Comboglize ndi mankhwala abwino omwe amagwiritsidwa ntchito popanga matenda a shuga a mtundu wachiwiri. Imathandizira matenda a shuga. Chipangizochi chimaphatikizira magawo awiri omwe amagwira ntchito, omwe amakupatsani mwayi kugwiritsa ntchito chida.
Dzinalo Losayenerana
INN: Metformin ndi Saxagliptin
Comboglize ndi mankhwala abwino omwe amagwiritsidwa ntchito popanga matenda a shuga a mtundu wachiwiri.
ATX
Code ya ATX: A10BD07
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa amapezeka pokhapokha piritsi. Mapiritsiwo akhoza kukhala ndi mtundu wina. Zimatengera kuzunzika kwa gulu lomwe limagwira ndi utoto mkati mwawo. Amakutidwa ndi chipolopolo chapadera.
Piritsi limodzi lili ndi 2.5 mg ya saxagliptin ndi 500 kapena 1000 mg ya metformin hydrochloride. Mapiritsiwo amakhala ndi mawonekedwe a convex oblong. Kutengera ndi kuchuluka kwa metformin, amatha kukhala ndi mtundu wa bulauni, pinki kapena wachikaso. Kumbali zonse ziwiri ndizotsatsira zomwe zimapangidwa ndi inki wabuluu. Zothandiza monga: carmellose sodium, magnesium stearate ndi cellulose.
Mankhwalawa amapezeka pokhapokha piritsi.
Mapiritsiwo ali m'matumba apadera oteteza 7 ma PC. m'modzi aliyense. Phukusi la makatoni limakhala ndi matuza 4 komanso malangizo onse ogwiritsira ntchito.
Zotsatira za pharmacological
Mankhwalawa amaphatikizika pazomwe zimapangidwa ndi 2 yogwira mankhwala. Izi zimapangitsa kukhala chida chachilengedwe pothandizira matenda a shuga a 2. Saxagliptin imagwira ntchito ngati choletsa, ndikuthandizira pakupanga zida za peptide, ndipo Metformin ndi m'gulu la Biguanides. Ma metabolites omwe amagwira ntchito amasulidwa muzisinthidwe zosiyanasiyana.
Metformin imatha kuchepetsa kuchepa kwa gluconeogeneis. Mafuta oxidation amasiya, ndipo insulin chiwopsezo chimakula kwambiri. Kugwiritsa ntchito shuga m'magazi kumathamanga. Mothandizidwa ndi Metformin, kuphatikiza glycogen kumatheka. Shuga amayamba kumizidwa pang'onopang'ono mu ziwalo zam'mimba, zomwe zimapangitsa kuti achepetse thupi kwambiri.
Saxagliptin imalimbikitsa kutulutsa insulin mwachangu kuchokera ku maselo a beta a kapamba. Njira imeneyi imatengera kuchuluka kwa shuga m'magazi am'magazi. Glucagon secretion amachepetsa, zomwe zimalepheretsa kuchuluka kwa shuga m'zinthu zina za chiwindi. Saxagliptin imathandizira kuchepetsa kukangika kwa mahomoni enaake, ma insretin. Nthawi yomweyo, kuchuluka kwa magazi awo kumakwera, ndipo kuchuluka kwa glucose okusala kumachepa pambuyo pa chakudya chachikulu.
Pharmacokinetics
Saxagliptin nthawi zonse amasinthidwa kukhala metabolite. Metformin, ngakhale utasefedwa bwino mu impso tubules, umachotsedwa m'thupi m'njira zosasinthika. Pazinthu zambiri pazogwira ntchito zimawonedwa maola 6 mutatha kumwa mapiritsi.
Metformin, ngakhale utasefedwa bwino mu impso tubules, umachotsedwa m'thupi m'njira zosasinthika.
Zizindikiro zogwiritsidwa ntchito
Chizindikiro chachikulu chogwiritsidwa ntchito ndi chithandizo chovuta kwambiri cha matenda a shuga a 2. Amagwiritsidwa ntchito ngati kuwonjezera pa zolimbikitsidwa zolimbitsa thupi ndi zakudya. Mankhwalawa amatchulidwa pokhapokha ngati mankhwala a Metformin ndi Saxagliptin ali oyenera kwa odwala.
Contraindication
Siligwiritsidwa ntchito pochiza matenda amishuga a mtundu woyamba 1, komanso pachitukuko cha matenda ashuga a ketoacidosis, chifukwa mikhalidwe imeneyi mankhwalawo sakhala ndi chithandizo chamankhwala.
Kuphatikiza apo, pali zovuta zingapo zotsutsana pamankhwala omwe timamwa:
- mkhutu yachilendo ntchito;
- lactic acidosis;
- lactose tsankho ndi ntchito zochizira waukulu Mlingo wa insulin;
- mtima mavuto;
- mtima mantha, septicemia;
- pachimake myocardial infarction;
- Hypersensitivity yogwira zigawo zikuluzikulu za mankhwala;
- pachimake komanso matenda metabolic acidosis;
- zaka mpaka 18;
- Zakudya zochepa zopatsa mphamvu;
- mimba ndi mkaka wa m`mawere;
- ntchito mankhwalawa okhala ndi ayodini omwe angayambitse kukula kwa impso.
Zotsutsana zonsezi ndizowona. Nthawi zambiri, ndi ma pathologies oterewa, insulin imagwiritsidwa ntchito pochiza matenda ashuga.
Ndi chisamaliro
Mosamala, muyenera kumwa mankhwalawa kwa okalamba, odwala omwe ali ndi chiwindi komanso matenda a impso. Zizindikiro zoyipa zikayamba kuwoneka, mankhwalawo angathandize.
Kodi kutenga combogliz?
Pankhani yogwiritsa ntchito mankhwala a antiglycemic, mlingo wa Combogliz uyenera kutumikiridwa aliyense wodwala, kutengera mtundu wa thanzi. Mankhwala tikulimbikitsidwa kuti amwe madzulo, bwino ndi chakudya. Kukula kwa mlingo umodzi wa Saxagliptin sikuyenera kupitirira 2,5 mg kapena kwa 5 mg wamkulu patsiku.
Ndikofunika kumeza miyala yonse osatafuna. Iyenera kutsukidwa ndi madzi ambiri owiritsa.
Mukaphatikizidwa ndikugwiritsa ntchito mobwerezabwereza ndi cytochrome isoenzymes, mlingo womwe umalimbikitsa ndi piritsi limodzi la 2,5 mg patsiku.
Ndikofunika kumeza miyala yonse osatafuna.
Chithandizo cha matenda ashuga
Njira yothandizira pochiza matenda amtundu wa 2 shuga. Mtundu woyamba wa mankhwalawa ndiwosatheka kuchiza. Musanayambe mankhwala osokoneza bongo, muyenera kuonana ndi endocrinologist. Poterepa, matenda onse a ziwalo zamkati ayenera kukumbukiridwa.
Zotsatira zoyipa za Comboglize
Odwala nthawi zambiri amawona kukula kosakhudzidwa kosafunikira:
- mutu, mpaka mawonekedwe a pafupipafupi migraine;
- Zizindikiro za kuledzera, zikuwonetsedwa ndi nseru, kusanza komanso kutsegula m'mimba kwambiri;
- kupweteka pamimba ya chilengedwe;
- matenda a kwamikodzo;
- kutupa kwa nkhope ndi miyendo;
- kufooka kwa mafupa kumawonjezeka, motero, izi zimawonjezera chiopsezo cha fractures mutatenga Saksagliptin (kusanthula kwa gulu kuchokera ku 2.5 mpaka 10 mg) ndi placebo;
- hypoglycemia;
- matupi awo sagwirizana ndi mawonekedwe a khungu totupa ndi urticaria;
- chisangalalo;
- Kuphwanya makonda azinthu zina ndizotheka.
Zizindikiro zotere ziyenera kutha kwathunthu pambuyo kusintha kwa mankhwalawo kapena kusiya mankhwala kwathunthu. Ngati zizindikiro za kuledzera zikhalabe, chithandizochi chitha kukhala chofunikira.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa samakhudza mwachindunji dongosolo lamanjenje. Koma zingakhale bwino kusiya kuyendetsa galimoto, chifukwa zovuta zina zomwe zimachitika mwadzidzidzi zimatha kusokoneza.
Malangizo apadera
Mukamamwa mankhwalawa, ndikofunikira kuyesedwa kuti muone kusintha kwa impso. Pali chiopsezo chachikulu cha lactic acidosis. Izi zimachitika makamaka kwa okalamba.
Mukamagwiritsa ntchito Saksagliptin, kuchepa kwa mankhwalawa kwa pafupifupi ma lymphocyte kumatha kuchitika. Zotsatira zake zimawonedwa pakumwa mlingo wa 5 mg mu regimen yoyambirira ndi Metformin poyerekeza ndi monotherapy ndi Metformin yokha.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Sitikulimbikitsidwa kutenga nthawi yakubala. Masiku ano, palibe kafukufuku wosakwanira ngati mapiritsi ali ndi mphamvu iliyonse pa mwana wosabadwayo. Mankhwala amatha kuthandizira kuoneka ngati ali ndi vuto pakukula kwa mwana wosabadwa komanso kuchedwa pakukula kwake. Ngati ndi kotheka, amayi onse apakati amasamutsidwa kupita ku chithandizo cha insulin pamtengo wotsika.
Iwo ali osavomerezeka kumwa mankhwala munthawi ya bere.
Palibe zambiri zodalirika ngati mankhwalawa amatha kudutsa mkaka wa m'mawere. Chifukwa chake, akatswiri amalangiza kuti asiye kuyamwa.
Kukhazikitsa Comboglize kwa ana
Ana sayenera kutenga. Sizinachitikepo zochiritsa ana ndi odwala osakwana zaka 18.
Gwiritsani ntchito mu ukalamba
Ndi chisamaliro chapadera, mankhwalawa amaperekedwa kwa okalamba. Ali ndi chiwopsezo chowonjezeka pamavuto osiyanasiyana, chifukwa chake, kuyang'anira nthawi zonse zaumoyo wa akatswiri ndi endocrinologist kumafunika. Ngati pakufunika izi, ndiye kuti mlingowo umachepetsedwa wotsika kwambiri, pomwe njira zochiritsira zabwino zimakwaniritsidwa. Kuti apange zochita za placebo, mavitamini owonjezera amalembedwa kwa odwala ena okalamba, makamaka omwe ali ndi vuto la m'maganizo.
The ntchito aimpso kuwonongeka
Pali chiwopsezo chowonjezeka cha metabolic acidosis yogwiritsidwa ntchito nthawi yayitali. Ndikwabwino kwa odwala omwe ali ndi vuto la aimpso kulephera kuchepetsa mlingo wochepa kapena kukana kumwa mankhwalawo.
Sizoletsedwa kutenga odwala omwe ali ndi vuto la chiwindi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Sizoletsedwa kutenga odwala omwe ali ndi vuto la chiwindi.
Kuchuluka kwa Comboglize
Mankhwalawa amaloledwa ndi odwala. Pali milandu yambiri ya bongo. Pokhapokha mwadzidzidzi kukonzekera kwa mlingo waukulu kumawoneka zina mwanjira zikusonyeza kukula kwa lactic acidosis. Chodziwika pakati pawo:
- mavuto ndi kupuma;
- kutopa ndi kukwiya kwambiri;
- minofu kukokana;
- kupweteka kwambiri pamimba;
- mawonekedwe akununkhira kwa acetone kuchokera mkamwa.
Pankhaniyi, chapamimba kapena hemodialysis chingathandize. Ndi hypoglycemia yofatsa pang'ono, amalimbikitsidwa kuti azidya zotsekemera kapena kumwa tiyi wokoma.
Kuchita ndi mankhwala ena
Kuphatikiza kwa Comboglize ndi mankhwala ena kumatha kuwonjezera plasma ndende ya lactate. Mankhwalawa ndi monga:
- kukonzekera kwa magnesium;
- Nicotinic acid;
- Rifampicin;
- okodzetsa;
- Isoniazid;
- mahomoni a chithokomiro;
- calcium tubule blockers;
- estrogens.
Kuphatikizika ndi Pioglitazone sikukukhudza pharmacokinetics a Saxagliptin. Kuphatikiza apo, kuphatikiza ndi kugwiritsidwa ntchito kamodzi kwa Saksagliptin, ndiye kuti patatha maola atatu 40 mg wa Famotidine, mawonekedwe azamankhwala nawonso sasintha.
Mukamatenga Combogliz, kugwiritsa ntchito ndalama mwanjira imeneyi kumatha kuchepa:
- Fluconazole;
- Erythromycin;
- Ketoconazole;
- Furosemide;
- Verapamil;
- Mowa.
Ngati wodwala atenga chimodzi mwazomwe zalembedwa, ndiye kuti muyenera kudziwitsa dokotala.
Kuyenderana ndi mowa
Mowa umaletsedwa kwa odwala omwe ali ndi matenda osokoneza bongo. Zimathanso kukhudzidwa kwa mankhwalawa.
Analogi
Njira zomwe zimasiyana pakapangidwe kake, koma zofanana kotheratu pakuchiritsa:
- Kutalika kwa Combogliz;
- Bagomet;
- Janumet;
- Galvus Met;
- Glibomet.
Musanayambe kulandira chithandizo chamankhwala, muyenera kuwerenga mosamala malangizo a mankhwala omwe mwasankha, popeza aliyense wa iwo atha kukhala ndi zotsutsana zambiri komanso zotsutsana. Kuphatikiza apo, mlingo wa mankhwalawo ndi wosiyana.
Kupita kwina mankhwala
Mankhwala angagulidwe ku pharmacy ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Amatulutsidwa pokhapokha atapereka chithandizo kuchokera kwa dokotala.
Mtengo wa combogliz
Mtengo wa mankhwalawo ndiwokwera kwambiri. Itha kugulidwa kuyambira 2400 rubles. Mtengo womaliza umadalira njira yomwe wopanga mankhwala adzaika ndi kuchuluka kwa mapiritsi omwe adzakhale nawo.
Zosungidwa zamankhwala
Sungani pamalo pomwe sipangachitike dzuwa. Kutentha kosungirako - chipinda. Mankhwalawa amayenera kusungidwa m'malo owuma ndikutetezedwa kwa ana aang'ono momwe angathere.
Mankhwala angagulidwe ku pharmacy ndi mankhwala.
Tsiku lotha ntchito
Ndi kusungidwa koyenera, moyo wa alumali ndi zaka 3 kuyambira tsiku lopangira lomwe lasonyezedwa phukusi loyambirira.
Wopanga
Bristol Myers squibb, USA.
Ndemanga za Comboglize
Madokotala
Stanislav, wazaka 44, katswiri wa matenda ashuga, St. Petersburg: "Ndakhala ndikugwiritsa ntchito mankhwalawa kwa nthawi yayitali mchitidwe wanga. Zotsatira zake ndi zabwino. Mulingo wa shuga m'magazi omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo amatsika pambuyo pa maphunziro. "Zimatenga ndalama zochepa kuposa nthawi yayitali, koma mphamvu zake zimakhala zofanana, kapangidwe kake kamafanana. Odwala ena amakhala ndi matendawa mosiyanasiyana mu uritisaria.
Varvara, wazaka 46, wodwala matenda am'madzi, a Penza: "Ndinkakonda kupereka mankhwala kuti magazi achepetse kuchuluka kwa shuga m'magazi. Koma panali ndemanga zambiri zoyipa kuchokera kwa odwala. Izi zimachitika chifukwa chakuti kuvuta kwambiri kumachitika nthawi zambiri. Zikatero, muyenera kusiya kulandira mankhwalawo ndikuganiza zolocha m'malo mwake. Chifukwa chake, ndikulimbikitsa kuti odwala ayambe ndi mlingo wotsika kwambiri kuti ayang'anire momwe thupi lilili.
Odwala
Valery, wazaka 38, ku Moscow: "Ndinalembera mapiritsi a endocrinologist. Ndimadwala matenda a shuga. Matenda a shuga amabwereranso mwachangu. Mfundozi zinakhalapobe kwakanthawi nditamaliza maphunziro anga. M'masiku oyambira, ndinayamba kumva kupweteka kwambiri komanso kupweteka m'mutu. Zonse zapita, mphamvu ya mankhwalawo yayamba kuchuluka. Mankhwalawa ndiokwera mtengo pang'ono. "
Andrei, wazaka 47, Rostov-on-Don: "Mankhwalawa sanakwanitse. Patatha piritsi loyamba ndinayamba kumva kupweteka. Nditayamba kusanza, mutu sunayime kwa nthawi yayitali. Ndinayenera kukaonana ndi dokotala. Anawauza kuti azidwala. Zonse zitatha kukhala zabwinobwino, mankhwala okhudzana ndi mankhwalawo adawerengedwa, komanso pambuyo pake panali zovuta zoyipa zoledzera. Kuphatikiza apo, zotupa zoyipa zimatuluka pakhungu.
Julia, wazaka 43, Saratov: "Ndikhutira ndi momwe mankhwalawo amathandizira. Thupi la shuga linayambanso kuyenda bwino.
