Momwe mungagwiritsire ntchito mankhwala Ofloxin 200?

Ofloxin 200 ndi mankhwala ochokera pagulu la fluoroquinolones, wothandizira pakuwonetsa antimicrobial. Ichi ndi chimodzi mwazomwe zimagwiritsidwa ntchito ngati mankhwala komanso maantibayotiki.

Dzinalo Losayenerana

INN - Ofloxacin.

ATX

J01MA01.

Kutulutsa mafomu ndi kapangidwe kake

Amapezeka mumitundu yosiyanasiyana ya mankhwala - olimba, amadzimadzi, ofewa. Ili ndi njira zingapo zogwiritsira ntchito. Chomwe chimagwira ntchito zamitundu yonse ndi chaloxacin, quinolone wa m'badwo wachiwiri.

Ofloxin 200 ndi mankhwala ochokera pagulu la fluoroquinolones, wothandizira pakuwonetsa antimicrobial.

Mapiritsi

Chophimbidwa ndikumakhala ndi magwiritsidwe osiyanasiyana a mfundo yogwira ntchito. Mapiritsi a Ofloxin, kuwonjezera pa yogwira popanga antiloxacin (200 ndi 400 mg aliyense), ali ndi zina zowonjezera:

• shuga mkaka;
• wowuma chimanga;
• talc;
• hypromellose 2910/5.

Mapiritsiwa amakhala ndi zokutira ndipo zimakhala ndi mfundo zingapo zogwira ntchito.

Mapiritsi amasiyana mosiyanasiyana ndi kusindikiza kosonyeza kuchuluka kwa zinthu zazikulu (200 ndi 400 mg iliyonse). Bokosi lililonse lili ndi matuza 1 okhala ndi mapiritsi 10.

Madontho

Makutu amaso ndi amaso akupezeka. 1 ml yankho lomveka bwino lili ndi:

• 3 mg ofloxacin;
• mchere njira;
• benzalkonium chloride;
• hydrogen chloride;
• madzi okonzedwa.

Atakulungidwa mu botolo la pulasitiki ndi dontho.

Ofloxin 200 imapezeka mu mawonekedwe a makutu amaso ndi amaso.

Ufa

Ilibe njira yotulutsidwa.

Njira Zothetsera

Njira yothetsera kulowetsedwa kwamtundu wobiriwira wachikasu ndikuyiyika mu mbale 100 ml. Botolo ili ndi 200 mg yofunikira ndi zotulukazo:

• mchere njira;
• Trilon B;
• hydrogen chloride;
• madzi okonzedwa.

Makapisozi

Makapisozi achikasu a gelatin okhala ndi kapu yofiirira yofiirira:

• ofloxacin - 200 mg;
• hypromellose;
• sodium lauryl sulfate;
• shuga mkaka;
• calcium phosphate bisubstituted anhydrous;
• talcum ufa.

Makapisozi achikasu a gelatin ali ndi matuza 10 zidutswa.

Makapisozi amadzaza matuza a zidutswa 10.

Mafuta

Mankhwala amapezeka wofatsa - mafuta ogwiritsira ntchito mabala (Oflokain) ndi mafuta am'maso atagona thumba la conjugate. Mafuta amaikidwa m'matumba a 15 kapena 30 g. Mu 1 g ya mankhwala ili:

• 1 mg ofloxacin;
• 30 mg ya lidocaine hydrochloride;
• propylene glycol;
• poloxamer;
• macrogol 400, 1500, 6000.

Mafuta amaso amapangidwa m'matumba a 3 ndi 5 g, omwe ali ndi:

• ofloxacin - 0,3 g;
• nipagin;
• nipazole;
• mafuta odzola.

Mankhwala amapezeka wofatsa - mafuta okuchiritsa mabala ndi mafuta am'maso atagona m'thumba la conjugate.

Makandulo

Ma suppositories anyama akupezeka pansi pa mayina osiyanasiyana.

Zotsatira za pharmacological

Mphamvu ya bactericidal ya Ofloxin 200 imachitika chifukwa cha kulepheretsa kwa DNA-gyrase - ma enzyme omwe amapangitsa kuti DNA ipangidwe m'maselo a bakiteriya ndi kubereka kwawo. Ma enzyme amenewa amatenga mbali ziwiri mwanjira zofunika kwambiri - kuzungulira ndikuwonetsetsa kuti khola lake likukhazikika. Fluoroquinolone amathandizira kuti chiwonongeko cha bakiteriya, kotero chiopsezo cha mitundu yosagonjetseka ndi chochepa.

Mankhwala omwe amagwiritsidwa ntchito kwambiri polimbana ndi mabakiteriya opanda gramu. Ofloxin 200 chandamale atavumbulutsidwa ndi topoisomerase II. Pakati pagulu la fluoroquinolones, mankhwalawa amayimira ntchito yake motsutsana ndi gramu-cocci. Cholinga chake ndi topoisomerase IV.

Mankhwala omwe amagwiritsidwa ntchito kwambiri polimbana ndi mabakiteriya opanda gramu.

Pharmacodynamics ya chinthu imakhazikitsidwa pakuwonongeka kwa kulumikizana pakati pamagetsi a DNA (kukhazikitsidwa kwa izo), komwe kumayambitsa kufa kwa khungu la bakiteriya. Kusankha kotereku kunapangitsa kuti ma atloxacin atchuke ndi ma fluoroquinolones ena - ambiri mwa mabakiteriya omwe amalimbana ndi mitundu ina ya maantibayotiki ndi sulfonamides amathandizira kuti awonongeke.

Mankhwalawa ali ndi zochepa zoyipa, monga imagwira ntchito pamtundu wa maselo a bakiteriya, popanda kuwononga kapangidwe ka DNA ya munthu. Chifukwa chake, mankhwalawa amagwiritsidwa ntchito muzochita za ana ndi zamankhwala.

Pharmacokinetics

Mankhwalawa amatengedwa mwachangu komanso mwamphamvu m'matumbo, mpaka kufika pazitupa zambiri m'magazi pambuyo pa maola atatu ndi atatu. Zakudya pang'ono zimalepheretsa kuyamwa, koma sizikhudza kukwana kwake. Mankhwalawa ali ndi imodzi mwazigawo zapamwamba kwambiri za digestibility pakati pa fluoroquinolones - pafupifupi 100%.

Mankhwalawa amatengedwa mwachangu komanso mwamphamvu m'matumbo, mpaka kufika pazitupa zambiri m'magazi pambuyo pa maola atatu ndi atatu.

Hafu ya moyo wake ndi maola 5-10, kotero mankhwalawa amatha kumwa kamodzi pa tsiku. Kuzungulira kwa zinthu mu minofu ndizofanana kapena kukwera kuposa seramu. Ngati mlingo waukulu wa mankhwalawo waperekedwa, ndiye kuti chinthucho chimadziunjikira:

• Pakati mantha dongosolo;
• machubu bronchial;
• thumba lamanja;
• dongosolo la urogenital;
• mkati mwa chitetezo cha mthupi.

Chifukwa cha izi, mankhwalawa amagwira ntchito mochizira matenda amkati. Ofloxacin amapitilira gawo losintha mthupi - 75-90% ya chinthucho sichimasinthidwa mkodzo, ndikofunikira pakuthandizira kwa matenda a impso komanso kwamikodzo.

Thupi lomwe limayenda m'madzi am'magazi silikhala ndi mapuloteni ndipo limalowa mu bedi lamitsempha.

Thupi lomwe limayenda m'madzi am'magazi silikhala ndi mapuloteni ndipo limalowa mu bedi lamitsempha. Mankhwalawa ndi osiyana:

• kugwira ntchito kulikonse pH;
• kusowa kwamphamvu pa pharmacokinetics ya methylxanthines;
• kukhalapo kwa postantibiotic kanthu;
• kuchepa kwa dysbiosis;
• mbiri yabwino yachitetezo.

Thupi silikhudzika kwa kukula kwamkati ndi chiberekero cha mwana wosabadwayo.

Zizindikiro zogwiritsidwa ntchito

Chizindikiro chothandizira matenda:

• kwamikodzo dongosolo;
• wamkazi kapena wamwamuna;
• STI
• matumbo;
• dongosolo la biliary;
• nosocomial ndi postoperative;
• kupuma thirakiti;
• septicemia ndi bacteremia;
• Pakati mantha dongosolo;
• chifuwa chachikulu, khate.

Ofloxin 200 akuwonetsedwa zochizira kwamikodzo matenda.

Ofloxin 200 akuwonetsedwa zochizira matenda am`mapapo matenda.

Ofloxin 200 akuwonetsedwa zochizira matenda abambo.

Mafutawa amagwiritsidwa ntchito pochiritsa matenda a pakhungu, matenda a mano, komanso mankhwalawa.

Contraindication

Malangizo monga contraindication ogwiritsa ntchito Ofloxin 200 akuwonetsa:

• Hypersensitivity;
• mimba ndi mkaka wa m`mawere;
• mankhwala a ana ochepera zaka 18;
• khunyu ndi kukokana kwa ubongo;
• kukhalapo kwa kuwonongeka kwa tendon chifukwa chogwiritsa ntchito fluoroquinolones;
• cytosolic enzyme akusowa (G6FD).

Ofloxin 200 ndi contraindicated vuto la hypersensitivity.

Ofloxin 200 ndi contraindified mu mkaka wa m`mawere.

Ofloxin 200 imaphatikizidwa kwa ana osakwana zaka 18.

Ndi chisamaliro

Mosamala:

• matenda amitsempha yamagazi;
• zovuta zamagazi muubongo;
• aimpso kuwonongeka;
• zodabwitsika chitukuko ndi chikhalidwe cha chapakati mantha dongosolo;
• kulephera kwa mtima kugundana ndi kutalika kwa gawo la QT.

Zophwanya zambiri zidawunikiridwa.

Kuchenjeza mankhwalawa amalembera zovuta zamagazi muubongo.

Kuchenjeza mankhwala amapatsidwa kuwonongeka kwaimpso.

Chenjezo limawonetsedwa pakulephera kwa mtima ndi nthawi yayitali ya QT.

Momwe mungatenge Ofloxin 200

Odwala achikulire amapatsidwa 200-600 mg. Kutalika kwa maphunzirowa ndi masiku 7-10. Mankhwala osokoneza bongo a 400 mg akhoza kumwa kamodzi, makamaka m'mawa kwa theka la ola kapena ola limodzi musanadye, mlingo waukulu umagawidwa pawiri. Ndikulimbikitsidwa kumeza mapiritsi ndi madzi. Mu matenda akulu ndi kunenepa kwambiri, kuchuluka kwa mlingo mpaka 800 mg / tsiku ndikuloledwa.

Ngati matenda otupa a m'munsi kwamikodzo dongosolo (prostatitis, cystitis, urethritis) sakhala ovuta, ndiye kuti ndikokwanira kumwa 200 mg 1 nthawi patsiku kwa masiku 3-5. Zochizira matenda a chinzonono, palimodzi mlingo wa 400 mg.

Mlingo ndi njira yothandizira odwala omwe ali ndi vuto la impso zimadalira chilolezo cha creatine:

Chithandizo cha mankhwalawa chimayamba ndi makonzedwe olimbitsa thupi, ndipo pakakhazikika pakukhazikika kwa mankhwalawa, kukonzekera pakamwa chimodzimodzi.

Mukadumpha mlingo

Ngati wodwalayo adayiwala kumwa mankhwalawo, ndiye kuti amaloledwa kumwa nthawi yomweyo wodwalayo akakumbukira za iwo.

Mankhwala mu mlingo wa 400 mg akhoza kumwa kamodzi, makamaka m'mawa, theka la ola kapena ola limodzi musanadye.

Kumwa mankhwala a shuga

Odwala omwe adapezeka ndi matenda a shuga panthawi yomwe ali ndi Ofloxin 200 amafunika kuwongolera shuga munthawi yomweyo kugwiritsa ntchito mankhwala ochepetsa shuga, insulin ndi fluoroquinolones angayambitse hypo- kapena hyperglycemia.

Zotsatira zoyipa zaloxine 200

Mankhwalawa amalekeredwa bwino - zoyipa zimachitika ndi 0.5-10% ya milandu. Komabe, zovuta zoyipa zimadziwika nthawi zina.

Odwala omwe apezeka ndi matenda ashuga nthawi yonse ya Ofloxin 200 amafunika kuwongolera shuga.

Matumbo

Ululu ndi kusasangalala kwam'mimba, mavuto a dyspeptic. Zosowa kwambiri:

• gastralgia;
• kulakalaka;
• hyperbilirubinemia;
• chiwindi.

Hematopoietic ziwalo

Anemia, leukopenia, pancytopenia, thrombocytopenia amadziwika.

Pakati mantha dongosolo

Mwanjira ya chizungulire, nkhawa, mavuto atulo. Zowonetsedwa kwambiri:

• mkhalidwe wokondwerera kapena wokhumudwa;
• psychosis ndi phobias;
• kuchuluka kwachuma chamkati;
• kuyerekezera;
• kukhumudwa

Zotsatira zoyipa za chapakati mantha dongosolo: chizungulire.

Zotsatira zoyipa zochokera ku dongosolo lamkati lamanjenje: kugona tulo.

Zotsatira zoyipa kuchokera ku dongosolo lamkati lamanjenje: kukhumudwa.

Kuchokera ku minculoskeletal system

Chotheka:

• tendonitis;
• kusweka kwa minofu;
• kutupa kwa olowa ndi ligamentous zida;
• kufooka kwa minofu ndi kupweteka.

Kuchokera ku kupuma

Zopanda chizindikiro.

Pa khungu

Mwanjira ya petychia, totupa, dermatitis.

Kuchokera ku genitourinary system

Kawirikawiri mu mawonekedwe a:

• hypercreatininemia;
• yade;
• onjezera urea.

Kuchokera pakhungu pamakhala zotupa.

Pa mbali ya mtima wamtima, kuthamanga kwa magazi kumachepa.

Kuchokera ku minculoskeletal system, pamatha kukhala zofooka ndi zizindikiro zopweteka m'misempha.

Kuchokera pamtima

Mtambo wamtima wasweka, kuthamanga kwa magazi kumachepa, mitsempha ya magazi imayatsidwa, kugwa kumayamba.

Dongosolo la Endocrine

Osadziwika.

Matupi omaliza

Khungu, kuyabwa, kufupika, chifuwa, kufooka kwa nkhope kapena khosi, chifuwa chamkati, edema ya Quincke, kuwopsa kwa anaphylactic.

Zokhudza mphamvu pakuwongolera njira

Sizoletsedwa kuyendetsa magalimoto ndikugwira ntchito ndi njira zovuta zomwe zimafuna kuyang'aniridwa.

Mutatha kumwa mankhwalawo, ndizoletsedwa kuyendetsa magalimoto.

Malangizo apadera

Zothandiza pa pathologies chifukwa cha chibayo kapena mycoplasmas - chifuwa, chibayo, bronchitis.

Ngati pali zizindikiro za chifuwa, zoyipa zamagetsi zamkati, muyenera kuletsa mankhwalawo.

Panthawi yamankhwala, kulowererapo, kukhudzana ndi ma radiation a UV mu solaramu ndi physiotherapy sayenera kuphatikizidwa.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Contraindicated chifukwa kuopseza kukula kwa ziwalo ndi mafupa a mwana wosabadwayo. Mukamayamwitsa, ndikofunikira kusamutsa khanda kukhala mwana wakhanda.

Kupangira Ofloxin kwa ana 200

Ana samapereka mankhwala mpaka makulidwe a minofu ndi mafupa atha. Komabe, pazifukwa zaumoyo komanso popanda zotsatira zoyipa za mankhwala ena, Ofloxin 200 amatha kuthandizidwa pa mlingo wa 7.5 mg pa 1 kg ya kulemera kwa thupi. Chokwanira chovomerezeka ndi 15 mg / kg.

Ana samapereka mankhwala mpaka makulidwe a minofu ndi mafupa atha.

Gwiritsani ntchito mu ukalamba

Amayikidwa mosamala chifukwa cha kusintha kwokhudzana ndi zaka komanso chiwopsezo chosasinthika.

The ntchito aimpso kuwonongeka

Ndikofunikira kusintha mlingo womwe umayang'aniridwa ndi milingo ya creatine.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Chidachi chimagwiritsidwa ntchito pokhapokha kuwunikira kuchuluka kwa bilirubin, ndi kuchuluka kwa mankhwalawa, mankhwalawa amasinthidwa kapena kutsekedwa.

Ngati chiwindi chalephera kugwira ntchito, mankhwalawa amagwiritsidwa ntchito pokhazikika kuwunika kwa bilirubin.

Kuchuluka kwa Ofloxin 200

Zizindikiro za kuledzera zimadziwika:

• mawonetseredwe a dyspeptic;
• Hypersomnia;
• chisokonezo.

Mankhwala amathetsedwa, kupukusidwa kwa m'mimba kumachitika. Ndi kuledzera kwambiri, hemodialysis ndiyotheka.

Kuchita ndi mankhwala ena

Imagwira mosiyanasiyana ndi magulu osiyanasiyana a mankhwala.

Kuphatikiza kophatikizidwa

Osagwiritsa ntchito nthawi imodzi ndi:

• NSAIDs - mwina kuchepetsa kutsekeka kwa ubongo;
• quinolones ndi mankhwala a impso kagayidwe - kuchuluka kwa kuchuluka kwa ofloxin ndi kukulitsa nthawi ya kutuluka kwake;
• antihypertensive othandizira, barbiturates - kuchepa kwambiri kwa magazi kumatheka;
• glucocorticoids - chiwopsezo chowonjezereka cha tendonitis;
• anthocyanins - kuchepetsa digestibility ya mankhwala;
• amatanthauza kuti kusuntha kwa pH kwamkodzo kupita ku mbali ya zamchere - zotsatira za nephrotoxic ndizotheka.

Osagwiritsa ntchito nthawi yomweyo

Sangagwiritsidwe ntchito munthawi yomweyo ndi anthocyanins - amachepetsa kugaya mankhwala.

Sizingagwiritsidwe ntchito munthawi yomweyo ndi NSAIDs - ndizotheka kuchepetsa cholowa cha matenda.

Osavomerezeka kuphatikiza

Sizoletsedwa kuphatikiza ndi:

• mavitamini a vitamini K - mwina amawonjezera magazi;
• Glibenkamide - achuluke kuchuluka kwa glibenclamide mu seramu yamagazi;
• mukafufuza, mankhwalawa amatha kupereka zotsatira zabodza za opiates ndi porphyrins mkodzo.

Kuphatikiza komwe kumafunikira kusamala

Milandu yowonjezereka yogwira ntchito ya anticoagulants pamlomo amadziwika ndi munthawi yomweyo chithandizo ndi fluoroquinolones.

Ndi makonzedwe omwewo omwe amaphwanya mtundu wa sinus, amafunika kuwongolera ECG.

Ofloxin 200 siyigwirizana ndi ethylate.

Kuyenderana ndi mowa

Zosagwirizana ndi ethylate.

Analogi

Magulu apakati ndi awa: Ofaxin, Oflo, Floksan, Oftagel, Ofor.

Kupita kwina mankhwala

Mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Ayi.

Mtengo wa Ofloxin 200

Ku Ukraine - 133.38-188 UAH. Pa gawo la Russian Federation - 160-180 rubles.

Mankhwala ndi mankhwala.

Zosungidwa zamankhwala

Pamalo amdima, ozizira, opanda chinyezi.

Tsiku lotha ntchito

Osapitirira zaka zitatu.

Wopanga

Republic Czech.

Ndemanga za Ofloxin 200

Analandira ndemanga zabwino kuchokera kwa madokotala ndi odwala.

Madokotala

Maxim Alexandrovich, dotolo, Minsk: "Mu ntchito yanga yonse ya udokotala ndakhala ndikugwiritsa ntchito mankhwala a fluoroquinolones pothandiza odwala. Ndimaona kuti Ofloxin 200 ndiwothandiza.

Galina Sergeevna, dokotala wazachipatala, ku Kiev: "Ofloxin 200 nthawi zambiri imalembedwa kwa odwala omwe ali ndi matenda a urogenital. Ndi mawonekedwe osavuta, ndikwabwino kuti musunge ndikuyang'anira. Ndi bwino kuti muyenera kungogwiritsa ntchito kawiri pa tsiku."

Odwala

Olga, wazaka 32, Kaluga: "Mankhwalawa adagwiritsidwa ntchito pochiza cystitis. Zinali zowopsa. Patatha masiku angapo kumwa Ofloxin 200, zizindikilo zonse zinatha.

Mikhail, wazaka 22, Omsk: "Ndidayamba kuzizira pantchito, mavuto ndi urology adapezeka.Dokotala adalemba mapiritsi a Ofloxin 200 - adagwira ntchito mwachangu. Wathandizidwa bwino. "

Tamara, wazaka 40, Gorlovka: "Ndinalandila mayeso oyipa okhudzana ndi matenda am'mbuyomu. Potsatira malingaliro a dokotala, ndinayamba maphunziro a Ofloxin. Posachedwa ndinapita ku labotale - zotsatirapo zake sizabwino."