Humulin ndi njira yochepetsera shuga m'magazi - omwe akuchita insulin. Ndibwino kuti mukumva, DNA yamphamvu kwambiri.
Chuma chake chachikulu ndikuyendetsa njira za metabolic m'thupi.
Mwa zina, chinthu ichi chimadziwika ndi zotsatira za anabolic komanso anti-catabolic pazinthu zina za thupi. M'matumba, mumakhala kuchuluka kwa glycogen, mafuta acid, glycerol, komanso kuchuluka kwa mapuloteni komanso kuchuluka kwa amino acid.
Komabe, kuchepetsa glycogenolysis, gluconeogeneis, lipolysis, mapuloteni catabolism ndi kutulutsidwa kwa amino acid kumatha kuyambika. Nkhaniyi ikufotokoza mwatsatanetsatane mankhwala omwe amalowa m'malo mwa ma pancreatic hormone omwe amatchedwa Humulin, analogues omwe amatha kupezekanso pano.
Analogi
Humulin ndimakonzedwe a insulin ofanana ndi anthu, omwe amadziwika nthawi yayitali.
Monga lamulo, kuyambika kwa vuto lake kumawonekera mphindi 60 pambuyo pa kuwongolera mwachindunji. Kuchuluka kwake kumatheka pafupifupi maola atatu jakisoni. Kutalika kwa kukopa kukuyambira maola 17 mpaka 19.
NPH
Chofunikira chachikulu cha mankhwalawa Humulin NPH ndi isophan protamininsulin, yomwe imafanana kwathunthu ndi munthu. Ili ndi nthawi yayitali yochitapo kanthu. Amawerengera odwala matenda a shuga omwe amadalira insulin.
Nthawi zambiri, akatswiri amalimbikitsa izi pokonzekera wodwala yemwe ali ndi vuto la endocrine la opaleshoni. Itha kugwiritsidwanso ntchito pamavuto akulu kapena matenda opweteka kwambiri.
Humulin NPH
Pankhani ya mankhwalawa, mankhwalawa amasankhidwa ndi adokotala. Komanso, monga lamulo, kuchuluka kwa Humulin NPH kumadalira mtundu wa thanzi la wodwala.
Mukamagwiritsa ntchito Humulin NPH mwanjira yake yoyenera, iyenera kuperekedwa kawiri pa tsiku. Izi ziyenera kuchitika kokha mwa kubaya jekeseni wamkati.
Nthawi zambiri, kufunikira kwa Humulin NPH kumatha kuwonjezeka panthawi yodwala kwambiri komanso kupsinjika. Imafalikira mukamamwa mankhwala ena ndi ntchito ya glycemic (yomwe imakulitsa shuga).
Zimafunikanso kuperekedwa pamiyeso yambiri pogwiritsa ntchito njira zakulera za pakamwa, corticosteroids, komanso mahomoni a chithokomiro.
Koma ponena za kuchepetsa Mlingo wa analogue wa insulin, izi ziyenera kuchitika ngati wodwala ali ndi vuto la impso kapena hepatic.
Komanso kufunika kwa mahomoni opanga ma pancreatic amatsika ndikumawatenga ndi ma MA inhibitors, komanso beta-blockers.
Mwa zina zoyipa, kutchulidwa kwambiri ndi kuchepa kwakukulu kwa kuchuluka kwamafuta m'thupi lathu. Vutoli limatchedwa lipodystrophy. Komanso, nthawi zambiri, odwala amazindikira kukana insulini (kusakhalapo kwathunthu kwa vuto la insulin)
Koma Hypersensitivity zimachitika yogwira pophika mankhwala sizomwe zimachitika. Nthawi zina odwala amafotokoza kuswala kwambiri komwe kumadziwika ndi khungu loyipa.
Nthawi zonse
Humulin Regular amakhala ndi tanthauzo la hypoglycemic. Chothandizira chophatikizika ndi insulin. Iyenera kulowetsedwa mapewa, ntchafu, matako kapena pamimba. Onse makonzedwe a intramuscular and intravenous amatha.
Humulin Wokhazikika
Momwe mulingo woyenera wa mankhwalawa, amadziwikiridwa payekhapayekha ndi dokotala wodziwa yekha. Kuchuluka kwa Humulin kumasankhidwa molingana ndi zomwe zili m'magazi.
Monga mukudziwa, mankhwalawa amaloledwa kuperekedwa limodzi ndi Humulin NPH. Koma zisanachitike, muyenera kuphunzira mwatsatanetsatane malangizo ophatikizira ma insulini awiriwa.
Mankhwalawa akuwonetsedwa kuti agwiritsidwe ntchito ndi mtundu wa matenda a shuga a insulin, hyperglycemic com (kuchepa kwa chikumbumtima, komwe kumadziwika ndi kusowa kwathunthu kwa zochita za thupi pazomwe zimachitika chifukwa cha kuchuluka kwambiri kwa glucose mthupi), komanso pakukonzekera wodwala yemwe ali ndi vuto la endocrine, kuchitapo kanthu opaleshoni.
Amalemberanso kuvulala komanso matenda opatsirana pachakudwala matenda ashuga.
Pankhani ya pharmacological kanthu, mankhwalawa ndi insulin, yomwe imafanana kwathunthu ndi munthu. Amapangidwa pamaziko a DNA yobwerezabwereza.
Ili ndi mndandanda wa ndendende wa amino acid womwe umakhala mu timadzi ta pancreatic ya anthu. Monga lamulo, mankhwalawa amadziwika ndi zochitika zazifupi. Chiyambitsi chake chabwino chimawonedwa pafupifupi theka la ola pambuyo poyendetsa mwachindunji.
M3
Humulin M3 ndi othandizira amphamvu komanso othandizira a hypoglycemic, omwe amaphatikiza ma insulin aafupi komanso apakati.
Gawo lalikulu la mankhwalawa ndi chisakanizo cha insulin yaumunthu yosungunuka komanso kuyimitsidwa kwa isofan insulin. Humulin M3 ndi DNA yothandizanso ndi insulin ya anthu nthawi yayitali. Ndi kuyimitsidwa kopanda phokoso.
Humulin M3
Chikoka chachikulu cha mankhwalawa chimawonedwa ngati malamulo a kagayidwe kazachilengedwe. Mwa zina, mankhwalawa ali ndi mphamvu ya anabolic. M'misempha ndi minyewa ina (kupatula ubongo), insulin imakwiyitsa mayendedwe achilengedwe a glucose ndi amino acid, ndikupangitsa mapuloteni anabolism.
Homoni ya pancreatic imathandizira kusintha glucose kukhala chiwindi glycogen, imalepheretsa gluconeogeneis komanso imathandizira kusintha kwa glucose owonjezera kukhala lipids.
Humulin M3 akuwonetsedwa kuti agwiritse ntchito matenda ndi mthupi, monga:
- shuga mellitus pamaso pazisonyezo zina zachangu za insulin;
- adapezeka koyamba matenda a shuga;
- kubereka mwana ndi endocrine matenda amtundu wachiwiri (osadalira insulini).
Zosiyanitsa
Zomwe zimasiyana ndi mitundu yosiyanasiyana ya mankhwalawa:
- Humulin NPH. Ndili m'gulu la ma insulin apakati. Pakati pa mankhwala omwe amapezeka kwa nthawi yayitali omwe amakhala m'malo a munthu pancreatic hormone, mankhwalawo amafunsidwa kwa anthu odwala matenda ashuga. Monga lamulo, zochita zake zimayamba mphindi 60 pambuyo pa kutsata mwachindunji. Ndipo kuchuluka kwake kwakukulu kumawonedwa pambuyo pafupifupi maola 6. Kuphatikiza apo, zimatha pafupifupi maola 20 motsatana. Nthawi zambiri, odwala amagwiritsa ntchito jakisoni zingapo nthawi imodzi chifukwa chachedwa pakuchitika kwa mankhwalawa;
- Humulin M3. Ndiwosakanikirana kwapadera ndi ma insulin osakhalitsa. Ndalama zoterezi zimakhala ndi zovuta zautali wa NPH-insulin komanso maholide a pancreatic a ultrashort ndi zochitika zazifupi;
- Humulin Wokhazikika. Amagwiritsidwa ntchito poyambira kudziwa matenda. Monga mukudziwa, ikhoza kugwiritsidwa ntchito ndi azimayi oyembekezera. Mankhwalawa ndi m'gulu la mahomoni a ultrashort. Ndi gululi lomwe limatulutsa mwachangu kwambiri ndipo nthawi yomweyo limachepetsa shuga la magazi. Gwiritsani ntchito malonda musanadye. Izi zimachitika kuti njira yogaya mafuta imathandizira kufulumiza kuyamwa kwa mankhwalawa munthawi yochepa kwambiri. Mahomoni ofulumira kuchitapo kanthu amatengedwa pakamwa. Zachidziwikire, ayenera kubweretsedwa kumalo amadzimadzi.
Ndikofunika kudziwa kuti insulini yokhala ndi nthawi yochepa ili ndi zotsatirazi:
- ayenera kumwedwa pafupifupi mphindi 35 chakudya chisanachitike;
- pakuyamba mwachangu, muyenera kulowa mankhwalawa ndi jakisoni;
- Nthawi zambiri imayendetsedwa m'mimba;
- jakisoni wa mankhwala akuyenera kutsatiridwa ndi chakudya chotsatira kuti athetse kwathunthu mwayi wa hypoglycemia.
Kodi pali kusiyana kotani pakati pa Humulin NPH insulin ndi Rinsulin NPH?
Humulin NPH ndi chithunzi cha insulin ya anthu. Rinsulin NPH imafanananso ndi mahomoni a pancreatic a anthu. Ndiye pali kusiyana kotani pakati pa awiriwa?
Rinsulin NPH
Ndikofunika kudziwa kuti onsewa ali m'gulu la mankhwala omwe amakhala nthawi yayitali kuchitidwe. Kusiyana kokhako pakati pa mankhwalawa ndikuti Humulin NPH ndi mankhwala achilendo, ndipo Rinsulin NPH amapangidwa ku Russia, motero mtengo wake umakhala wotsika kwambiri.
Wopanga
Humulin NPHs amapangidwa ku Czech Republic, France, ndi UK. Humulin Wokhazikika wopangidwa ku USA. Humulin M3 amapangidwa ku France.
Machitidwe
Monga tanena kale, Humulin NPH amatanthauza mankhwala omwe amakhala ali pakatikati pa zochita. Humulin pafupipafupi amaikidwa m'gulu la mankhwala osokoneza bongo osokoneza bongo. Koma Humulin M3 amadziwika kuti ndi insulin yokhala ndi yochepa.
Makanema okhudzana nawo
Zokhudza mitundu ya insulini yomwe imagwiritsidwa ntchito pochiza matenda a shuga mu kanema:
Kuchokera pazidziwitso zonse zomwe zawonetsedwa m'nkhaniyi, titha kunena kuti kusankha koyenera kwambiri kwa insulin, kuchuluka kwake ndi njira yodulira zimatengera zinthu zingapo. Kuti mudziwe njira yoyenera komanso yotetezeka, muyenera kufunsa katswiri wodziwa za matenda a endocrinologist.
