Ntchito malangizo Metformin

Pochiza matenda a shuga, othandizira osiyanasiyana a hypoglycemic amatengedwa. Piritsi la Metformin limagwiritsidwa ntchito kwambiri pazochita zamankhwala zamatenda.

Mankhwalawa akuphatikizidwa pamndandanda wa mankhwala ofunikira omwe amachepetsa shuga mu mtundu 2 wa shuga.

Zambiri, kapangidwe ndi mawonekedwe ake amasulidwe

Metformin ndi mankhwala omwe amagwiritsidwa ntchito kwambiri pochiza matenda amtundu wa 2. Ndilo gulu la Biguanides. Amadziwika ndi kulolera bwino, mavuto omwe amagwiritsidwa ntchito moyenera ndi osowa. Ndi mankhwala okhawo omwe ali mu kalasi lawo omwe samavulaza anthu omwe ali ndi vuto la mtima.

Zimathandizira kuchepetsa triglycerides ndi LDL. Itha kuyikidwanso mu zovuta mankhwala pothandizira kunenepa. Zisakhudze kulemera, zimachepetsa chiopsezo cha zovuta zamtima mu shuga. Mukamamwa mankhwalawo, chiopsezo cha hypoglycemia sichidziwika.

Chizindikiro chachikulu chogwiritsidwa ntchito ndi mtundu wa 2 shuga. Itha kuperekedwa kwa kutha msanga, ndi ovomerezeka ya polycystic, matenda ena a chiwindi. Mankhwalawa amathandizanso odwala omwe ali ndi boma la prediabetes.

Yogwira ntchito ya mankhwala ndi metformin hydrochloride.

Piritsi lililonse limakhala ndi mulingo wosiyana wa zomwe zimagwira: 500, 800, 1000 mg.

Amapezeka m'mapiritsi a chipolopolo. Paketi ili ndi matuza 10. Chithuza chilichonse chimakhala ndi mapiritsi 10.

Pharmacological kanthu ndi pharmacokinetics

Mankhwala amachepetsa onse okwanira shuga ndi kukhazikika pakudya. Thupi limakhudzidwa ndi kukondoweza kwa glycogen synthesis ndikuyambitsa magazi mu chiwindi. Zimalepheretsa gluneocogenesis mthupi. Imachepetsa LDL ndikuwonjezera HDL.

Chombochi chimachedwetsa kufalikira kwa zinthu zosalala za m'mitsempha yamagazi. Amachepetsa mayamwidwe am'mimba m'matumbo, amachepetsa kudya. Kuchepa kwa kuchuluka kwa shuga kumafotokozedwa ndikusintha kwa kugaya kwake maselo chifukwa cha kuchuluka kwa insulin.

Thupi siliyambitsa kupangika kwa insulin, kumachepetsa milingo ya glucose, pomwe sikumapangitsa chidwi cha hypoglycemic. Mukamagwiritsa ntchito mankhwalawa mwa anthu athanzi, palibe kuchepa kwa glucose. Imayimitsa hyperinsulemia, yomwe imakwiyitsa kulemera ndikukula kwamavuto.

Pambuyo makonzedwe, thunthu limakhala litalowa kwathunthu. Pambuyo maola 2,5, ndende imafika pazokwanira zake. Mukamagwiritsa ntchito mankhwalawa mukudya, kuchuluka kwa mayamwidwe kumachepa.

Pambuyo pa maola 6, ndende ya Metformin imachepa, mayamwidwe ake amasiya. Pambuyo maola 6.5, theka la moyo wa mankhwalawa limayamba. Mankhwalawa samamangirira mapuloteni am magazi. Pambuyo maola 12, kuchotseratu kumachitika.

Zizindikiro ndi contraindication

Zomwe amamwa mankhwalawa ndi:

• shuga wosadalira insulin (Type 2 matenda ashuga) monga monotherapy pakalibe zotsatira zoyenera pambuyo pakudya;
• Mtundu wachiwiri wa matenda a shuga limodzi ndi othandizira odwala matenda ashuga;
• Mtundu wachiwiri wa matenda ashuga wothandizila ana kuyambira wazaka 10 akaphatikizidwa kapena mosiyana;
• pamodzi ndi insulin;
• mu zovuta mankhwala a kunenepa kwambiri, ngati zakudya sizinabweretse zotsatira;
• Kuchotsa matenda ashuga.

Mankhwala ali osavomerezeka kuti mugwiritse ntchito potsatira:

• matenda ashuga ketoacidosis;
• tsankho ku zigawo zikuluzikulu za mankhwala;
• myocardial infarction;
• uchidakwa;
• kulephera kwaimpso;
• kafukufuku wa radiographic ndikuyambitsa kusiyana kwapadera;
• matenda oopsa opatsirana;
• matenda a shuga;
• kulephera kwa chiwindi.

Malangizo ogwiritsira ntchito

Malangizo kwa akuluakulu: kumayambiriro kwa chithandizo chamankhwala, osachepera 500 mg ndi mankhwala. Mankhwalawa amatengedwa 2 pa tsiku mukatha kudya. Pambuyo pa masabata awiri, shuga amayeza ndipo mlingo umasinthidwa kutengera zotsatira zake.

Mankhwala akuwonetsa zochizira pambuyo masiku 14 a makonzedwe. Kuchulukitsa kwa mankhwalawa kumachitika pang'onopang'ono - izi zimachepetsa zotsatira zoyipa pamimba.

Kuchuluka kwa tsiku ndi tsiku ndi 3000 mg.

Malangizo kwa ana: Poyamba, 400 mg ya mankhwalawa ndi mankhwala (piritsi logawidwa pakati). Kenako, phwando limachitikira kwa zomwe zikuchitika. Mulingo wapamwamba tsiku lililonse ndi 2000 mg.

Mankhwalawa amaphatikizidwa ndi insulin. Metformin imatengedwa mwachizolowezi: 2-3r. patsiku. Mlingo wa insulin umatsimikiziridwa ndi dokotala potengera zotsatira za kusanthula.

Odwala Apadera ndi Mayendedwe

Gulu la odwala apadera limaphatikizapo:

1. Amimba komanso kuyatsa. Mankhwalawa sagwiritsidwa ntchito pa nthawi yoyembekezera komanso mkaka wa m'mawere. Dokotala amatiuza mankhwala a insulin.
2. Ana. Kwa ana ochepera zaka 10, mankhwalawa amatsutsana. Chitetezo chovomerezeka pakatha msanga sichinakhazikitsidwe.
3. Anthu okalamba. Amalembedwa mosamala kwa achikulire, makamaka atatha zaka 60. Mlingo wake umasankhidwa poganizira momwe impso imagwirira ntchito.

Kugwiritsa ntchito mankhwalawa kwa nthawi yayitali kumafunanso kuwunika impso. Kamodzi pa miyezi isanu ndi umodzi, mankhwala a creatinine amayenera kuwunikira - chizindikiro> 135 mmol / l, mankhwalawo amathetsedwa. Makamaka ziyenera kuyang'aniridwa mosamala kwambiri zikuwonetsa kuphwanya thupi.

Mukamamwa Metformin, mowa uyenera kutayidwa. Izi zimakhudzanso ndi mankhwala omwe ali ndi mowa. Musanayambe kuphatikiza mankhwalawa ndi mankhwala ena omwe si a shuga, muyenera kudziwitsa dokotala. Mukaphatikizidwa ndi mankhwala a sulfonylurea, kuwunika bwino kwamisempha yamagazi kumafunika.

Pamaso pa opaleshoni, Metformin imathetsedwa m'masiku awiri. Yambitsaninso ntchito musanadutse masiku awiri pambuyo pa njirayi, poganizira momwe impso zikuyendera. M'maphunziro a radiology (makamaka pogwiritsa ntchito kusiyanitsa), mankhwala osokoneza bongo amathetsedwanso m'masiku awiri ndikuwabwezeretsa pambuyo masiku 2, motsatana.

Zotsatira zoyipa ndi bongo

Zotsatira zoyipa mukamagwiritsa ntchito mankhwalawa:

• lactic acidosis;
• megaloblastic anemia;
• chiwindi ntchito;
• urticaria, kuyabwa, zotupa, erythema;
• kawirikawiri hepatitis;
• aimpso kuwonongeka;
• kulakwira;
• mawonetseredwe pafupipafupi amawonekera kuchokera kumimba: kuperewera kwa chakudya ndi mseru, kukhumudwa pang'onopang'ono, kugona, kusanza;
• kuchepa mayamwidwe a B12.

Mukamamwa mankhwalawa, palibe chiwonetsero cha hypoglycemia, mosiyana ndi mankhwala ena a gulu la odwala matenda ashuga. Ndi kuwonjezeka kwa mlingo, lactic acidosis imayamba. Ndi zovuta kuthandizira pogwiritsa ntchito mankhwala a sulfonylurea, hypoglycemia imatha kuchitika.

Posankha hypoglycemia, wodwalayo akulimbikitsidwa kutenga 25 g shuga. Ngati lactic acidosis ikukayikira, wodwalayo amapita kuchipatala kuti amveketse bwino (kutsutsa) matenda ake, kumwa mankhwalawo kumachotsedwa. Ngati ndi kotheka, hemodialysis imachitidwa.

Kuyanjana Ndi Mankhwala Ndi Analogi

Chisamaliro chapadera chimaperekedwa poyanjana ndi Metformin ndi mankhwala ena. Ena amatha kukulitsa shuga, ena, mmalo mwake, otsika. Kugwiritsa ntchito mankhwala munthawi yomweyo popanda kufunsa dokotala mulimbikitsidwa.

Danazole imayambitsa hyperglycemia. Ngati ndi kotheka, mankhwalawa amathandizira kusintha kwa Metformin ndikuwongolera shuga. Ma diuretics, glucocorticosteroids, mahomoni achikazi, antidepressants, mahomoni a chithokomiro, adrenaline, nicotinic acid zotumphukira, shuga amachepetsa mphamvu yake.

Mukamagwiritsidwa ntchito palimodzi ndi ma fibrate, mahomoni amphongo, zotumphukira za sulfonylurea, ma insulin a ACE, insulini, maantibayotiki ena, acarbose, clofibrate zotumphukira, ndi mankhwala ena othandizira, zotsatira za Metformin zimatheka.

Kumwa mowa kumatha kuyambitsa kukula kwa lactic acidosis. Mankhwala, mankhwala okhala ndi ethanol samaperekedwanso kunja. Chlorpromazine amachepetsa kutulutsa insulin.

Mankhwala ofanana omwe ali ndi vuto lofananalo akuphatikizapo: Metamine, Bagomet, Metfogamma, Glycomet, Meglifort, Dianormet, Diaformin Sr, Glyukofazh, Insufor, Langerin, Meglukon. Chofunikira kwambiri mwa mankhwalawa ndi metformin hydrochloride.

Kanema kochokera kwa Dr. Malysheva okhudza Metformin:

Malingaliro a odwala ndi akatswiri

Odwala ambiri omwe akupatsidwa chithandizo cha Metformin amawona kusintha kwamphamvu pazowunika. Unikani ntchito zake komanso kusunthika bwino. Odwala ena adawona zotsatira zabwino pakuwongolera thupi, mtengo wotsika mtengo wa mankhwalawo. Pakati pa mfundo zoyipa - vuto la m'mimba.

Adalemba Metformin chifukwa cha matenda ashuga pambuyo poti zakudya zomwe zidaperekedwa sizinathandize. Imawongolera shuga bwino komanso sizimayambitsa mavuto. Patatha milungu ingapo, adotolo anasintha. Mothandizidwa ndi mankhwalawa, ndinatha kutaya kilos owonjezera. Msuzi wa shuga umatsika bwino. Ponseponse, mankhwala abwinobwino.

Antonina Stepanovna, wazaka 59, Saratov

Chipangizocho chinabwereranso kuzowonetsa osati shuga, komanso cholesterol yathunthu. Amathandizira polimbana ndi kunenepa kwambiri. Ndinkadzimva kuti ndikudziwonetsa ndekha - kusowa chidwi cha chakudya komanso nseru. Ndikuwona kuti kulandiridwa kwa mankhwala ena antidiabetesic sikunayende bwino. Ndikuganiza kuti Metformin adadziwonetsera zabwino.

Roman, wazaka 38, wa St.

Kumayambiriro kwa kudya, zotsatira zoyipa zinali zamphamvu - matenda otsekula m'mimba kwa masiku awiri ndi kusowa kwamphongo. Ndinafuna kusiya kutenga Metformin. Ndinkamwa ma decoctions ndipo patatha masiku 4 chopondapo chidabweranso. Zotsatira zakutenga ndi mulingo wabwinobwino shuga ndikuchepetsa makilogalamu asanu olemera. Ndikufunanso kuwona mtengo wotsika mtengo wa mankhwalawo.

Antonina Aleksandrovna, wazaka 45, Taganrog

Akatswiri amaonanso zabwino za mankhwalawo komanso kulekerera kwa mankhwalawa, koma amalimbikitsa kugwiritsa ntchito mankhwalawa chifukwa chake, osati kuwonda.

Metformin imawonedwa ngati mankhwala othandiza odwala matenda ashuga amtundu wa 2. Imatha kulolera bwino ndikuvomera koyenera ndikutsatira malingaliro a dokotala. Mosiyana ndi mankhwala ena othandizira odwala matenda ashuga, Metformin ali ndi chiopsezo chochepa cha hypoglycemia. Kafukufukuyu adatsimikiza kuti ndizovulaza kwathunthu kwa anthu omwe ali ndi vuto la mtima. Odwala omwe ali ndi thanzi labwino salimbikitsa kugwiritsa ntchito mankhwalawa kukonza thupi.

Antsiferova S.M., endocrinologist

Mtengo wa mankhwalawo ndi pafupifupi ma ruble 55. Metformin ndi mankhwala.

Metformin ndi mankhwala omwe amapangidwa kuti achepetse shuga mu shuga omwe amadalira insulin. Amadziwika ndi kulolera bwino ndi chiopsezo chochepa cha kuchuluka kwa glycemia. Amakonzanso kulemera kwa thupi ndi anthu omwe ali ndi matenda ashuga, amachepetsa cholesterol yoyipa. Choyimira chachikulu ndi lactic acidosis.