Momwe mungagwiritsire ntchito mankhwala Trulicity?

Trulicity ndi othandizira kwambiri a hypoglycemic, omwe ndi agonist wa glucagon-polypeptide (GLP) receptors. Zimapereka zotsatira zabwino mu non-insulin-basedabetes mellitus (mtundu 2). Zingwe zitha kugwiritsidwa ntchito limodzi ndi mankhwala a monotherapy, komanso kuwonjezera pa mankhwala omwe ali kale ndi antidiabetes.

Dzinalo Losayenerana

Adagawidwa pansi pa dzina Dulaglutid.

ATX

Ili ndi code A10BJ05 (othandizira a hypoglycemic).

Kutulutsa mafomu ndi kapangidwe kake

Njira yotheka popanda kupaka utoto. 1 cm³ imakhala ndi 1.5 mg kapena 0,75 mg wa piritsi lantiglutide. Cholembera chovomerezeka chimakhala ndi 0,5 ml ya yankho. Singano ya hypodermic imaperekedwa ndi syringe. Pali ma syringes anayi phukusi limodzi.

Cholembera chovomerezeka chimakhala ndi 0,5 ml ya yankho.

Zotsatira za pharmacological

Popeza agonist a GLP-1 receptors, mankhwalawa amachepetsa shuga chifukwa cha kupezeka kwa molekyulu ya analogues ya peptide yosinthika ya glucagon. Zimagwirizanitsidwa ndi tsamba la anthu omwe amasinthidwa immunoglobulin IgG4. Molekyulu ya zinthu yapangidwa kuti ichepetse mphamvu ya chitetezo cha mthupi.

Ndi kuchuluka kwa shuga, mankhwalawo amathandizira kupanga insulin. Nthawi yomweyo, mankhwalawa amakakamiza kupanga shuga kwa anthu odwala matenda ashuga a 2. Pankhaniyi, kuchuluka kwa shuga m'magazi a chiwindi kumachepa, chifukwa chake ndizotheka kuwongolera kuchuluka kwa shuga m'magazi.

Odwala omwe apezeka ndi matenda a shuga a 2, mankhwalawo amachokera jakisoni woyamba. Mwakutero, zimathandizira kutsitsa muyeso musanadye chakudya cham'mawa, musanadye komanso pambuyo chakudya. Izi zimasungidwa kwa masiku onse 7 asanayambitsidwe kwina kwa mankhwala.

Ndi kuchuluka kwa shuga, mankhwalawo amathandizira kupanga insulin.

Kafukufuku wokhudzana ndi chinthu adawonetsa kuti mankhwalawa amachititsa magawo onse a kapangidwe ka insulin m'matumba a kapamba. Jakisoni imodzi imalola kuwonjezera njira yopanga insulin kwambiri anthu omwe akudwala matenda a shuga omwe amadalira insulin.

Pharmacokinetics

Pambuyo pa mankhwala, mankhwalawa kwambiri adasungidwa patatha masiku awiri. Kachigawo kakakulu ka plasma kanadulitsidwa ndi masabata 2-4 kuyambira pakuyamba chithandizo. Zizindikirozi sizinasinthe ngakhale kuti ndi gawo liti la thupi lomwe mankhwalawo adalowetsedwa. Itha kupundidwa ndi mphamvu yofanana pansi pa khungu la malo ololedwa a thupi molingana ndi malangizo, omwe amakupatsani mwayi wophatikiza malo opangira jekeseni.

The bioavailability popereka kuchuluka kwa 0,75 mg ndi pafupifupi 65%, ndipo pa 1.5 mg yochepera theka. Mankhwalawa amang'ambika kukhala ma amino acid m'thupi. Zaka, jenda, mtundu wa anthu sizikhudza pharmacokinetics yamankhwala. Ndi osakwanira aimpso ntchito, njira magawikidwe ndi kuchotsedwa kwa mankhwala kuchokera mthupi kusintha pang'ono.

Ndi osakwanira aimpso ntchito, njira magawikidwe ndi kuchotsedwa kwa mankhwala kuchokera mthupi kusintha pang'ono.

Zizindikiro zogwiritsidwa ntchito

Mankhwalawa adalembedwa:

• ndi monotherapy (chithandizo ndi mankhwala amodzi), pamene zochita zolimbitsa thupi pamlingo woyenera komanso zakudya zopangidwa mwapadera zokhala ndi chakudya chochepa cha mafuta sizikukwanira pakuwongolera shuga;
• Ngati mankhwala a Glucophage ndi mawonekedwe ake amafanikiridwa pazifukwa zilizonse kapena mankhwalawa saloledwa ndi anthu;
• Mankhwala ophatikizika pamodzi ndi kugwiritsa ntchito munthawi yomweyo mankhwala ena ochepetsa shuga, ngati chithandizo chotere sichimabweretsa chithandizo chofunikira.

Mankhwalawa sanatchulidwe kuchepa thupi.

Kuti achepetse kuchuluka kwa shuga m'magazi, amatenga njira ya Diaformin.

Malangizo ogwiritsira ntchito Metformin-Teva.

Mukamasintha kuchuluka kwa shuga, mapiritsi a Amaryl amagwiritsidwa ntchito. Werengani zambiri za mankhwalawa apa.

Contraindication

Otsimikizika muzochitika zotere:

• kukhudzika kwakukulu pazogwira ntchito;
• shuga wodalira insulin, pamene wodwalayo amakakamizidwa kulandira jakisoni wa insulin;
• matenda ashuga ketoacidosis;
• kutchulidwa aimpso ntchito, pamene zikuwonetsa ntchito zawo ndi chizolowezi chosamutsa wodwala kuti dialysis kapena kumuika;
• mtima wowopsa komanso kuperewera kwam mtima chifukwa cha zovuta za matenda a shuga;
• matenda akulu am'mimba, makamaka, kutchulidwa kwa chapamimba;
• kutupa kwachimbudzi kwa kapamba (odwala oterewa pambuyo pake amafunika kusamutsidwa ku insulin);
• manja
• nthawi ya mkaka wa m`mawere;
• azaka zapakati pa 18 (maphunziro azachipatala pachitetezo cha kugwiritsa ntchito ana sanachitepo).

Mwa zina zotsutsana ndi munthu wazaka zosakwana 18.

Mu kutupa kwapakhungu, mankhwalawa amatsutsana.

Osagwiritsa ntchito mankhwalawa panthawi yoyamwa.

Saloledwa kugwiritsa ntchito mankhwalawa matenda akulu am'mimba.

Ndi chisamaliro

Trulicity iyenera kulembedwa mosamala kwa anthu omwe amagwiritsa ntchito mankhwala omwe amafunikira kuti amidwe m'mimba ndi matumbo. Ndi chisamaliro chachikulu, lembani ndalama kwa anthu azaka zopitilira 75.

Momwe mungatengere Trulicity

Kumwa mankhwala a shuga

Mankhwalawa amagwiritsidwa ntchito pokhapokha. Mutha kuchita jakisoni pamimba, ntchafu, phewa. Intramuscular kapena intravenous management sikoletsedwa. Subcutaneally amatha kubayidwa nthawi iliyonse masana, mosasamala zakudya.

Ndi monotherapy, 0,75 mg uyenera kuperekedwa. Pankhani ya chithandizo chophatikiza, 1.5 mg ya yankho iyenera kuperekedwa. Kwa odwala azaka zapakati pa 75 ndi kupitilira, 0,75 mg ya mankhwalawa amayenera kuperekedwa, mosasamala mtundu wa chithandizo.

Ngati mankhwalawa adawonjezeredwa kwa mankhwala a Metformin ndi mankhwala ena ochepetsa shuga, ndiye kuti mlingo wawo suwosinthidwa. Pochiza ndi analogues ndi zotumphukira za sulfonylurea, prandial insulin, ndikofunikira kuchepetsa kuchuluka kwa mankhwalawa kuti mupewe chiopsezo cha hypoglycemia.

Ngati mlingo wotsatira wa mankhwalawo watayika, ndiye kuti uyenera kutumikiridwa posachedwa, ngati masiku opitilira atatu atatsala jakisoni wotsatira. Ngati masiku osakwana 3 asiyidwa jakisoni asanachitike, ndiye kuti kutsata kwotsatira kumapitilira malinga ndi dongosolo.

Mankhwalawa amagwiritsidwa ntchito pokhapokha. Mutha kuchita jakisoni pamimba, ntchafu, phewa.

Kumayambiriro kumatha kuchitika pogwiritsa ntchito cholembera. Ichi ndi chipangizo chimodzi chokhala ndi 0,5 ml ya mankhwala omwe ali ndi yogwira ya 0,5 kapena 1.75 mg. Cholembera chimayambitsa mankhwalawo atangosinikiza batani, pomwepo amachichotsa. Zotsatira za jakisoni motere:

• chotsani mankhwalawo mufiriji ndikuwonetsetsa kuti mawuwo ndi abwino;
• yang'anani cholembera;
• sankhani malo a jakisoni (mutha kudziyambitsa nokha m'mimba kapena ntchafu, ndipo wothandizira akhoza kupanga jakisoni mapewa);
• chotsani kapu ndipo musakhudze ndi singano yosabala;
• kanikizani pansi mpaka pakhungu paja jakisoni, muzungulire mphete;
• kanikizani ndikuyika batani m'malo ano mpaka litadina;
• pitilizani kukanikiza pansi mpaka kudina kwachiwiri;
• chotsani chogwirizira.

Pang'onopang'ono, mankhwalawa amatha kubayidwa nthawi iliyonse masana, mosasamala zakudya.

Maphunzirowa amatenga nthawi yayitali bwanji

Kutalika kwa mankhwala ndi miyezi itatu. Popeza mankhwalawa ndi oyenera kulandira chithandizo chamanthawi yayitali, adokotala amatha kuwonjezera nthawi yolowa.

Zotsatira zoyipa Trulicity

Nthawi zambiri, odwala amawona mawonekedwe a kukhumudwa m'mimba ndi matumbo. Kusintha konseko kudadziwika kuti kunali kofatsa komanso koyenera. Nthawi zina odwala amakhala ofatsa atrioventricular block. Kumwa mankhwalawa mu Mlingo woyenera kungayambitse kuchuluka kwa mtima pafupipafupi - kumenyedwa ndi pafupifupi 2 pamphindi. Zilibe tanthauzo m'chipatala.

Kulandila kumalumikizidwa ndi kuwonjezereka kwa ntchito ya ma pancreatic enzymes. Izi sizinayambitse zizindikiro za pancreatitis pachimake.

Pazithandizo, odwala adawona mawonekedwe a kukhumudwa m'mimba ndi matumbo.

Matumbo

Kuchokera kugaya ziwalo za odwala, nseru, kutsegula m'mimba, ndi kudzimbidwa zinaonedwa. Nthawi zambiri pamakhala zochitika za kuchepa kwa chidwi mpaka kukomoka, kutulutsa ndi matenda a gastroesophageal. Nthawi zina, kuvomereza kumayambitsa pancreatitis yovuta kwambiri, yomwe imafunikira opaleshoni yofunikira mwachangu.

Matenda a metabolism komanso zakudya

Anthu odwala matenda ashuga nthawi zambiri amakhala atapitirira mu hypoglycemia. Izi zinadzuka chifukwa chogwiritsa ntchito Metformin kapena prandial insulin kukonzekera, kuphatikiza Glargina. Nthawi zambiri, odwala anakumana ndi hypoglycemia monga yankho la monotherapy ndi mankhwalawa.

Pakati mantha dongosolo

Pafupifupi, kuyambika kwa mankhwalawa kunayambitsa chizungulire, minyewa.

Nthawi zina, munthawi ya chithandizo ndi mankhwalawa, odwala adazindikira mawonekedwe a kutsegula m'mimba ndi kudzimbidwa.

Mwa odwala ena, mankhwalawa amayambitsa nseru.

Pa chithandizo, chizungulire sichimachotsedwa.

Momwe thupi limasokoneza.

Matupi omaliza

Pafupipafupi, odwala anali ndi machitidwe osiyanasiyana monga Quincke's edema, urticaria wamkulu, zotupa zambiri, nkhope, milomo ndi larynx. Nthawi zina mantha a anaphylactic amakula. Odwala onse omwe amamwa mankhwalawo, ma antibodies ena aomwe amapangira mankhwala, amoglutide, sanapangidwe.

Nthawi zina, pakhala zochitika zakumaloko zomwe zimakhudzana ndikuyambitsa yankho pansi pakhungu - zotupa ndi zotupa. Zochitika ngati izi zinali zofooka ndipo zidapita mwachangu.

Zokhudza mphamvu pakuwongolera njira

Iyenera kuchepetsa ntchitoyo ndi njira zovuta komanso kuyendetsa odwala omwe ali ndi chizolowezi ndipo chizungulire magazi.

Ngati pali chizolowezi chotsika magazi, ndiye kuti pakanthawi kokhala chithandizo ndikofunika kusiya kuyendetsa galimoto.

Malangizo apadera

Kapangidwe kakeglutide kumathandizira kuchedwetsa kutuluka kwa zinthu zam'mimba. Chifukwa chake, zimakhudzanso kuyamwa kwa kuchuluka kwakukulu kukonzekera pakamwa.

Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pochiza odwala omwe ali ndi matenda ashuga a mtundu woyamba. Palibe zokuchitikirani ndi kugwiritsa ntchito mankhwala osokoneza bongo omwe ali ndi vuto lalikulu mtima.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Palibe chidziwitso cha mankhwala omwe mankhwalawa amupatsa panthawi ya bere. Kafukufuku wokhudzana ndi ntchito ya kudyaglutide mu nyama yathandizira kuzindikira kuti ili ndi poizoni pa mwana wosabadwayo. Pachifukwa ichi, kugwiritsidwa ntchito kwake mu nthawi ya phwando ndizoletsedwa.

Mkazi yemwe amalandila chithandizo ndi mankhwalawa amatha kukonza pakati. Komabe, zizindikilo zoyambirira zikawoneka zomwe zikusonyeza kuti mimba yachitika, njira yothetsera mankhwalawa iyenera kuthetsedwera ndikuyimiliratu zotetezedwa. Simuyenera kuchita chiopsezo kupitiliza kumwa mankhwala panthawi yomwe muli ndi pakati, chifukwa kafukufuku amawonetsa kuti angakhale ndi mwana wofooka. Mankhwala amatha kusokoneza mafupa.

Palibe chidziwitso chokhudza kuyamwa kwa lulaglutide mkaka wa amayi. Komabe, chiopsezo cha zotsatira zoyipa kwa mwana sichitha, chifukwa chake, mankhwalawa amaletsedwa panthawi yoyamwitsa. Ngati pakufunika kupitiliza kumwa mankhwalawo, ndiye kuti mwana amasinthidwa kudyetsa mankhwala osokoneza bongo.

Palibe chidziwitso cha mankhwala omwe mankhwalawa amupatsa panthawi ya bere.

Kupangira Trulicity kwa ana

Sanapatsidwe.

Gwiritsani ntchito mu ukalamba

Mosamala, muyenera kubaya jakisoni mutatha zaka 75.

Kuchulukitsa kwa Trulicity

Pankhani ya mankhwala osokoneza bongo, zizindikiro za kuperewera kwa m'mimba thirakiti ndi kuchepa kwa shuga zitha kuwonedwa. Chithandizo cha zinthuzi ndi chizindikiro.

Kuchita ndi mankhwala ena

Milandu yodziwika kwambiri yokhudzana ndi mankhwala osokoneza bongo ndi awa:

1. Paracetamol - kuchuluka kwa mankhwalawa sikofunikira, kutsika kwa mayiyo ndi kochepa.
2. Atorvastatin ilibe kusintha kofunikira pochiritsa mukamagwiritsidwa ntchito mosiyanasiyana.
3. Mankhwalawa ndi kuhlalaglutide, kuchuluka kwa Digoxin sikofunikira.
4. Mankhwala amatha kupatsidwa mankhwala ena onse a antihypertensive.
5. Zosintha pakugwiritsa ntchito warfarin sizofunikira.

Ngati mankhwala osokoneza bongo, zizindikiro za kusokonezeka kwam'mimba thirakiti zimawonedwa.

Kuyenderana ndi mowa

Zosagwirizana ndi mowa. Kulephera kutsatira lamuloli kumawopseza zovuta zazikulu komanso kukhazikika kwa hypoglycemia.

Analogi

Ma Analogs ndi:

• Dulaglutide;
• Liraglutide;
• Saxenda;
• Exenatide;
• Victoza.

Kupita kwina mankhwala

Kugulitsa kokha pakupereka mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Mankhwalawa sangagulidwe popanda mankhwala. Pali chiopsezo chachikulu chopeza zabodza, zomwe zimatha kuvulaza thupi.

Mtengo Wotsika

Mtengo wopakika mankhwala kuchokera ku ma ampoules 4 ku Russia amachokera ku ruble 11,000.

Zosungidwa zamankhwala

Cholembera chimbale chimasungidwa mufiriji. Ngati palibe zoterezi, ndiye kuti zimasungidwa kwa milungu yopitilira 2. Pambuyo pa nthawi imeneyi, kugwiritsa ntchito mankhwalawa ndizoletsedwa, chifukwa amasintha malowo ndikuyamba kufa.

Mankhwalawa sangaphatikizidwe ndi mowa.

Tsiku lotha ntchito

Malondawa ndi oyenera kugwiritsidwa ntchito kwa zaka 2 kuyambira tsiku lopangira, malinga ngati lisungidwa mufiriji. Ikasungidwa kutentha, kufunda kumachepetsa kukhala masiku 14.

Wopanga

Yopangidwa ku Eli Lilly & Company, United States of America. Eli Lilly & Co, Lilly Production Center, Indianapolis, USA.

Ndemanga za Trulicity

Madokotala

Irina, wodwala matenda ashuga, wazaka 40, ku Moscow: "Mankhwalawa akuwonetsa kugwiritsidwa ntchito bwino kwa mankhwalawa a matenda a matenda a shuga a mtundu wa 2. Ndimamupatsiratu monga mankhwala ndi Metformin ndi mankhwala ake. Popeza mankhwalawo amafunika kuperekedwa kwa wodwala kamodzi pa sabata, palibe zotsatirapo zake za mankhwalawa. amawongolera kuchuluka kwa shuga wamagazi mukatha kudya ndikulepheretsa kukula kwa mitundu yoopsa ya hyperglycemia. "

Oleg, endocrinologist, wazaka 55, Naberezhnye Chelny: "Pogwiritsa ntchito chida ichi, ndizotheka kuyendetsa bwino njira ya odwala omwe samadalira insulin m'magulu osiyanasiyana a odwala. Ndimapereka mankhwala ngati mankhwala a Metformin sabweretsa zotsatira zomwe akufunazo ndipo wodwalayo amakhalabe wokwera shuga pambuyo pamapiritsi a Glucofage. Zizindikiro za matenda ashuga ndipo zimatsimikizira mitengo yokhazikika. "

Odwala

Svetlana, wazaka 45, Tambov: "Mothandizidwa ndi mankhwalawa ndizotheka kukhala ndi thanzi labwino la shuga. Ndikamamwa mapiritsiwa, ndimakhalabe ndi shuga wambiri, ndimatopa, ndimva ludzu, nthawi zina ndimalephera chifukwa cha kuchepa kwambiri kwa shuga. Mankhwalawa adathetsa zovutazi, tsopano ndikuyesera sungani kuchuluka kwa shuga m'magazi anu. "

Sergey, wazaka 50, ku Moscow: "Chida chothandiza kuthana ndi matenda a shuga. Ubwino wake ndikuti muyenera kupaka jakisoni kamodzi pa sabata. Ngati mugwiritsa ntchito mankhwalawa munthawi imeneyi, palibe zotsatirapo zake. "glycemia yakhazikika, thanzi layamba bwino. Ngakhale mtengo uli wokwera, ndikufuna kukonza kupitiliza chithandizo."

Elena, wazaka 40, ku St. Petersburg: "Kugwiritsa ntchito mankhwalawa kumakuthandizani kuti muchepetse matenda ashuga ndikuchotsa zizindikiro za matendawa. Nditabayidwa jakisoni, ndinazindikira kuti index ya shuga yayamba kuchepa, ndipo idayamba bwino, ndipo kutopa kumatha.Ndimayang'anira mawonetsero a glucose tsiku lililonse. Ndakwanitsa kuti pamimba yopanda kanthu gluceter samawonetsa pamwamba 6 mmol / l. "