Jardins ndi mankhwala a shuga omwe amagwiritsidwa ntchito kutsitsa shuga wamagazi akafunika. Yogwira popanga mankhwala ndi empagliflozin. Kapangidwe kameneka kamachepetsa ntchito ya mapuloteni omwe amayambitsa kutulutsa shuga kuchokera ku impso kupita m'magazi.
Kuchulukitsa kwa mapuloteni kumapangitsa kuti shuga wambiri m'thupi ayambe kuchotsedwamo ndi mkodzo. Kugwiritsa ntchito mankhwalawa kumapangitsa kuti pakhale kuwunika bwino shuga m'magazi pamaso pa mitundu yachiwiri ya matenda a shuga.
Mankhwala Jardins samakhudza zochitika za insulin ya mahomoni. The pharmacological zimatha mankhwala akhoza kuchepetsa mwayi kukhala hypoglycemic mkhalidwe wodwalayo zochepa.
Jardins amachiza matenda ashuga, kugwiritsa ntchito kwawo komwe kumapangitsa kuti shuga achotse mthupi ndi mkodzo, zomwe zimapangitsa kuti magazi azikhala ochepa, ndipo izi zimapangitsa kuchepa kwa magazi.
Zambiri pazamankhwala, kapangidwe kake
Mankhwala Jardins amagwiritsidwa ntchito kuwongolera shuga m'magazi panthawi ya monotherapy. Kuphatikiza apo, chida ichi chitha kugwiritsidwa ntchito ngati gawo pa zovuta pakuchiza matenda ashuga.
Chida ichi chitha kugwiritsidwa ntchito limodzi ndi mankhwala ena a hypoglycemic. Mankhwalawa atha kuphatikizira insulin kapena metformin.
Mankhwala pamsika wa mankhwala a pharmacological amagulitsidwa m'mitundu iwiri yosiyanasiyana mu kuchuluka kwa mankhwala omwe amapanga.
Kutengera mlingo wa mankhwala othandizira, piritsi limodzi lokonzekera limatha kukhala ndi 10 kapena 30 mg ya mankhwala othandizira.
Kuphatikiza pazomwe zimagwira, zida zotsatirazi zimaphatikizidwa ndikupanga piritsi limodzi la mankhwala:
- lactose monohydrate;
- ma cellcose a microcrystalline;
- hyprolosis;
- croscarmellose sodium;
- silika;
- magnesium wakuba.
Mapiritsi a mankhwalawa ndi zokutira, zomwe zimakhala ndi izi:
- Opadra chikasu;
- hypromellose;
- titanium dioxide;
- talc;
- macrogol 400;
- iron oxide ndi chikasu.
Mukamagwiritsa ntchito mankhwalawa, muyenera kukumbukira kuti kugwiritsa ntchito Jardins kuti shuga asakhale m'magazi a wodwala wodwala matenda a mtundu wa 2 sikungapulumutse munthu kudwala.
Chachikulu pharmacological zimatha mankhwala
Mankhwala Jardins nthawi zambiri amagwiritsidwa ntchito ngati mankhwala amakono kukonza shuga yayikulu yamagazi mwa munthu yemwe ali ndi matenda a shuga a 2.
Ndemanga ya akatswiri azachipatala akuwonetsa kuti chida ichi chimapangitsa kuti azitha kuwongolera bwino zomwe zili mthupi la wodwalayo ndikupeza zotsatira zabwino.
Empagliflozin, yemwe ali gawo lalikulu la mankhwalawo, ndiwosankha, wogwiritsidwanso ntchito wampikisano wothamanga wa transporter wapadera wama protein.
Chipangizochi chimawongolera kutha kuwongolera shuga mthupi la wodwala yemwe ali ndi matenda ashuga a 2. Zomwe zimagwiritsidwa ntchito ndi mankhwalawa ndikuti zimathandizira kuchepetsa kufalikira kwa glucose pamagulu a impso. Mukamagwiritsa ntchito mankhwalawa, shuga mumkodzo amachulukana, zomwe zimathandiza kuti magazi athetse msanga m'thupi.
Kugwiritsa ntchito mankhwalawa sikungawononge ntchito ya maselo a beta. Pulogalamu yogwira imakhala ndi phindu pancreatic minofu, yomwe imathandizira kukonza magwiridwe ake.
Kukhazikitsidwa kwa empagliflozin m'thupi kumakhudza bwino kayendedwe kowotcha mafuta ndikuthandizira kuchepetsa kulemera kwa wodwala ndi matenda a shuga a 2. Izi zowonjezera chifukwa chogwiritsa ntchito mankhwalawa ndizofunikira kwambiri kwa anthu omwe ali onenepa kwambiri ndi matenda a shuga a 2.
Hafu ya moyo wa yogwira mankhwala amapangidwa kwa maola 12. Mlingo wokhazikika mthupi la wogwira ntchito limodzi ndi mlingo umodzi wa mankhwalawa patsiku umatheka mukalandira mlingo wachisanu.
Kuchokera mthupi la munthu, mpaka 96% ya mankhwalawo omwe amwedwa amachotsedwa. Excretion ya metabolites imachitika pogwiritsa ntchito matumbo ndi impso. Kudzera m'matumbo, pawiri yogwira imachotsedwa osasinthika. Mukapukusidwa kudzera mu impso, ndi 50% yokha ya mankhwala omwe amagwiritsidwa ntchito omwe amachotsedwa osasinthika.
The ndende ya yogwira pawiri mu thupi amathandizidwa kwambiri ndi kupezeka kwa wodwalayo aimpso kapena kwa chiwindi ntchito.
Kulemera kwa thupi la munthu, jenda ndi zaka zake sizimakhudza kwambiri pharmacokinetics yogwira mankhwala.
Malangizo ogwiritsira ntchito mankhwalawa
Mankhwalawa amagwiritsidwa ntchito popangira mankhwala a mono - kapena zovuta. Mlingo woyenera ndi 10 mg - piritsi limodzi patsiku. Mankhwalawa amaperekedwa pakamwa.
Ngati tsiku ndi tsiku 10 mg yalephera kupereka yachilendo matenda a glycemic, mlingo womwe umagwiritsidwa ntchito umatha kuchuluka mpaka 25 mg pa tsiku. Mulingo wovomerezeka wa mankhwalawa ukhoza kukhala 25 mg.
Mankhwalawa amaloledwa kumwa nthawi iliyonse, mosasamala mtundu wa chakudya.
Ngati mukusowa nthawi yomwe mumamwa mankhwalawa, simuyenera kumwa kawiri mlingo wa mankhwalawa patsiku.
Ndi kulephera kwakukulu kwa aimpso, mankhwalawa samalimbikitsidwa kuti azigwiritsidwa ntchito, chifukwa chosagwira ntchito bwino chifukwa cha kugwiritsa ntchito mankhwalawa.
Ngati wodwala ali ndi vuto la chiwindi, lomwe limawoneka ngati kulephera kwa chiwindi, kusintha kwa mankhwalawa kwa mankhwalawa sikofunikira.
Sitikulimbikitsidwa kugwiritsa ntchito mankhwalawa mukanyamula mwana ndikuyamwitsa, chifukwa chosowa chidziwitso pakuyenda bwino komanso chitetezo cha mankhwalawa kwa mayi ndi mwana panthawiyi.
Pankhani ya kulephera kwa impso, mphamvu ya mankhwalawa imatengera kuchuluka kwa kulephera kugwira ntchito.
Ndikulimbikitsidwa kuti ntchito ya impso iyesedwe mankhwala osagwiritsidwa ntchito ndi mankhwala, ndipo tikulimbikitsidwa kuti ntchito ya impso iyang'anitsidwe kamodzi pachaka pogwiritsa ntchito Jardins.
Ndi zoletsedwa kugwiritsa ntchito mankhwalawa muubwana. Kuletsa kugwiritsa ntchito kumagwiranso kwa odwala onse osakwana zaka 18. Izi ndichifukwa chosowa kafukufuku pazothandiza komanso chitetezo cha mankhwalawa.
Sikulimbikitsidwa kugwiritsa ntchito mankhwalawa pochiza odwala azaka zopitilira 75. Izi nthawi zambiri zimagwirizanitsidwa ndi kukula kwakukulu kwa mkhalidwe wamadzipi.
Simuyenera kugwiritsa ntchito chida pochiza odwala omwe ali ndi matenda a shuga 1 komanso odwala matenda ashuga a ketoacidosis.
Pogwiritsa ntchito mlingo woyenera wa mankhwala a Jardins, pafupifupi 113 mg ya lactose imalowa m'thupi la wodwalayo.
Chida ichi sichiyenera kugwiritsidwa ntchito ngati wodwala ali ndi vuto lactase, lactose tsankho kapena glucose-galactose malabsorption m'thupi.
Zotsatira zoyipa ndi contraindication mukamagwiritsa ntchito mankhwalawa
Zotsatira zoyipa kwambiri za kutenga empagliflozin ndikoyamba kwa zizindikiro za hypoglycemia.
Nthawi zambiri, zotsatira zoyipa za hypoglycemia zimadziwonetsera pogwiritsa ntchito mankhwala osakanikirana ndi sulfonylurea kapena ndi insulin.
Kuphatikiza pa hypoglycemia, odwala omwe amagwiritsa ntchito empagliflozin amatha kulimbana ndi zovuta zingapo.
Zotsatira zoyipa zomwe mukugwiritsa ntchito mankhwalawa ndi izi:
- Maonekedwe a matenda opatsirana komanso ma parasitic monga vulvovaginitis, balanitis, vagidi candidiasis, ndi matenda amkodzo thirakiti.
- Zotsatira za kusintha kwa kagayidwe kazakudya mthupi, hypovolemia ikhoza kuchitika.
- Kuwonjezeka kwakukulu pokodza.
- Kupezeka kwa zizindikiro za kuchepa madzi m'thupi, komwe kumawonedwa nthawi zambiri mukamagwiritsa ntchito mankhwala okalamba.
Kuunikiridwa kwa mankhwalawa, anthu omwe amawagwiritsa ntchito, akuwonetsa kuti zovuta zoyipa m'thupi la wodwala ndizosowa kwambiri. Zizindikiro zoyambirira za zotsatira zoyipa zikaonekera, muyenera kusiya kumwa mankhwalawo ndikupempha thandizo kwa dokotala.
Mfundo zazikuluzikulu zogwiritsa ntchito mankhwalawa ndi izi:
- mtundu 1 matenda a shuga;
- otsika ochepa kwambiri gliderular kusefera;
- matenda ashuga ketoacidosis;
- lactose tsankho;
- mimba ndi mkaka wa m`mawere;
- mkhalidwe wamthupi womwe umawopseza kupezeka kwa madzi m'thupi.
Musanagwiritse ntchito mankhwalawa, muyenera kufunsa dokotala ndikuwunikira thupi kuti mupeze zotsutsana zilizonse.
Mgwirizano wa mankhwalawa, mtengo wake komanso kucheza ndi mankhwala ena
Pa msika wa mankhwala ku Russia, ndi mankhwala a Jardins okha, omwe amapangidwa pamaziko a empagliflozin, omwe amagulitsidwa. Kuchokera pomwe titha kunena kuti palibe fanizo la mankhwalawa pamsika waku Russia. Othandizira ena omwe ali ndi machitidwe a hypoglycemic ali ndi zotsatira zosiyana mthupi.
Mtengo wa mankhwalawa umatengera dera lomwe mankhwalawo amagulitsidwa, komanso kwa amene akuwapatsirani mankhwalawo. Mtengo wapakati wa mankhwalawa Jardins ku Russia amachokera ku 850 mpaka 1030 rubles.
Mukamagwiritsa ntchito mankhwalawa, tiyenera kukumbukira kuti amatha kupatsa mphamvu diuretic yamagwiritsidwe ntchito ena a thiazide diuretics, omwe angathandize kukulitsa kuchepa kwa madzi m'thupi komanso kuwononga thupi.
Sikoyenera kuphatikiza Jardins ndi mankhwala omwe amapangidwa kuti azithamanga magazi.
Kugwiritsa ntchito pamodzi kwa mankhwala a insulin, Jardins ndi mankhwala omwe amachititsa kuti mahomoni achilengedwe azitha kupanga mawonekedwe a hypoglycemia. Pochita zovuta mankhwala, kusintha mosamala mlingo wa mankhwalawo komanso kuyamwa kwa mankhwala omwe amayang'aniridwa ndi adokotala amafunikira. Ndipo vidiyo yomwe yatchulidwa munkhaniyi ikamba za matenda a shuga.
