Atherosclerosis ndimatenda ofala kwambiri pakalipano. Amadziwika ndi kudziunjikira kwa cholesterol, kapena makamaka cholesterol, m'thupi la munthu, makamaka makamaka m'matumbo ake.
M'mitsempha ya odwala omwe ali ndi atherosulinosis, ma cholesterol plaque amayikidwa, omwe amachepetsa kuyenda koyenera kwa magazi ndipo angayambitse zotsatira zomvetsa chisoni monga infrction ya myocardial ndi stroke. Atherosclerosis imakhudza pafupifupi 85-90% ya anthu padziko lapansi, chifukwa kuchuluka kwakukulu pazinthu zosiyanasiyana kumathandizira kukulitsa kwa matenda awa. Kodi ndingatani mankhwalawa komanso kupewa?
Mankhwala othandizira atherosulinosis ndi matenda ena a metabolic, magulu oterewa amagwiritsidwa ntchito ngati ma statins (Lovastatin, Atorvastatin, Rosuvastatin), fibrate (Fenofibrate), sequestrants anion, okonzekera omwe amakhala ndi nicotinic acid ndi zinthu zonga vitamini (Lipoic acid).
Tilankhule zambiri za mankhwala onga mavitamini pazitsanzo za lipoic acid.
Limagwirira ntchito ndi zotsatira za lipoic acid
Lipoic acid, kapena alpha lipoic, kapena thioctic ndi pawiri yogwira ntchito.
Lipoic acid ndi m'gulu la mankhwala omwe ali ngati vitamini.
Acid amagwiritsidwa ntchito pochita zachipatala kuchiza matenda ambiri.
Kukula kwake kwachilengedwe ndi motere:
- lipoic acid ndi cofactor - chinthu chopanda mapuloteni, chomwe ndichinthu chofunikira kwambiri cha enzyme iliyonse;
- molunjika pazochita za anaerobic (zomwe zimachitika popanda kupezeka kwa okosijeni) glycolysis - kuwonongeka kwa mamolekyulu a glucose kupita ku pyruvic acid, kapena, monga amatchedwa mwachidule, pyruvate;
- potentiates zotsatira za mavitamini a B ndikuwathandizira - amatenga nawo gawo pama metabolism a mafuta ndi chakudya, amathandizira kuwonjezera kuchuluka ndi kusungidwa kwa glycogen m'chiwindi, kumachepetsa shuga;
- amachepetsa kuledzera wa chamoyo chilichonse, kuchepetsa mphamvu ya poizoni wa ziwalo ndi minofu;
- Ndi gulu la antioxidants chifukwa chitha kumanga ma free radicals omwe ndi poizoni m'thupi lathu;
- moyenera komanso poteteza zimakhudza chiwindi (hepatoprotective effect);
- amachepetsa magazi mafuta m'thupi (hypocholesterolemic effect);
- anawonjezera njira zingapo zoyeselera jakisoni, kuchepetsa mwayi wamomwe zimachitikira.
Chimodzi mwa mayina a lipoic acid ndi vitamini N. Itha kupezeka osati ndi mankhwala okha, komanso tsiku ndi tsiku ndi chakudya. Vitamini N imapezeka muzakudya monga nthochi, ng'ombe, anyezi, mpunga, mazira, kabichi, bowa, mankhwala amkaka ndi nyemba. Popeza zinthu zotere zimaphatikizidwa muzakudya za munthu aliyense, kufooka kwa lipoic acid sikungachitike kawirikawiri. Komabe zikukula. Ndipo ndikusowa kwa alpha-lipoic acid, mawonetsedwe otsatirawa akhoza kuchitika:
- Chizungulire, kupweteka pamutu, limodzi ndi mitsempha, zomwe zimawonetsa kukula kwa mitsempha.
- Kusokonezeka kwa chiwindi, komwe kungayambitse kuchepa kwamafuta ake komanso kusakhazikika pakapangidwe ka bile.
- Madera a atherosselotic zolembera pamakoma amitsempha yamagazi.
- Kusunthika kwa acid-base usawa ku acid mbali, chifukwa cha momwe metabolic acidosis imayamba.
- Zodziwikiratu spasmodic minofu contraction.
- Myocardial dystrophy ndikuphwanya zakudya ndikugwira ntchito kwa minofu yamtima.
Komanso kuperewera, kuchulukirapo kwa lipoic acid m'thupi la munthu kumatha kuchitika. Izi zikuwonetsedwa ndi zizindikiro monga:
- kutentha kwa mtima;
- hyperacid gastritis chifukwa chaukali wa hydrochloric acid m'mimba;
- kupweteka kwa epigastrium ndi epigastric dera;
Kuphatikiza apo, zovuta zamtundu uliwonse zimatha kuwoneka pakhungu.
Zizindikiro ndi contraindication ntchito lipoic acid kukonzekera
Alpha lipoic acid imapezeka mitundu mitundu. Zodziwika kwambiri ndi mapiritsi ndi mayankho a jakisoni mu ma ampoules.
Piritsi ili ndi mlingo wa 12,5 mpaka 600 mg.
Zachikasu mwachikaso. Ndipo ma ampoules a jakisoni ali ndi yankho la kuchuluka kwa kuchuluka.
Mankhwalawa ndi gawo limodzi lamagulu ambiri azakudya zomwe zimatchedwa thioctic acid.
Mankhwala aliwonse omwe ali ndi lipoic acid amawayikidwa malinga ndi zomwe akuwonetsa:
- Atherosulinosis, yomwe imakhudza mitsempha ya coronary.
- Kutupa kwa chiwindi komwe kumayambitsidwa ndi ma virus, komanso limodzi ndi jaundice.
- Kutupa kosalekeza kwa chiwindi mu gawo la pachimake.
- Kuwonongeka kwa lipid kagayidwe m'thupi.
- Pachimake chiwindi kulephera.
- Kuwonongeka kwamafuta kwa chiwindi.
- Kuledzera kulikonse komwe kumachitika chifukwa cha mankhwala osokoneza bongo, mowa, kugwiritsa ntchito bowa, zitsulo zolemera.
- Njira yotupa yopatsirana m'mapapo omwe amayamba chifukwa chomwa mowa kwambiri.
- Matenda a shuga.
- Kuphatikizika kwa kutupa kwa ndulu ndi kapamba mu mawonekedwe osakhazikika.
- Cirrhosis chiwindi (kwathunthu m'malo ake parenchyma ndi zolumikizana minofu).
- Chithandizo chokwanira kuti chithandizire njira ya oncological mu magawo osasintha.
Contraindication pakumwa mankhwala ali ndi lipoic acid ndi awa:
- kuwonetsedwa kwazinthu zilizonse zam'mbuyomu;
- mimba ndi mkaka wa m`mawere;
- zaka mpaka 16.
Mankhwala onsewa ali ndi mavuto:
- Mawonetseredwe amatsutsa.
- Ululu pamimba yapamwamba.
- Kutsika kowopsa kwa shuga m'magazi, komwe ndi kowopsa kwambiri kwa odwala matenda ashuga;
- Kuyika m'maso.
- Kupuma movutikira.
- Zosiyanasiyana khungu zotupa.
- Matenda ophatikizika, amawonetsedwa mwanjira yotulutsa magazi.
- Migraines
- Kusilira ndi mseru.
- Mawonetsero olimbikitsa.
- Kuchulukitsa kwachulukira.
Kuphatikiza apo, maonekedwe a zotupa zokhazikika pakhungu ndi mucous nembanemba.
Malangizo ogwiritsira ntchito mankhwalawa
Lipoic acid iyenera kumwedwa mosamala, kutengera zomwe dokotala wakupatsani. Kuchuluka kwa madyerero masana kumatsimikiziridwa ndi kuchuluka kwa mankhwalawa. Kuchuluka kwa thioctic acid patsiku, omwe amakhala otetezeka komanso ovomerezeka, ndi 600 mg. Zakudya zotchuka kwambiri zimakhala mpaka kanayi pa tsiku.
Mapiritsi amatengedwa musanadye, osambitsidwa ndi madzi ambiri mwanjira iliyonse, osafuna kutafuna. Kwa matenda a chiwindi mu gawo lowopsa, 50 mg ya lipoic acid ayenera kumwedwa kanayi patsiku kwa mwezi umodzi.
Chotsatira, muyenera kupuma, nthawi yomwe dokotala azindikire. Komanso, monga tanena kale, kuphatikiza mitundu ya mapiritsi, majekiseni amapezekanso. Lipoic acid imayendetsedwa kudzera m'mitsempha yamagazi komanso matenda oopsa. Pambuyo pa izi, odwala nthawi zambiri amasamutsidwa kuti agwiritsidwe ntchito mapiritsi, koma pamlingo womwewo monga jakisoni amapangidwira - ndiye kuti kuchokera 300 mpaka 600 mg patsiku.
Mankhwala aliwonse omwe ali ndi lipoic acid amaperekedwa kokha ngati amupatsa mankhwala, chifukwa adanenapo zochitika ndipo sangaphatikizidwe ndi mankhwala ena.
Kukonzekera mwanjira iliyonse yotulutsidwa (mapiritsi kapena ma ampoules) ziyenera kusungidwa m'malo owuma, amdima komanso ozizira.
Pogwiritsa ntchito vitamini N kwambiri, zizindikiro za bongo zimachitika:
- matupi awo sagwirizana, kuphatikiza anaphylaxis (pompano thupi lawo siligwirizana);
- kupweteka ndi kukoka kwa zomverera mu epigastrium;
- dontho lakuthwa kwa shuga m'magazi - hypoglycemia;
- kupweteka mutu;
- nseru ndi chimbudzi.
Zizindikiro zotere zikadzachitika, ndikofunikira kusiya mankhwala ndikuyamba kupangidwira chithandizo ndi kubwezeretsanso mphamvu zamagetsi.
Zotsatira zina za thioctic acid
Kuphatikiza pazinthu zonse pamwambapa za lipoic acid, zitha kuthandiza anthu onenepa kwambiri. Mwachilengedwe, kugwiritsa ntchito kokha mankhwala popanda kuchita masewera olimbitsa thupi komanso zakudya zina zopatsa thanzi sizingapereke zotsatira zomwe zikuyembekezeka mwachangu komanso mosatha. Koma pophatikiza mfundo zonse za kunenepa moyenera, zonse ziyenera kuchitika. Munthawi imeneyi, lipoic acid imatha kumwa mphindi 30 musanadye kapena mutatha chakudya cham'mawa, mphindi 30 musanadye chakudya chamadzulo kapena mutatha kuchita masewera olimbitsa thupi. Mlingo wofunikira wa kuchepa thupi umachokera ku 25 mpaka 50 mg patsiku. Mwanjira imeneyi, mankhwalawa amatha kukonza kagayidwe ka mafuta ndi chakudya ndikugwiritsa ntchito cholesterol ya atherogenic.
Komanso, kukonzekera ndi zowonjezera zomwe zimakhala ndi lipoic acid zingagwiritsidwenso ntchito kutsuka khungu lamavuto. Zitha kugwiritsidwa ntchito ngati zigawo kapena zowonjezera zama moisturizer ndi mafuta othandizira. Mwachitsanzo, ngati mukuwonjezera madontho ochepa a jakisoni yankho la thioctic acid ku zonona zilizonse zamkaka kapena mkaka, gwiritsani ntchito tsiku ndi tsiku komanso pafupipafupi, ndiye kuti mutha kusintha bwino khungu, kuyeretsa ndikuchotsa litsiro zosafunikira.
Chimodzi mwazinthu zofunikira kwambiri za thioctic acid ndi mphamvu yake ya hypoglycemic (kuthekera kuchepetsa shuga m'magazi). Izi ndizofunikira kwambiri kwa anthu omwe ali ndi matenda amtundu wa 1 komanso a 2. Mtundu woyamba wamatenda, kapamba, chifukwa cha kuwonongeka kwa autoimmune, sangathe kupanga insulin, yomwe imayendetsa magazi m'magazi, ndipo minyewa yachiwiri ya thupi imayamba kugonjetsedwa, ndiye kuti, singagwirizane ndi insulin. Poganizira zovuta zonse za insulin, lipoic acid ndiye wotsutsana naye.
Chifukwa cha hypoglycemic effect, imatha kulepheretsa kukula kwa zovuta monga matenda ashuga angioretinopathy (kusokonezeka m'maso), nephropathy (matenda operewera aimpso), neuropathy (kukulira kwamphamvu kwa chidwi, makamaka pamiyendo, yomwe imafooka ndi kukula kwa mikwingwirima ya kumapazi). Kuphatikiza apo, thioctic acid ndi antioxidant ndipo imalepheretsa njira za peroxidation ndikupanga ma free radicals.
Tiyenera kukumbukira kuti mukamamwa alpha-lipoic acid pamaso pa anthu odwala matenda ashuga, muyenera kumayezetsa magazi nthawi zonse ndikuyang'anira momwe akuchitira, komanso kutsatira malangizo a dokotala.
Ma Analogs ndi ndemanga zamankhwala
Ndemanga za mankhwala okhala ndi lipoic acid nthawi zambiri zimakhala zabwino. Ambiri amati alpha lipoic acid kutsitsa cholesterol ndi chida chofunikira kwambiri. Ndipo izi zilidi choncho, chifukwa ndi "gawo lachilengedwe" lathupi lathu, mosiyana ndi mankhwala ena a anticholesterolemic ngati ma statins ndi ma fibrate. Musaiwale kuti atherosclerosis nthawi zambiri imagwirizanitsidwa ndi matenda a shuga, ndipo mu nkhani iyi, thioctic acid imakhala njira yovuta yokonzera mankhwala.
Anthu omwe ayesa mankhwalawa akuti awona kusintha kwazomwe akuchita. Malinga ndi iwo, amalimba mphamvu komanso kufooka kumatha, kudzimva kachulukidwe ndikuwonjezereka kwamaso am'manja kumatha, nkhope imatsukidwa, zotupa ndi mitundu yosiyanasiyana yamatenda amkhungu amachoka, kulemera kumachepetsedwa mukamamwa mankhwala olimbitsa thupi komanso zakudya, ndipo matenda a shuga amachepa pang'ono shuga wamagazi, amachepetsa kuchuluka kwa cholesterol mwa odwala atherosulinosis. Chofunikira kuti mukwaniritse kufunika kofunikira ndi chikhulupiriro pamankhwala komanso chithandizo.
Lipoic acid ndi gawo limodzi la mankhwalawa komanso zowonjezera zamankhwala monga Oktolipen, Berlition 300, Complivit-Shine, Espa-Lipon, Alphabet-Diabetes, Tiolepta, Dialipon.
Tsoka ilo, zida zonsezi sizotsika mtengo kwenikweni, koma zothandiza.
Lipoic acid akufotokozedwa mu kanema munkhaniyi.
