Mapiritsi a Rosucard: malangizo a ntchito ndi kuwunikiranso mankhwalawa

Rosucard amatanthauza ma statins omwe amachepetsa kwambiri kuchuluka kwa cholesterol m'magazi. Dzinalo losavomerezeka la mankhwalawa ndi Rosuvastatin (Rosuvastatin).

Mankhwala akutengedwa mankhwala a hypercholesterolemia, kupewa mapangidwe atherosselotic zolengeza ndi mtima pathologies. Dokotalayo ndi amene amawona muyezo wa mankhwalawa potengera kuopsa kwa matendawa komanso mikhalidwe ya wodwalayo.

Nkhaniyi ili ndi zidziwitso zazikuluzikulu za Rosucard (10.20.40 mg), mtengo wake, ndemanga za odwala ndi analogues.

Mawonekedwe ndi kapangidwe kake ka mankhwala

Rosucard amadziwika kuti ndi mankhwala omwe ali ndi vuto la kuchepetsa lipid. Gawo lolimbikira limalepheretsa kupanga kwa HMG-CoA reductase. Chifukwa cha enzyme iyi, HMG-CoA imasinthidwa kukhala mevalonic acid, yomwe imayang'anira mafuta a cholesterol.

Kampani yopanga mankhwala ku Czech Zentiva imayambitsa mankhwalawa. Rosucard imapangidwa mu mawonekedwe apiritsi yokhala ndi filimu kuti mugwiritsidwe ntchito pakamwa. Piritsi ili ndi mtundu wa pinki wopepuka, mawonekedwe a convex mbali zonse ziwiri komanso mawonekedwe.

Yogwira pophika mankhwala ndi rosuvastatin. Piritsi limodzi la Rosucard limatha kukhala ndi 10, 20 kapena 40 mg yogwira ntchito. Kuphatikiza pa izi, mankhwalawa amaphatikiza othandizira, omwe ndi:

1. crosscarmellose sodium;
2. ma cellcose a microcrystalline;
3. lactose monohydrate;
4. magnesium wakuba.

Kanemayo amakhala ndi zinthu monga talc, macrogol 6000, red oxide, hypromellose ndi titanium dioxide.

Chithuza chimodzi chimakhala ndi mapiritsi 10. Kuyika mapaketi kumatulutsidwa, matuza atatu kapena asanu ndi anayi. Ma CD a Rosucard nthawi zonse amayenda ndi pepala logwiritsira ntchito mapiritsi.

Limagwirira a zochita za chinthu chachikulu

Kuchita kwa rosuvastatin cholinga chake ndikukulitsa kuchuluka kwa zolandila za LDL mu maselo a chiwindi parenchyma (hepatocytes). Kuwonjezeka kwa ziwerengero zawo kumaphatikizapo kuwonjezereka kwa kukhudzidwa ndi kusindikizidwa kwa LDL, kuchepa pakupanga VLDL ndi zonse zomwe zili ndi cholesterol "choyipa".

Kuchuluka kwa lipid-kutsitsa kwa Rosucard kumadalira mwachindunji pa mlingo womwe watengedwa. Pambuyo pa sabata 1 mutamwa mankhwalawa, kuchepa kwa cholesterol kumawonedwa, pambuyo pa masabata awiri 90% yayikulu kwambiri yamankhwala imatheka. Pofika sabata 4, kukhazikika kwa ndende ya cholesterol pamlingo wovomerezeka kumawonedwa.

Mankhwalawa amathandizira kukulitsa milingo ya HDL, yomwe si atherogenic ndipo siyikusungidwa mwa mawonekedwe amipanda ndi zophuka pamakoma amitsempha.

Kudya kwa tsiku ndi tsiku kwa rosuvastatin sikusintha magawo a pharmacokinetic. Thupi limalumikizana ndi mapuloteni am magazi (osachepera amamangirana ndi albumin), kuyamwa kumachitika kudzera pachiwindi. Gawo likhoza kudutsa placenta.

Pafupifupi 90% ya rosuvastatin amachotsedwa m'thupi kudzera m'matumbo, ena kudzera impso. Ma pharmacokinetics aomwe amagwira ntchito samadalira jenda komanso zaka.

Zizindikiro ndi contraindication kuti mugwiritse ntchito

Dokotalayo amapereka mankhwala a Rosucard ngati matenda omwe wodwalayo ali nawo akuphatikizidwa ndi cholesterol yowonjezereka.

Kudzichitira nokha mankhwala nkoletsedwa.

Pali ma pathologies ambiri omwe kulephera kwa lipid metabolism kumachitika.

Kugwiritsa ntchito mapiritsi ndikofunikira kwa:

• Hypercholesterolemia yoyamba kapena yosakanikirana.
• The zovuta mankhwala a hypertriglyceridemia.
• Banja (cholowa) homozygous hypercholesterolemia.
• Kuchepetsa kukula kwa atherosulinosis (kuwonjezera zakudya).
• Kupewa kwa mtima ndi ma pathologies a mtima kutsutsana ndi maziko a atherosulinosis (kupweteka kwa mtima, matenda oopsa, stroko ndi mtima).

Kugwiritsa ntchito mankhwala omwe ali ndi mlingo wa 10 ndi 20 mg ndi zotsutsana:

1. kukhalapo kwa chidwi cha munthu pazigawo;
2. kunyamula mwana kapena kuyamwitsa;
3. osafika zaka 18;
4. kukula kwa myopathy (matenda a neuromuscular);
5. mankhwalawa zovuta ndi cyclosporine;
6. kuchuluka kwa CPK enzyme yoposa kasanu;
7. kukana kwa mkazi kulera koyenera;
8. kulephera kwa chiwindi ndi pachimake ziwalo;
9. makonzedwe ovuta a HIV proteinase blockers.

Palinso mndandanda wazikhalidwe zotsutsana ndi 40 mg:

• Khalidwe lodziletsa la myopathy.
• Uchidakwa wopitilira muyeso.
• Kulephera kwachiwiri kwa chikhalidwe chotchulidwa.
• Myelotoxicity mutatenga HMG-CoA reductase blockers ndi ma fiber.
• Chithokomiro.
• Kugwiritsa ntchito mitundu yamafuta.
• Ma pathologies osiyanasiyana obweretsa kuwonjezereka kwa kuchuluka kwa rosuvastatin m'magazi.

Sitikulimbikitsidwanso kugwiritsa ntchito kuchuluka kwa 40 mg ndi oimira mtundu wa Mongoloid chifukwa cha kupezeka kwa machitidwe ake.

Malangizo ogwiritsira ntchito mankhwalawa

Mapalewo safunikira kulumidwa kapena kutafunidwa, amameza madzi. Kumwa mankhwalawa sikudalira nthawi yatsiku kapena kumwa chakudya.

Asanapereke mankhwala a Rosucard, dokotala amalimbikitsa mwamphamvu kuti wodwalayo azitsatira zakudya zomwe zimachepetsa kuchuluka kwa mafuta a m'thupi.

Mlingo woyamba wa mankhwalawa ndi mapiritsi a 0.5-1 (5-10 mg). Pambuyo pa milungu inayi, mlingowo ukhoza kuwonjezeredwa ndi dokotala. Kuwonjezeka kwa tsiku ndi tsiku 40 mg mg pokhapokha ngati cholesterol yapamwamba kwambiri ikhoza kukhala ndi vuto la mtima, pamene tsiku lililonse 20 mg siyothandiza.

Gome ili pansipa likuwonetsa machitidwe ogwiritsira ntchito Rosucard mwa anthu amtundu wa Mongoloid, omwe ali ndi matenda a biliary system ndi neuromuscular disorder.

Moyo wa alumali ndi miyezi 24, ukatha nthawi imeneyi, kumwa mankhwalawo ndizoletsedwa. Katemera amasungidwa kutali ndi ana ang'ono pamtunda wa 25 ° C.

Zochita Zosiyanasiyana

Zotsatira zoyipa zitha kuchitika mukamamwa mankhwalawo.

Pakachitika zovuta, wodwala ayenera kusiya kugwiritsa ntchito Rosucard ndi kukaonana ndi katswiri wazachipatala.

Zotsatira zoyipa zimatengera mwachindunji muyezo wa mankhwalawa, motero, nthawi zambiri amawonedwa chifukwa cha mapiritsi omwe amapezeka ndi 40 mg.

Malangizowa ali ndi chidziwitso chokhudza zinthu zoipa:

1. Matenda a dyspeptic - kuukira kwa mseru komanso kusanza, kupweteka m'dera la epigastric, nthawi zina kukula kwa kapamba ndi chiwindi.
2. Genitourinary zimachitika - proteinuria (kukhalapo kwa mapuloteni mu mkodzo), hematuria (kukhalapo kwa magazi mu mkodzo).
3. Mawonekedwe a thupi lawo siligwirizana - kuyabwa, zotupa pakhungu, urticaria.
4. Matenda a minofu ndi mafupa - kupweteka kwa minofu, kutupa kwa minofu, kuwonongeka kwa minofu.
5. Kusowa kwa CNS - migraine ya nthawi zina, kukomoka, kugona pang'ono komanso zolakwika, kukhumudwa.
6. Kuphwanya ziwalo zoberekera - kukula kwa tinthu tating'onoting'ono ta amuna.
7. Khungu komanso kuchepa kwa minyewa yotupa ndi Stevens-Johnson syndrome (kapena necrotic dermatitis).
8. Zosokoneza mu endocrine dongosolo - kukula kwa osagwirizana ndi insulin omwe amadalira shuga mtundu II.
9. Kulephera kuwongolera - kutsokomola komanso kupuma movutikira.

Popeza pharmacokinetics ya yogwira pophika siyodalira mlingo, bongo wosakhazikika sukula. Nthawi zina zimakhala zotheka kuwonjezera zizindikiro zovuta.

Mankhwalawa akuphatikiza miyeso monga chapamimba cham'mimba, kugwiritsa ntchito ma sorbents ndikuchotsa zizindikiro.

Kugwirizana kwina ndi mankhwala ena

Kuphatikiza kwa Rosucard ndi mankhwala ena kumatha kubweretsa kuchepa kapena mosinthika kumawonjezera mphamvu ya ntchito, komanso kupezeka kwa zotsatira zoyipa.

Pofuna kuti adziteteze ku zovuta zomwe zimachitika, wodwalayo ayenera kudziwitsa dokotala za matenda onse okhala pamodzi ndi mankhwala omwe adamwa.

Otsatirawa ndi tebulo lomwe lili ndi mndandanda wa mankhwala omwe munthawi yomweyo makonzedwe ake amachepetsa kapena amachepetsa kuchiritsa kwa Rosucard.

Pali chidziwitso chakuti pogwiritsa ntchito zovuta za Rosucard ndi Warfarin ndi ena othandizira a vitamini K, kuchepa kwa INR ndikotheka.

M'nthawi ya zoyesa za sayansi, palibe zotsatira zazikulu zamankhwala zomwe zidawonedwa pakati pa zigawo za Rosucard ndi Ketoconazole, Fluconazole, Itraconazole, Digoxin, Ezetimibe.

Ndi zoletsedwa kumwa mankhwalawa komanso mowa nthawi yomweyo. Kupewa mowa ndi kusuta kumathandizira kuti muchepetse cholesterol kuti ikhale yovomerezeka.

Mtengo komanso malingaliro a odwala

Popeza Rosucard ndi mankhwala ochokera kunja, mtengo wake ndi wokwera kwambiri. Ngakhale mankhwalawa amagwira bwino ntchito, mtengo wake umakhalabe wabwino kwambiri.

Pafupipafupi, Rosucard 10 mg (mapiritsi 30) angagulidwe pamtengo wa 595 ma ruble, 20 mg kwa 875 rubles, 40 mg kwa 1155 rubles. Kuti musunge ndalama zanu, mutha kuyitanitsa pa intaneti patsamba la woimira boma.

Odwala ambiri amawona zabwino zochizira mankhwalawa. Zopindulitsa zazikulu ndi njira yabwino ya Mlingo komanso kufunika kogwiritsa ntchito nthawi 1 yokha patsiku.

Komabe, ndemanga zoyipa za odwala zimapezekanso pa intaneti.

Madokotala othandizira odwala matenda amisala amakhudzana ndi zochitika zosiyanasiyana zosagwirizana ndi zovuta zamankhwala. Ndi zomwe adotolo N.S. anena Yakimets:

"Ndidawerengera momwe mankhwalawa amagwiridwira ntchito - imakhazikitsa kagayidwe kazinthu kamene kamayambitsa matenda osagwira ntchito komanso zovuta zina, kuphatikiza kwake ndizotsika mtengo, poyerekeza ndi Krestor. Pali zovuta zina, koma sizinali zofunikira kwambiri, chifukwa ndimapereka mankhwala a 5-10 mg pakuwonetsa zovuta zazing'ono."

Zizindikiro ndi fanizo la mankhwalawa

Muzochitika zomwe wodwala amaletsedwa kutenga Rosucard chifukwa cha contraindication kapena mavuto, dokotala amasankha wogwirizira wogwira ntchito.

Pa msika wa mankhwalawa mutha kupeza ma synylms ambiri a mankhwalawa, omwe ali ndi chinthu chimodzi chogwira. Zina mwa izo ndi:

• Rosuvastatin;
• Crestor
• Rosistark;
• Tevastor
• Akorta;
• Roxer;
• Rosart
• Mertenyl;
• Rosulip.

Palinso ma analogi omwe amasiyana ndi zomwe zimagwira, koma amaphatikizidwa ndi gulu la ma statins:

1. Zokor.
2. Atoris.
3. Vasilip

Zokor. Mulinso yogwira pophika simvastatin, yomwe imachepetsa HMG-CoA reductase. Amapangidwa ndi makampani azachipatala a USA ndi Netherlands. Mtengo wapakatikati wa ma CD (No. 28 10mg) ndi 385 ma ruble.

Atoris. Ichi ndi chiwonetsero chotsika mtengo cha Rosucard, chifukwa mtengo wa ma CD (No. 30 10mg) ndi ma ruble 330. Chomwe chimagwira ndi atorvastatin, chomwe chimawonjezera ntchito za LDL zolandilira mu chiwindi ndi minyewa yowonjezera.

Vasilip. Mankhwala ali ndi simvastatin mu mlingo wa 1020 ndi 40 mamililita. Ilinso ndi zofananira ndi ma contraindication monga Rosucard. Mankhwalawa amatha kugula ma ruble 250 okha (No. 28 10mg).

Za mankhwala ozikidwa pa rosuvastatin akufotokozedwa mu kanema munkhaniyi.