Metglib ndi Metglib Force - malangizo, ndemanga za anthu odwala matenda ashuga, olowa mmalo

Metglib ndi mankhwala awiri othandizira odwala matenda ashuga okhala ndi zinthu ziwiri: glibenclamide ndi metformin. Ichi ndiye chophatikiza chotchuka kwambiri cha othandizira a hypoglycemic; amagwiritsidwa ntchito padziko lonse lapansi.

Metglib imapangidwa ndi Canonfarm, kampani yokhazikitsidwa ku Moscow yodziwika chifukwa cha machitidwe ake apamwamba komanso maziko amakono opangira. Mankhwalawa amakhudza glucose wamagazi kuchokera mbali ziwiri: amachepetsa kukana kwa insulin ndipo amathandizira kuphatikizika kwa insulin. Mtundu wachiwiri wa matenda ashuga, Metglib itha kugwiritsidwa ntchito ngati monotherapy, kapena ikhoza kuphatikizidwa ndi mapiritsi ochokera m'magulu ena komanso insulin.

Ndani amakupatsani mankhwala?

Kukula kwa Metglib ndi mtundu wachiwiri wa matenda ashuga. Komanso, mankhwalawa amawonetsedwa osati kumayambiriro kwa matendawa, koma ndi momwe akumvera. Kumayambiriro kwa matenda ashuga, odwala ambiri adanenanso kuti insulin ikukana, ndipo palibe kusintha kapena kusintha kwenikweni pa kapangidwe ka insulin. Chithandizo chokwanira panthawiyi ndi chakudya chamafuta ochepa, masewera olimbitsa thupi, ndi metformin. Metglib imafunika pakakhala kuchepa kwa insulin. Pafupipafupi, vutoli limawonekera patatha zaka 5 kuchulukitsa koyamba kwa shuga.

Mankhwala a Metglib omwe ali ndi magawo awiri amatha kutumikiridwa:

• ngati chithandizo cham'mbuyomu sichimapereka kapena pamapeto pake chinasiya kupereka chindapusa cha matenda ashuga;
• atazindikira mtundu wa matenda a shuga a 2, ngati wodwala ali ndi shuga wokwanira (> 11). Pambuyo pakukula kwa kulemera ndi kuchepa kwa insulin kukana, pali kuthekera kwakukulu kuti mulingo wa Metglib udzachepetsedwa kapena kusinthidwa kukhala wa Metformin kwathunthu;
• ngati mayeso a C-peptide kapena insulini ali pansipa, mosatengera kutalika kwa matenda ashuga;
• kugwiritsa ntchito mosavuta, odwala matenda ashuga omwe amamwa mankhwala awiri, glibenclamide ndi metformin. Kutenga Metglib kumakuthandizani kuti muchepetse chiwerengero cha mapiritsi. Malinga ndi odwala matenda ashuga, izi zimachepetsa kwambiri ngozi yakuyiwala kumwa mankhwalawo.

Zotsatira za pharmacological

Kuchepetsa shuga kwa Metglib kumachitika chifukwa cha kupezeka kwa zinthu ziwiri m'mapangidwe ake:

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

1. Metformin - Mtsogoleri wodziwika polimbana ndi insulin. Amachepetsa kupanga kwa glucose m'thupi, kuchedwetsa mayamwidwe ake m'mimba, kumathandizira kuchepa thupi, komanso kusintha ma lipids. Mankhwalawa amagwira ntchito kunja kwa kapamba, chifukwa chake ndiotetezeka kwathunthu kwa iwo. Odwala ena omwe ali ndi matenda a shuga a mellitus metformin salekerera bwino, chifukwa cha zovuta zamagayidwe am'mimba, nseru, matenda am'mimba. Komabe, mankhwalawa amagwiritsidwanso ntchito, motero, metformin imalembedwa pafupifupi kwa onse odwala matenda ashuga.
2. Glibenclamide - mankhwala amphamvu ochepetsa shuga omwe amathandizira kupanga insulin yowonjezera, sulfonylurea derivative (PSM). Amamangirira kwa beta-cell receptors kwa nthawi yayitali, chifukwa chake imayambitsa hypoglycemia. Komanso, amaonedwa kuti ndi mankhwala okhwima kwambiri ochokera ku gulu la sulfonylurea. Zotsatira zoyipa zama cell a beta zimatchulidwa kuposa zomwe zimafotokozedwa masiku ano - glimepiride ndi glyclazide (MV Gliclazide) yosinthika. Malinga ndi madokotala, odwala matenda ashuga omwe akutenga glibenclamide ayandikira kuyamba kwa insulini kwazaka zingapo. Mwambiri, kutsika kofanana kwa glycemia kumatha kupezeka munjira zotetezeka: PSM yofatsa komanso gliptins (Galvus, Januvia).

Pharmacokinetics

Zambiri za mayamwidwe ndi chimbudzi cha Metglib, deta yomwe yatengedwa kuchokera ku malangizo:

Malinga ndi ndemanga, zotsatira za Metglib zimayamba pakati pa maola 2 itatha nthawi yoyang'anira. Ngati mumwa mankhwalawo nthawi yomweyo monga chakudya, zidzakuthandizani kuchotsa shuga omwe amalowa m'mitsempha yamagazi panthawi ya kuwonongeka kwa chakudya pang'ono. Chiwopsezo chochita chikugwera maola 4. Pakadali pano, chiopsezo cha hypoglycemia ndi chambiri kwambiri. Kuti mupewe izi, ndikofunikira kuti zochuluka pazomwe zimagwirizana ndizokolola.

Popeza Metglib imapangidwa ndi chiwindi ndikuchotseredwa ndi impso, chisamaliro chapadera chiyenera kulipira thanzi la ziwalozi. Ndi njira yosokonezeka yochotsa mankhwalawa m'thupi, wodwalayo amatha kudwala matenda obwera chifukwa cha hypoglycemia.

Mlingo

Mankhwalawa amapezeka m'mitundu iwiri. Metglib yokhazikika ili ndi mulingo wa 400 + 2,5: metformin 400 mmenemo, glibenclamide 2,5 mg. Kwa odwala matenda ashuga omwe ali ndi vuto la mtundu 2 komanso kusungika kwambiri kwa insulin (kusuntha kochepa, kuthamanga), chiwerengerochi sichabwino. Kwa iwo, Metglib Force adamasulidwa ndi mawonekedwe apamwamba a metformin - 500 + 2,5. Anthu odwala matenda ashuga popanda kulemera kwambiri komanso kuchepa kwa insulini ndizoyenera kwambiri Metglib Force 500 + 5.

Mlingo woyenera amasankhidwa ndi dokotala, poganizira glycemia ndi mkhalidwe waumoyo wa wodwalayo. Kupewa zotsatira zoyipa za metformin, mulingo wa Metglib umachulukitsidwa pang'onopang'ono, kupatsa thupi nthawi kuti lizolowere zinthu zatsopano.

Momwe mungayambire kutenga Metglib:

1. Yoyambira mlingo - piritsi 1. Metglib kapena Metglib Force, kwa okalamba - 500 + 2,5. Amamwa m'mawa.
2. Ngati wodwalayo amamwa kale metformin ndi glibenclamide payokha, mlingo wa Metglib suyenera kukhala waukulu kuposa woyamba.
3. Ngati mankhwalawa sapereka chiwopsezo cha glycemia, mlingo wake umatha kuchuluka. Kuchulukitsa kwa mankhwala kumaloledwa osapitilira milungu iwiri. Metforminum ikhoza kuwonjezeredwa 500 mg, glibenclamide - mpaka 5 mg.
4. Mlingo wapamwamba wa Metglib 400 + 2,5 ndi Metglib Force 500 + 2,5 ndi mapiritsi 6, a Metglib Force 500 + 5 - 4 ma PC.
5. Kwa odwala okalamba komanso odwala matenda ashuga omwe ali ndi matenda a impso, asanayambe chithandizo, malangizowo akutsimikizira kuti ayesere kuyesa ntchito ya impso. Ngati pali kusintha koyambirira kwa matenda, mlingo wa Metglib uyenera kuchepetsedwa. Ngati GFR ndi ochepera 60, kugwiritsa ntchito mankhwalawo ndizoletsedwa.

Momwe mungatenge Metglib

Zakumwa za Metglib nthawi yomweyo ndi chakudya. Mankhwala ali ndi zofunika zapadera pazomwe zimapangidwira. Mu shuga mellitus, zakudya zopatsa mphamvu ziyenera kupezeka mu chakudya chilichonse, gawo lawo lalikulu liyenera kukhala ndi index yotsika ya glycemic.

Ndi kuchuluka kwa mapiritsi, amagawika pawiri (m'mawa, madzulo), kenaka ndikuyamba kukhala atatu.

Mndandanda wazotsatira zoyipa

Mndandanda wazotsatira zoyipa zomwe zingachitike mutatenga Metglib:

Zotsatira zoyipa kwambiri za Metglib zimatchedwa hypoglycemia. Kupezeka kwake kumadalira zochita za wodwala yemwe ali ndi matenda ashuga, motero kuopsa kwake ndikosatheka. Popewa madontho a shuga, muyenera kudya chakudya chamafuta nthawi zonse tsiku lonse, osadumpha chakudya, kulipira zakudya zazakudya zazitali zamoto, mungafunike zakudya zamkati nthawi yophunzirira. Ngati izi sizikuthandizani, ndi bwino kusiya Metglib ndi mankhwala osalala.

Contraindication chithandizo

Malangizowa amaletsa kutenga Metglib a matenda a shuga mu milandu yotsatirayi:

• ketoacidosis ya zovuta;
• kulephera kwa aimpso kapena chiwopsezo chake chachikulu;
• matenda obwera ndi minofu hypoxia, kuphatikizapo aakulu;
• mtundu 1 shuga;
• pachimake zinthu zofuna kwakanthawi insulin mankhwala;
• ziwengo kwa chinthu chilichonse cha Metglib;
• kusowa kwa zakudya zopatsa thanzi (<1000 kcal);
• mimba, chiwindi B;
• mankhwalawa miconazole;
• mbiri ya lactic acidosis;
• zaka za ana.

Chifukwa chiopsezo cha lactic acidosis, malangizowo salimbikitsa kumwa Metglib kwa odwala matenda ashuga amtundu woposa zaka 60 omwe amakhala ndi zovuta zolimbitsa thupi.

Momwe mungasinthire Metglib

Ma analogi a Metglib amapangidwa ku Russia komanso kumayiko ena. Mankhwala oyamba amadziwika kuti ndi Glybomet wa ku Germany wopangidwa ndi Berlin-Chemie, mtengo wake ndi 280-370 rubles. 40 mapiritsi 400 + 2,5.

Zofananira zonse:

Pakakhala chophatikizika chopangidwa ndi glibenclamide ndi metformin mufamu, mutha kugula padera, mwachitsanzo, Maninil ndi Glyukofazh.

Mtengo wongoyerekeza

Mtengo wa phukusi la mapiritsi 40 ndi pafupifupi ma ruble 200. Mapiritsi 30 a Metglib Force, ngakhale atakhala mlingo, angagulidwe kwa ma ruble a 150-170. Ma analogu onse opangidwa ku Russia ali ndi mtengo wofanana.

Ndemanga za Odwala