Pharmacological zochita ndi malangizo kugwiritsa ntchito mankhwala Jardins

Pochiza matenda ashuga, kusankha mankhwala ndikofunikira kwambiri. Amalandira ndi madokotala, koma odwala sangalephere kudziwa mawonekedwe a mankhwala ena ake. Chimodzi mwazomwe zimatchulidwa mu radar ndikugwiritsa ntchito kuthana ndi glucose ndi Jardins.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Mankhwalawa amapangidwa ku Germany. Ndi piritsi yamkati yodziwika ndi zotsatira za hypoglycemic. Iyenera kugwiritsidwa ntchito pokhapokha pakugwirizana ndi adokotala omwe amapezeka, chifukwa nthawi zina, kuwonongeka kumatha kuchitika.

Poterepa, muyenera kuwunika mosamala zakusintha mu boma, pozindikira zochitika zomwe sizili bwino. Kugwiritsa ntchito moyenera pakutsatira malangizowo kumathandizira kuchepetsa kuchuluka kwa shuga m'magazi ndikukhala ndi mphamvu zambiri.

Chipangizocho chikuwonetsedwa m'mapiritsi amitundu iwiri, osiyana mu kuchuluka kwa ntchito. Izi ndi empagliflozin. Mankhwala akukwaniritsidwa ndi 10 kapena 25 mg wa chinthucho.

Piritsi lililonse ndilopanda pake komanso loutenga. Chojambula chimayikidwa pa icho (mbali inayo pali chizindikiro cha wopanga, winayo - Mlingo wa chinthu chomwe chikugwira).

Kuphatikiza pa Empagliflozin, Jardins akuphatikiza zowonjezera:

• ma cellcose a microcrystalline;
• lactose monohydrate;
• stesiate ya magnesium;
• colloidal silicon dioxide;
• hyprolosis;
• talc;
• titanium dioxide;
• utoto.

Chogulitsacho chimagulitsidwa m'matumba a makatoni, pomwe mabulangeti okhala ndi miyala (10 ma PC). Phukusili lili ndi matuza 1 kapena 3.

Njira zamachitidwe ndi pharmacokinetics

Empagliflozin ndi mtundu wa 2 glucose transporter inhibitor. Zotsatira zake zimapereka kuwongolera kuchuluka kwa shuga mu mtundu 2 shuga. Chifukwa cha izi, kuphatikiza shuga ndi impso kumachepa.

Ntchito ya glucose excretion wa impso imakhudzidwa ndi kuchuluka kwa zomwe zili m'magazi komanso kuchuluka kwa kusefedwa kwa glomerular. Ndikumamwa mankhwalawa odwala matenda ashuga, njira yochotsa shuga ndi mkodzo imathandizira kwambiri, zomwe zimapangitsa kutsika kwake kuchuluka kwake.

Chowonjezera china cha Jardins ndichabwino pa ntchito ya maselo a beta ndi kuyambitsa kwamayendedwe oyaka mafuta. Izi zimapereka kuchepa thupi, zomwe zimathandiza kwa odwala omwe ali ndi kunenepa kwambiri.

Kuthiridwa kwa Empagliflozin kumachitika mwachangu, komwe kumachitika m'makoma amtundu wa m'mimba. Thupi limakhala ndende yake yokwanira 1.5 patatha piritsi. Kupitilira apo, kuchuluka kwake mu plasma kumatsika kwambiri, chifukwa kufalikira kumachitika. Metabolism ndiyosachedwa.

Zachilengedwe mphamvu ya mankhwala amakhala kwambiri ndi kuchuluka Mlingo. Kumutenga ndi zakudya zamafuta kumachepetsa mphamvu yake. Koma kusintha kumeneku ndikosafunikira, kotero, mankhwalawa amatha kuledzera musanayambe kudya komanso mutatha kudya.

Empagliflozin imapanga mgwirizano wolimba ndi mapuloteni amwazi, ndikupanga mitundu itatu ya metabolites. Koma zomwe ali nazo poyerekeza ndi kugwiritsidwa ntchito kwa zinthu sizigwirizana. Kuchoka kwa mankhwalawa kumachitika pafupifupi osasinthika ndowe ndi mkodzo.

Zizindikiro ndi contraindication

Ntchito yayikulu ya mankhwalawa imawonedwa ndikuwongolera kwa shuga m'magazi a matenda ashuga.

Amasankhidwa kuti akhale ndi matenda amtundu wa 2 m'mikhalidwe yonga:

• monotherapy (posakhala ndi zotsatira za zakudya ndi tsankho la mankhwala osokoneza bongo a Metformin);
• kuphatikiza mankhwala (kuphatikiza mankhwalawa ndi ena, kuphatikiza insulin, ngati kudya sikugwira ntchito).

Pali nthawi zina pomwe zoletsedwa kugwiritsa ntchito chida:

• mtundu 1 shuga;
• kukula kwa ketoacidosis mu shuga;
• kulephera kwaimpso;
• lactose tsankho;
• kuchepa kwa lactase;
• mkaka wa m`mawere ndi pakati;
• zaka za senile (kuyambira zaka 85);
• zaka za ana (mpaka zaka 18);
• kupezeka kwa chidwi ndi zigawozi.

Kuphatikiza pa contraindication okhwima, pali zochitika zina pamene kugwiritsa ntchito mankhwalawa kumaloledwa, koma pamaso pa kuyang'aniridwa ndi achipatala.

Izi zikuphatikiza:

• matenda am`mimba thirakiti, limodzi ndi chizolowezi chofuna madzi m'thupi;
• matenda amtunduwu;
• kufunika kwa chakudya chamafuta ochepa;
• mwayi wa hypovolemia;
• zovuta pakagwiritsidwe ntchito ka maselo a beta a kapamba;
• mbiri ya matenda ashuga a ketoacidosis;
• zaka odwala ndi zoposa 75 zaka.

Mu izi ndi zina zofanana, mankhwalawa amatha kuikidwa, koma pokhapokha pazifukwa.

Malangizo ogwiritsira ntchito

Jardins amayenera kumwa ndi pakamwa. Kugwiritsidwa ntchito kwake kumaloledwa musanadye komanso pambuyo chakudya.

Mlingo uyenera kufotokozedwa ndi adokotala, koma pakalibe malangizo apadera, piritsi limodzi (10 mg) limayikidwa patsiku.

Ngati dongosolo lotere la kugwiritsa ntchito mankhwalawa silibweretsa kufunika, ndikulimbikitsidwa kugwiritsa ntchito chida chomwe mlingo wa yogwira 25 mg.

Amayeneranso kumwa gawo limodzi patsiku. Mulingo waukulu wa mankhwalawa ndi 25 mg.

Kutumizidwa kawiri kwa Jardins sikuyenera kumwa, ngakhale mankhwalawo sanaledzere nthawi. Pankhaniyi, akuyenera kumwa mapiritsi atangomaliza kukumbukira zomwe adalakwitsa.

Odwala Apadera ndi Mayendedwe

Kwa magulu ena a odwala, malamulo apadera amagwiranso ntchito.

Izi zikuphatikiza:

1. Amayi pa nthawi yoyembekezera komanso yoyamwitsa. Zambiri za momwe Empagliflozin amathandizira odwala oterewa sanapezekebe, chifukwa kafukufuku wamderali sanachitike. Izi zikutanthauza choletsa kugwiritsa ntchito mankhwalawo.
2. Ana ndi achinyamata. Kugwiritsa ntchito mankhwalawa komanso kuopsa kwake kwa mankhwalawo sikunafufuzidwe nawonso. Poteteza odwala oterewa, amalimbikitsidwa kugwiritsa ntchito mankhwala ena.
3. Anthu azaka za senile. Kuyambira wazaka 75, odwala amatha kusowa madzi am'mimba nthawi yothandizidwa ndi wothandizira. Chifukwa chake, ayenera kuyang'anitsitsa chitetezo. Dotolo atha kutumiza a Jardins ngati odwala, koma ayenera kuwunika thanzi lawo mosamala. Pazaka zoposa 85, mankhwalawa amatsutsana.

Magulu ena odwala angagwiritse ntchito mankhwalawa posakhala zoletsa zina komanso motsogozedwa ndi katswiri.

Kupezeka kwa malangizo apadera okhudzana ndi mankhwalawa kumagwirizana ndi momwe impso yake imakhudzira. Chifukwa chake, adotolo, asanalembe Jardins, ayenera kuonetsetsa kuti palibe cholakwika chilichonse.

Komanso, mukamagwiritsa ntchito mankhwalawa kwa nthawi yayitali, amayenera kuwongolera kukhazikitsidwa kwa ntchito zaimpso poyesa wodwalayo. Nthawi zina (ngakhale ndi zovuta mu chiwindi), kusintha kwa mankhwalawa sikofunikira.

Zotsatira zoyipa ndi bongo

Mukamagwiritsa ntchito mankhwalawa, zotsatira zosafunikira nthawi zina zimatha kuchitika.

Mitu ikuluikulu ndi:

• hypoglycemia;
• Khungu;
• hypovolemia;
• zovuta zamkodzo (kufulumira kapena kusapezeka);
• candidiasis;
• matenda a kwamkodzo thirakiti;
• vulvovaginitis.

Mfundo zoyenera kuchitidwa ngati izi zimatengera kuuma kwawo. Nthawi zambiri, zikachitika, Jardins amasinthidwa ndi mapiritsi ena. Ndi kufooka kwapang'onopang'ono kwa zotsatira zosafunikira kapena kufooka kwawo, chithandizo chitha kupitilizidwa.

Milandu ya bongo mopitirira muyeso kutsatira malangizo sizinadziwikebe. Ndi gawo limodzi lokha la kuchuluka kwa 80 mg, kupatukanso sikunachitike. Ngati zovuta zazikulu chifukwa chopitilira muyeso wapezeka, mawonekedwe amomwe amachotsedwera zimatengera zizindikirocho.

Kuyanjana Ndi Mankhwala Ndi Analogi

Malangizo olondola amachepetsa chiopsezo cha kuphatikiza kwa Jardins ndi mankhwala ena. Ndikosayenera kuphatikiza mankhwalawa ndi okodzetsa, chifukwa amathandizira kulimbitsa zochita zawo, zomwe zimabweretsa kuchepa kwa madzi ndi kuchepa kwa magazi.

Ngati pali zifukwa zokanira chida ichi, chitha kusintha ndi analogi.

Mitu ikuluikulu ndi:

1. Repodiab. Chosakaniza chophatikizika m'mapiritsiwa ndi Repaglinide. Chida chimadziwika ndi zofanana ndi zotsutsana zina, zomwe kulephera kwa chiwindi kumawonjezeredwa. Iyenera kuphatikizidwanso mosamala ndi mankhwala ena, popeza pali zoletsa zina pamenepo.
2. Novonorm. Mankhwalawa amakhazikikanso pa Repaglinide. Zoyipa zotsutsana ndi chida ichi ndi zofanana ndi za Jardins, kupatula ntchito yaimpso yolakwika (panthawiyi, itha kugwiritsidwa ntchito moyang'aniridwa ndi achipatala).
3. Attokana. Chida ichi ndi choyenera kuchiza matenda amishuga a 2. Zomwe zimagwira ndi Kanagliflozin. Mankhwala ndi ofanana kwambiri ndi ake Jardins, amadziwika ndi contraindication omwewo ndi zotsatira zoyipa.

Chithandizo cha dokotala chimayenera kugwiritsa ntchito mankhwalawa komanso zina za analog.

Malingaliro a Ogwiritsa Ntchito

Kuchokera pa ndemanga zambiri za odwala omwe adatenga Jardins, titha kunena kuti mankhwalawa amachepetsa shuga m'magazi ndipo ndi osavuta kugwiritsa ntchito, komabe, zotsatira zoyipa za chikhodzodzo ndi impso zimawonedwa, zomwe zidasinthira kufananiza ndi mankhwalawa. Mtengo wokwera wa mankhwalawo umadziwikanso.

Ndinayamba kutenga a Jardins mogwirizana ndi endocrinologist. Ndinkakonda kwambiri zotsatirapo zake, koma kenako adasowa kuzipatala, ndipo ndinayenera kugwiritsa ntchito mankhwala ena. Atakwanitsa, adabweranso kudzalandira Jardins, chifukwa amawongolera bwino shuga. Vuto lokhalo ndi mtengo wa mankhwalawo.

Igor, wazaka 49

Poyamba, mankhwalawa amandigwira, chifukwa amasunga shuga bwino. Koma chifukwa cha iye, ndinali ndi mavuto ndi chikhodzodzo - ndimayenera kupita kuchimbudzi nthawi zambiri. Kenako kuyabwa kumaliseche. Dotolo adati izi ndizotsatira zoyipa. Ndidayesera kuzolowera, koma ndidakakamizidwa kupempha mankhwala ena.

Irina, wazaka 36

Ndimakonda kuti a Jardins ali ndi mitundu iwiri. M'mbuyomu, mapiritsi 10 mg anali okwanira kwa ine, ndiye ndimayenera kuwonjezera mlingo. Ndikukhulupirira kuti m'chilimwe ndingathe kubwerera njira yodziwira kale, chifukwa nthawi yotentha ndimakhala mdziko muno. Pali mpweya watsopano, ntchito zambiri, masamba ochokera m'mundawo, kotero kuyang'anira shuga kuyenera kukhala kosavuta. Mankhwalawa amandigwira bwino, samayambitsa mavuto komanso osavuta - kamodzi kokha patsiku.

Valentina, wazaka 57

Makanema pazomwe zimayambitsa matenda a shuga a 2:

Mtengo wa mankhwala Jardins zimatengera kuchuluka kwa yogwira ntchito pamapiritsi. Pa mlingo wa 10 mg, mankhwalawa amatha kugulidwa pamtengo wa 2000-2200 rubles. Ngati mukufuna mankhwala omwe ali ndi Mlingo wa 25 mg, ndiye kuti muyenera kugwiritsa ntchito ma ruble 2100-2600 pamenepo. Awa ndi mitengo ya phukusi lokhala ndi miyala 30. Mukamagula phukusi lokhala ndi mapiritsi 10, mudzafunika ma ruble 800-1000.

Mankhwalawa, ngati atamwa mosayenera, amatha kuvulaza wodwala. Chifukwa chake, kulandiridwa kwake ndikololedwa kokha ndikuloledwa ndi dokotala. Mankhwala amangogulitsa ndi mankhwala okha.