LIPODYSTROPHY MU SHUGA - NJIRA NDI NJIRA ZOCHIRITSIRA

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Mankhwala a insulin, ngakhale atachitidwa molingana ndi malingaliro azachipatala, ali ndi zovuta zambiri zosatsimikizika (onani nkhani yokhudza insulini regimens).

Popeza vuto lililonse la matenda ashuga limangokhala munthu payekhapayekha (monga momwe amachitira ena ma endocrinologists ena, pali mitundu yambiri ya matenda amtundu wa shuga monga odwala omwewo), zomwe zimachitika pakuwonjezera kwa mahomoni a insulini m'thupi sianthupi. Chimodzi mwazotsatira zoyipa za insulin.

Onani zomwe anomatic iyi ndi yotani, momwe imawonekera, momwe ingathetsedwere, ndi njira zomwe zikuyenera kuchitidwa popewa kukula kwa lipodystrophy.

Kodi lipodystrophy (zambiri)

Mwa njira yayitali ya mawu akuti lipodystrophy ndi chodabwitsa cha kukhalapo kwa minofu ya adipose m'thupi.

Nthawi zina, kuwonjezeka kwa minofu ya adipose kwa munthu amene akudwala matendawa nkosatheka ngakhale atasintha mtundu wa chakudya (kuwonjezera zakudya zamafuta, "zopatsa mphamvu" zopatsa thanzi) kuzakudya.

Kusiyanitsa kwakukulu pakati pa lipodystrophy ndi classical dystrophy: ndi kuchepa kwamafuta, minofu ya minofu ndi zizindikiro zina zofowoka m'thupi sizimachepetsedwa. Nthawi zambiri pamakhala zotsutsana - minofu yambiri (yokhala ndi chakudya choyenera ndi masewera olimbitsa thupi) ikukula, yomwe imakhala ndi phindu pa chithunzi.

Lipodystrophy mu shuga imayamba chifukwa cha jakisoni wa insulin.

Zosagwirizana nthawi zambiri zimakhala zachilengedwe ndipo zimakhazikika m'malo omwe mumathandizira kuti jakisoni wothandizirana. Atrophy ya adipose minofu imakonda kupezeka mwa akazi ndi ana.

Pali njira yosinthira: hypertrophy minofu ya adipose - mapangidwe a mafuta owonda (lipoma) pamalo a jekeseni wa insulin.

Mokulira, lipodystrophy yokhala ndi insulin Therapy imawonedwa mwa magawo anayi mwa odwala onse omwe amapatsidwa mahomoni olimbitsa thupi. Mwanjira imeneyi, matenda a zam'mimba amawonetsedwa popanda kulumikizana ndi kuchuluka ndi mtundu wa mankhwala omwe amaperekedwa. Zisakhudze kukhalapo kwa lipodystrophy ndi kuopsa kwa matendawa, komanso kuchuluka kwa chiphuphu.

Mitundu, zizindikiro ndi zotheka za lipodystrophy

Kwakukulukulu, milomo yocheperako komanso yofatsa yomwe ilibe vuto lalikulu ku thanzi: ili ndi vuto lochita zodzikongoletsera. Komabe, nthawi zina zimasokoneza mkhalidwe wamaganizidwe a odwala, makamaka azimayi.

Mantha amayamba chifukwa cha zilonda zam'mimba kwambiri m'magawo osiyanasiyana a thupi, ndipo makamaka, panalibe jakisoni wa insulin. Kwambiri, lipodystrophy imadziwika ndi kusowa mafuta kwathunthu pakhungu. Patsamba la lipoatrophy, pamakhala kuipiraipira kwa vascularization (mkhalidwe wa mtima wam'mimba), womwe umapangitsa kuphatikizira kwa insulin. Izi, zimalepheretsa kubwezeretsa matendawa ndikulepheretsa kuwerengera kwa nthawi ya kukonzekera kwa insulin. Zochitika zotsirizazi ndizowona makamaka kwa mankhwala omwe ali ndi mphamvu yayitali.

Kuwonongeka kwamafuta kumayamba munthawi zosiyanasiyana za mankhwala a insulin - kuyambira mwezi umodzi mpaka zaka zingapo. Kukula kwake kumasiyanasiyana kuchokera ku fossa yaying'ono yomwe imabayidwa jekeseni mpaka kufika pakalibe mafuta osunthika a malo ambiri. Jakisoni amakhala wowawa kwambiri, zomwe ndizovuta kawiri kwa odwala.

Ponena za hypertrophy (kuchuluka kwa mawonekedwe) a zotupa za adipose mu zigawo za jakisoni, kusinthaku kumakhudzanso kudana ndi kulowa kwa zinthu zomwe zimapangira insulin. Kuphatikiza apo, lipomas (adipose) ndi chilema chooneka bwino.

Milandu yokhudzana ndi kukula kwa lipodystrophy popanda jakisoni wa insulin amadziwika: zinthu zotere zimabuka motsutsana ndi maziko a cholowa cha metabolism. Lipodystrophy yopanda jakisoni imatha kukhala chifukwa cha kukana insulini ndipo nthawi zambiri imaphatikizidwa ndi kupezeka kwa metabolic syndrome. Matendawa amakhala ndi kuphwanya kwa lipid komanso carbohydrate metabolism.

Zoyambitsa lipodystrophy

Zomwe zimayambitsa zovuta zamtundu wa adipose ndi insulin.

Komabe, makina otukuka ndi pathogenesis ya kupezeka kwa lipodystrophy mwa odwala omwe ali ndi matenda ashuga samamvetsetsa bwino ndi mankhwala. Amakhulupirira kuti chitukuko cha pathological zimachitika chifukwa cha acidic malo okonzekera insulin.

Zoyambitsa zina zomwe zimayambitsa ndi zomwe zimayambitsa lipodystrophy:

Makulidwe olakwika a insulini (njira yolakwika ya jakisoni yomwe imatsogolera kuvulala);
Kutentha kwamphamvu kwa mankhwala;
Minofu kuvulala pamalo jakisoni insulin;
Zochita za insulin monga chinthu chomwe chimapangitsanso lipolysis;
Osakwanira mayankho chitetezo.

Ofufuza ambiri amtunduwu amakhulupirira kuti kuwonjezereka kwa mafuta m'thupi la wodwala yemwe ali ndi jakisoni wa jakisoni wambiri chifukwa cha chitetezo chamthupi. Thupi laumunthu limawona kuti jekeseniyo ndiwopseza thanzi lake ndipo m'njira inayake imayankha jakisoni.

Pali malingaliro akuti zotsatira za mahomoni "achilendo" pamthupi zimawonetsedwa mu "kubwezeretsanso" kwa ma metabolic metabolism. Zotsatira zake, njira za metabolic zimayamba kuchitika m'njira zopanda pake - makamaka, metabolism yamafuta imasokonekera: minofu ya lipoid imayamba kusandulika mphamvu.

Posachedwa, malingaliro awonjezereka afotokozedwa za ntchito yakuperewera kwa insulin. Izi zimawerengedwa kuti ndizomwe zimayambitsa kwambiri lipodystrophy. Pankhaniyi, insulin imagwira ntchito ngati antigen yomwe imagwiritsa ntchito chitetezo cha mthupi, nthawi yomweyo imawononga zigawo zamafuta.

Katundu wotchuka kwambiri wa antigenic amadziwika kuti amakonzekera insulin yomwe imapezeka kuchokera ku ng'ombe. Pachifukwa ichi, odwala omwe amakonda lipodystrophy ali osavomerezeka kuti azigwiritsa ntchito mankhwala ochepetsa kuyera. Makonda ndi insulin yaumunthu.

Chithandizo cha Mankhwala ndi Kupewa

Chithandizo cha matenda a matenda a m'mitsempha cholinga chake ndikuchepetsa kapena kuthetseratu zomwe zimapangitsa kuti mafuta asokonezeke. Pofuna kupewa makina, kutentha ndi kukwiya kwa mankhwala, njira yolondola ya insulin iyenera kutsatiridwa mosamalitsa.

Sichikhala chopanda pake kukumbukira kuti:

Insulin iyenera kugwiritsidwa ntchito pokhapokha kutentha, komanso kutentha kwa thupi (koletsedwa kugwiritsa ntchito mankhwalawo mwachangu mufiriji);
Ndikofunikira kuti musinthe njira yoperekera mankhwala - jakisoni pamalo omwewo simunachitikenso masiku 60 aliwonse (dokotala adzakuwuzani mwatsatanetsatane za kutembenuka koyenera kwa jakisoni wa insulin);
Jakisoni amapangidwa ndi jakisoni wa pulasitiki wotayika (ndi singano zopyapyala) kapena zolembera, womwe umachepetsa mwayi wamisala;
Kugunda kwa jakisoni jakisoni atangolowa jakisoni;
Ngati kupukutira khungu ndi njira yothanirana ndi jekeseni musanayambe jekeseni (zomwe ndizosowa kwambiri masiku ano), ndikofunikira kudikirira mpaka mowa utayamba kuchokera pakhungu.

Madokotala ena amalimbikitsa kugwiritsa ntchito mapampu a insulin, omwe amachepetsa mwayi wokhala ndi jakisoni wina pambuyo pobayidwa. Ofufuza ena a lipodystrophy akuti akamagwiritsa ntchito munthu kapena porcine monocomponent insulin (osachita nawo ph ph), ndiye kuti palibe milandu yamafuta ofooka.

Ngati lipodystrophy yoopsa ilipo kale, musanathetse zotsatirapo zake, ndikofunikira kupenda zomwe zidapangitsa kuti matenda amenewa afalikire. Poyamba, kuyika kwa mankhwala a mahomoni kumadera omwe adipose minofu ya atipor imayenera kutsutsidwa kwathunthu. Mwa ena, kuyambitsa insulin kumathandiza ndi mankhwala a Novocaine.

Kuthetsa zotsatira za lipodystrophy, njira zotsatirazi zitha kutumikiridwa:

Electrophoresis ya madera omwe akhudzidwa (makonzedwe a Novocaine kapena Lidase mwa kukondoweza kwa magetsi);
Ntchito za parafini pamadera omwe akhudzidwa;
Inductometry ndi njira yolimbitsa thupi yochokera pakukonzekera mphamvu yayitali yamagetsi;
Kusintha kukonzekera kwa insulin (kuphatikiza ndi kutikita minofu pamalo a jekeseni);
Ultrasound mankhwala - ultrasound imakwiyitsanso mawotchi oyenda mu ma tishu akuya kwambiri, omwe amathandizira kuyendetsa magazi ndi kagayidwe: zotsatira za ultrasound zimaphatikizidwa ndi chithandizo cha omwe akhudzidwa ndi mafuta a hydrocortisone;
Kukhazikitsidwa kwa mankhwala a mahomoni a gulu la anabolic kuti mulimbikitse kupangika kwamafuta.

Chithandizo chabwino kwambiri chothandizira chimapezeka ngati njira zingapo zamankhwala zimaphatikizidwa - kukondoweza kwamagetsi, kukhudzana ndi mankhwala, kutikita minofu (zida zam'manja kapena zolemba).

Kuphatikiza kwa inductometry ndi ultraphonophoresis kumagwiritsidwanso ntchito. Mulingo uliwonse wamankhwala wokhala ndi lipodystrophy ndi munthu payekha, motero, njira zamankhwala zochizira zimapangidwa ndi adotolo pamaziko a chithunzi chomwe apezeka pano. Kuyesa kwodziyimira kwa odwala kuti athetse mafuta a atrophy nthawi zambiri sikuti kumabweretsa zotsatira zabwino, ndipo nthawi zina zitha kukulitsa vutoli.

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