Telsartan N ndi wa gulu la antihypertensive mankhwala. Uku ndikukonzekera magawo awiri. Amadziwika ndi kuphatikiza kwakukulu. Izi zimasiyana ndi ma analogi a Telsartan pamaso pa okodzetsa. Chifukwa cha gawo ili, zotsatira zabwino zamankhwala zokhala ndi matenda oopsa zimachitika mwachangu.
Dzinalo Losayenerana
Telmisartan + Hydrochlorothiazide
ATX
C09DA07
Kutulutsa mafomu ndi kapangidwe kake
Mutha kugula mankhwala m'mapiritsi. Zosakaniza zomwe zikuwonetsa ntchito za antihypertensive ndi: telmisartan (40 ndi 80 mg); hydrochlorothiazide (12.5 mg). Mukamapereka mankhwala, ziyenera kukumbukiridwa kuti yachiwiri ya zinthu zonse imakhala mu mgawo womwewo, ndipo kuchuluka kwa telmisartan kumawonjezeka 2 times.
Mankhwala Telsartan N amapezeka m'matuza okhala ndi mapiritsi 6, 7 kapena 10.
Mankhwalawa amapezeka m'matumba okhala ndi mapiritsi 6, 7 kapena 10. Kuchuluka kwa ma CD mumakatoni amakhodi kumasiyana ndipo ndi ma 2, 3 ndi 4 ma PC.
Zotsatira za pharmacological
Telmisartan imagwira ngati angiotensin II receptor antagonist. Izi zikutanthauza kuti ntchito yawo imalephereka motsogozedwa ndi chinthuchi. Mphamvu yofunikayo imatheka chifukwa cholumikizana ndi angiotensin II receptors ndi AT1. Kuwonjezeka kwa lumen kwa mitsempha yamagazi kumachitika kudzera mu kutuluka kwa mahomoni (angiotensin II), omwe amakhudza kamvekedwe ka makoma awo.
Chifukwa cha izi, kuchuluka kwa kuthamanga kwa magazi kumachepa, kukakamizidwa kumachitika. Telmisartan imachita mwanjira yoti panthawi ya chithandizo, kuyankha kwachilengedwe kwa receptor sikuchitika panthawi yolumikizirana. Zotsatira zake, zombo sizimakonda kuchepera. Ndi chizolowezi chowonjezera matenda oopsa, mankhwalawa amapereka zotsatira zabwino pamene wodwalayo akuchitidwa. Mukamaliza kutsata, matendawa amatha kukulirakonso, popeza telmisartan sithetsa chomwe chimayambitsa matendawa.
Mankhwala ali ndi zinthu zomwe zimasiyanitsa ndi mitundu yambiri:
- kusowa kulepheretsa ntchito ya renin mu magazi seramu;
- sichimaletsa kugwira ntchito kwa angiotensin-kutembenuza enzyme;
- pali mathamangitsidwe akuwonongeka kwa bradykinin;
- kuchepa kwa ndende ya aldosterone m'madzi am'magazi.
Pa mankhwala, kupanikizika kumachepa (systolic, diastolic arterial). Komabe, njirayi sikuyenda limodzi ndi kusintha kwa mtima. Izi zikutanthauza kuti odwala omwe amatenga Telsartan H sakhala pachiwopsezo cha zotsatira zoyipa kuchokera ku mtima, koma pokhapokha ngati mankhwalawo sakusokoneza.
Ngati mankhwalawa mankhwala motsutsana maziko a chiopsezo chachikulu chotenga mtima ndi matenda a mtima, ndiye chifukwa cha telmisartan mwayi wokhala ndi vuto la mtima, stroko imachepa. Chiwopsezo cha kufa chikuchepa.
Chothandizira chinanso (hydrochlorothiazide) ndi cha gulu la thiazide diuretics. Katunduyu amathandizira kuthamanga kukhathamiritsa kwamadzi kuchokera mthupi. Komabe, palibe zoletsa pakudya zamchere. Hydrochlorothiazide amalimbikitsa kuphipha kwa sodium ndi chloride. Mphamvu ya antihypertensive imawonetsedwa mwa kuchepetsa kuchuluka kwa magazi omwe amayatsidwa mumitsempha.
Nthawi yomweyo, pakhala kuwonjezeka kwa ntchito ya aldosterone yopanga. Zotsatira zake, zinthu za potaziyamu m'magazi zimachepa, koma nthawi yomweyo kuyika kwake kwamkodzo kumawonjezeka. Telmisartan yomwe m'mbuyomu amaganiza imathandiza kuti muchepetse njira yowonongeka ya potaziyamu. Chifukwa cha kuphatikiza kwa zida izi, zotsatira zomwe mukufuna zimatheka.
Pharmacokinetics
Zochita za okodzetsa zimasungidwa kwa maola 6-12. Kuwonjezeka kwa kuchuluka kwa madzi amadzimadzi amawonedwa pambuyo pa mphindi 120 mutatha kumwa mankhwala koyamba. Mphamvu yapamwamba ya hydrochlorothiazide imatheka pambuyo maola 4. Poyerekeza, telmisartan imayamba kuchita zambiri pambuyo pa maola atatu. Zomwe zimapezeka zimatha tsiku limodzi. Antihypertensive effect imasungidwa kwa maola 48 otsatira.
Matenda a wodwalayo panthawi yamankhwala a Telsartan N amapezeka pang'onopang'ono. Zotsatira zabwino kwambiri zitha kupezeka masabata 4 atayamba chithandizo. The bioavailability wa telmisartan ndi 50%. Pogwiritsa ntchito nthawi yomweyo chakudya, mphamvu ya mankhwala imachepa. Komabe, maora atatu atatha kumwa mankhwalawa, kuphatikizika kwa madzi am'magazi kumakhala koyenera.
Zizindikiro zazikulu za pharmacokinetics za telmisartan mwa akazi ndizochulukirapo 2-3 kuposa amuna. Ngakhale izi, mankhwalawa ndi othandizanso pochiza odwala omwe ali m'magulu onse awiri. Palibe kuwonjezeka kwa antihypertensive zotsatira pa mankhwala azimayi. Zinthu zomwe zimapezeka chifukwa cha kusinthika kwa telmisartan sizikuwonetsa ntchito. Kutalika kwa moyo wa chinthuchi kumadziwika. Amachotseredwa pakatha maola 20 mutatha kumwa kotsiriza.
Hydrochlorothiazide sanapangidwe. Katunduyu amachotsedwa m'thupi limodzi ndi impso. Kutha kumangiriza mapuloteni a plasma ndi bioavailability wa hydrochlorothiazide, motero 64 ndi 60%.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amadziwika ndi dera laling'ono logwiritsira ntchito. Amawerengera matenda oopsa. Kuphatikiza apo, chisonyezo chogwiritsa ntchito Telsartan N ndi monotherapy ndi telmisartan kapena hydrochlorothiazide, ngati sizotheka kupeza zotsatira zomwe mukufuna.
Mankhwala Telsartan N amadziwika ndi dera laling'ono logwiritsira ntchito, amapatsidwa mankhwala oopsa.
Contraindication
Matenda aumunthu omwe ndi osathandiza kugwiritsa ntchito mankhwalawa:
- Hypersensitivity zimachitikira yogwira chigawo;
- matenda amitsempha, komwe njira yochotsa bile imasokonezeka;
- matenda a m'magazi momwe mtundu wa creatinine umafika 30 ml kwa mphindi ndikuchepa;
- kusowa kwa potaziyamu;
- calcium yambiri
- shuga galactose malabsorption syndrome;
- kusowa kwa lactase m'thupi;
- zoipa hypersensitivity zimachitika ndi kuchuluka kwa lactose.
Ndi chisamaliro
Chida chomwe chatengedwa chimagwiritsidwa ntchito moyang'aniridwa ndi katswiri muzochitika zingapo:
- ochepa hypotension;
- kuchepa kutchulidwa kwa lumen ya mitsempha ya impso, yomwe imachitika chifukwa cha stenosis (njira yochotsa theka la moyo wa zinthu zomwe zimagwira pang'onopang'ono, zimayambitsa kuwonjezeka kwa kuchuluka kwa mankhwalawa komanso kuwonjezeka kwa zotsatira zake zazikulu);
- mankhwala aposachedwa omwe ali ndi gulu la okodzetsa;
- potaziyamu yambiri;
- kuchira pambuyo kupatsidwa impso;
- zoopsa zamtima, kuphatikizapo kulephera kwa mtima;
- kuphatikiza kolesterol, triglycerides, calcium yayikulu;
- matenda akulu a chiwindi panthawi yogwira chitukuko (chiopsezo cha kuyambitsidwa kwa hepatic chikomokere);
- kuchepa kwa lumen kwa mitral ndi valavu ya aortic;
- matenda a shuga;
- kusintha kwa gouty;
- kuchuluka kwa uric acid m'magazi;
- kuwonongeka kwambiri kwa ziwalo zamasomphenya.
Mankhwala amatengedwa mosamala ngati chiwopsezo chachikulu cha ziwalo za masomphenyawo chikuchitika.
Momwe angatenge Telsartan N?
Kuchuluka kwa tsiku ndi tsiku ndi piritsi limodzi (12.5 + 40 mg). Mlingo wapamwamba wa mankhwalawa (12.5 + 80 mg) amagwiritsidwa ntchito ngati kukhazikika sikupereka zotsatira zomwe mukufuna. Kuchuluka kwa telmisartan tsiku ndi tsiku kumawonjezeka kufika pa 160 mg pa vuto lalikulu la matenda oopsa.
Ndi matenda ashuga
Mankhwalawa pogwiritsa ntchito mankhwalawa. Kuwunikira kosalekeza kwa zizindikiro zazikulu zamagazi ndikofunikira. Nthawi zambiri, odwala ndi omwe amapatsidwa mlingo woyenera wovomerezeka wa mankhwalawa.
Zotsatira zoyipa Telsartan N
Matumbo
Kukula kwa mapangidwe a gasi kumachuluka, pakamwa kowuma kumawonekera. Kapangidwe ka ndowe zimasintha (kukhala madzi). Kudzimbidwa, njira zosokonekera m'mimba sizachulukana, kusanza, kupweteka pamimba kumachitika, ndipo njira yoperekera ndowe imakhala yovuta kwambiri.
Hematopoietic ziwalo
Zovuta monga hyponatremia, hypokalemia imakula. Kukumana kwa uric acid m'madzi am'magazi kumawonjezeka.
Pakati mantha dongosolo
Nthawi zina, mavuto, kugona, kusowa tulo. Kuda nkhawa kumaonekera, nthawi zina kukhumudwa kumayamba.
Kuchokera kwamikodzo
Mavuto a matenda a impso.
Kuchokera ku kupuma
Kutupa kwamapapu, kufupika, chibayo.
Pa khungu
Erythema.
Kuchokera ku genitourinary system
Kugonana pazoyipa za kusokonekera kwa erectile.
Kuchokera pamtima
Kusintha kwa kugunda kwa mtima, hypotension.
Kuchokera musculoskeletal system ndi minofu yolumikizana
Ululu kumbuyo, minofu yofewa, kupweteka kwa minofu ya ng'ombe.
Pa mbali ya chiwindi ndi biliary thirakiti
Mavuto okhala ndi matenda a chiwindi.
Matupi omaliza
Urticaria, angioedema.
Kupweteka kumbuyo ndi kupweteka kwa minofu yofewa kumatha kuchitika mutatha Telsartan N.
Zokhudza mphamvu pakuwongolera njira
Popeza kuopsa kwa chizungulire, kugona, kusamala kuyenera kuchitidwa poyendetsa. Ngati ndi kotheka, ndikofunika kukana kuchita nawo zinthu zina zofunika kuzisamalira.
Malangizo apadera
Ndi a impso artery stenosis, mwayi wokhala ndi hypotension ukuwonjezeka.
Poyerekeza ndi matenda ashuga, chiopsezo cha matenda a mtima, matenda amtima ukuwonjezeka.
Ndi khungu-kutsekeka glaucoma, chithandizo cha panthawi yake chofunikira, chifukwa ngati sichoncho, kusinthanso kwa maso kumapangitsa kuti khungu lithe kulowa m'maso.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa sanatchulidwe kwa azimayi okhala ndi mwana ndi kuyamwitsa. Izi ndichifukwa choti kafukufuku wa zamankhwala wokhudzana ndi mankhwalawa pa fetus sanachitike.
Kuika Telsartan N kwa ana
Sichikugwira ntchito, chifukwa palibe chidziwitso chokwanira pokhudzana ndi chitetezo cha malonda.
Gwiritsani ntchito mu ukalamba
Palibe chifukwa chosinthira kuchuluka kwa mankhwalawa, chifukwa njira zamachiritso a odwala a gululi zimachitika mwachangu komanso mwamphamvu monga mwa achinyamata.
The ntchito aimpso kuwonongeka
Palibe chifukwa chosinthira kuchuluka kwa telmisartan ndi hydrochlorothiazide. Mankhwalawa amavomerezedwa kuti agwiritsidwe ntchito, koma pokhapokha ngati pakuchepa kapena kufooka kwa impso kukukula. Ndikowonongeka kwakukulu kwa chiwalochi, mankhwalawa sagwiritsidwa ntchito. Izi ndichifukwa choti impso zimakhudzidwa ndikuchotsedwa kwazinthu zothandiza m'thupi. Mwanjira yayikulu, mlingo wa mankhwalawa ukhoza kusinthidwa (kuchuluka kwake kumayikidwa). Potere, wodwalayo amayang'aniridwa ndi achipatala mosalekeza.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi mankhwala a Telsartan H, kuchuluka kwa bioavailability kwa telmisartan mpaka 100% kumadziwika. Hafu ya moyo wa chinthu ichi sichisintha. Gawo lachiwiri logwira ntchito limachotsedwa mthupi pang'onopang'ono, zomwe zimatha kuyambiranso mlingo. Kuwonongeka kwakukulu kwa chiwindi ndi kuphwanya kugwiritsa ntchito kwake.
Bongo
Milandu yachitukuko cha mawonekedwe owoneka molakwika kumbuyo kwa kuchuluka kwake sichinalembedwe. Komabe, zinthu zomwe zimagwira payekhapayekha zimathandizira kukulitsa tachycardia, hypotension, ndikuphwanya mulingo wamagetsi wamadzi.
Mogwirizana ndi mankhwala ena a Telsartan N
Ndi kugwiritsa ntchito pamodzi kwa telmisartan ndi mankhwala ena, zomwe zimapangidwa kuti zichepetse kupanikizika, kuchuluka kwa mankhwalawa ndi mankhwala omwe amafunsidwa kumadziwika.
Kukumana kwa lithiamu kumawonjezeka panthawi ya mankhwala omwe ali ndi mankhwala a lithiamu.
Kusankhidwa nthawi yomweyo kwa NSAIDs ndi Telsartan N kungayambitse kulephera kwa impso. Izi zikutanthauza kuti wodwala amayesedwa pafupipafupi pakumwa.
Poyerekeza ndi kumbuyo kwa kutenga Aliskiren, kuwonjezereka kwa zochitika zoyipa kumadziwika.
Kugwiritsa ntchito munthawi yomweyo mankhwala osafunsidwa komanso njira zamagulu a narcotic analgesics, barbiturates ndi ethanol ndizomwe zimathandizira kukulitsa orthostatic hypotension.
Kuyenderana ndi mowa
Sichikulimbikitsidwa kumwa zakumwa zoledzeretsa zamkati mwa nthawi yamankhwala, monga Chiwopsezo cha kupumulanso kwambiri zombo ziwonjezereka, zomwe zimabweretsa zovuta zazikulu.
Analogi
M'malo mogwira mtima:
- Telpres Plus;
- Telzap Plus;
- Telsartan.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Kuikidwa kwa dokotala ndikofunikira.
Mtengo wa Telsartan N
Mtengo wapakati ndi ma ruble 400.
Zosungidwa zamankhwala
Kutentha kolimbikitsidwa - osati kupitirira + 25 ° ะก.
Tsiku lotha ntchito
Mankhwalawa amasungabe katundu kwa zaka ziwiri kuyambira tsiku lomwe watulutsa.
Wopanga
Izi zimapangidwa ndi Dr. Reddy's ku India.
Analogue ya mankhwalawa itha kukhala Telpres Plus.
Ndemanga pa Telsartan N
Valentina, ali ndi zaka 48, Kaluga
Anamwa mankhwalawa kwa nthawi yayitali, nthawi ndi nthawi akupuma. Ndimalipirira mosavuta, koma nthawi zina zimakhala zovuta: chizungulire, kusowa tulo. Pokhapokha atathetsa kukakamizika kumawonjezeranso.
Galina, wazaka 39, Novomoskovsk
Telsartan sanakwanitse. Mankhwala ndi amphamvu. Sindinatenge nthawi yayitali, chifukwa nthawi iliyonse chizungulire. Koma amachepetsa kuthamanga, ndipo masana, kuthamanga kwa magazi kumakhalabe kosadukiza.
