Thrombomag - mankhwala a gulu la NSAID, amawonetsa antiplatelet. Chifukwa cha ichi, chiopsezo chotenga zovuta zomwe zimayambitsidwa ndikupanga magazi kumachepetsedwa. Kuphatikiza apo, mankhwalawa amawonetsera katundu wina, makamaka, amathandiza kuthetsa kutupa.
Dzinalo Losayenerana
Acetylsalicylic acid + Magnesium hydroxide
Thrombomag - mankhwala a gulu la NSAID, amawonetsa antiplatelet.
ATX
B01AC30
Kutulutsa mafomu ndi kapangidwe kake
Mankhwalawa akhoza kugulidwa kokha ngati mapiritsi. Amayimira gulu la zida ziwiri. Ntchito zowonetsera pazinthu zimadziwika ndi katundu wosiyanasiyana. Monga yogwira zinthu ndi:
- acetylsalicylic acid;
- magnesium hydroxide.
Mapiritsi ali ndi kuchuluka kosiyanasiyana kwa zinthuzi. Mwachitsanzo, mlingo wa ASA ndi 0,75 ndi 0,1515. Magnesium chloride uli ndi piritsi limodzi mu 15.2 ndi 30.39 mg. Mapiritsiwa adakutidwa, koma mosiyana ndi fanizo, amaloledwa kupukusa musanatenge. Kuphatikiza apo, zigawo za Thrombomag zimaphatikizapo zinthu zomwe sizikuwonetsa ntchito zotsutsana ndi zotupa:
- wowuma chimanga;
- wowuma mbatata;
- ma cellcose a microcrystalline;
- citric acid;
- magnesium wakuba.
Mankhwalawa amaperekedwa m'matumba (3 ndi 10 ma PC), Iliyonse ili ndi mapiritsi 10.
Mankhwalawa akhoza kugulidwa kokha ngati mapiritsi.
Zotsatira za pharmacological
Cholinga chachikulu cha mankhwalawa ndikuletsa zolengedwa za thromboxane A2. Izi zimatheka popewa kapangidwe ka COX-1 isoenzymes. Komabe, pali kuchepa kwa kukula kwa kupanga kwa impso prostaglandins. Chifukwa cha izi, mawonekedwe owoneka otupa amatuluka pang'onopang'ono kapena kuuma kwawo kumachepa kwambiri.
ASA imagawidwa mthupi lonse, osangopereka ma antithrombotic, anti-yotupa, komanso yopereka antipyretic. Otsiriza a malowo ali chifukwa chakuchulukirachulukira kwa hypothalamus komanso likulu la thermoregulation. Mutatha kumwa mankhwalawa, acetylsalicylic acid umapukusika, chifukwa chake, ma salicylates amasulidwa. Zinthu izi zimathandizira kuchepetsa mphamvu ya algogenic ya bradykinin, chifukwa chomwe amachepetsa kwambiri kupweteka.
Chifukwa cha kuchuluka kwazinthu zomwe zimadziwika ndi ASA, thunthu limayambitsidwa pakupanga mankhwala ambiri. Mphamvu yake ya antiplatelet imachitika chifukwa sangathe kuletsa kaphatikizidwe kamapulateni, komanso kuchepetsa kutsika kwake. ASA imakhudzanso nembanemba yama cell ofiira, pomwe mavuto awo amachepa. Zotsatira zake, njira yodutsa maselo ofiira am'magazi kudzera mwa ma capillaries imathandizidwa, chifukwa momwe mawonekedwe a magazi amadziwika, madzi ake amachepa.
Mphamvu ya mankhwalawa imawonjezera magazi. Chuma china cha ASA yophatikizira ndikuchotsa ziwalo zamagazi. Zotsatira zonse zoperekedwa ndi izi ndizolumikizidwa. Chifukwa chake, katundu wothandizira kuphatikiza amatsimikiziridwa ndi kumasulidwa kwa ma prostaglandins, koma ndi mtundu wina wa zochitika. Izi zimachepetsa calcium ya ionized, yomwe imathandizira kuchepetsa kuthekera kwa kuphatikiza mapulateleti.
Katundu wanyumba ya ASA ndiye kuchotsedwa kwa magazi.
Choipa cha mankhwalawa ndi kuponderezedwa kwa kapangidwe ka antithrombotic prostaglandins. Izi zimaperekedwa ngati mankhwalawa amamwa mlingo waukulu. Zotsatira zake ndi zosemphana ndi zomwe mukufuna. Pachifukwa ichi, mlingo wa tsiku ndi tsiku womwe wopangidwa ndi wopanga (osaposa 325 mg) uyenera kutsatiridwa.
Gawo lina lolimbikira lomwe limapangidwa likuwonetsa katundu wa antacid ndi mankhwala ofewetsa tuvi tolimba. Chifukwa cha ichi, chiwopsezo cha zovuta panthawi ya mankhwala amachepetsa, chifukwa mankhwalawa amachepetsa mphamvu ya ASA pamitsempha ya m'mimba. Mutatha kumwa mankhwalawa, magnesium hydrochloride imalumikizana ndi madzi am'mimba, omwe amatsogolera pakupanga kwa magnesium chloride.
Vutoli likakafika m'matumbo, zimakhala zotupa. Izi ndichifukwa chakutha kusungunuka bwino m'malo oterowo. Magnesium chloride amadzutsa peristalsis wa chiwalo. Chuma china ndichotheka kumanga ndi bile acid. Izi zimadyedwa ndi thupi pang'onopang'ono, zomwe zimathandizira kuti zizichita nthawi yayitali.
Mutatha kumwa mankhwalawa, magnesium hydrochloride imalumikizana ndi madzi am'mimba, omwe amatsogolera pakupanga kwa magnesium chloride.
Pharmacokinetics
Ndikulimbikitsidwa kuti mupeze mankhwalawo mosiyana ndi chakudya, chifukwa kuyamwa kwa zinthu zomwe zimagwira kumatha kuchepa, zomwe zingakhudze kumasulidwa kwawo. Zigawo za mankhwalawa zimamwetsedwa nthawi yomweyo, komanso zonse. Njira yosinthira acetylsalicylic acid ndiyambiriyambiri. Choyamba, salicylic acid imamasulidwa, yomwe imapangidwa pambuyo pake ndikuwoneka kwa mitundu ingapo: phenyl salicylate, glucuronide salicylate, salicyluric acid.
Kuchita bwino kwa mankhwalawa kumachitika mphindi 10-20 mutamwa mapiritsi. Kugawa kwambiri mthupi lonse chifukwa chakugwirizana kwambiri ndi mapuloteni amwazi. Komabe, njirayi imatengera muyeso wa ASA: kuchuluka kwa kuchuluka kwa mankhwalawa, ndiye kuti molekyu mamolekyulu a zinthu amaphatikizika ndi mapuloteni a plasma.
Zigawo zomwe zimagwira zimachotsedwa m'magazi mwachangu - mkati mwa mphindi 20, metabolites imachedwa kwakanthawi. ASA imachoka kwathupi pambuyo masiku 1-3. Impso ndi zomwe zimayambitsa ntchito yochotsa zigawo zikuluzikulu. Gawo lachiwiri lothandiza (magnesium hydrochloride) silikuwakhudza bioavailability wa acetylsalicylic acid.
Ndi bwino kumwa mankhwalawo mosiyana ndi chakudya.
Zizindikiro zogwiritsidwa ntchito
Njira yothetsera mankhwalawa imalembedwa pamikhalidwe yotere:
- kupewa kwakukulu kwa matenda osiyanasiyana a CVD: embolism ndi thrombosis ya mitsempha ndi mitsempha, kulephera kwa mtima, ngati pali zifukwa zowopsa: matenda ashuga, matenda oopsa, zizolowezi zoipa, monga kusuta fodya kapena kuledzera;
- angina pectoris wa chikhalidwe chosakhazikika;
- kupewa kwachiwiri kwa myocardial infarction;
- kupewa mavuto pambuyo opaleshoni, chiopsezo cha izi zimawonjezeka pambuyo pa kugwirana kwa mitsempha yodutsa, kumalumikizana.
Kodi ingathandize kuthamanga kwa magazi?
Mankhwala omwe akufunsidwa amathandizira kuchepa kwa kuthamanga kwa magazi, koma kwakukulu kwambiri izi zimawonekera pambuyo podyera mapiritsi asanagone. Tiyenera kukumbukira kuti mothandizidwa ndi Thrombomag, kupsinjika kumatha kugonja. Pazifukwa izi, siziyenera kugwiritsidwa ntchito pomwa mankhwala a antihypertensive.
Contraindication
Mankhwala ali ndi zoletsa zambiri pakusankhidwa kwake:
- kuwonongeka kwa kupuma dongosolo pa mankhwala ndi acetylsalicylic acid;
- Zotsatira zoyipa za munthu wina pakulowa kwa ASA ndi ziwalo zina kapangidwe kake;
- seti la pathologies: mphumu ya bronchial, kuchulukana kwa mphuno, hypersensitivity kwa acetylsalicylic acid, Pankhaniyi, chiopsezo cha kupuma chimawonjezeka;
- magazi m'mimba;
- matenda am'mimba;
- Kukula kwa kukokoloka kwa kapangidwe ka makoma am'mimba;
- chiopsezo chotaya magazi (motsutsana ndi maziko a thrombocytopenia, kuchepa kwa vitamini K, etc.);
- shuga-6-phosphate dehydrogenase akusowa.
Ndi chisamaliro
Pali chiwerengero chochulukirapo cha zotsutsana mwanjira yomwe chovomerezeka chitha kugwiritsa ntchito mankhwalawa, koma muyenera kusamala:
- Hyperuricemia
- gout
- sepsis
- kale adazindikira zilonda zam'mimba ndi zilonda zam'mimba;
- mtundu wofatsa wa chiwindi ndi impso;
- mphumu ya bronchial;
- matenda a kupuma dongosolo;
- nthawi yogwira ntchito;
- chizolowezi cha ziwengo.
Kodi kutenga thrombomag?
Nthawi zambiri, kumwa kwa mapiritsi osaposa 1-2 patsiku ndi omwe amapatsidwa. Mankhwala amatengedwa kamodzi. Njira zochizira zingasiyane. Mwachitsanzo, pofuna kupewa CCC pathologies, 150 mg patsiku imayikidwa koyamba, ndiye kuti kuchuluka kwake kumachepetsedwa ndi 2 times. Nthawi zina, amatenga kuti piritsi limodzi pakhale piritsi lililonse la ASA (75 kapena 150 mg), zimatengera kutha kwa matendawa.
Ndi mawonekedwe ofatsa a impso ndi chiwindi, mankhwalawa ayenera kumwedwa mosamala.
Ndi matenda ashuga
Mankhwala amavomerezedwa kuti agwiritsidwe ntchito, kusintha kwa mankhwalawa sikuchitika, koma wodwalayo ayenera kuyang'aniridwa.
Zotsatira zoyipa za Thrombomagus
Zotsatira zoyipa pakagwiritsidwe ntchito ka mankhwala ndi othandizawa sizachilendo kwenikweni poyerekeza ndi Acetylsalicylic acid, chifukwa kuchuluka kwa zosakaniza ndizochepa, ndipo zotsatira za mapiritsi zimachepetsedwa. Zotsatira zoyipa zomwe zimachitika nthawi zambiri:
- mutu
- magazi
- bronchospasm;
- kusanza ndi kusanza
- kutentha kwa mtima.
Kupezeka kwa zizindikiro zotere kumakhala kochepa kwambiri:
- kufooka kwathunthu;
- Chizungulire
- kusamva makutu, limodzi ndi tinnitus wokhazikika;
- matenda am'mimba;
- kusokonekera kwa hematopoietic system, yomwe imawonetsedwa ndi kuchepa kwa magazi, thrombocytopenia, etc.
- kuchuluka kwa zilonda zam'mimba, zomwe nthawi zambiri zimayambitsidwa ndi kupweteka pamimba;
- mitengo;
- osiyanasiyana mawonekedwe a chifuwa: kutupa kwa kupuma thirakiti, kuyabwa, zidzolo, hyperemia, rhinitis;
- matenda aimpso.
Zokhudza mphamvu pakuwongolera njira
Kuyendetsa galimoto si kuphwanya malamulo. Komabe, poti pakabuka zovuta zina munthawi ya mankhwalawa, muyenera kusamala.
Malangizo apadera
Mukapereka mankhwala omwe mukufunsidwa musanachite opareshoni, ziyenera kukumbukiridwa kuti katundu wothana ndi mankhwala amatha kuchitika patatha masiku atatu kuchokera piritsi lomaliza.
Mankhwalawa odwala omwe ali ndi vuto la impso, ndikofunikira kuyang'anitsitsa zikuluzikulu za zomwe zikuchitika m'thupi.
Pamankhwala oyambira komanso omaliza a mankhwalawa, kuwunika kwa magazi kuyenera kuchitika.
Gwiritsani ntchito mu ukalamba
Odwala a gululi, chiopsezo chotaya magazi chikawonjezeka ngati mankhwala a Trobomag osachepera atengedwa. Popewa zovuta, magazi ndi chiwindi chazomwe zimapangidwa zimayang'aniridwa nthawi zonse.
Mwa odwala okalamba, chiopsezo chotaya magazi chimawonjezera ngati mlingo wochepa wa Trobomag watengedwa.
Kupatsa ana
Zosagwiritsidwa ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa sanatchulidwe panthawi ya bere, zoletso zimangogwiritsidwa ntchito kwa I ndi III trimesters. Kutsutsana koteroko kumachitika chifukwa cha chiwopsezo cha kukulitsa ma pathologies. Kuwona kwotseka msanga kwa ductus arteriosus mu fetus kumadziwika. Khansa ya mumtima mwa mwana imatha kukula. Mu trimester II, amaloledwa kugwiritsa ntchito mankhwalawa osaposa 150 mg patsiku.
Mukamayamwitsa, mankhwala omwe amafunsidwanso sasankhidwa.
The ntchito aimpso kuwonongeka
Kusamala kuyenera kuchitidwa, popeza kuti magnesium hydrochloride imatha kulowa m'magazi a m'magazi. Poterepa, poizoni wa zinthu zimachuluka. Njirayi imawonetsedwa ndi kukhumudwa kwa dongosolo lamanjenje lamkati.
Kulephera kwambiri kwaimpso, mankhwalawa sagwiritsidwa ntchito. Pankhaniyi, muyenera kuyang'anitsitsa chizindikiro cha creatinine chilolezo (zosakwana 30 ml pa miniti).
Kuwonongeka kwambiri kwa chiwindi ndi kuphwanya kumwa kwa mankhwalawa.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Zowonongeka zamtunduwu ndizobayira mankhwala.
Mankhwala osokoneza bongo a Thrombomag
Zotsatira zoyipa zingapo zomwe zafotokozedwa pamwambapa zimalimbikitsidwa. Ngati milingo yayikulu idatengedwa, zizindikilo zamatenda akulu zimachitika. Zizindikiro
- malungo
- Hyperventilation yamapapo;
- hypoglycemia;
- zamchere;
- ketoacidosis;
- kuwonongeka kwakukulu kwa mtima ndi kupuma.
Pankhaniyi, chithandizo chamankhwala chimaphatikizapo kufunikira kwa chifuwa cha m'mimba. Wodwala tikulimbikitsidwa kuti atenge ndi sorbent muunyinji, hemodialysis, zamchere alkaline ndi zina. Zoyesedwa zikutengedwa kuti ibwezeretse kuchuluka kwa magetsi amagetsi. Pakakhala mankhwala osokoneza bongo, wodwalayo amagonekedwa m'chipatala.
Mankhwala osokoneza bongo, mankhwala amaphatikizapo kukomoka kwa m'mimba.
Kuchita ndi mankhwala ena
Mphamvu ya methotrexate, valproic acid imatheka.
Mankhwala ndi zinthu zingapo zimadziwika, ndi munthawi yomweyo zomwe zimapangitsa zotsatirapo zoyipa:
- narcotic analgesics;
- NSAIDs;
- Insulin
- mankhwala a hypoglycemic;
- antiplatelet, anticoagulant ndi thrombolytic othandizira;
- sulfonamides;
- Digoxin;
- lifiyamu;
- Mowa.
Mulingo wogwira wa ASA umachepetsedwa motsogozedwa ndimankhwala ndi zinthu zingapo: GCS yogwiritsidwa ntchito mwadongosolo, Ibuprofen, ma antacid ena, omwe ali ndi magnesium kapena aluminium hydroxide.
Mphamvu ya Methotrexate imalimbikitsidwa pamene itengedwa ndi Thrombomag.
Kuyenderana ndi mowa
Chenjezo liyenera kuchitika pakumwa mankhwala ndi Thrombomagum, pomwe mumamwa zakumwa zoledzeretsa.
Analogi
Zinthu zomwe zingagwiritsidwe ntchito m'malo mwa mankhwalawa:
- Cardiomagnyl;
- Phasostable;
- Supombital;
- Clopidogrel Kuphatikiza.
Kupita kwina mankhwala
Mankhwalawa ndi gulu la mankhwala osokoneza bongo.
Kodi ndingagule popanda kulandira mankhwala?
Pali mwayi wotere.
Mtengo
Mtengo umasiyanasiyana kuchokera ku ruble 100 mpaka 200.
Zosungidwa zamankhwala
Kutentha kotsimikizika - osapitirira + 25 ° ะก.
Tsiku lotha ntchito
Ndizololedwa kugwiritsa ntchito malonda kwa zaka 2 kuyambira tsiku lotulutsidwa.
Wopanga
Hemofarm, Russia.
Ndemanga
Veronika, wazaka 33, wa St.
Mankhwala abwino. Adagwira pambuyo pakuchita opareshoni Zotsatira zoyipa, kupatula mawonekedwe a pakhungu poyambira koyamba, sizinali. Chifukwa cha Thrombomag, panalibe zovuta, zomwe ndizofunikira, chifukwa magazi anga ndi wandiweyani.
Elena, wazaka 42, Alupka.
Ndi matenda oopsa, ndikofunikira kuwongolera mlingo wa mankhwalawa. Ngati mumamwa mosasamala, kuthamanga kwa magazi kumatha kutsika kwambiri.Ndinali ndi mlandu: Ndinaiwala kumwa mankhwalawa nthawi, ndiye ndinakumbukira ndikumwa nthawi yomweyo, koma posakhalitsa nthawi yotsatira idzafika. Sindinasamale izi ndipo ndinayambitsa kulandira. Zotsatira zake, sanataye mtima, mwakuti mavuto ambiri adachitika.
