Siofor 500 imagwiritsidwa ntchito kutsitsa glucose wamagazi. Amagwiritsidwanso ntchito ngati pofunika kukhazikika ndikuchepa. Kugwiritsa ntchito kwambiri kwa mankhwalawa kumachitika chifukwa cha zovuta zake: njira zingapo zamitundu mitundu zimasinthidwa panthawi ya mankhwala.
Dzinalo Losayenerana
Metformin
Siofor 500 imagwiritsidwa ntchito kutsitsa glucose wamagazi.
ATX
A10BA02
Kutulutsa mafomu ndi kapangidwe kake
M'mafakitala, mumatha kupeza mankhwala okhawo omwe ali ndi mapiritsi. Pazomwe mankhwala amafunsidwa, mlingo wa chinthu chachikulu (metformin hydrochloride) umasungidwa - 500 mg. Pali mitundu inanso yamankhwala yomwe imasiyana mu kuchuluka kwa chinthu ichi: 850 ndi 1000 mg.
Mankhwalawa amapangidwa m'matumba a cell omwe ali ndi mapiritsi 10 ndi 15. Bipangujo bivule bimobimo mu makatoni kadi: 2, 3, 4, 6, 8, 12.
Zotsatira za pharmacological
Siofor ndi gulu la othandizira a hypoglycemic. Mankhwalawa ndi a biguanides. Amagwiritsidwa ntchito nthawi zambiri molumikizana ndi njira zina. Kuphatikiza apo, mankhwalawa amangoperekedwa kwa odwala omwe samadalira insulin. Mwachindunji mankhwalawa sakukhudzira momwe thupi la Horona limayambira, zotsatira zoyipa zokha sizidziwika. Chifukwa chake, pochita ndi Siofor, mphamvu ya kupanga kwa insulin ndi maselo a pancreatic sikukula. Komabe, pali kuwonjezeka kwa chidwi cha thupi m'thupi ili.
Makina a metformin amatengera kubwezeretsanso njira zingapo zamitundu mitundu:
- kuchuluka kwa kugwiritsira ntchito shuga kumachuluka, chifukwa, glycemia imayamba kuchepa;
- kukula kwa njira yonyamula chakudya zamagulu ndi ziwalo za m'mimba m'mimba kumachepa;
- kupanga kwa shuga m'chiwindi kumachepa;
- kukula kwa inactivation a insulin kumachepera.
Chifukwa cha zovuta pa unyolo wa njira zomwe zimathandizira kuphatikizika ndi kugwiritsa ntchito shuga, kuchepa kwake kumachitika m'madzi a m'magazi kumadziwika. Kuphatikiza pa izi, gawo logwira ntchito la Siofor limakhudza kupanga glycogen. Nthawi yomweyo, kuchuluka kwa ma protein a mucous glucose kumakulanso.
Siofor ndi gulu la othandizira a hypoglycemic.
Ngakhale kuti palibe inshuwaransi mwachindunji pakapangidwe ka insulin, kuchepa kwa chiwerengero cha insulini kumasulidwa kumadziwika. Pamodzi ndi izi, pali kuwonjezeka kwa kuchuluka kwa insulin kwa proinsulin. Chifukwa cha njirazi, chidwi cha minofu ya timadzi timeneti timakula.
Komabe, mankhwalawa ali ndi mphamvu pa lipid metabolism. Mwanjira iyi, kupanga ma free acid acids kumayamba kuchepa kwambiri. Mafuta oxidation amachepetsa. Chifukwa cha izi, kukula kwa njira yamafuta kagayidwe kamachepa, komwe kumathandiza kukhazikika pamankhwala. Kukumana kwa cholesterol (yonse ndi LDL), komanso triglycerides, kumakhalanso kuchepa. Zotsatira zake, njira yoponyera mafuta imasokonekera. Chifukwa cha izi, kulemera kumachepetsedwa motsutsana ndi momwe zakudya zimakhalira ndikukhalabe olimbitsa thupi lokwanira.
Chowonjezera china cha metformin ndi kuthekera kolimbikitsa kusintha kwa thrombosis. Katunduyu akuwonekera pang'onopang'ono. Tikuthokoza, Siofor amalimbikitsa kuyambiranso kwa magulu.
Pharmacokinetics
Gawo lolimbikira limalowa m'magazi kuchokera m'mimba, pomwe mucosa imalowa mwachangu. Mapiritsiwa ndi utoto-filimu. Izi zimathandizira kuti amasulidwe achilengedwe okha m'matumbo. Mafuta a metformin apamwamba kwambiri amapezeka pambuyo maola 2,5. Kudya kumathandizira kuti mankhwalawa ayambe kuchepetsedwa.
Metformin imakonda kufalikira thupi lonse. Komabe, kwakukulu, izi zimangochedwa kulowa ziwalo zina (chiwindi, impso), komanso m'magazi amalovu. The bioavailability wa mankhwala wathanzi thupi ukufika 60%. Siofor amasiyana ndi ma analogues poti sangathe kumanga mapuloteni a plasma.
Zogwira ntchito Siofor 500 sizisintha.
Chomwe chimagwira sichikusintha. Ikachotsedwa m'thupi, impso zimakhudzidwa. Hafu ya moyo ndi maola 6.5. Amadziwika kuti ngati vuto laimpso lawonongeka, komanso kuchepa kwa ndende ya creatinine, kuchuluka kwa metformin m'thupi kumachepa. Zotsatira zake, kuchuluka kwa yogwira mu plasma nthawi yomweyo kumachuluka.
Kodi limayikidwa kuti?
Njira yayikulu yogwiritsira ntchito Siofor yokhala ndi metformin 500 mg ndi chithandizo cha odwala omwe ali ndi matenda a shuga a 2. Chizindikiro chogwiritsa ntchito mankhwalawa ndi kuchuluka kwa shuga m'magazi. Komabe, mankhwalawa amatha kuperekedwa kwa odwala omwe samadalira insulin. Izi ndichifukwa choti Siofor imakulitsa chidwi cha minyewa kupita ku insulin. Chifukwa chake, kuwonjezeka kokumbidwa kwa zomwe timadzi timene timapanga mu ma cell kungayambitse zovuta.
Mankhwala omwe akufunsidwa amalimbikitsidwa kuti agwiritsidwe ntchito kunenepa kwambiri, komwe kunayamba chifukwa cha matenda ashuga. Komabe, ndikofunika kugwiritsa ntchito Siofor limodzi ndi mankhwala othandizira kudya komanso kuchita masewera olimbitsa thupi. Mankhwalawa amaperekedwa limodzi ndi mankhwala ena. Nthawi zambiri (mu 5-10% ya milandu), amavomerezeka kuti agwiritsidwe ntchito ngati njira yodziyimira payokha.
Chizindikiro chogwiritsa ntchito mankhwalawa ndi kuchuluka kwa shuga m'magazi.
Contraindication
Sikoyenera kupereka mankhwalawa mwanjira zotere:
- mtundu 1 matenda a shuga;
- zochita za wina zosavomerezeka ku chinthu chogwira ntchito kapena chothandiza popanga Siofor;
- kuwonongeka kwa kagayidwe kazakudya poyambira matenda a shuga;
- kudwala matenda asanakwane;
- matenda ndi zina zingapo zoyipa zomwe zimayambitsa matenda a chiwindi, izi zimaphatikizira matenda oopsa, kuchepa magazi;
- zotupa zomwe zimabweretsa kukula kwa hypoxia: kuphwanya kwa mtima, kupuma, kuchepa kwamtima, chodabwitsa;
- kuchuluka kwakukulu kwa lactate, limodzi ndi kuphwanya kwa pH kwa magazi ndikuwonetsedwa kwa kusalinganika kwa electrolyte;
- poyizoni wa ethanol, uchidakwa wambiri;
- mankhwala othandizira pakudya, malinga ndi kuchuluka kwa zopatsa mphamvu tsiku ndi tsiku ndizofanana kapena zosakwana 1000.
Ndi chisamaliro
Kusamalidwa kwapadera kumafunikira pochiza ana azaka 10 mpaka 12. Kuphatikiza apo, chisamaliro chikuyenera kuchitika mukamamwa mankhwalawa muukalamba (kuyambira zaka 60 kapena kupitirira), malinga ngati wodwalayo akudzipereka kwambiri. Pankhaniyi, mwayi wokhala ndi lactic acidosis, wophatikizika ndi kusalinganika kwa electrolyte, kuchuluka kwa lactate komanso kuphwanya kwa pH kwa magazi, kumawonjezeka.
Kodi kutenga Siofor 500?
Mankhwalawa amatchulidwa pakudya kapena mutatha kudya. Kutalika kwa chithandizo kumatsimikiziridwa payekhapayekha. Yambani maphunziro a zamankhwala ochepa. Pang'onopang'ono, kuchuluka kwa metformin kumawonjezeka. Komanso, mlingo wake uyenera kuchuluka sabata iliyonse. Chifukwa cha izi, thupi limasinthika bwino ndi mankhwala.
Mankhwalawa amatchulidwa pakudya kapena mutatha kudya.
Chithandizo cha matenda ashuga
Pa gawo loyamba, 500-1000 mg ya mankhwalawa ayenera kumwedwa. Pang'onopang'ono, kuchuluka kwa tsiku lililonse kwa mankhwalawa kumafika - 3000 mg (kwa odwala akuluakulu). Mlingo womwe watchulidwa umagawidwa pawiri.
Kuthandiza ana kumachitika mogwirizana ndi malangizo omwewo, koma ndi kusiyana pang'ono: m'masabata awiri oyamba, 500 mg patsiku ayenera kumwedwa. Kenako mlingo waukulu wa tsiku ndi tsiku wa Siofor umatheka pang'onopang'ono - 2000 mg (kwa odwala azaka 10 mpaka 18).
Kuchepetsa thupi
Popeza kuti mankhwalawa amatha kuperekedwa kwa anthu omwe ali ndi matenda osokoneza bongo a mellitus, kuti achepetse kulemera kwa thupi, ndizovomerezeka kugwiritsa ntchito mankhwala ena onse. Komanso, kudya komanso kuchita masewera olimbitsa thupi moyenera sikuyenera. Mankhwala omwe akufunsidwa sangathe kusintha izi.
Zotsatira zoyipa
Lactic acidosis imayamba, mayamwidwe a vitamini B12 amasokonezeka.
Matumbo
Pali kutaya kwa kukoma, nseru kumawonekera, kawirikawiri - kusanza. Kutsegula m'mimba kumatha kuchitika. Nthawi zina pamakhala kupweteka pamimba. Kulakalaka kusokonezedwa, ndipo nthawi yomweyo kumakhala kukokedwa kwachitsulo mkamwa. Zizindikiro zimatha pazokha ngati mankhwala akupitilizidwa kumwa mankhwalawa katatu patsiku. Chiwopsezo chokhala ndi zotsatila zimachulukira koyamba kwa chithandizo. Pankhaniyi, thupi silinazolowere metformin.
Hematopoietic ziwalo
Anemia
Pa khungu
Kuyabwa, hyperemia, zotupa.
Matupi omaliza
Urticaria.
Malangizo apadera
Metformin imakonda kudziunjikira m'thupi pochiza ndi Siofor. Ndi vuto la chiwindi kapena impso, izi zimakhala zamphamvu. Chifukwa cha kuchuluka kwa metformin, kuchuluka kwa asidi m'magazi kumachulukanso. Zotsatira zake, lactic acidosis imayamba. Pankhaniyi, muyenera kusiya njira yamankhwala. Kugoneka kwa wodwala ndikofunikira.
Kuphatikizidwa kwa metformin ndi zakumwa zokhala ndi mowa ndizomwe zimayambitsa zovuta kwambiri.
Popewa kukula kwa lactic acidosis, zinthu zonse zoopsa zimatsimikiziridwa ndipo ngati kuli kotheka, siziyenera kuzichitira pakumwa. Zomwe zimayambitsa matenda a pathological:
- mowa
- kulephera kwa chiwindi;
- kusala kudya;
- hypoxia.
Musanatenge Siofor, ndikofunikira kudziwa mulingo wa creatinine. Izi ndichifukwa choti zomwe zimagwira zimapukusidwa ndi impso.
Ndikofunikira kupuma pomwa mankhwalawo musanayambe kuphunzira ndi anthu omwe ali ndi ayodini. Njira yamankhwala imasokonekera masiku awiri tsiku lisanafike ndipo limapitilira masiku awiri atatha mayeso.
Kuyenderana ndi mowa
Kuphatikizidwa kwa metformin ndi zakumwa zokhala ndi mowa ndizomwe zimayambitsa zovuta kwambiri.
Zokhudza mphamvu pakuwongolera njira
Siofor sichimathandizira pakuchepetsa kwakukulu kwa glycemia, chifukwa chake, palibe zoletsa pamene mukuyendetsa magalimoto panthawi ya chithandizo ndi chida ichi. Komabe, muyenera kusamala mukamayendetsa.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Osagwiritsa ntchito pochiza odwala pazinthu izi, chifukwa palibe chidziwitso chokwanira chokhudza chitetezo cha mankhwalawa.
Sitikulimbikitsidwa kutenga chida ichi kwa odwala ochepera zaka 10.
Kusankhidwa kwa Siofor kwa ana 500
Sitikulimbikitsidwa kutenga chida ichi kwa odwala ochepera zaka 10.
Gwiritsani ntchito mu ukalamba
Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito.
The ntchito aimpso kuwonongeka
Zowonongeka zamtunduwu ndi chifukwa choletsa kugwiritsa ntchito kwa Siofor pofuna kubwezeretsa glycemia mu shuga. Choyimira chozindikira ndikuchepa kwa ndende ya creatinine mpaka 60 ml pamphindi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mu matenda owopsa a chiwalo ichi, Siofor siivomerezeka.
Bongo
Ngati mankhwala a metformin 85 g atengedwa, mavuto samayamba. Mankhwala akachuluka kwambiri, chiwopsezo cha lactic acidosis chikuwonjezeka. Pankhaniyi, kuchipatala ndikofunikira. Kuchepetsa kuchuluka kwa lactic acid ndi metformin m'magazi pogwiritsa ntchito hemodialysis.
Kuchita ndi mankhwala ena
Kuphatikiza kophatikizidwa
Kuphatikiza kwa mankhwala okhala ndi ayodini koma Siofor sikuvomerezeka. Pankhaniyi, chiopsezo chokhala ndi kulephera kwa aimpso chimakulirakulira, pomwe zizindikiro za lactic acidosis zimawonekera.
Kuphatikiza kwa mankhwala okhala ndi ayodini koma Siofor sikuvomerezeka.
Osavomerezeka kuphatikiza
Osamamwa mowa pakumwa mankhwalawo. Nthawi yomweyo, chiopsezo chokhala ndi lactic acidosis imakulanso. Zotsatira zomwezi zimapereka kuphatikiza kwa mankhwala a metformin ndi ethanol.
Kuphatikiza komwe kumafunikira kusamala
Danazole amathandizira kukulitsa glycemia. Ngati pakufunika kumwa mankhwalawa, kusintha kwa metformin ndikofunikira.
Mkulu wama glucose amakulanso ndi kuphatikiza kwa othandizira, zinthu:
- kulera kwamlomo;
- mahomoni a chithokomiro;
- Epinephrine;
- nicotinic acid;
- glucagon;
- zotumphukira za phenothiazine.
Kuphatikizika kwa Siofor kumawonjezeka kwambiri ndi mankhwala a Nifedipine. Morphine ndi mankhwala ena a cationic amapereka chimodzimodzi.
Amachokera ku sulfonylureas, insulin - mankhwalawa amachititsa kuti metformin iwonjezeke.
Mankhwala omwe akufunsidwa amathandizira kuchepetsa mphamvu ya anticoagulants osadziwika (aspirin, ndi zina).
Analogi
Zotheka m'malo mwa Siofor:
- Diaformin;
- Glyformin;
- Glucophage Kutalika;
- Fomu;
- Metformin ndi ena
Zinthu za tchuthi Siofora 500 kuchokera ku malo ogulitsa mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi, mutha kugula mankhwalawo pokhapokha ngati mwalangizidwa ndi dokotala.
Mtengo
Mtengo wapakati ndi ma ruble 250.
Malo osungirako a Siofor 500
Kutentha kotsika kwambiri ndi + 25 ° C.
Tsiku lotha ntchito
Mankhwalawa amasungabe katundu kwa zaka zitatu kuyambira tsiku lotulutsidwa.
Wopanga
Berlin - Chemie AG (Germany).
Ndemanga za Siofor 500
Madokotala
Vorontsova M.A., wazaka 45, endocrinologist, Kaluga
Ndimapereka mankhwala ndikulimbana ndi insulin. Pakati pa odwala anga palinso ana a achinyamata. Mankhwalawa amalekeredwa bwino, kuwonetsera koyipa kumachitika kawirikawiri ndipo makamaka kuchokera m'mimba. Kuphatikiza apo, mtengo ndi wotsika, poyerekeza ndi analogues.
Lisker A.V., wazaka 40, othandizira, Moscow
Mankhwalawa amachita mwachangu, amagwira ntchito kwambiri. Pachifukwa ichi, chitha kugwiritsidwa ntchito pochiza hyperglycemia komanso ndi cholinga chochepetsa thupi mukatha kufunsa dokotala. Siofor akuwonekera pofotokoza angapo momwe angathandizire kuti matendawo akhale ndi polycystic ovary. Pankhaniyi, azimayi amakhala ndi zizindikiro zosiyana: tsitsi pakhungu ndi nkhope, kulemera kumawonjezeka. Mankhwalawa ali ndi mphamvu pamapangidwe am'madzi, tsitsi limachotsedwa m'thupi limawonedwa, kulemera kumachepetsedwa.
Odwala
Veronika, wazaka 33, Samara
Anamwa mankhwalawo ndi hyperglycemia. Siofor adachitapo kanthu mwachangu. Ndipo sindinawone zomwe zandichitira ndekha.
Anna, wazaka 45, Sochi
Mankhwalawa ndiokwera mtengo komanso ogwira ntchito. Matenda a shuga amapezeka kwa nthawi yayitali, mwa ine ndizovuta kusankha mankhwala a hypoglycemic, thupi nthawi zambiri siziwazindikira. Koma Siofor ndiwofatsa modabwitsa.
Kuchepetsa thupi
Olga, wazaka 35, mzinda wa Kerch
Sindinachepetse thupi ndikamamwa mankhwalawa. Ndinkayembekeza kuti ma kilogalamu angapo achoka. Kulemera kumayima chilili, koma osachepera, zomwe zilinso zabwino.
Marina, wazaka 39, Kirov
Amachita masewera kwambiri (momwe angathere ndi matenda ashuga), panali zakudya zoyenera. Zotsatira zake ndizofooka - kulemera kwake sikunadutse. Koma ndimatsatira dongosolo la chithandizo kwakanthawi kochepa, mwina ndiye mfundo.
