Clindamycin ndi antibacterial wothandizira omwe ali ndi gulu lodziwika bwino la antimicrobial, lomwe ndi gulu la lincosamides. Amagwiritsidwa ntchito ngati matenda a bakiteriya mwa akulu ndi ana. Mankhwala siothandiza viral matenda.
Mayina apadziko lonse lapansi
Dzina Lachilatini la antibayotiki ndi Clindamycin.
Ath
Khodi ya ATX (anatomical and achire mankhwala gulu) la mankhwala ndi D10AF51. Gulu - D10AF.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapangidwa m'mapiritsi a gelatin a 150 mg, mu mawonekedwe a kirimu, othandizira kuti ayikidwe mu nyini (Clindacin) ndi yankho mu ma ampoules a 300 mg.
Mankhwala olimbana ndi mankhwalawa amapezeka mu njira yotsimikizika bwino, yopanda utoto kapena chikasu pang'ono.
Njira Zothetsera
Mankhwala olimbana ndi mankhwalawa amapezeka mu njira yotsimikizika bwino, yopanda utoto kapena chikasu pang'ono. Mankhwala omalizidwa, amaperekedwa mwanjira ya phosphate. Kuchuluka kwa mankhwala othandizira mu 1 ml ya yankho ndi 150 mg. Zina mwa yankho lake ndi chosakanikirana ndi disodium, mowa ndi madzi. Mankhwalawa amaikidwa mu ma ampoules a 2 ml, omwe amawaika m'matumba ndi maselo kapena mapaketi a makatoni.
Makapisozi
Ma kapisolo opha maantibayotiki ndi kukula 1, wokhala ndi vuto lofiirira ndi kapu yofiyira. Zomwe zili ndi ufa woyera. Maantibayotiki mumapiritsi amaperekedwa mwa mawonekedwe a hydrochloride. Zothandiza pazinthu za mankhwalawa ndi: lactose, talc, magnesium stearate ndi wowuma wa chimanga. Chovindikirachi chimakhala ndi titaniy dioxide, utoto wa quinoline wachikasu ndi kapezi wa Ponceau 4R. Mlanduwo uli ndi gelatin, azurobin ndi utoto wakuda. Mu makapisozi ndi 150 mg wa antiotic.
Makapisozi a antibiotic ndi kukula 1. Mu makapisozi ndi 150 mg wa antiotic.
Makandulo
Mankhwala olimbana ndi mankhwalawa amagwiritsidwa ntchito ngati mawonekedwe a ukazi wokhala ndi mawonekedwe a cylindrical. Mtundu - kuchokera pazoyera mpaka pang'ono chikaso. Palibe malingaliro okhudzana ndi gawo lalitali la suppositories. Zomwe zimagwira mu makandulo zimawonetsedwa mwanjira ya phosphate. Zothandiza zothandizira ndizopanga ma glycerides. Mu 1 suppository ndi 100 mg ya antibacterial.
Mafuta
Mankhwala olimbana ndi mankhwalawa samapezeka ngati mafuta, koma amagwiritsidwa ntchito ngati galasi ndi kirimu yoyera ya 2% yoyera. Zothandiza zothandizira za mankhwalawa ndi: sodium benzoate, mafuta a castor, polyethylene oxide ndi propylene glycol. Kirimuyi imaperekedwa m'machubu aluminiyamu. Mlingo umodzi (5 g) uli ndi 100 mg ya antiotic.
Mankhwalawa amagwiritsidwa ntchito ngati galasi ndi kirimu yoyera ya 2% yoyera.
Zotsatira za pharmacological
Maantibayotiki amathandizira pazinthu zambiri zazikulu. Imagwira pakulimbana ndi mabakiteriya omwe samasokoneza pogwiritsa ntchito njira ya Gram. Mankhwalawa ali ndi bacteriostatic, ndiye kuti, amalepheretsa kukula ndi kubereka kwa ma virus pama cell. Kupanga kwa antibacterial kanthu kumalumikizidwa ndi kuphwanya mapangidwe a protein.
Staphylococci (kuphatikiza epidermal), streptococci, enterococci, peptococci, peptostreptococci, causative wothandizila wa botulism, bacteriao, mycoplasmas, ureaplasmas, bacilli ndi anaerobes omwe sangathe kupanga spores akumvera mankhwala. Mankhwalawa amatikumbutsa lincomycin ake achire.
Pharmacokinetics
Kulowetsedwa kwa mankhwalawa m'mimba ndi matumbo kumachitika mwachangu komanso mokwanira. Kudya kumachepetsa mayamwidwe (mayamwidwe). Mankhwalawa amalowa mosavuta ndikugawidwa mu zimakhala. Mankhwala ochepetsa mphamvu pang'ono amalowa mu ubongo.
Maantibayotiki amalowa m'magazi mofulumira kwambiri akapatsidwa mtsempha.
Kuchuluka kwa mankhwalawa kumakhala m'magazi pambuyo pa ola limodzi (mukamagwiritsa ntchito makapisozi), pambuyo pa ola limodzi (mutabayidwa mu minofu ya gluteus) mwa ana ndipo mukatha maola atatu kwa akuluakulu. Maantibayotiki amalowa m'magazi mofulumira kwambiri akapatsidwa mtsempha. Mankhwala achire ndende amakhala m'magazi kwa maola 8-12. Mu minofu ya chiwindi, mankhwalawa amapukusidwa. Mankhwalawa amachotseredwa ndi impso ndi mkodzo komanso matumbo.
Zizindikiro zogwiritsidwa ntchito
Matenda omwe mankhwalawa angafotokozedwe ndi:
- Matenda a ziwalo za ENT (kutupa kwa pharynx, larynx, khutu, zamphongo, mapapo, bronchi, ma abscesses), kupuma kwa ma pathologies.
- Kutentha thupi.
- Diphtheria.
- Matenda amtundu wa genitourinary (kuwonongeka kwa chiberekero, vulvovaginitis, colpitis, salpingoophoritis, chlamydia).
- Staphyloderma, pyoderma, abscesses, peritonitis.
- Septicemia (poyizoni wa magazi popanda kuwononga kwa minyewa yamkati).
- Kutupa kwamphamvu kwa mafupa a minyewa (osteomyelitis).
- Bacterial endocarditis (kutupa kwamkati mwa mtima ndikuwonongeka kwa valavu).
Mankhwalawa atha kutumikiridwa monga njira yothandizira kupweteketsa ndi kukonzanso kwa khoma lamatumbo. Pankhaniyi, makonda amapatsidwa jakisoni wamkati kapena wamkati.
Contraindication
Otsatirawa contraindication kugwiritsa ntchito mankhwala zotchulidwa malangizo:
- myasthenia gravis (kufooka kwa minofu);
- ziwengo clindamycin ndi lincomycin kukonzekera;
- mphumu
- ulcerative mawonekedwe a colitis (kutukusira kwa colon);
- kutenga pakati (kirimu ndizotetezeka mu 2nd ndi 3 trimesters);
- nthawi ya mkaka wa m`mawere;
- zaka mpaka zaka 3 (yankho);
- zaka mpaka 8 zaka kapena kulemera kwa mwana zosakwana 25 makilogalamu (makapisozi).
Mosamala, muyenera kumwa mankhwala a anthu okalamba komanso anthu.
Mosamala, muyenera kumwa mankhwalawa kwa achikulire ndi anthu omwe ali ndi impso ndi hepatic matenda.
Momwe angatenge
Ana opitirira zaka 15 ndi akulu akulimbikitsidwa kumwa mankhwala 1 kapisolo panthawi ya maola 6. Woopsa milandu, dokotala amatha kuwonjezera kuchuluka kwake. Jekeseni amafunika kuchitidwa kawiri pa tsiku (2 times 300 mg). Mankhwalawa odwala wamkulu kuposa zaka 3, mlingo ndi 15-25 mg / kg / tsiku.
Ndi kukomoka kwa chiwindi ndi impso, komanso ngati pali maulendo apakati (maola 8 kapena kupitirirapo), kusintha kwa mlingo sikofunikira.
Kumwa mankhwala a shuga
Mu shuga mellitus, maantibayotiki amagwiritsidwa ntchito onse m'njira zothandizira pakamwa, komanso m'njira zowonjezera makonzedwe a intravaginal and solution. Pa mankhwala, tikulimbikitsidwa kuwongolera shuga.
Zotsatira zoyipa
Nthawi zambiri, zimatha kusintha ndipo zimazimiririka chithandizo ukasiya.
Mu shuga mellitus, maantibayotiki amagwiritsidwa ntchito ngati momwe amachitira pakamwa.
Matumbo
Mukamagwiritsa ntchito clindamycin, izi ndizotheka:
- dyspepsia (kudzimbidwa mwanjira ya m'mimba, nseru);
- Zizindikiro za kutupa kwammero (zovuta kumeza, kutentha kwa mtima, kupweteka);
- kutulutsa khungu
- kuchuluka kwa michere yotupa ya chiwindi;
- kuchuluka kwa chiwindi michere mu magazi;
- kuchuluka kwa bilirubin m'magazi;
- matumbo dysbiosis.
Nthawi zina odwala amakhala ndi pseudomembranous colitis.
Mukamagwiritsa ntchito mankhwalawa, dysbiosis ndiyotheka.
Hematopoietic ziwalo
Mbali ya magazi ndi ziwalo zopanga magazi, zosintha izi ndizotheka:
- dontho la kuchuluka kwa maselo oyera;
- kuchepa kwa neutrophil;
- agranulocytosis;
- kupindika.
Kuchokera pamtima
Ngati mankhwalawa alowa m'mitsempha mwachangu kwambiri, chizungulire, kuchepa kwa mavuto, kugwa ndi kufooka ndikotheka.
Kuchokera ku minculoskeletal system
Nthawi zina, kufalitsa kufooka kwa mitsempha kuchokera ku mitsempha kupita ku minofu kumawonedwa.
Matupi omaliza
Mitundu yotsatirayi yamomwe thupi limakumana nayo imatheka:
- urticaria (zotupa mu mawonekedwe a matuza m'malo osiyanasiyana a thupi);
- maculopapular zidzolo;
- dermatitis;
- eosinophilia (kuchuluka kwa eosinophils m'magazi);
- anaphylaxis (mantha, edema ya Quincke).
Zotheka ziwengo mu mawonekedwe a urticaria.
Malangizo apadera
Ngati pseudomembranous colitis ikapezeka, ma resion a ion amasinthana. Iyenera kuletsa mankhwala othandizira. Ngati ndi kotheka, mankhwala ozikidwa pa metronidazole amagwiritsidwa ntchito ndipo kulowetsedwa kumachitika.
Malangizo ogwiritsira ntchito akuwonetsa kuti mutatenga clindamycin, simungathe:
- gwiritsani ntchito mankhwala omwe amachititsa kuti matumbo asamayende bwino;
- kumwa mowa;
- gwiritsani ntchito zinthu zina zazimayi (zonona ndi zowonjezera).
Pogwiritsa ntchito nthawi yayitali ya clindamycin, monga erythromycin, chiopsezo chogwiritsa ntchito yisiti ngati buluzi ndi kukula kwa candidiasis kumawonjezeka.
Kuyenderana ndi mowa
Mosasamala za mlingo wa tsiku ndi tsiku, mankhwalawa sayenera kumwedwa nthawi yomweyo ndi mowa.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa samayambika chifukwa cha chizungulire komanso vuto la kayendedwe, kotero sizikhudza kasamalidwe ka kayendedwe ka kayendedwe kazinthu ndi kuyendetsa.
Mosasamala za mlingo wa tsiku ndi tsiku, mankhwalawa sayenera kumwedwa nthawi yomweyo ndi mowa.
Clindamycin wa ana
Popereka mankhwala kwa ana, zaka zawo ndi kulemera kwa thupi zimaganiziridwa. Makapisozi sangagwiritsidwe ntchito mpaka zaka 8, ndipo yankho lake - mpaka zaka zitatu.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa mu mawonekedwe a yankho ndi makapisozi amatsutsana pakhungu. Kirimu ya Vaginal ikhoza kugwiritsidwa ntchito pongowonetsa mwamphamvu, pomwe phindu la chithandizo lipitilira vuto lomwe lingachitike kwa mwana wosabadwayo. M'miyezi itatu yoyambirira ya gestation, makandulo sinafotokozedwe, chifukwa nthawi imeneyi ziwalo zofunika za mwana zimayikidwa.
Kugwiritsidwa ntchito kwa clindamycin mu mawonekedwe a kirimu panthawi ya mkaka wa m'mawere ndi kuyamwitsa ndikotheka ndikuganizira chiopsezo.
Gwiritsani ntchito mu ukalamba
Mankhwala obaya jekeseni ndikugwiritsa ntchito pakamwa muukalamba ayenera kugwiritsidwa ntchito mosamala kwambiri.
Bongo
Ngati mlingo wa tsiku ndi tsiku wa mankhwala umaposa, ndiye kuti kuwonjezeka kwa zotsatira zosayenerera ndikotheka. Mankhwala osokoneza bongo amapezeka ndi ululu wam'mimba, kutentha thupi komanso zizindikiro zina. Hemodialysis (kuyeretsa magazi) pankhaniyi sikuthandiza. Odwala ndi mankhwala wothandizira. Palibe mankhwala. Mankhwala osokoneza bongo osokoneza bongo monga kirimu kapena supplementory ndi osowa kwambiri.
Ngati muledzera tsiku ndi tsiku mlingo wa mankhwalawo, ndiye kuti malungo amatha.
Kuchita ndi mankhwala ena
Mankhwala amalimbikitsa achire zotsatira za mankhwala otsatirawa:
- aminoglycosides (streptomycin, gentamicin);
- rifamycin zotumphukira (rifampicin);
- opuma minofu.
Kugwiritsa ntchito nthawi yomweyo maantibayotiki ndi ampicillin, magnesia, zotumphukira za barbituric acid ndi calcium gluconate ndizoletsedwa. Clindamycin antagonists ndi erythromycin ndi chloramphenicol.
Mankhwalawa samayenda bwino ndi mankhwala a antidiarrheal, kukonzekera kwa mavitamini a B ndi phenytoin. Ngati mumagwiritsa ntchito narcotic analgesics palimodzi, ndiye kuti kupuma kumatha kuyima.
Analogi
Zotsatira zamankhwala omwe amapangidwa ndi zonona ndi Dalacin, Klindes ndi Klindatsin. Zonsezi zimasonyezedwa matenda a gynecological. Ma Gels ogwiritsa ntchito zakunja amapangidwa Klindatop, Klenzit-S ndi Klindovit. Ndizofunikira kwambiri pakugwiritsira ntchito zovuta za ziphuphu (ziphuphu).
Clindacin B Prolong Cream imapezekanso. Zimasiyanasiyana kuti zimaphatikizapo antifungal chinthu butoconazole nitrate, yomwe imakulitsa mawonekedwe owonetsa antimicrobial. Analogue ya clindamycin mu mawonekedwe a yankho ndi Zerkalin. Zimatsuka khungu la ziphuphu zakumaso ndi ziphuphu, komanso mankhwala a Adapalen.
Kupita kwina mankhwala
Mankhwalawa amaperekedwa ndi mankhwala.
Mtengo wa Clindamycin
Makapisozi amatenga ndalama kuchokera ku ma ruble 170, ndipo mtengo wa yankho malinga ndi maantibayotiki ndioposa ma ruble 600. Kirimuyu amatenga ma ruble 350., Mankhwalawa mu mawonekedwe a makandulo - oposa ruble 500.
Kusungidwa kwa mankhwala Clindamycin
Njira yothetsera vutoli imasungidwa mu kuwala kwamdima pa kutentha kwa + 15 ... + 25ºC. Malo osungira maantibayotiki sayenera kupezeka kwa ana. Mankhwalawa ndi a mndandanda B. Zowonjezera zimasungidwa pansi pazomwezi, chipindacho chizikhala chowuma. Mukasunga zonona, kutentha sikuyenera kupitirira 20ºC. Clindamycin (Klindatop) galasi sayenera kuzizira ndi kusungidwa mufiriji.
Tsiku lotha ntchito
Kirimu, jekeseni ndi gelisi zimasungidwa kwa zaka ziwiri. Moyo wa alumali wamakandulo ndi makapisozi ndi zaka zitatu.
Ndemanga za Clindamycin ndi madokotala ndi odwala
Nikolai, wazaka 22, ku Moscow: "Ziphuphu zakhala zikuvutikira kwa zaka zingapo. Dotolo adalangiza mankhwalawa chifukwa cha clindamycin Klindatop. Patangotha milungu yochepa, ndinamva kusintha: kufiyira, kuyabwa, ndi khungu linakhala loyera."
Svetlana, wazaka 37, Kaliningrad: "Posachedwa tidazindikira kuti vaginosis wadwala. Tidada nkhawa ndi kutaya kuchokera ku maliseche komanso kusowa kwa msambo.
Julia, wazaka 43, Novosibirsk: "Kwa zaka zambiri ndakhala ndikulembera odwala anga mapiritsi, makamaka matenda opumira. Mankhwala abwino kwambiri."
