kudekha kwam'mimba, zimbudzi zotayirira (zingasinthane ndi zovuta zotumphukira), pakamwa pouma. Chomwe chimakonda ndi mawonekedwe akusanza.
Kuchokera kumbali ya kagayidwe
Matenda a anorexia.
Pafupipafupi - kuchepa kwa glycemia, ndipo izi sizimagwirizanitsidwa ndi kuphatikiza kwa zinthu zomwe zili gawo la Yanumet. Panthawi ya mayesero azachipatala, zidapezeka kuti kuchepa kwa glycemia kumachitika chifukwa cha machitidwe a thupi pazinthu zosiyanasiyana zamkati ndi zakunja zosagwirizana ndi mankhwalawa.
Chiwopsezo cha hypoglycemia mwa odwala omwe amamwa mankhwalawa ndiwofanana ndi omwe amachokera ku gulu lomwe metformin adayikidwa ndi placebo.
Pa khungu
Kutupa, kuyabwa, kutupa, vasculitis, matenda a Stevens-Johnson.
Kuchokera pamtima
Zosawonedwa.
Matupi omaliza
Urticaria, limodzi ndi kuyabwa, zotupa, kutupa.
Zokhudza mphamvu pakuwongolera njira
Palibe maphunziro ngati omwe adachitidwapo. Komabe, ziyenera kukumbukiridwa kuti mankhwalawa amachititsa kuti pakhale zovuta zingapo zamagetsi amkati (kugona, chizungulire, ndi zina). Chifukwa chake, kusamala kuyenera kugwiritsidwa ntchito poyendetsa magalimoto.
Malangizo apadera
Pali zambiri zokhudzana ndi ubale pakati pa kumwa mankhwalawa komanso kukula kwa kapamba. Zizindikiro zikawoneka, chithandizo ndi Yanumet chimayimitsidwa.
Pogwiritsa ntchito mankhwalawa pogwiritsa ntchito chida ichi, kamodzi pachaka, zizindikiro za impso zimayang'aniridwa. Ndi kuchepa kwakukulu kwa chilolezo cha creatinine, mankhwalawa amathetsedwa.
Ngati Yanumet imagwiritsidwa ntchito nthawi yomweyo ndi insulin kapena njira yamagulu ena a sulfonylurea, mlingo wotsiriza umasinthidwa (pansi).
Pali zambiri zokhudzana ndi ubale pakati pa kumwa mankhwalawa komanso kukula kwa kapamba. Zizindikiro zikawoneka, chithandizo ndi Yanumet chimayimitsidwa.
Ndi mankhwala omwe ali ndi mankhwala okhala ndi sitagliptin, chiwopsezo cha hypersensitivity zimachitika. Komanso, mawonekedwe osalimbikitsa samachitika nthawi yomweyo, koma patatha miyezi yochepa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Momwe muli ndi mwana, ndizovomerezeka kugwiritsa ntchito Yanumet, komabe, mankhwalawa amawanenedwa pokhapokha ngati zotsatirapo zake mu mphamvu zimakulirakulira.
Pa mkaka wa m`mawere, mankhwala omwe amagwiritsidwa ntchito sagwiritsidwa ntchito.
Kukhazikitsidwa kwa Yanumet kwa ana 850
Mankhwala sanatchulidwe.
Gwiritsani ntchito mu ukalamba
Sitikulimbikitsidwa kugwiritsa ntchito Janumet kwa odwala omwe ali ndi zaka zopitilira 80. Kusiyana kwake ndi pamene kuchuluka kwa creatinine mwa okalamba kumakhala koyenera.
Sitikulimbikitsidwa kugwiritsa ntchito Janumet kwa odwala omwe ali ndi zaka zopitilira 80.
The ntchito aimpso kuwonongeka
Ndi kuwonongeka kofooka, kwapakati komanso koopsa ku chiwalo ichi, Janumet sakulimbikitsidwa kuti atengedwe, chifukwa muzochitika zake zilizonse kuzungulira kwa thupi kumachuluka.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Palibe chidziwitso pa cholinga cha mankhwalawo pakufunsidwa ndikuchepa kwakukulu kwa impso. Pachifukwa ichi, muyenera kupewa kumwa mankhwalawa kwambiri chifukwa cha kusakwanira kwa ntchito ya thupi.
Mankhwala ochulukirapo a Janumet 850
Palibe chidziwitso pakukula kwa zovuta mutamwa mankhwalawa. Komabe, mankhwala osokoneza bongo a metformin amathandizira kuti pakhale lactic acidosis. Njira yayikulu yothandizira ndi hemodialysis. Chifukwa cha izi, kuchuluka kwa metformin mu seramu yamagazi kumachepa.
Kuchita ndi mankhwala ena
Othandizira angapo ndi zinthu zina zimadziwika zomwe kutha kwake kumatsika mothandizidwa ndi Yanumet:
- okodzetsa;
- glucocorticosteroid mankhwala;
- phenothiazines;
- mahomoni a chithokomiro;
- phenytoin;
- nicotinic acid.
Phatikizani Janumet ndi zakumwa zoledzeretsa siziyenera kukhala. Mowa umawonjezera mphamvu ya metformin pa metabolic njira yogwirizana ndi kusintha kwa lactic acid.
Ndipo, mmalo mwake, kugwiritsa ntchito nthawi imodzi ndi insulin, NSAIDs, Mao inhibitors ndi ACE inhibitors, othandizira a hypoglycemic, kuwonjezeka kwa kukula kwa zotsatira za Janumet m'thupi kumadziwika.
Kulandila kwa furosemide ndi chifukwa chakuwonjezeka kawiri m'ndende pazinthu zazikulu za wothandizirazo.
Ntchito za Digoxin zimawonjezeka panthawi ya mankhwala ndi Yanumet.
Kuchuluka kwa sitagliptin kumawonjezeka pamene mukutenga Cyclosporin ndi Yanuvia.
Kuyenderana ndi mowa
Phatikizani Janumet ndi zakumwa zoledzeretsa siziyenera kukhala. Mowa umawonjezera mphamvu ya metformin pa metabolic njira yogwirizana ndi kusintha kwa lactic acid.
Analogi
Pali ambiri m'malo mwa omwe amasiyana momwe amagwirira ntchito ndi kapangidwe kake. Mukamasankha, munthu ayenera kuganizira kuchuluka kwaukali kwa momwe amathandizira thupi, komanso mawonekedwe akumasulidwa. Zotheka:
- Gluconorm;
- Glucovans;
- Glibomet;
- Galvus Met et al.
Yoyamba mwa izi ndi kukonzekera magawo awiri, koma ili ndi metformin ndi glibenclamide. Yachiwiri ya zinthuzo imanena za zotumphukira za sulfonylurea, zomwe zikutanthauza kuti ndi mankhwalawa, chiopsezo cha mavuto amabwera. Gluconorm imasiyana ndi Yanumet chifukwa singagwiritsidwe ntchito panthawi yapakati komanso pakubala. Mtengo wa mankhwalawa ndi wotsika (ma ruble 250).
Glucovans ndi analogue ya Gluconorm. Kuphatikizikako kumaphatikizanso metformin ndi glibenclamide. Mankhwala angagwiritsidwe ntchito m'malo mwa Janumet, ngati palibe contraindication. Komabe, sayenera kugwiritsidwa ntchito m'malo mwa Gluconorm.
Glibomet ili ndi metformin ndi glibenclamide. Kuchuluka kwa zinthu zomwe zimagwira mosiyanasiyana kumatha kusinthasintha pang'ono, kumachulukitsa kapena kuchepetsa mphamvu ya mankhwala pakhungu lomwe liyenera kukumbukiridwa, chifukwa ngakhale kusintha kochepa muyezo wa kumwa mankhwala a hypoglycemic kungayambitse kukula kwa zovuta.
Galvus Met ndi yosiyana pakupanga. Ili ndi metformin ndi vildagliptin. Monga momwe zinalili kale, mlingo wa metformin umaposa kuchuluka kwa gawo lachiwiri. Mankhwalawa sangathe kugwiritsidwa ntchito panthawi yoyembekezera Komabe, itha kugwiritsidwa ntchito limodzi ndi insulin, mankhwala ochokera ku gulu la zotumphukira za sulfonylurea.
Galvus Met imakhala ndi metformin ndi vildagliptin, itha kugwiritsidwa ntchito limodzi ndi insulin, ndalama zochokera ku gulu la zotumphukira za sulfonylurea.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Palibe kuthekera koteroko; kuthandizidwa ndi adokotala ndikofunikira.
Mtengo wa Janumet 850
Mutha kugula malonda pamtengo wa ma ruble 2800.
Zosungidwa zamankhwala
Ndikulimbikitsidwa kuti tisunge kutentha kwa chipinda mkati mwa + 25 ° С.
Tsiku lotha ntchito
Kukonzekera komwe kuli ndi 850 ndi 50 mg wa zinthu kumakhalabe ndi malo kwakanthawi kochepa kuposa ma analog 500 a 500 ndi 50 mg. Alumali moyo wa malonda omwe amafunsidwa ndi zaka 2.
Wopanga
Kampani "Pateon Puerto Rico Inc." ku USA.
Ndemanga za Yanumet 850
Valeria, wazaka 42, Norilsk
Ndinazindikira kale kuti matendawa ndazindikira kale, kuyambira pamenepo nthawi zambiri ndimamwa mankhwala a hypoglycemic. Munthawi yakuchulukirachulukira, mankhwala omwe ali mgawo limodzi amathandiza bwino. Nthawi ngati izi, adotolo adalimbikitsa kutenga Janumet. Imathandiza pafupifupi nthawi yomweyo, koma zochita zake zimatha mofulumira. Kuphatikiza apo, mtengo wa mankhwalawo ndiwokwera.
Anna, wazaka 39, Bryansk
Chida chake ndichothandiza, ndimachisunga kunyumba kanyumba kamankhwala. Ndimakondanso chilengedwe chake: kulemera kumakhazikika, milingo ya glycemia imasintha, kaphatikizidwe ka insulini sikunayambitsa. Ndikhulupirira kuti kugwiritsidwa ntchito kwake ndi kuphatikiza kokha, ngati simukuphwanya njira yothandizira.
