Masiku ano, matenda a mtima ndi malo oyamba pakati pa matenda omwe amapha anthu. Nthawi zambiri, kuphwanya kumene kumakwiyitsa atherosclerosis, yomwe imapangidwa chifukwa chodzikundikira cholesterol yoyipa ndi cholesterol plaques mthupi.
Pofuna kupewa zovuta za matenda ashuga, ndikofunikira kuyamba chithandizo munthawi yake. Pambuyo pakuwunika ndikusanthula, dokotala yemwe akupezekapo adzakuwuzani ma statin a cholesterol omwe ndi othandiza komanso otetezeka.
Mankhwalawa amachepetsa chiwindi, amachepetsa m'magazi a ma lipids oyipa m'magazi, kuyeretsa mitsempha yamagazi ndikuwongolera moyo wa wodwalayo.
Mitundu ya mankhwala
Ma Statin amatha kukhala achilengedwe komanso opanga, opangidwa mwaluso. Komanso, mankhwala a cholesterol amagawika m'mibadwo inayi.
Mankhwala a m'badwo woyamba amaphatikiza ma statin achilengedwe, omwe amapatulidwa ndi bowa. Mankhwala amibadwo yotsalira amapangidwa ndi kupanga excretion.
Simvastatin ndi Lovastatin ndi zolengedwa zam'badwo woyamba. Amakhala ndi matchulidwe achire ndipo amayambitsa mavuto osiyanasiyana. Kugwiritsanso ntchito kwa nthawi yambiri kumafuna mankhwala a mibadwo yachiwiri, omwe akuphatikizapo fluvastatin. Zitha kusungidwa m'magazi a anthu kwanthawi yayitali.
Mankhwala a m'badwo wachitatu amathandizira kuchepa kwakukulu kwa kuchuluka kwa ma triglycerides ndi ma lipoproteins otsika, pakati pomwe Atorvastatin amadziwika kuti ndiotchuka kwambiri. Kukonzekera kwa cholesterol yokweza ya m'badwo wachinayi kumathandizira kuwonjezeka kwakukulu kwa chitetezo ndi chitetezo, poyerekeza ndi fanizo zoyambirira.
Kuphatikiza pa ntchito zoyambira zotsitsa lipid, mankhwala ali ndi mawonekedwe apadera komanso zowonjezera.
Katundu wa Statin
Mankhwala a gulu la statin amakhudza kupanga kwa cholesterol ndi chiwindi ndi zoletsa zake. Izi zimachitika chifukwa ma enzyme omwe akukhudzidwa ndi kapangidwe ka cholesterol ndi oletsedwa. Ma enzyme amenewa amathandizira kuti apange mevalonic acid, yemwe amathandizira kuyambitsa mafuta m'thupi.
Statin amakhudzanso endothelium yamitsempha yamagazi, amachepetsa kutupa ndikuchepetsa chiwopsezo cha magazi, amalimbikitsa kapangidwe ka nitric oxide, kamene kamachepetsa ndikusintha mitsempha yamagazi, kamakhazikika pakapangika kazinthu zamagazi.
Kuphatikiza apo, mankhwalawa amalepheretsa kulowetsedwa kwa myocardial. Chifukwa chake, mwachitsanzo, Rosuvastatin yatsimikizira kuti ndi mankhwala othandiza pochepetsa chiopsezo chokhala ndi mtima wa mtima. Munthawi yakukonzanso pambuyo vuto la mtima, ndimatumbo omwe amatengedwa, chifukwa amathandizira kupititsa patsogolo machiritso.
Kuphatikiza mapiritsi kumatha kuwonjezera kuchuluka kwa lipids zabwino.
Ubwino wama statins
Mitundu ya mankhwalawa imagwiritsidwa ntchito popewa komanso kuchiza matenda a atherosulinosis, pamene njira zina zochiritsira sizinasonyeze zotsatira zomwe mukufuna. Statin amachepetsa chiwopsezo cha kugunda kwa mtima, kusakhalitsa kwa ischemic, stroko, atherosulinosis.
Komanso, mapiritsi amatithandizanso kugwira ntchito ya mtima ndi matenda a mtima ndi angina pectoris, siyani zizindikiro za matenda ashuga, kuchepetsa kunenepa kwambiri, komanso kuchepetsa kutupa m'mitsempha yamagazi. Mankhwala amatha kuonda magazi ndi kulepheretsa kukula kwa thrombosis, kusintha kagayidwe kachakudya ka michere, kukulitsa mitsempha, ndikuchotsa zolembera za atherosselotic.
Mankhwala amakupatsani imathandizira kukonza kukonzanso ndi stenting, ischemic stroke, coronary artery bypass grafting, angioplasty, myocardial infarction, pulmonary embolism.
Ndani amatsutsana ndi mankhwala a statin
Musanayambe chithandizo, muyenera kufunsa dokotala. Ikuthandizani kusankha mankhwala ndi Mlingo, poganizira mawonekedwe a thupi ndi kupezeka kwa matenda ang'onoang'ono. Popeza ma satana amakhala ndi zotsutsana zingapo, mankhwala omwe amadzipangira okha sayenera kuchitika.
Kugwiritsa ntchito mankhwalawa kuyenera kusiyidwa kwathunthu pamaso pa sayanjana komanso kusalolera kwa zinthu zomwe zimagwiritsidwa ntchito ndi mankhwala, matenda a impso, kusokoneza chithokomiro cha chithokomiro ndi endocrine.
Komanso, mapiritsi sangathe kugwiritsidwa ntchito ngati akuphwanya dongosolo la minofu ndi mafupa, chiwindi ndi matenda a chiwindi. Mu shuga mellitus, chisamaliro makamaka chikuyenera kuthandizidwa posankha njira yotsitsira mafuta m'thupi. Pa nthawi yomwe mayi ali ndi pakati, mankhwalawa amatha kuvulaza mwana wosabadwayo, choncho ndi bwino kusintha mankhwalawo ndi njira ina yabwino kapena kusiya kumwa mankhwala onse.
Muyenera kumvetsetsa kuti kumwa mankhwala kumatha kuyambitsa zovuta zina.
- Nthawi zina, myopathy amakula. Kuphwanya koteroko kumatengera zaka za wodwalayo, mlingo wa mankhwalawa, kupezeka kwa zovuta za shuga.
- Nthawi zina ntchito yamkati yamanjenje imasokonekera. Amadziwonetsera ngati mutu, chizungulire, kusokonezeka kwa tulo, kufooka kwathunthu.
- Mukadziwika ndi kupuma kwamankhwala nthawi zina, rhinitis, bronchitis imayamba.
- Komanso, wodwalayo amatha kusanza, kusanza, kudzimbidwa.
Mwambiri, ndimapiritsi oyenera, osamala komanso oyenera, mutha kuwona zotsatira zabwino. Koma ngati mankhwala osokoneza bongo atagwiritsidwa ntchito kwa nthawi yayitali, wodwalayo akhoza kukumana ndi mavuto monga:
- Ululu m'mimba ndi matumbo aang'ono, kudzimbidwa, kusanza;
- Amnesia, kusowa tulo, paresthesia, chizungulire;
- Thrombocytopenia kapena kuchepa kwambiri kwa ndende
- Kutupa, kunenepa kwambiri, kusabereka mwa amuna;
- Minofu kukokana, kupweteka kwa msana, nyamakazi, myopathy.
Komanso, vuto losafunikira lingawonedwe ngati hypolipidemic ndi mitundu ina ya mankhwala osagwirizana imagwiritsidwanso ntchito.
Zabwino ndi zoyipa zama statins
Ngati mumachiza ndikutsatira malangizo onse azachipatala, gulu la mankhwalawa limachepetsa chiopsezo cha kufa ndi matenda a mtima komanso sitiroko ndi 40 peresenti. Mankhwalawa amatha kuchepetsa kuchuluka kwa cholesterol yoyipa m'magazi ndi 50 peresenti. Kuti mupeze vutoli, ndikulimbikitsidwa kamodzi pamwezi kuti mupereke magazi mpaka mulingo wa lipids zovulaza.
Awa ndi mankhwala otetezeka, omwe amapatsidwa mlingo, alibe poizoni m'thupi. Mankhwala obwera mwatsopano ali ndi zovuta zochepa ndipo, popanda zotsatira zake, amalola kulandira chithandizo cha matenda ashuga. Masiku ano, pali ma analogi ambiri ogulitsa pamitengo yotsika mtengo, kotero aliyense angathe kusankha mankhwala, kuyang'ana luso lawo lazachuma.
Zoyipa zake ndi monga mtengo wokwera, kukonzekera koyambirira Rosucard, Krestor, Leskol Forte ndiokwera mtengo kwambiri.
Koma pamashelefu nthawi zonse mumakhala mapiritsi otsika mtengo, omwe akhoza kukhala ndi chinthu chimodzi chogwira ntchito.
Ma statin othandiza kwambiri komanso otetezeka
Kuti tiyankhe funso loti ndi ma statins ati omwe amatha kusintha mkhalidwe wa munthu popanda kuvulaza thanzi, kafukufuku wambiri wa sayansi wapangidwa. Zotsatira zake, zidapezeka kuti mankhwala othandiza kwambiri komanso osawopsa kwa Atorvastatin. Mu malo achiwiri simodalirika komanso othandiza Rosuvastatin, ndipo chachitatu - Simvastatin.
Dokotala atha kukupatsani mapiritsi a atorvastatin a matenda a mtima ndi mafuta amthupi ambiri. Mankhwalawa adziwonetsa okha m'maphunziro ambiri azachipatala ndipo machitidwe adatsimikizira kuti amatha kuchepetsa chiopsezo cha stroke chifukwa cha 50 peresenti. Malinga ndi umboni wa dotolo, mankhwalawa ndi 40-80 mg m'mawa kapena madzulo, kutengera ndi kuchuluka kwa matendawo.
Rosuvastatin ndi mankhwala opangidwa mwaluso. Ili ndi mphamvu yotchedwa hydrophilic athari, yomwe imayambitsa kuchepa kwa zotsatira zoyipa ndikuyimitsa kupanga cholesterol yoyipa. Mosiyana ndi mapiritsi ena, mankhwalawa samatulutsa myopathy ndi minofu kukokana.
- Mlingo wa 40 mg umachepetsa kuchuluka kwa lipoprotein otsika ndi 40 peresenti ndikuonjezera kuchuluka kwa cholesterol yabwino ndi 10 peresenti.
- Zotsatira zakugwiritsa ntchito mankhwalawa zimatha kuonedwa kale patadutsa masiku asanu ndi awiri, patatha mwezi umodzi zotsatira zake zimakhala zochuluka, ndipo matendawa amatha kuzikhalanso kwa nthawi yayitali.
Simvastatin ingachepetse chiopsezo chokhala ndi matenda ammimba ndi mtima mwa 10 peresenti pambuyo pa vuto la mtima, sitiroko, ndi matenda a shuga. Ngati mutamwa mankhwalawa kwa nthawi yayitali, muthanso kusintha kuchuluka kwa cholesterol yoyipa ndi yabwino, kuchepetsa chiopsezo cha coronary artery thrombosis.
Monga momwe madokotala amawonera mu malingaliro awo, ma statin ndi mankhwala otetezeka. Koma ndikofunikira kuwerenga malangizo musanagwiritse ntchito, kumbukirani mawonekedwe a thupi, kutsatira mosamala mlingo, kusamala pamaso pa matenda ang'onoang'ono ndipo musamayendetse.
Pofuna kukonza zambiri, tikulimbikitsidwa kupanga mankhwala opangira mankhwala azitsamba, kuphatikiza chakudya chamasamba menyu, ndikugwiritsa ntchito maphikidwe otetezeka mukaphika.
Mankhwala ofanana
Iliyonse mwamankhwala omwe ali pamwambawa ali ndi dzina losiyana. Chifukwa chake, dokotala wothandizapo atha kukupatsirani mankhwala ofanana ngati, mwanjira ina, pamtengo wabwino.
Zomwe zimagwira ntchito ya Simvastatin ndizinthu zosadziwika zomwe zimakhala ndi lipid-kuchepetsa. Mndandanda wa analogues umaphatikizapo Zovatin, Arieskor, Simvakor, Simgal, Vasilip, Zosta, Zokar, Simvastol, Vastatin.
Mankhwala a m'badwo woyamba Pravastatin amatha kuthandizidwa ndi Pravospres, Lipostat. Malo opezeka ku Lovastatin akuphatikizapo Mevacor, Lovagexal, Lovacor, Apextatin, Rovacor, Holetar, Cardiostatin, Medostatin, Lovasterol, Liprox.
Mankhwala opangidwa ndi Atorvastatin akuphatikizapo Tulip, Canon, Atoris, Atorvox, Atomax, Lipitor, Liprimar, Torvakard, Anvistat, Liptonorm. Zofananira zosagwira bwino komanso zotetezeka za Rosuvastatin zochepetsa cholesterol yamagazi ndi Rosart, Rosulip, Roxera, Krestor, Tevastor, Mertenil, Novostatin, Akorta.
Statins akufotokozedwa mu kanema munkhaniyi.
