Atoris ndi wothandizira wa hypolipidemic wokhudzana ndi ma statins. Zomwe zimagwira ndi atorvastatin. Mphamvu yake ndi kuthekera kwa puloteni inayake yomwe imachitika mu cholesterol synthesis reaction.
Mwa kuletsa kupanga cholesterol, chidwi cha receptors to atherogenic lipids mu hepatocytes ndi maselo ena amachulukitsidwa. Zomanga izi za receptor zimatha kumanga mamolekyulu a LDL ndikuzigwiritsa ntchito kuchokera ku plasma, yomwe, pamapeto pake, imayambitsa kutsika kwa kuchuluka kwa atherogenic zigawo za lipoproteins m'magazi. Mphamvu ya chinthu cha hypolipidemic imayamba chifukwa cha mphamvu yake ya endothelium yamitsempha yamagalamu ndi zinthu zooneka.
Mothandizidwa ndi atorvastatin, vasodilation imachitika. Ma molekyulu a Atorvastatin amachepetsa cholesterol yathunthu, tizigawo ta atherogenic a lipoproteins, TG ndi zinthu zina za atherogenic. Zimathandizanso kukulitsa mulingo wa antiatherogenic lipoproteins. The achire zotsatira amakula pambuyo 2-3 milungu kuyambira chiyambi cha Atoris ntchito. Pakatha mwezi umodzi, kuchuluka kwake kwakukulu kumawonedwa.
Atoris imaphatikizapo mwachindunji atorvastatin ndi zida zina zothandizira.
Limagwirira a ntchito ya mankhwala ndi zikuonetsa ntchito
Ambiri mwa mankhwalawa amalowetsedwa m'mimba. Chifukwa cha kuchuluka kwa kagayidwe kachakudya pakadutsa chiwindi, kukhudzana kwa mankhwalawa sikupitirira 12%.
Atorvastatin sawoloka chotchinga cha mitsempha. Pulogalamuyo imagwiritsidwa ntchito makamaka pakuphatikizidwa kwa bile. Pafupifupi theka la chinthucho limatayidwa ndi ndowe, pafupifupi magawo awiri - ndi mkodzo.
Zizindikiro za Atoris poyerekeza ndi Hyperlipidemic zinthu. Pofuna kuchepetsa seramu yathunthu cholesterol, atherogenic lipoproteins ndi triglycerides.
Mikhalidwe yotsatirayi ndikuwonetsa kuikidwa kwa Atoris:
- Hyperlipidemia yoyambira: kuphatikiza polygenic hypercholesterolemia, hypercholesterolemia ndi zosakanikirana zosiyanasiyana. Kudya kwa atoris kumawonjezera lipoprotein zamagulu a anti-atherogenic m'magazi ndipo amachepetsa kuchuluka kwa atherogenic anti-atherogenic. Amagwiritsidwa ntchito pomwe sizingatheke kukonza milingo ya lipid kudzera pazakudya ndi njira zina zosagwiritsa ntchito mankhwala.
- Pofuna kupewa matenda a mtima.
- Pangozi ya pachimake Cardiogenic odwala mu subclinical Inde matenda a mtima, koma omwe ali pachiwopsezo. Gulu lamavuto limaphatikizapo anthu omwe zaka zawo ndizoposa zaka 55, omwe amasuta fodya, matenda am'mimba, omwe amakhala ndi lipoproteins yapamwamba kwambiri, omwe ali ndi vuto lobadwa nalo.
- Pa chiopsezo cha zovuta za pachimake pamtima mwa odwala omwe ali ndi matenda amtima kuti achepetse chiopsezo cha kufa, pachimake coronary syndrome, ngozi ya pachimake yodwala, kuchipatala kwachiwiri kuchipatala chifukwa cha kusakhazikika kwa angina komanso kusinthika.
Kutulutsa kwa atoris - mapiritsi. Mlingo wotsatira wa mankhwalawa ulipo - mapiritsi okhala ndi 10 mg, 20 mg, 30 mg ndi 40 mg.
Malangizo ogwiritsira ntchito mankhwalawa
Asanayambe mankhwala ndi Atoris, wodwalayo ayenera kuyamba kutsatira zakudya zomwe zimachepetsa lipid kuti achepetse milingo ya serum lipid.
Mankhwalawa adapangira pakumwa pakamwa, ngakhale zakudya. Ndikofunika kumwa mankhwalawa madzulo. Dokotala amakhazikitsa muyeso wa mankhwalawa ndipo amatha kusiyanasiyana kuchokera pa mamiliyoni 10 mpaka 80 pa mlingo umodzi kwa maola 24. Kusankhidwa kwa Mlingo kumachitika poganizira koyamba mafuta a cholesterol, cholinga cha mankhwala ndi mawonekedwe a mankhwalawa pa munthu payekha.
Ndizotheka kugwiritsa ntchito atorvastatin mu mtundu wina wamasulidwa. Chodabwitsa pakugwiritsa ntchito Atoris ndikofunikira kusunga nthawi yeniyeni yoyendetsera tsiku ndi tsiku. The achire zotsatira amapezeka kale pambuyo 2 milungu kuyambira chiyambi cha mankhwala, ndipo pazipita amakwaniritsa mwezi umodzi chiyambireni chithandizo. Motere, mlingo wa mankhwalawa sasintha kale kuposa mwezi umodzi atayamba kumwa mankhwalawo.
Kumayambiriro kwa chithandizo komanso momwe mankhwalawo amasinthira, magawo azigawo a lipid m'magazi amayenera kuyang'aniridwa. Malinga ndi kusintha kwa lipid mbiri, kusintha kwa mankhwalawa ndikofunikira.
Mu chachikulu hypercholesterolemia ndi hyperlipidemia wosakanikirana, mankhwalawa amayamba ndi osachepera achire othandizira, omwe amatha kuwonjezereka pambuyo pa mwezi wazithandizo, poganizira momwe wodwalayo amayankhira chithandizo.
Ndi cholowa cha hypercholesterolemia, Mlingo umafanana ndi usology wam'mbuyomu. Mlingo woyambirira amasankhidwa poganizira zomwe wodwalayo ali nako, komanso kuganizira kuopsa kwa matendawa. Kwa odwala ambiri, mlingo waukulu wa achire umagwira.
Ndizotheka kugwiritsa ntchito Atoris kuphatikiza njira zina zochizira (mwachitsanzo ndi plasmapheresis) kapena monotherapy.
Zotsatira zoyipa za kumwa Atoris
Zotsatira zoyipa za mankhwala osokoneza bongo nthawi zina zimayimira pawokha komanso nthawi yayitali.
Ngakhale izi, zotsatira zoyipa zimadziwika kwambiri kwa odwala omwe atenga nthawi yayitali pakumwa mankhwala.
Zoyipa zazikulu zimakhudzana ndi izi:
- Kupweteka pamutu pafupipafupi, chizungulire, mpaka ku migraine. Matenda osiyanasiyana ogona, mpaka kukulitsa zolakwika. Kutopa, kufooka, malaise wamba.
- Asthenia, kusokonekera kwa kukumbukira. Paresthesia, zotumphukira neuropathy, olfaction ndi kukoma zosokoneza.
- Kusokonezeka kwa m'maganizo ndi kuvutikira kwakamtima. Matenda okhumudwitsa.
- Maso owuma. Kutaya kwa magazi kwa Petechial pansi pa conjunctiva, glaucoma.
- Tachycardia, ochepa matenda oopsa (kuthamanga kwa magazi), kusokonezeka kwa miyendo, kupweteka kumbuyo kwa sternum.
- Phlebitis, vasculitis. Lymphadenopathy, kuchepa kwa chiwerengero cha maselo am'magazi.
- Aseptic bronchitis, rhinitis; chifukwa cha mphumu ya bronchial, mphuno.
- Kusokonezeka kwa m'mimba: thirakiti, kusanza, kumva moto kuseri kwa sternum, chopondapo, kutulutsa magazi, kuchepa thupi, kuchuluka kapena kuchepa kwa chakudya, kuchepa thupi, pakamwa pouma kwambiri, kugona mosalekeza, kusinthika kwa milomo yamkamwa; esophagus; nembanemba ya lilime, m'mimba, matumbo ochepa. Mwina kuphatikiza zilonda zam'mimba, magazi amkati, zotupa zamagazi ndi tenesmus. Kutulutsa magazi kwambiri m'mkamwa. Kupendekeka mwamphamvu kwa minyewa ya mwendo, kusintha kwamatumbo mu thumba lolumikizana, kufooka kwa minofu, kupweteka kwa minofu ndi kutsikira kumbuyo.
- Prostensity to genitourinary matenda. Kuphwanya kwamikodzo ntchito, komanso kuchepa kwa maselo ofiira am'madzi mu mkodzo.
- Kutupa kwakamaso, magazi a chiberekero. ICD.
- Kutupa kwa epididymis, kusowa pogonana mwa amuna. Kuchulukitsa thukuta. Tizilombo totupa tambiri, seborrhea, kuyabwa kwa khungu. Thupi lawo siligwirizana: dermatitis; urticaria; Edema ya Quincke, kugwedezeka kwa anaphylactic ndikotheka.
- Systemic mtima kutupa. Hypersensitivity ku UV rays, Stevens-Johnson syndrome, Lyell
- Shuga wochepa wamagazi (hypoglycemia).
- Kutupa.
Mavuto osowa akuphatikizapo gynecomastia; kuchuluka kwa kuphwanya kagayidwe kachakudya matenda; malungo, genesis osadziwika bwino komanso khani.
Zolepheretsa ndi zovuta zake
Muzochita zama geriatric, osavomerezeka kuti musinthe mankhwalawa oyamba a mankhwalawa. Kwa anthu omwe ali ndi vuto lalikulu la chiwindi, ndikofunikira kugwiritsa ntchito mankhwalawa mosamala kwambiri (popeza kuchuluka kwa kagayidwe kake ndi kugwiritsidwa ntchito kwa atorvastatin kumachepetsedwa).
Pankhaniyi, tikulimbikitsidwa kuwunika pafupipafupi kuchuluka kwa ma lipid profiles ndi chiwindi ntchito. Ndi kuchuluka kwamankhwala a chiwindi, kuchuluka kwa mankhwala omwe amagwiritsidwa ntchito kumalimbikitsidwa kuti muchepetse kapena kukana chithandizo.
Odwala omwe ali ndi matenda a mtima, komanso oimira ena omwe ali pachiwopsezo chachikulu cha matenda amtima, cholinga chamankhwala ndi kuchepetsa kuchuluka kwa LDL osakwana 3 mmol / L ndi cholesterol yokwanira yosakwana 5 mmol / L.
Zomwe zimapangitsa kuti Atoris akhazikitsidwe zimaphatikizapo zinthu zotsatirazi:
- pachimake chiwindi matenda, kuphatikizapo matenda a chiwindi;
- hepatic cell cholephera;
- kusintha kwa cirrhotic mu minofu ya chiwindi;
- kuchuluka kwa chiwindi michere yosadziwika etiology;
- matenda otupa a minofu;
- mimba ndi mkaka wa m`mawere;
- galactose tsankho;
- chiopsezo chachikulu cha kutenga pakati;
- pachimake kapamba;
- zaka za ana;
- kusalolera payekha.
Sitikulimbikitsidwa kupereka mankhwala pa nthawi ya pakati komanso mkaka wa m`mawere. Chipangizocho chimaloledwa kugwiritsidwa ntchito ndi azimayi azaka zakubadwa pokhapokha ngati ali ndi mwayi wochepa wokhala ndi pakati komanso mkazi akudziwa zonse za mphamvu ya teratogenic ya mankhwalawa.
Amayi azaka zoyambira kubereka panthawi yotenga Atoris akulimbikitsidwa kuti adziteteze ku mimba. Pankhani yakonzekera kukonzekera, siyani kumwa mankhwalawo masabata anayi isanafike tsiku lokonzekera kutenga pakati.
Amadzipaka kugwiritsa ntchito mankhwala osokoneza bongo ana.
Malangizo apadera ogwiritsira ntchito Atoris
Asanayambe Atoris, wodwalayo ayenera kuyamba kutsatira zakudya zapamwamba za hypolipidemic. Zakudya zoterezi zimawonjezera phindu la mankhwalawa. Mukamamwa Atoris, kuwonjezeka kwa ntchito ya michere ya chiwindi ndikotheka. Kuwonjezeka koteroko kwa transaminases kumakhala kwakanthawi, koma kumafuna kuwunikira pafupipafupi zizindikiro za hepatocyte function.
Therapy imayimitsidwa pakuwonjezereka kupitiliratu katatu kwamankhwala a chiwindi. Atorvastatin amathanso kukweza kuwonjezeka kwa ntchito ya creatine phosphokinase ndi aminotransferase. Ngati muli ndi vuto la ululu kapena vuto la minofu, muyenera kulankhulana ndi dokotala nthawi yomweyo.
Mukamamwa Atoris, mitundu yosiyanasiyana ya myopathies imatha kukhala, mpaka rhabdomyolysis, ndikutsatira kulephera kwaimpso.
Chiwopsezo chachikulu cha rhabdomyolysis mwa odwala omwe amaphatikiza mitundu iyi ndi ma statins:
- Fibates.
- Nicotinic acid ndi zotumphukira zake.
- Ma antimetabolites.
- Mankhwala a antibacterial, gulu la macrolides.
- Ma antimycotic othandizira (azoles).
- Mankhwala ena ophatikizidwa ndi mankhwala ochepetsa mphamvu ya kachilomboka.
Pazizindikiro zoyambirira zamatenda omwe amapanga myopathy, mulingo wa creatine phosphokinase uyenera kutsimikiziridwa nthawi yomweyo.
Ndiwonjezeka kambiri pantchito ya enzyme, mankhwala amasiya pomwepo.
Mankhwala pochita
Atoris, malangizo ake ogwiritsira ntchito, mtengo wokwera, owunika pafupipafupi amapangitsa anthu kufunafuna ma fanizo a mankhwalawo.
Malangizo ogwiritsira ntchito ndiovuta kwambiri komanso osagwiritsidwa ntchito kwambiri m'magulu onse a mankhwala ochepetsa lipid. Ichi ndichifukwa cha kuwopsa kwa ndalamazi. Koma bukuli lili ndi malongosoledwe athunthu a pharmacokinetics ndi pharmacodynamics a mankhwalawo, zotheka zovuta komanso contraindication. Zotsatira zakunyalanyaza kuwerenga malangizo zimatha kupha.
Chithandizo cha atoris chiyenera kutumizidwa ndi dokotala. Palibe chifukwa chomwe muyenera kudzilingalira. Izi zimachitika makamaka chifukwa chakuti chida sichigwirizana ndi zinthu zambiri. Palibe kuyanjana ndi mankhwala monga cyclosporine, fluconazole, spirolactone, etc.
Lingaliro logwiritsira ntchito mankhwalawa ndi mnzanu wapakhomo wovomerezeka liyeneranso kuvomerezedwa ndi adokotala. Kusiyanako, mwatsoka, kungakhale kofunikira.
Popeza mankhwalawa amakhudza cholesterol, iyenera kuyang'aniridwa pafupipafupi kuti azitsatira mlingo wocheperako wa mankhwala.
Komanso, malinga ndi mawonekedwe, mowa sagwirizana ndi zomwe zimagwira - atorvastatin. Kuphatikiza koteroko sikotetezeka kwa thupi.
Ma analogues odziwika a Atoris mu gulu lama pharmacological ndi Rosuvastatin ndi Simvastatin.
Mtengo wa Atoris umasiyanasiyana malinga ndi tsiku lotumiza ndi malo ogulitsa. Mutha kugula mankhwala aliwonse ku Russia. Mtengo wa mankhwalawa ku Russia umasiyana 357 mpaka 1026 rubles. Pochita, chidachi chili ndi ndemanga zabwino komanso zoyipa zama akatswiri azachipatala.
Zambiri zokhudzana ndi ma statins zimaperekedwa kanema munkhaniyi.
