Biosulin ndi insulin yopangidwa ndi anthu. Mankhwalawa adayambitsidwa machitidwe azachipatala posachedwapa. Ngakhale izi, adziyambitsa kale ngati njira yothandiza yolamulira glycemia.
Dzinalo Losayenerana
Isulin insulin.
Ath
A10AC01 - dongosolo la anatomical-achire-mankhwala-gulu.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amamasulidwa mu mawonekedwe a kuyimitsidwa komwe kumapangidwira kukonzekera kwa subcutaneous. Kuyimitsidwa ndi madzi oyera. Ndikosungika nthawi yayitali, mbewa yoyera imagwera pansi. Poterepa, madzi pamwamba pamatope amakhalabe wowonekera. Ndi kugwedeza mwamphamvu, nyanjayo imagawidwanso chimodzimodzi.
Chithandizo chogwira mankhwalawa chimapangidwa ndimtundu wa insulin. Zinthu zothandiza ndi:
- disodium hydrogen phosphate dihydrate;
- zinc oxide;
- metacresol;
- protamine sulfate;
- glycerol;
- crystalline phenol;
- madzi a jakisoni.
Biosulin ndi insulin yopangidwa ndi anthu.
Kusintha pH, yankho la sodium hydroxide 10% kapena yankho la hydrochloric acid 10% imagwiritsidwa ntchito.
Ma CD a Biosulin atha kukhala:
- 5 ml kapena 10 ml mbale. Amapangidwa ndigalasi lopanda utoto ndipo losindikizidwa ndi kapu yolumikizira. Mabotolo oterowo amatha kuikidwa mu 1 pakatoni kapena 2-5. pakukumata matuza.
- 3 ml makatiriji. Amapangidwa kuchokera ku galasi lopanda utoto ndipo ali ndi chipewa chophatikizira ndi cholembera (biomatikpen). Makatoni atatu amaikidwa phukusi la foni.
Zotsatira za pharmacological
Biosulin N amatanthauza othandizira a hypoglycemic ndipo amadziwika nthawi yayitali.
Mukamamwa, insulin imakhudzana ndi ma receptors panja ya cytoplasmic cell. Zotsatira zake, insulin receptor tata imapangidwa. Ali ndi udindo wolimbikitsa njira zamkati mwake, kuphatikizapo kaphatikizidwe ka michere yofunika.
Kuphatikiza apo, motsogozedwa ndi insulin yopanga ma genetic, kutulutsa kwa shuga kwa glucose kumalimbikitsidwa ndipo kupezeka kwake mu minofu kumathandizira. Njira monga glycogenogeneis ndi lipogeneis zimayendetsedwa. Mosiyana ndi izi, ntchito ya chiwindi popanga insulin imachepa. Kusintha kotereku pakugwira ntchito kwa thupi la munthu kumabweretsa kutsika kwa kuchuluka kwa shuga m'magazi.
Kuchulukitsa kwa zochizira zotsatira zake kumadalira njira ndi malo oyang'anira (matako, matako, matumbo).
Pambuyo subcutaneous makina a hypoglycemic wothandizira, ntchito ya mankhwalawa imawonekera pambuyo pa maola 1-2. Kuchuluka kwake kumatheka pambuyo pa maola 6-12. Mankhwalawa amakhala ndi nthawi yayitali (maola 18 mpaka 24), yomwe imawasiyanitsa ndi mankhwala osokoneza bongo osakhalitsa.
Pharmacokinetics
Mlingo wa kuyambika kwa mankhwalawa komanso kuchuluka kwa kuyamwa kwa zinthu zogwira ntchito m'njira zambiri zimadalira njira ndi malo oyang'anira (matako, matako, matumbo). Mu minofu, kugawa sikusiyana.
Jini insulin ya munthu sangathe kudutsa chotchinga.
Metabolism imapezeka mu impso ndi chiwindi. Pafupifupi 30-80% ya chinthucho imatuluka m'thupi ndi mkodzo.
Mwachidule kapena kutalika
Biosulin yokhala ndi zilembo zowonjezera "H" ndi othandizira pa hypoglycemic nthawi yayitali.
Zizindikiro zogwiritsidwa ntchito
Biosulin imakhala ndi malire. Amawerengera zotsatirazi:
- mtundu I matenda ashuga mellitus;
- lembani matenda a shuga a II II mellitus (osavulala pakamwa kapena m'magazi othandizira pakhungu).
Mankhwalawa ndi mankhwala makamaka a shuga.
Contraindication
Mndandanda wazopikisana uli ndi zinthu zochepa. Pakati pawo:
- tsankho limodzi pazigawo za yankho;
- kukhalapo kwa hypoglycemia.
Momwe mungatengere biosulin n
Biosulin imamasulidwa mu mawonekedwe a kuyimitsidwa komwe kumapangidwa kuti ikwaniritse kayendetsedwe ka subcutaneous. Mlingo wa wodwala aliyense amapatsidwa gawo lililonse. Poterepa, dotolo amaganizira kufunika kwa insulin. Monga muyezo mlingo, 0,5-1 IU / kg kulemera kwa thupi amasonyezedwa malangizo.
Mutha kulowa mankhwalawo m'malo angapo (ntchafu, phewa, matako kapena khoma lam'mimba lakutsogolo). Popewa kuthamanga kwa mafuta osakanikirana, malo operekera jakisoni amayenera kusinthidwa pafupipafupi.
Popereka mankhwala, dokotalayo ayenera kufotokozera mwatsatanetsatane kwa wodwalayo momwe njira ikuwonekera.
Biosulin imatsutsana pamaso pa hypoglycemia.
Mukamagwiritsa ntchito cartridge, muyenera kuyipukutira pakati pama manja anu ndikuigwedeza mwamphamvu. Pankhaniyi, phokoso liyenera kugawidwa. Mukagwedezeka, mapangidwe a thovu ayenera kupewedwa, chifukwa izi zimapangitsa kuti zikhale zovuta kukhazikitsa kuyimitsidwa. Cartridges sioyenera kuphatikiza insulin ndi mankhwala ena.
Pogwiritsa ntchito cholembera chapadera, mulingo uyenera kukonzedwa musanayende. Ma penti a singano ndi syringe amagwiritsidwa ntchito pokhapokha.
Ndi matenda ashuga
Biosulin ndi mankhwala a hypoglycemic ogwiritsidwa ntchito ndi odwala omwe ali ndi mtundu 1 ndi mtundu wa 2 matenda osokoneza bongo kuthana ndi shuga m'magazi.
Zotsatira zoyipa za biosulin n
Zotsatira zoyipa zambiri zimawonekera kuchokera ku mbali ya metabolism. Kuwonjezeka kwa zizindikiro za retinopathy ndikothekanso (ngati wodwalayo kale anali ndi zizindikiro za matenda awa). Nthawi zina, pali kuphwanya kwa Refraction komanso kwakanthawi amaurosis.
Kuchokera kumbali ya kagayidwe
Chimodzi mwazinthu zoyipa kwambiri ndizotsatira za hypoglycemia. Cholinga cha kukula kwake ndikupitirira muyeso womwe umafunidwa ndi thupi. Zosiyanasiyana zingapo za hypoglycemia zimawonjezera mwayi wokhala ndi zizindikiro zamitsempha. Zikatere, wodwalayo amatha kudwala komanso kukomoka.
Chochitika chinanso chofala ndichakuti kuchepa kowopsa kwa shuga m'magazi. Ndi chidziwitso cha Reflex activation cha anthu achifundo amanjenje, hypokalemia imachitika, nthawi zina, matenda a edema.
Mikhalidwe ya Hypoclycemic nthawi zambiri imayendera limodzi ndi thukuta lochulukirapo, khungu lotumbululuka, kuzizira, kuzizira, kunjenjemera, ndi njala. Odwala amadandaula mutu, kuchuluka kukondoweza, chizungulire ndi kupweteka kwa minyewa yamlomo.
Matupi omaliza
Hypersensitivity zikuchokera mankhwala amachititsa hyperemia, kuyabwa ndi kutupa m`malo mankhwala.
Zokhudza mphamvu pakuwongolera njira
Pankhani yogwiritsa ntchito kwambiri insulin ya anthu kapena kusintha kwa mitundu ina ya insulini poyendetsa galimoto kwakanthawi iyenera kusiyidwa. Madokotala samalimbikitsanso kuchita masewera oopsa.
Pankhani yogwiritsa ntchito kwambiri insulin ya anthu kapena kusintha kwa mitundu ina ya insulini poyendetsa galimoto kwakanthawi iyenera kusiyidwa.
Malangizo apadera
Musanagwiritse ntchito Biosulin, vial amayenera kugwedezeka mwamphamvu. Mtengowo uyenera kupasuka kwathunthu kumadzimadzi omveka, pambuyo pake kuyimitsidwa kumakhala koyera komanso yunifolomu. Izi ngati sizichitika, botolo silikulimbikitsidwa.
Pogwiritsa ntchito Biosulin mwa wodwala, kuchuluka kwa shuga m'magazi kuyenera kuwunika pafupipafupi.
Pankhani ya Mlingo wolakwika, zizindikiro zimayamba kuonekera pang'onopang'ono. Kulimba kwawo kumawonjezeka kuposa maola angapo kapena masiku.
Kuwongolera muyezo wofunikira ndikofunika kwa anthu omwe ali ndi zotsatirazi:
- matenda a chithokomiro;
- matenda akulu a impso ndi chiwindi;
- Matenda a Addison;
- matenda opatsirana osiyanasiyana etiologies.
Nthawi zina, kukonza kungafunike pambuyo poti wodwalayo azilimbitsa thupi kapena asinthe kadyedwe kake.
Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa alibe mphamvu yodutsa chotchinga chachikulu. Pachifukwa ichi, kulandira chithandizo ndi Biosulin ndikotheka panthawi yoyembekezera. Mu trimester yoyamba, kufunika kwa insulini kungakhale kopanda pake, koma mu yachiwiri ndi yachitatu trimester, kufunikira kumawonjezeka.
Mukamayamwitsa, insulin imapitirirabe. Mwa odwala ena, kufunikira kwake kogwiritsa ntchito kumatha kuchepa.
Kupangira biosulin kwa ana
Ngati ndi kotheka, dokotala atha kuperekera mankhwala a Biosulin kwa ana odwala matenda ashuga. Kwa iwo, mlingo umasankhidwa payekha kutengera zosowa za insulin.
Gwiritsani ntchito mu ukalamba
Kwa odwala omwe ali ndi zaka zopitilira 65, mlingo wake umasinthidwa.
Mankhwala osokoneza bongo a biosulin n
Ngati wodwala amatenga mlingo wa mankhwalawa wopitilira zosowa zathupi, hypoglycemia imachitika. Woopsa, pali chiopsezo cha kukhala chikomokere.
Madokotala amalimbikitsa kuti anthu odwala matenda ashuga nthawi zonse azikhala ndi madzi otsekemera, makeke kapena maswiti.
Wodwalayo amatha kuchotsa zofooka yekha. Kuti muchite izi, muyenera kudya zakudya zamafuta ambiri kapena shuga. Madokotala amalimbikitsa kuti anthu odwala matenda ashuga nthawi zonse azikhala ndi madzi otsekemera, makeke kapena maswiti.
Pakumala kukomoka, chithandizo chamankhwala ndichofunikira. Kuti matenda asinthe, vutoli limaperekedwa kwa 40% ya odwala. Kuphatikiza apo, glucagon ndikulimbikitsidwa. Itha kuperekedwa m'njira zingapo (subcutaneously, intramuscularly or intravenously). Wodwala akayambanso kuzindikira, amapatsidwa zakudya zomwe zimakhala ndi chakudya chamagulu ambiri.
Kuchita ndi mankhwala ena
Kuchita bwino kwa Biosulin kumatheka ndi:
- hypoglycemic mankhwala pakamwa;
- kaboni anhydrase zoletsa;
- angiotensin otembenuza enzyme zoletsa;
- bromocriptine;
- monoamine oxidase zoletsa;
- sulfonamides;
- osasankha beta-blockers;
- octreotide;
- onjezerani;
- tetracyclines;
- mebendazole;
- anabolic steroids;
- pyridoxine;
- ketoconazole;
- theophylline;
- kukonzekera komwe kumakhala ndi lithiamu;
- fenfluaramine;
- cyclophosphamide;
- mankhwala okhala ndi Mowa.
Ethanol imawonjezera mphamvu ya mankhwalawa.
Hypoglycemic katundu wa Biosulin amachepetsedwa atatengedwa:
- glucocorticosteroids;
- kulera kwamlomo;
- mahomoni a chithokomiro;
- heparin;
- thiazide okodzetsa;
- danazole;
- ma tridclic antidepressants;
- clonidine;
- sympathomimetics;
- calcium blockers;
- chikonga;
- phenytoin;
- morphine;
- diazoxide.
Kuyenderana ndi mowa
Ethanol imawonjezera mphamvu ya mankhwalawa. Pazifukwa izi, zizindikiro zosokoneza bongo zitha kuwoneka.
Analogi
Mwa mankhwalawa omwe ali ndi vuto lofananalo, ayenera kutchedwa:
- Biosulin P;
- Protamine insulin mwadzidzidzi;
- Rinsulin NPH;
- Gansulin N;
- Rosinsulin C;
- Insuman Bazal GT.
Kupita kwina mankhwala
Mankhwalawa amagawidwa m'mafakisoni motsogozedwa.
Kodi ndingagule popanda kulandira mankhwala?
Simungagule biosulin popanda mankhwala.
Mtengo wa biosulin n
Mtengo wa mankhwalawa umatengera muyeso ndi kuchuluka kwa mabotolo omwe ali phukusi:
- botolo la 10 ml (1 pc.) - kuchokera ku ma ruble 500.;
- 3 ml cartridge (5 ma PC.) - kuchokera ku ma ruble 1000.;
- makatoni + 3 ml syringe cholembera (5 ma PC.) - kuchokera 1400 rub.
Zosungidwa zamankhwala
Sungani mankhwalawo pa kutentha kwa + 2 ... + 8 ° C. Kuzizira kwa mankhwalawo ndizoletsedwa. Botolo kapena cartridge lomwe limagwiritsidwa ntchito limasungidwa pamalo amdima pa kutentha kwa + 15 ... + 25 ° ะก
Tsiku lotha ntchito
Zaka 2 kuyambira tsiku lopangidwa. Botolo kapena katoni yomwe imagwiritsidwa ntchito iyenera kusungidwa kwa milungu yopitilira 4.
Wopanga
Biosulin imapangidwa ndi kampani yopanga mankhwala Pharmstandard-UfaVITA OJSC (Russia).
Ndemanga za biosulin n
Madokotala ndi odwala amakhala ndi mankhwalawa mosiyanasiyana. Pakadali pano, posankha mankhwala, simuyenera kungoyang'ana ndemanga.
Madokotala
Anton, wazaka 40, Moscow
Kutalika kwapakati-biosulin nthawi zambiri kumayesedwa ngati gawo la zovuta zovuta kwa odwala omwe amamwa mankhwala a hypoglycemic omwe samapereka zotsatira zofunika. Kuyimitsidwa kumavomerezedwa bwino ndi odwala ndipo kumapereka zotsatira zosatha.
Olga, wazaka 34, St. Petersburg
Nthawi zambiri sindigwiritsa ntchito mankhwalawa. Ndiwotsika mtengo komanso wogwira ntchito, komanso pali othandizanso ogwira ntchito omwe amagwiritsidwa ntchito mosavuta.
Odwala
Eugenia, wazaka 26, Vladivostok
Mayi anga anapatsidwa mankhwala apakamwa kuti athetse shuga. Amapezeka ndi matenda ashuga amtundu 2. Ngakhale poganizira za kadyedwe, sizinali zotheka kutsitsa shuga. Mukamapereka mayeso pamimba yopanda kanthu idawululira 14 mmol. The endocrinologist adakonzanso njira zamankhwala ndikuwonjezera Biosulin. Tsopano shuga yatsika mpaka 8 mmol.
Alexander, wazaka 37, Voronezh
Ndili ndi matenda ashuga. Pambuyo pa mayeso otsatira, adotolo adatumiza Biosulin. Mankhwalawa amathandizira kuchepetsa shuga osakhala oyipa, sindinapeze zotsatira zoyipa zilizonse.
