Kuphatikiza kwa Amlodipine ndi Lisinopril kumayikidwa ngati kayendetsedwe kawo kokha sikupereka zotsatira zomwe zikuyembekezeka. Tsopano amapanganso mankhwala, komwe kukonzekera kumakhala ndi Mlingo wa chinthu chilichonse (mayina ogulitsa: Equator, Equacard, Equapril).
Mawonekedwe a Amlodipine
Amlodipine ndi calcium blocker mu cell membrane. M'maselo amitsempha yamagazi, olimbana nawo awa amawongolera kayendedwe ka calcium ion, ndikuthandizira kuletsa hypotensive ndi antianginal zotsatira.
Amlodipine ndi calcium blocker mu cell membrane.
Mothandizidwa ndi Amlodipine:
- Hyperkalemia sichitha;
- arterioles ndi mitsempha ikukula;
- kuthamanga kwa magazi kumachepa;
- maselo amtima amadzala ndi mpweya;
- myocardial contractile ntchito imabwezeretseka (imachepetsa ndi tachycardia, imawonjezeka ndi bradycardia).
Mphamvu ya mankhwalawa:
- ngakhale limodzi mlingo atha kupereka antihypertensive kwenikweni;
- amathandizira ndi angina pectoris ndi ischemia;
- ali ndi ofooka natriuretic zotsatira;
- sizikhudza kagayidwe;
- imachepetsa katundu pamtima, yomwe imakupatsani mwayi wambiri wolamulira ziwalo za chifuwa mukamachita masewera olimbitsa thupi.
Kodi lisinopril imagwira ntchito bwanji?
Lisinopril amagwira ntchito monga ACE inhibitor yomwe imalepheretsa kupangika kwa aldosterone (mahomoni omwe amayambitsa kuphipha kwa mchere wa Na ndi K) ndi angiotensin 2 (timadzi timene timayambitsa vasoconstriction), yomwe imalimbikitsa kupanga bradykinin (mtsempha wamagazi wotulutsa peptide).
Pansi pa lisinopril:
- kuthamanga kwa magazi kumachepa;
- kupsinjika mkati mwa mapira m'mapapo kumachepa;
- kuchuluka kwaimpso kuthamanga;
- Myocardial magazi amapereka;
- hypertrophy ya stenotic mitsempha yafupika.
Mphamvu ya mankhwalawa:
- bwino magazi ndi ischemia;
- kubwezeretsanso kumanzere kwamitsempha yamagazi pambuyo pakukokoloka kwa mtima;
- amachepetsa albuminuria (mapuloteni mu mkodzo);
- samatsogolera ku hypoglycemia.
Kuphatikiza
Zotsatira zophatikizidwa za mankhwala a 2 zimabweretsa zomwe zimachitika:
- antihypertensive (kutsika kwa kuthinitsidwa);
- vasodilating (vasodilating);
- antianginal (kuthetsa kupweteka kwa mtima).
Kuphatikiza kwapawiri kwa mankhwala 2 kumayambitsa antianginal reaction (kupweteka kwa mtima kumachotsedwa).
Zizindikiro zogwiritsidwa ntchito munthawi yomweyo
Izi zimathandizira achire zotsatira zamankhwala oopsa chifukwa cha:
- kulephera kwa mtima;
- Kuchepetsa ziwiya za impso (stenosis ya mitsempha ya impso);
- aakulu aimpso kulephera (mkhutu aimpso ntchito);
- thyrotoxicosis (matenda a chithokomiro);
- atherosulinosis ya msempha (zolembera pamakoma);
- matenda a endocrine dongosolo (kuphatikizapo shuga mellitus).
Contraindication
Amlodipine wokhala ndi lisinopril sanalembedwe kuti:
- Hypersensitivity;
- kutupa kwa m'mimba;
- Cardiogenic mantha;
- pachimake ochepa hypotension;
- angina wosakhazikika (kupatula mawonekedwe a Prinzmetal);
- kupatsidwa impso;
- hepatic kukanika;
- zokhudza zonse lupus erythematosus;
- metabolic acidosis;
- mimba ndi mkaka wa m`mawere;
- wosakwana zaka 18.
Momwe mungatenge amlodipine ndi lisinopril?
Mankhwala amapezeka mu Mlingo wa 5, 10, 20 mg ndipo amagwiritsidwa ntchito pakamwa. Malangizo apamwamba kwambiri:
- Mlingo umodzi wa 10 mg kamodzi patsiku (m'mawa kapena madzulo);
- mapiritsi onse awiriwa akuwonetsa kuti ndi munthawi yomweyo
- kutsukidwa ndi madzi okwanira;
- Zakudya sizimadyedwa pakudya.
Mosamala, othandizira antihypertgency amaperekedwa kwa odwala omwe adakumana ndi hemodialysis.
Mochenjera, antihypertensives amaperekedwa kwa odwala omwe adachita hemodialysis (kowonjezera kuyeretsa kwamadzi a m'magazi) komanso m'malo ovuta kufooka kwamadzi.
Mlingo woyambirira wa kukonza mankhwalawa kwa anthu omwe ali ndi vuto la Impso amasankhidwa payekha.
Mu nthawi yonseyi, amafunika kuwunika mawonekedwe a impso, mulingo wa K ndi Na mu seramu yamagazi. Ngati Zizindikiro ziwonjezeka, mlingo umachepetsedwa kapena kuthetsedwa.
Ndi matenda ashuga
Kuphatikizidwa kwa matenda ashuga ndi matenda oopsa kumawonjezera chiopsezo cha zovuta zazing'ono komanso zazikulu kwambiri. Chithandizo cha lisinopril ndi amlodipine chimasintha ntchito ya mtima mwa odwala omwe ali ndi matenda ashuga komanso oopsa. Mu matenda a shuga, mankhwala amawonetsedwa moyang'aniridwa ndi dokotala.
Mu matenda a shuga, mankhwalawa omwe amawaganizira akuwonetsedwa moyang'aniridwa ndi dokotala.
Kuchokera pamavuto
Ma antihypertensives awa amawonetsedwa pa chithandizo cha kuthamanga kwa magazi, kupatula masabata 4 oyamba atakumana ndi vuto la mtima. Pambuyo pakutha kwa nthawi yofunikira kubwezeretsa zizindikiro zamatenda, zovuta zimatengedwa molingana ndi zomwe zimapangidwa zakale (10 + 10 mg kamodzi patsiku).
Zotsatira zoyipa za Amlodipine ndi Lisinopril
Zotsatira zoyipa zimayamba chifukwa cha mankhwala osokoneza bongo. Mawonetsero omwe angathe:
- mutu
- kufooka
- idachepetsa chidwi;
- arrhythmia;
- kutsokomola
- kapamba
- hepatitis;
- arthralgia;
- myalgia;
- kukokana
- neutropenia;
- bronchospasm;
- psoriasis
Malingaliro a madotolo
Antonova M.S., wothandizira, Tver
Zovuta zake zidakhazikitsidwa kale. Amlodipine amatha kudzutsa vuto la edema. Ndipo mawonekedwe amakomoka amachotsedwa poika Phenytoin.
Kotov S.I., katswiri wa zamtima, Moscow
Kuphatikiza kotchuka komanso kogwira mtima. Malangizo okhawo - musagule Amlo wowerengeka komanso osagwiritsa ntchito okodzetsa.
Skurikhina L.K., endocrinologist, mzinda wa Naro-Fominsk
Osadzisilira. Mankhwalawa onse ali ndi mndandanda wokulirapo wa contraindication. Ndikofunikira kuyang'anitsitsa kuthamanga kwa magazi, apo ayi mutha kuphonya kuyambika kwa hypotension yacute.
Ndemanga za Odwala Amlodipine ndi Lisinopril
Anna, wazaka 48, Penza
Amlodipine mu zovuta adapangidwira 5 mg. Warfarin adawonjezedwanso pachimake. Koma zotsatira zoyipa zinaoneka - kutulutsa magazi m'kamwa (makamaka kuchokera ku Warfarin, kumapangitsa magazi).
Tatyana, wazaka 53, Ufa
Anandisankhira maphunziro osiyana - Amlodipine 5 mg ndi Lisinopril 10 mg. Koma ndili ndi cystitis pafupipafupi, yomwe ndidawauza adotolo.
Peter, wazaka makumi asanu ndi limodzi ndi zitatu, aku Moscow
Chifukwa cha kulephera kwa mtima, adatenga Digoxin ndi diuretic Allopurinol kwazaka zambiri. Potsatira upangiri wa adotolo, adasintha mawonekedwe atsopano, koma chifuwa chowuma chidayamba, ndipo adotolo adasinthira Lisinopril ndi Indapamide. Osati kusankha nokha chiwembucho, pitani kwa dokotala.
