Chimodzi mwazinthu zofunika komanso zofunika kwambiri kwa thupi la munthu ndi cholesterol. Ndikofunikira kwambiri kuti zisonyezo zake zigwirizane ndi chizolowezi, chifukwa kuchepa kapena kupezeka kwambiri kumabweretsa thanzi. Kuwonjezeka kwa LDL m'magazi kumapangitsa kuti ma atherosclerosis awoneke, omwe amadziwika ndi kusintha kwa mitsempha yamagazi komanso kuchepa kwawo.
Pakadali pano, maziko othandizira matenda osiyanasiyana a mtima ndi mankhwala osokoneza bongo omwe amaphatikizidwa ndi kayendedwe ka cholesterol metabolism m'thupi la munthu. Pali mitundu yambiri. Chimodzi mwazida zapamwamba kwambiri, zogwira ntchito komanso zotetezeka za lipid ndi Rosart.
Pakugwiritsa ntchito bwino, Rosart amatenga gawo lotsogola pakati pa gulu la ma statins, kutsitsa bwino zizindikiro za "zoyipa" (otsika osalimba lipoproteins) ndikuchulukitsa kuchuluka kwa cholesterol "yabwino".
Kwa ma statin, makamaka, Rosart, mitundu yotsatirayi ya zochizira ndi mawonekedwe:
- Imalepheretsa zochita za ma enzymes omwe amatenga nawo gawo pakuphatikizika kwa cholesterol mu hepatocytes. Chifukwa cha izi, kuchepa kwakukulu kwa cholesterol ya plasma kumawonekera;
- Amathandizira kuchepetsa LDL mwa odwala omwe ali ndi cholowa chotengera homozygous hypercholisterinemia. Ichi ndi chuma chofunikira kwambiri cha ma statins, chifukwa mankhwalawa samathandizidwa pogwiritsa ntchito mankhwala a magulu ena azachipatala;
- Imakhala ndi phindu pa ntchito ya mtima ndi mtima, imachepetsa kwambiri zovuta pamagwiritsidwe ake ndi ma pathologies omwe amagwirizana nawo;
- Kugwiritsidwa ntchito kwa mankhwalawa kumabweretsa kuchepa kwa cholesterol yochulukirapo kuposa 30%, ndi LDL - mpaka 50%;
- Kuchulukitsa HDL mu plasma;
- Simalipira mawonekedwe a neoplasms ndipo alibe mphamvu yotulutsa thupi.
Kuphatikizikako kumaphatikizapo chinthu chachikulu chogwira - calcium rosuvastatin ndi zina zothandizira zomwe zimathandizira kugawa kwathunthu komanso yunifolomu komanso kuyamwa kwotsatira.
Kukula kwa kuchuluka kwa achire kumachitika chifukwa cha kukula kwa mlingo womwe umamwa. Amapezeka mu Mlingo wa 10, 20, 40 mg. Zotsatira zabwino zitha kuwonekera patatha sabata limodzi ndikugwiritsa ntchito. Pambuyo masiku 14, 90% zotsatira zimatheka, zomwe patatha mwezi umodzi ndizokhazikika.
Ntchito yayikulu ya chithandizo chamtundu wapamwamba ndikwaniritsa zotsatira zapamwamba za lipid panthawi yochepa kwambiri. Pankhaniyi, ndikofunikira kugwiritsa ntchito mankhwala ochepa kwambiri kuti asawononge thupi la wodwalayo.
Rosuvastatin imalepheretsa ma enzymes omwe amatenga gawo la cholesterol biosynthesis, imabweretsa kuwonjezeka kwa hepatic LDL receptors pamtundu wa cell membrane, ndipo imagwira nawo gawo la LDL. Kuphatikiza apo, Rosart amathandizira kuchepetsa kwambiri kuchuluka kwa ma pracylglycerides, apoliprotein B ndikukulitsa kuchuluka kwa HDL.
Mutamwa mankhwalawo, kuchuluka kwake m'magazi kumadziwika pambuyo pa maola asanu.
Kudzera m'magazi, gawo lozungulira limalowetsa chiwindi, lomwe limasinthidwa. Hafu ya moyo wa mankhwalawa ndi pafupifupi maola 19.
Kuchuluka kwa mankhwala omwe amamwa pakumwa kumachotsedwa m'thupi limodzi ndi ndowe.
Mapiritsi a Rosart cholesterol amalimbikitsidwa panthawi yomwe chithandizo chosavuta cha hypercholesterolemic chithandizo sichimabweretsa zotsatira zomwe mukufuna. Pali zizindikiro zotsatirazi pakugwiritsa ntchito ndalama za cholesterol yayikulu:
- Kuchulukitsa kwa matenda osagwirizana ndi plasma cholesterol;
- Kufunika kochotsa zotsatirapo za kukhalapo kwa matenda amtima;
- Hypercholesterolemia - matenda omwe amadziwika ndi kuwonjezeka kwa LDL m'magazi, omwe amatsogolera kuwoneka kwa matenda a mtima, atherosclerosis, kunenepa kwambiri komanso zina;
- Hypercholesterolemia yolowa, pomwe kuchuluka kwamafuta m'madzi am'mimba kumachitika chifukwa chophwanya chromosome ya 19. Izi matenda amtundu wochokera kwa kholo limodzi kapena awiri nthawi imodzi;
- Hypertriglyceridemia, yomwe imadziwika ndi cholesterol wambiri, komanso mafuta ena m'magazi amunthu;
- Monga prophylactic yoletsa kukula kwa atherosulinosis ndi matenda ena a mtima, komanso zovuta zokhudzana ndi matenda a sitiroko: kugunda kwa mtima.
Ndikofunikira kuti muzitsatira zakudya zopanda mafuta a kolesterol musanagwiritse ntchito komanso panthawi ya chithandizo.
Mlingowo umawerengeredwa ndi katswiri aliyense payekhapayekha kwa wodwala aliyense ndipo zimatengera mawonekedwe a thupi lake komanso kuopsa kwa matendawa. Mlingo woyenera kwambiri ndi pafupifupi 5-10 mg wa patsiku. Ngati ndi kotheka, imatha kuwonjezeka pambuyo pa mwezi wovomerezeka. Mlingo wofunikira uyenera kutengedwa kamodzi, safunikira kuigwirizanitsa ndi kudya ndi nthawi ya tsiku. Phalelo siliphwanyidwa ndikutsukidwa ndi madzi opanda kanthu.
Nthawi zambiri, mlingo umakulitsidwa mpaka 20 mg pambuyo pa masabata anayi akugwiritsa ntchito mankhwalawa. Muzochitika zomwe chizindikiro chokhazikika cha cholesterol chimakhala sichinachitike, kuwonjezeka kwa mlingo ndipo wodwalayo ayenera kuyang'aniridwa mosalekeza chifukwa chotsatira cha zovuta zina. Izi ndizofanana kwa odwala omwe ali ndi mitundu yayikulu ya matenda a pathologies, makamaka ndi cholowa cholowa hypercholesterolemia.
Monga mankhwala aliwonse, chinthu chimatha kulumikizana ndi mankhwala ena. Chifukwa chake, popereka mankhwalawa, ndikofunikira kulabadira mankhwala ena omwe wodwala amatenga:
- Cyclosporin imakhala ndi mphamvu yosangalatsa pa rosuvastatin, chifukwa chake, ikagwiritsidwa ntchito pamodzi ndi Rosart, imayikidwa muyezo wochepa - osapitirira 5 mg patsiku;
- Hemofibrozil imawonjezera kukhudzana kwa rosuvastatin, chifukwa chake, othandizira anzawo ayenera kupewedwa. Mlingo wapamwamba kwambiri wa Rosart sayenera kupitirira mamiligalamu 10 patsiku;
- Ma Protease inhibitors amatha kukulitsa chiwonetsero cha rosuvastatin kangapo. Zikatero, mlingo wa Rosart suyenera kupitirira 10 milligrams kamodzi patsiku;
- Kugwiritsa ntchito limodzi ndi erythromycin, ma antacid ndi njira yolerera pakamwa kumachepetsa achire zotsatira za rosuvastatin;
- Kugwiritsa ntchito mankhwalawa molumikizana ndi ma anticoagulants kumawonjezera ngozi;
- Mankhwala odana ndi kachilombo ka HIV amathandizira kuledzera wa rosuvastatin.
Ngati pakufunika kugwiritsa ntchito Rosart molumikizana ndi mankhwala ena, ndikofunikira kuwerengetsa mosamala mlingo womwe ungaganizire kuyanjana kuti mupewe zotsatira zoyipa.
Mankhwalawa ali ndi zotsutsana zingapo, momwe sizingagwiritsidwe ntchito.
Contraindication ndi tsankho la munthu payekha pazosakaniza; matenda a chiwindi mu gawo yogwira kapena anomalies yantchito yake; nthawi ya kukonzekera kwa pakati, kutenga bere ndi mkaka wake; zaka mpaka 18; myopathy Aimpso kulephera ndi mkhutu aimpso ntchito.
Pali malo angapo omwe Rosart amayenera kuyikidwa mosamala kwambiri, popeza momwe angagwiritsidwire ntchito pazinthu izi zingakhale zovulaza, koma osapindulitsa:
- Wodwalayo amalandira chithandizo chamankhwala;
- Kugwiritsa ntchito wowerengeka njira, homeopathy zochizira matenda;
- Kupezeka kwa minofu minofu kuphipha;
- Kuthamanga kwa magazi;
- Chithokomiro chodwala;
- Matenda a shuga;
- Kuchita masewera olimbitsa thupi mopitirira malire.
Mankhwalawa ali ndi zoyipa zingapo, mwa izi zotsatirazi zimapezeka kwambiri:
- Maonekedwe a thupi lawo siligwirizana;
- Chizungulire, kupweteka mutu, asthenia;
- Kusanza, kupweteka kwam'mimba, kudzimbidwa;
- Pharyngitis;
- Kukana insulini;
- Kuchulukana kosiyanasiyana kwa kupweteka minofu ndi mafupa;
- Nthawi zina pamakhala zizindikiro za kuwonongeka kwa impso mu mawonekedwe a mapuloteni mumkodzo.
Mapiritsi a Rosart cholesterol ali ndi gulu lalikululi la ofanana omwe ali ofanana mu kapangidwe kake ndi kuchuluka kwa yogwira mankhwala kapena gulu la mankhwala.
Crestor. Ndi mankhwala a piritsi lotulutsidwa, chinthu chachikulu chomwe ndi rosuvastatin. Imathandizira kuchepetsa cholesterol. Imakhala ndi njira yothanirana mwachangu, imatuluka m'matumbo;
Akorta. Ndi mankhwala ochepetsa lipid-okhala ndi rosuvastatin, omwe amawongolera kuchuluka kwa LDL ndi HDL mu plasma. Amapezeka mu mapiritsi a 10 ndi 20 mg;
Mertenil. Ndi piritsi yokhala ndi filimu yokhala ndi rosuvastatin. Ili ndi zotsutsana zingapo, chifukwa isanagwiritse ntchito ndikofunikira kufunsa katswiri;
Atoris. Chomwe chimagwiritsa ntchito mankhwalawa ndi atorvastatin, yemwe ali m'gulu la ma statins. Amapezeka mu mawonekedwe a piritsi okhala ndi zosiyana. Ili ndi zotsutsana zingapo komanso zoyipa zingapo. Mphamvu ya anti-atherosulinotic ya Atoris imawonetsedwa chifukwa cha atorvastatin pazinthu zamagazi ndi makoma amtsempha wamagazi;
Rosucard. Mapiritsi a pinki opepuka omwe amagwiritsidwa ntchito pochiza hypercholesterolemia. Chosakaniza chophatikizacho ndi rosuvastatin, chomwe chimachepetsa magazi m'thupi.
Masiku ano, Rozart imagwiritsidwa ntchito mwachangu, chifukwa pali ndemanga zambiri za izi. Odwala amayankha mankhwalawo ngati njira yothandiza komanso yothandiza, zindikirani kusintha kwawumoyo komanso kusakhalapo kwa zotsatira zoyipa mukakomoka.
Kusiyana kwa mtengo wamankhwala a Rosart cholesterol kumatengera zomwe zili mwa iwo (mg) ndi kuchuluka kwa mapiritsi omwewo.
Mtengo wa Rosart 10 milligrams a 30 zidutswa phukusi lidzakhala pafupifupi ma ruble 509, koma mtengo wa Rosart wokhala ndi zinthu zomwezo zogwira ntchito, koma zidutswa 90 mu phukusi ndizokwera kawiri - pafupifupi 1190 rubles.
Rosart 20 mg 90 zidutswa pa paketi iliyonse pama ruble 1,500.
Mutha kugula mankhwala m'mafakisoni mwa mankhwala. Tiyenera kukumbukira kuti musanayambe kulandira chithandizo, muyenera kupita ku katswiri, kukafufuza kwathunthu ndikukhala ndi moyo wathanzi kuti mukwaniritse bwino.
Momwe mungatenge akatswiri a statins anganene mu kanema munkhaniyi.
