Kugwiritsa ntchito ma proteinase inhibitors zochizira kapamba

Ndi pancreatitis, kutsegula kwa mapuloteni kumabweretsa kutupa kwa chiwalo ndikukula kwa malo a necrotic.

Popewa njira zamatenda zamtunduwu, katswiriyo amalembera Contrical, Trasilol, Gordoks kapena Antagozan. Kugwiritsa ntchito mankhwalawa kwa intravenous makonzedwe ndikofunikira tsiku loyamba la kapamba pachimake.

Mitundu ya Pancreatic Enzymes

Ntchito yayikulu ya kapamba ndikuchita ntchito za endocrine (zamkati) komanso za exocrine (zakunja). Ntchito ya Endocrine imakhala pakupanga mahomoni - insulin, yomwe imatsitsa shuga, ndi glucagon, zomwe zimapangitsa kuti shuga chiwindi chiwonjezeke.

Ntchito ya prancine ya kapamba ndikupanga ma enzymes apadera (ma enzymes) okumba chakudya. Iyenera kugawidwa m'magulu angapo - lipolytic, amylolytic ndi michere ya proteinolytic. Tiyeni tikambirane mwatsatanetsatane gawo lililonse.

Lipolytic michere. Gululi ndi lomwe limayambitsa kuthana ndi mafuta kupita ku mafuta acids ndi glycerol. Prolipase ndi pulase yosaoneka ya lipase yomwe, ikalowa duodenum, imalumikizana ndi colipase.

Kutsegula kwa lipase kumachitika ndi kuchuluka kwa mchere wa bile ndi trypsin. Kuwonongeka kwa zigawo za lipolytic kumachitika maola 7-14. Renal glomeruli ndi omwe amachititsa kusefedwa kwawo: amalimbikitsa kuyamwa kwa lipase mu kapangidwe ka minofu, kotero tinthu tating'onoting'ono ta lipolytic sapezeka mkodzo. Zinthu zofanana ndi lipase zimapangidwanso ndi chiwindi, mapapu ndi matumbo.

Michere ya Amylolytic. Pali mitundu ingapo - alpha, beta ndi gamma amylase. Gulu la ma enzymes amenewa limatchedwanso kuti wowuma. Mukugaya, ndi alpha-amylase wokha yemwe amakhudzidwa.

Amapangidwanso pang'ono ndi tiziwalo tating'ono, makamaka kutafuna chakudya. Chifukwa chake, timamva kukoma kwinaku kutafuna zakudya zokhala wowuma - mpunga kapena mbatata yosenda. Chifukwa cha amylase, njira yothandizirana ndi wowuma komanso michere ina yovuta imakhala yosavuta.

Mapuloteni a Proteolytic. Ntchito yayikulu ya gululi ndikuwonongeka kwa mapuloteni. Ma enzymes a Proteolytic amathandizira kuwonongeka kwa ma amino acid omwe ali m'matumbo ndi mapuloteni. Pali mitundu iwiri yosiyanasiyana ya proteinase mu madzi a pancreatic:

1. Peptidase, kapena exopeptidase, yemwe amachititsa hydrolization ya mankhwala akunja a peptides.
2. Proteinase, kapena endopeptidase, yomwe imaphwanya zida zamkati za peptides.

Chifukwa chake, lipase, amylase ndi proteinase amapanga madzi a pancreatic, omwe, pomwe amalowa mu duodenum, amaphwanya mamolekyulu azakudya zovuta kukhala mankhwala osavuta.

Amayambitsa ndi Zizindikiro za kapamba

Mwa munthu wathanzi, kutsegula kwa ma pancreatic michere kumachitika mu duodenum.

Ngati kugwira ntchito kwa amylase, proteinase ndi lipase kuyambika mu kapamba palokha, titha kulankhula za kulephera kwa limba.

Pancreatitis imamveka ngati gawo limodzi lama syndromes ndi matenda omwe amaphatikizidwa ndi ma enzymes mu gland, omwe amatsogolera ku "kudzimbidwa". Zotsatira zake, salowa mu duodenum, ndipo chimbudzi chimasokonekera.

Pali zifukwa zingapo zomwe zimatitsogolera ku izi:

• kumwa pafupipafupi
• kulephera kutsatira zakudya zoyenera;
• kumwa kwambiri zakudya yokazinga ndi mafuta;
• kudya zakudya zopatsa thanzi mukatha kudya kwambiri kapena kusala;
• kudya kosalamulirika kwa mankhwala ena;
• kugaya chakudya dongosolo
• matenda a matenda opatsirana.

Ndi kutsegula kwa ma enzymes mu kapamba, kutupa kumachitika: kumachulukana kukula, ndipo madera a necrotic amawonekera. Njira zotere sizingakhale asymptomatic, kuphatikiza apo, ndikuphwanya kwam'mimba thirakiti.

Ndi kuchepa kwa ma pancreatic enzymes mu duodenum ndi kutupa kwa kapamba, zizindikiro zotsatirazi zimawonedwa:

1. Ululu kumanzere hypochondrium, nthawi zambiri wa shingles chikhalidwe.
2. Kuchepetsa kwakukulu kwa kulumala, malaise wamba ndi kufooka.
3. Dyspeptic matenda - kutulutsa, kusanza kapena kusanza, kusowa kwa chakudya, kusokonekera chopondapo.

Zizindikiro za matendawa zimatha kukhala zosiyana kutengera kusowa kwa enzyme inayake:

• Kuperewera kwa Amylase kumatsogolera ku matenda am'mimba, kuchepa kwa vitamini, kuchepera thupi. Tizilomboto timakhala madzi, tinthu tosaphatikizika tomwe timakhalamo.
• Kuchulukitsa kwa lipase komwe kumaphwanya mafuta kumayambitsa steatorrhea - kuwonjezeka kwa kuchuluka kwa mafuta mu chopondapo. Ndi kapamba, matumbo amayenda chikasu kapena lalanje, kusakanikirana kwa ntchofu kumaonekera mwa iwo.
• Ndi kuchepa kwa proteinase, ulusi wama protein osaphatikizika umapezeka mumizimbayo. Chizindikiro chakhazikitso ndi kukula kwa magazi m'thupi.

Ngati munthu azindikira zizindikilo zotere, ayenera kupita kuchipatala msanga. Dotolo adzalembera mayendedwe ake komanso mayeso okwanira.

Natural Pancreatic Enzyme Inhibitors

Thupi limangotulutsa osati zinthu za enzymatic zomwe zimathandizira kuwonongeka kwa mamolekyulu, komanso zoletsa za katulutsidwe ka pancreatic, i.e. zigawo zomwe zimalepheretsa kupanga kwambiri pancreatic madzi.

Ma enzyme blockers amaphatikizapo pancreatic polypeptide (PPP), YY peptide, somatostatin, glucagon kapamba, pancreastatin ndi neuropeptides.

Zisumbu za Langerhans, zomwe zimangokhala mchira wa kapamba, zimatulutsa timadzi tambiri, PPP, yomwe imalepheretsa kapangidwe ka madzi, ma enzyme ndi ma bicarbonates. Imalepheretsanso kupanga acetylcholine.

Kubisalira kwa PPP kumawonjezeka pamilandu yotere:

1. ndi kulingalira kudyetsa kapena kudya chakudya;
2. pambuyo kukondoweza kwa vagus mitsempha;
3. ndi acidization wa duodenum;
4. tikakumana ndi gastrin ndi gastrin-yotulutsa peptide;
5. mukakumana ndi secretin, cholecystokinin ndi VIP.

The distal ileum ndi colon imatulutsa YY peptide atangolowa mafuta kulowa m'mimba. Peptide iyi imathandizira kuchepetsa chiwopsezo cha gland ku zotsatira za cholecystokinin ndi secretin.

Ma cell a Pancreatic D komanso mucous membrane wam'mimba wogaya amatulutsa somatostatin. Hormoni iyi imalepheretsa kupanga ma enzyme ndi ma bicarbonates. Dongosolo lamanjenje la autonomic limatenga nawo gawo popanga somatostatin, atangolowa mafuta ndi ma amino acid kuchokera ku chakudya.

Ma pancreatic inhibitors ena amaimiridwa ndi mahomoni otere:

• Pancreatic glucagon, yomwe imaletsa kupanga zamadzimadzi, ma bicarbonate ndi ma enzyme.
• Pancreatin, kuletsa kumasulidwa kwa acetylcholine. Amapangidwa kumapeto kwa mitsempha ya vagus.
• Neuropeptides, yomwe imakhala ndi calcitonin-information peptide (imalimbikitsa somatostatin) ndi enkephalins (amachepetsa kupanga acetylcholine).

Ndi njira zowonongeka mu gland, secretion ya pancreatic enzyme inhibitors ikhoza kukhala yovuta, chifukwa chake, mankhwala ayenera kumwedwa.

Mfundo zochizira pancreatitis

Magawo awiri ofunikira othandizira matendawa ndi chakudya komanso mankhwala. Njira zochizira matendawa zimapangidwa payekha kutengera zovuta za matendawa komanso kuwonongeka kwa kapamba.

Zakudya zopatsa thanzi zapakhansa zimakhazikika pazakudya 5 malinga ndi Pevzner. Amathetsa kudya mochulukirapo kwa zakudya zamafuta ndi mafuta, komanso cholinga chake kudya zakudya zama protein.

Ndi isanayambike chifuwa chachikulu, masiku atatu a kusala kudya ndi mankhwala. Panthawi imeneyi, muyenera kukana kudya ndikumwa madzi ofunda amchere, mwachitsanzo, Borjomi.

Pambuyo panjala ndi kapamba, zakudya zosakhalitsa zimayambitsidwa m'zakudya zomwe sizingakulemetseni m'mimba. Odwala omwe ali ndi kapamba amaloledwa kugwiritsa ntchito:

• mitundu ya zakudya ndi nsomba;
• msuzi wamasamba ndi ma broth odedwa;
• mkate dzulo ndi masikono;
• skim mkaka;
• zipatso zatsopano, zitsamba ndi masamba;
• mbewu zophika m'madzi kapena mkaka wa skim;
• mazira ochepa;
• msuzi wa rosehip, uchi kapena kupanikizana (ochepa).

Ndi kutupa kwa kapamba, ndikofunikira kukana chakudya chomwe chimakulitsa chimbudzi:

1. Zogulitsa chokoleti, makeke, makeke.
2. Mkate watsopano.
3. Zakudya zokazinga.
4. Kusunga, kusuta nyama ndi zipatso.
5. Zakudya zamafuta ndi nsomba.
6. Zinthu zamafuta mkaka.
7. Zakumwa za kaboni.
8. Zonunkhira.
9. Ma broth olemera.
10. Pali mazira ambiri.
11. Tiyi wamphamvu komanso khofi.
12. Masoseji.
13. Nthambi ndi tomato.

Ndi kuchulukitsa kwa matenda kapamba, m`pofunika kutsatira pogona.

Chithandizo cha kapamba zimaphatikizapo kugwiritsa ntchito:

• enzyme zoletsa kuchepetsa kutsegula kwa ma pancreatic proteinase (proteinases);
• antibacterial othandizira kupewa kutukusira kwa m'mimba, kupukusira kwa pursa yam'mimba, kukulitsa kwa necosis ya penancitis ndikuzungulira cellulitis ya cell kumbuyo kwa peritoneum;
• Ma blockers a H2 kuti achepetse kupanga kwa hydrochloric acid;
• Maantacidids kuti muchepetse hydrochloric acid m'matumbo;
• antispasmodics ya kupweteka kwa minofu yosalala yokhudzana ndi kuphwanya kwa sphincter ntchito mu pancreatic duct;
• mankhwala a anticholinergic kuti atseke njira zachilendo mu ganglia ndi matenda osokoneza bongo;

Kuphatikiza apo, ma enzymatic othandizira amagwiritsidwa ntchito pokonzanso chimbudzi ndikuchotsa vuto la dyspeptic.

Mankhwala othandiza

Patsiku loyamba la kukomoka kwa mawonekedwe, kugwiritsa ntchito mapuloteni othandizira pancreatitis ndi ofunikira. Mankhwalawa amachotsa chomwe chimayambitsa kuwoneka kwa yotupa ya foci komanso kufalikira kwa malo a necrotic.

Mankhwala amachokera ku pulmonary parenchyma ndi ng'ombe kapamba.

Pansipa pali mankhwala othandiza kwambiri, mlingo wake womwe umatsimikiziridwa payekha ndi adokotala. Sapezeka mu mawonekedwe a mapiritsi, koma mawonekedwe amtundu wambiri kapena wa lyophilisate wa kulowetsedwa.

Chithandizo cha pancreatitis ndi zoletsa ndi mtsempha wa magazi makonzedwe ikuchitika mu supine udindo. Komanso, namwino ndi dotolo ayenera kuyang'anitsitsa momwe wodwalayo alili. Zakudya Nambala 5 ziyeneranso kuyang'aniridwa mosamalitsa, zomwe, kuphatikizapo mankhwala othandizira, zimatsimikizira kuti wodwalayo akuchira popanda zovuta zilizonse.

Momwe mungachitire pancreatitis afotokozedwa ndi akatswiri mu kanema munkhaniyi.