Glucophage xr 500 imagwiritsidwa ntchito mosamala pochiza matenda osokoneza bongo omwe amadalira shuga. Metformin imagwira ngati chinthu chachikulu chomwe chimagwira, chomwe chimakhudza glycemia.
Masiku ano, zinthu zatsopano za chinthuchi zikupezeka ndipo kugwiritsidwa ntchito kwake kukukula mokwanira, kugwiritsa ntchito mankhwalawa osagwiritsa ntchito zovuta ndi chitukuko cha matenda.
Ndi mankhwala ati omwe amagwiritsidwa ntchito pochiritsa matenda?
Type 2 shuga mellitus ndi endocrine matenda omwe maselo amthupi amakana insulini yopangidwa ndi kapamba.
Zotsatira zake, maselo amalephera kumva kukoma kwa timadzi tam'magazi, glucose sangathe kulowa mu minofu, kudzikundikira m'thupi.
Nawonso, kuwonjezeka kwamankhwala a insulin kumawonekeranso, chifukwa kapamba amayamba kupanga kuchuluka kwa timadzi timeneti.
Mpaka pano, chithandizo cha mtundu wachiwiri wa matenda a shuga ndi kugwiritsa ntchito gulu limodzi mwamagulu azida zamankhwala:
- Mankhwala omwe amachokera ku sulfonylurea. The pharmacological tingati kulimbikitsa katulutsidwe wa amkati insulin. Ubwino waukulu wa gulu la mankhwalawa ndi kulekerera mosavuta kwa mankhwalawa kwa odwala ambiri.
- Zogulitsa kuchokera ku gulu la Biguanide. Zotsatira zawo cholinga chake ndikuchepetsa kufunika kwa katemera wa insulin.
- Mankhwala omwe amachokera ku thiazolidinol amathandizira kuchepetsa shuga m'magazi ndipo amathandizanso kusintha kwa mawonekedwe a lipid.
- Amayamwa.
Pamtima wamankhwala onse ochokera ku gulu la Biguanide ndi chinthu chogwira ntchito ngati metformin. Type 2 shuga mellitus nthawi zambiri amawonetsedwa molumikizana ndi insulin - kulephera kwa maselo kudziwa bwino mahomoni opangidwa ndi kapamba.
Zotsatira zazikulu zamankhwala zomwe mankhwala ochokera ku gulu la Biguanide ndi:
- kuchepetsa shuga m'magazi;
- malamulo othandizira insulin ndi kapamba, omwe amalola kuti achepetse kuchuluka kwake mthupi;
- sizimathandizira pakukula kwa hypoglycemia.
Kuphatikiza apo, mankhwala osokoneza bongo pamodzi ndi chithandizo choyenera cha zakudya amatha kuchepetsa thupi komanso kuthana ndi kunenepa kwambiri, zomwe ndizofunikira kwambiri kwa odwala omwe ali ndi vutoli.
Metformin amagwiritsidwa ntchito pochiza matenda osokoneza bongo chifukwa chowonjezera insulin. Imachepetsa kuyamwa kwa glucose m'matumbo ang'onoang'ono ndikuchepetsa mphamvu yake yopanga maselo a chiwindi.
Kuchuluka kwa Mlingo wa mankhwalawa kutengera mlingo wake. Mpaka pano, mapiritsi oterewa akupezeka ndi 400, 500, 850 kapena 100 mg ya mankhwala othandizira piritsi limodzi.
Ndi mankhwala ati a gululi omwe amaperekedwa pamsika wamankhwala? Choyambirira, mankhwalawa amaphatikiza othandizira pakamwa awa:
- Siofor.
- Glucophage.
- Glformin.
- Metpho-gamma.
- Dianormet.
Kuphatikizika kwa mankhwalawa kuli ndi chinthu chachikulu chomwe chimagwira - metformin, yomwe imatha kuperekedwa mosiyanasiyana ndipo, mwanjira ina, imakhala ndi zotsatira zina. Mankhwalawa amagawidwa m'mafakisoni amzindawo pokhapokha ngati mwalandira mankhwala.
Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa
Glucophage ndi mankhwala omwe nthawi zambiri amaperekedwa kwa odwala omwe ali ndi matenda a shuga.
Mapiritsi amathandizira kuchepetsa shuga wamagazi, komanso amathandizira pakuchepetsa thupi.
Mankhwalawa amagwiritsidwa ntchito ngati wodwalayo ali ndi zisonyezo zina zoti agwiritse ntchito.
Zizindikiro zazikulu pakugwiritsira ntchito mankhwalawa ndi:
- osagwirizana ndi insulin omwe amadalira odwala matenda a shuga monga akulu mankhwala kapena njira yochizira yokwanira;
- muubwana (pambuyo zaka khumi).
Mankhwala amakonzedwa ndi adotolo atatha kudya komanso kuchita masewera olimbitsa thupi osaneneka.
Kuphatikiza apo, zopindulitsa za mapiritsi a Glucophage ndi izi:
- Imathandizira kuteteza ubongo ku ukalamba, womwe umalola kuti uzigwiritsira ntchito prophylactic zolinga motsutsana ndi matenda a Alzheimer's.
- Mosangalatsa zimakhudza mitsempha yamagazi ndi mitsempha. Chifukwa chake, mothandizidwa ndi Metformin, kukula kwa mitsempha ya mitsempha, kulephera kwa mtima, matenda oopsa, komanso kupimitsa mtima kwamitsempha.
- Amachepetsa mwayi wokhala ndi khansa.
- Amathandizira kusintha kwa potency mwa abambo, omwe anali opuwala chifukwa cha matenda osiyanasiyana a senile.
- Zimalepheretsa kukula kwa mafupa a anthu odwala matenda ashuga. Makamaka nthawi zambiri, azimayi amakhala ndi vuto la mafupa osaneneka atasiya kusamba, popeza pali kuchepa kwakukulu kwa mahomoni - estrogen.
- Zokhudza bwino chithokomiro cha chithokomiro.
- Ili ndi ntchito yoteteza mokhudzana ndi njira yopumira.
Kusiyana kwakukulu kwa Glucophage ndikuwonetsera zazotsatira monga:
- pali njira yogwirira ntchito ndikupanga makondedwe amafuta a thupi;
- chakudya chamagulu omwe amalowa mthupi limodzi ndi chakudya amalowetsedwa m'makoma am'mimba kwambiri;
- pali kukondoweza ndi kutsegula kwa glucose processing ndi minofu minofu;
- kuchuluka kwa cholesterol yoyipa m'thupi yafupika;
- chifukwa cha zonse zomwe tafotokozazi, kunenepa kwambiri kumachoka pang'onopang'ono.
Ichi ndichifukwa chake Glucophage nthawi zambiri imagwiritsidwa ntchito ndi anthu odwala matenda ashuga, makamaka ngakhale kutsatira kwambiri chithandizo chamankhwala sikubweretsa zotsatira zoyenera.
Pharmacological katundu wa mankhwala
Chofunikira chachikulu cha mankhwala Glucofage XP ndi metformin hydrochloride, silicon dioxide, povidone, magnesium stearate, ndi macrogol amagwiritsidwa ntchito ngati zida zothandizira.
Metformin ndi chinthu chochokera ku gulu la Biguanides ndi kuchepetsa shuga.
Dziwani kuti kukonzekera kwa piritsi kumathandizira kukula kwa shuga m'magazi am'magazi, komanso kuwongolera kudumpha kwa shuga mukatha kudya.
Kugwiritsa ntchito bwino kwa mankhwalawa ndikuwonetsa zinthu zitatu zomwe zimagwira ntchito:
- Zimathandizira kuchepetsa kupanga shuga kwa chiwindi poletsa gluconeogeneis ndi glycogenolysis.
- Kuchulukitsa chidwi cha maselo ndi minyewa kupita ku insulin ya mahomoni, yomwe imakhudza bwino kugwidwa ndi kupukusa kwa shuga m'magazi.
- Imachepetsa mayamwidwe a shuga m'matumbo.
Mutatha kumwa mapiritsiwo, gawo lalikulu lomwe limagwira ntchito limagawilidwa pazinthu zina zathupi, pomwe silikugwirizana ndi mapuloteni amwazi.
Monga zikuwonetsedwa ndi malangizo a Glucofage XP 500, mankhwalawa amachotsedwa m'thupi osasinthika.
Ubwino wawukulu wa chida chachipatala chotere ndikuti kumwa mankhwalawa sikuti kumayambitsa chitukuko cha hypoglycemia, monga zimakhalira nthawi zambiri ndi zotumphukira za sulfonylurea.
Malangizo ogwiritsira ntchito mankhwalawa
Njira yoyendetsera, kuchuluka ndi kuchuluka kwa mankhwalawa ndiudokotala.
Mlingo umatengera kuuma kwa matenda, m'badwo wa wodwalayo ndi chithunzi chake chonse chachipatala.
Tiyenera kudziwa kuti masiku ano pali mitundu ingapo ya mankhwalawa, yomwe imasiyana malinga ndi kuchuluka kwa zinthu zomwe zimagwiritsidwa ntchito:
Mitundu yotsatira ya zida zamankhwala:
- Glucophage xr 500 (imakhala ndi mazana asanu mg a chigawo chogwira ntchito);
- Glucophage xr 850;
- Glucophage xr 1000.
Kukonzekera kwa piritsi kuyenera kugwiritsidwa ntchito ngati mankhwala odziyimira pawokha kapena molumikizana ndi mankhwala ena ochepetsa shuga, kutengera malangizo a dokotala.
Kuyambitsa njira yothandizira mankhwalawa ndi Glucofage xr, mlingo woyambirira umakhazikitsidwa pa 500 mg ya mankhwala othandizira. Mankhwalawa amatengedwa madzulo atatha kudya. Pakatha masiku khumi mpaka khumi ndi anayi, mlingo woyambirira umatha kusintha ngati pakufunika kutero, kutengera zotsatira za kuyezetsa magazi. Ndiwonjezereka pang'onopang'ono komanso pang'ono pang'onopang'ono pamankhwala omwe amachepetsa chiopsezo chodana ndi zovuta. Mlingo woyenera kwambiri ndikutenga mapiritsi anayi patsiku, ndiye kuti, osaposa mamililita 3,000 a chinthucho. Ndikulimbikitsidwa kuti mukulitse mlingo kuti musatengedwe kamodzi pa sabata ndi mamiligalamu mazana asanu.
Kuphatikiza apo, nthawi zina, adokotala angakulimbikitseni kumwa mankhwalawa kawiri patsiku - m'mawa ndi madzulo. Poterepa, chizolowezi cha tsiku ndi tsiku chimagawidwa kawiri.
Nthawi zina, kuti zitheke zotsatira zabwino, mapiritsi a Glucofage amapatsidwa limodzi ndi insulin. Kuphatikizikako kumakupatsani mwayi wowongolera kuchuluka kwa shuga m'magazi.
Kuwonetsa pamachitidwe ati omwe amayenera kusamala nawo?
Kugwiritsa ntchito molakwika mankhwalawa kapena kulephera kutsatira malangizo omwe atengedwa kungayambitse kuyambika kwa zovuta.
Pakakhala mankhwala osokoneza bongo, wodwala amayenera kugonekedwa m'chipatala nthawi yomweyo kuti athandizidwe. Monga lamulo, mankhwala othandizira amachitidwa. Kuti muchotse mankhwalawa mwachangu m'thupi, mumagwiritsidwa ntchito zinthu monga hemodiliasis.
Zotsatira zoyipa zomwe zingachitike pa nthawi ya achire ndi mankhwalawa zimawonekera mu:
- Kukhazikitsidwa kwa chithandizo kumayambitsa limodzi ndi kuwonetsa nseru, nthawi zina ndi kusanza. Wodwalayo amatha kudandaula za kulawa kwazitsulo pamlomo wamkamwa, kupweteka pamimba, kuchuluka kwaulemu, kutsegula m'mimba komanso kusowa kwa chakudya.
- Pogwiritsa ntchito mankhwalawa kwa nthawi yayitali, acidosis imayamba, popeza kuchepa kwa kuchuluka kwa mavitamini a B mu seramu yamagazi. Potere, adotolo apanga chisankho chokhudza kuthetsedwera kwa mankhwalawa.
- chiwindi ntchito ndi hepatitis mankhwala.
- Mwina kuwoneka ngati totupa kapena kuyabwa pakhungu, kakulidwe ka matenda am'mimba, matenda a shuga.
Akaphatikizidwa ndi mankhwala ena, odwala amafunikira kusamala makamaka, popeza chiwopsezo cha zotsatira zoyipa ndi thanzi labwino zimawonjezeka. Ichi ndichifukwa chake adotolo omwe amayenera kuphunzitsidwa ayenera kudziwitsidwa za matenda onse okhudzana, komanso kumwa mankhwala ena. Kukhazikitsa pamodzi kwa Glucofage xr ndi okodzetsa zambiri kumayambitsa lactic acidosis.
Kutenga Glucofage xr ndi chlorpromazine nthawi yomweyo, pali kuwonjezeka kwambiri kwa shuga m'magazi ndipo kutulutsidwa kwa insulin ya m'madzi kumachepa.
Kodi pali zoletsa zoletsa kugwiritsa ntchito mankhwalawa?
Glucophage xr, yomwe imaphatikizapo mainformin yogwira pophika, sigwirizana ndi kumwa nthawi yomweyo.
Kuphatikiza apo, lero pali zoletsa zina pa kugwiritsa ntchito mapiritsi otere, omwe muyenera kudziwa.
Chachikulu contraindication kugwiritsa ntchito mankhwala:
- Pamaso pa kuwonjezeka kwa kumverera kwa chinthu chimodzi kapena zingapo zomwe ndi gawo la mankhwala.
- Mkhalidwe wa matenda a diabetes ketoacidosis kapena kholo la odwala matenda ashuga amawonekera.
- Zowonongeka zamkati zimawonedwa. Diagnosis ikuwonetsa zotsatira za clearine zotsika kuposa 60 ml / min.
- Matenda opatsirana kwambiri.
- Kuthetsa madzi m'thupi
- Kukula kwa ma pathologies mu mitundu yovuta kapena yovuta yomwe ingayambitse minofu hypoxia.
- Lactic acidosis.
- Matenda owopsa a chiwindi.
- Iwo ali osavomerezeka kuti azigwiritsa ntchito mankhwalawa panthawi yoyembekezera komanso mkaka wa m`mawere.
- Muubwana, mpaka zaka khumi.
Popewa chiopsezo chokhala ndi vuto la chikomokere cha hyperglycemic, mankhwalawa saloledwa kutengedwa nthawi yomweyo ndi danazol.
Katswiri muvidiyoyi munkhaniyi afotokoza mwatsatanetsatane za Hypoglycemic zotsatira za Glucofage.
