Lozap 50 ndi mankhwala omwe amaperekedwa kwa odwala omwe ali ndi matenda a CCC.
Dzinalo Losayenerana
Losartan.
ATX
Khodi ya ATX ndi C09C A01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi filimu. Piritsi lililonse lili ndi 50 mg yogwira pophika. Chofunikira chachikulu pa mankhwalawa ndi losartan.
Mankhwala amapezeka monga mapiritsi okhala ndi mafilimu, piritsi lililonse limakhala ndi 50 mg yogwira mankhwala.
Mapiritsi okhala ndi chinthu chofunikira cha 12,5 mg amagulitsidwanso. Mapiritsiwa ndi oyera mu utoto, oblong biconvex mawonekedwe.
Zotsatira za pharmacological
Losartan ndi chinthu chomwe chimamangiriza ma receptors ku angiotensin II. Imagwira pa AS1 receptor subtype; ma receptors otsala a angiotensin samanga.
Yogwira pophika mankhwala siziletsa ntchito za michere yomwe imakhudza kutembenuka kwa angiotensin I ku angiotensin II. Malangizo a kuthamanga kwa magazi amatsimikiziridwa ndikuchepetsa milingo ya aldosterone ndi adrenaline m'magazi. Palibe kusintha kwa kuchuluka kwa angiotensin II m'magazi.
Mothandizidwa ndi Lozap, kukana kwa zotumphukira zamagazi kumachepa. Chidacho chimachepetsa kukanikizika m'mitsempha ya kufalikira kwa m'mapapo, kumathandizira kuwonjezeka kwa diuresis.
Kutsika kwa katundu pambuyo pamitsempha yamtima kumalepheretsa kusintha kwa kusintha kwa hypertrophic mu myocardium. Losartan amachepetsa katundu pamtima pa zochitika zolimbitsa thupi mwa odwala omwe ali ndi vuto la mtima.
Lozap 50 ndi mankhwala omwe amaperekedwa kwa odwala omwe ali ndi matenda a mtima.
Kutenga mankhwalawa sikuyenda limodzi ndi kuwonongeka kwa bradykinin. Zotsatira zoyipa zomwe zimagwirizanitsidwa ndi njirayi sizimachitika pakumwa ndi Lozap. Chifukwa chakuti zochita za eniotensin-zotembenuza sizimaponderezedwa, zomwe zimachitika mu angioedema ndi zochitika zina zowopsa zimachitika nthawi zambiri.
Mphamvu ya antihypertensive ya mankhwalawa imawonekera pakangotha maola 6 mutatha kumwa mapiritsi. Zotsatira zimasungidwa tsiku lotsatira, pang'onopang'ono kuchepa.
Lozap ikuwonetsa kuyendetsa bwino pambuyo pakukonzekera kosalekeza kwa mwezi umodzi kapena kupitirira. Pankhaniyi, chithandizo chothandizira chimayendera limodzi ndi kuchepa kwa ma protein a plasma ndi ma immunoglobulins G mumkodzo mwa odwala omwe alibe matenda a shuga mellitus.
Mankhwala kumabweretsa kukhazikika kwa ndende ya urea mu plasma. Zilibe kukhudzana ndi ntchito ya Reflexic system. Mukamamwa muyezo waukulu, sasintha kuchuluka kwa shuga m'magazi.
Pharmacokinetics
Mayamwidwe yogwira zigawo zikuluzikulu za wothandizira limapezeka m'matumbo aang'ono. Pakadutsa koyamba kudzera mu thirakiti la hepatobiliary, zimatha kutuluka posinthika. Cytochrome CYP2C9 isoenzyme ikuchita nawo njirayi. Chifukwa cha kulumikizana kwamankhwala, metabolite yogwira imapangidwa. Mpaka 15% ya mlingo wotengedwa watembenuka.
Kutalika kwambiri kwa bioavailability kwa chinthu chogwira ntchito kumapitirira 30%. Yaikulu plasma ndende amawona ola limodzi pambuyo m`kamwa makonzedwe. Chizindikiro chofananira cha metabolite yogwira chimapezeka pambuyo pa maola 3-4.
Chigawochi chimagwira pafupifupi zigawo zonse za plasma. Kulowera kudzera mu BBB kuli pamlingo wochepera.
Madokotala amaletsa Lozap 50 pochiza matenda a mtima osalephera.
Yogwira pophika mankhwala imapukusidwa kudzera m'matumbo ndi impso. Hafu ya moyo wa chinthu chosasinthika ndi pafupifupi maola awiri, chizindikiro chofananira cha metabolite yogwira ntchito chimachokera ku maola 6 mpaka 9.
Zomwe zimafunikira
Lozap adafotokozeredwa motere:
- ndi matenda oopsa;
- kuchepetsa chiopsezo chokhala ndi CVD pathologies mwa anthu omwe akudwala matenda oopsa;
- ndi nephropathy chifukwa cha kagayidwe kachakudya matenda osagwirizana ndi insulin;
- zochizira matenda a mtima osalephera.
Contraindication
Zoyipa zogwiritsidwa ntchito ndi mankhwalawa ndi:
- Hypersensitivity payekha yogwira thunthu kapena zinthu zina zomwe zimapanga;
- kuphatikiza kwa mankhwala ndi aliskiren pamaso pa shuga kapena kulephera kwa impso;
- nthawi ya bere;
- nthawi ya mkaka wa m`mawere;
- zaka zakubadwa kwa ana mpaka zaka 18 (kupezeka nthawi zina).
Muyenera kusamala mukamamwa Lozap 50 pa matenda a mtima.
Ndi chisamaliro
Chenjezo makamaka mukamamwa mankhwalawa liyenera kuonedwa kwa odwala omwe ali ndi:
- Hyperkalemia
- kulephera kwa mtima limodzi ndi zovuta aimpso;
- ngozi zam'magazi;
- kulephera kwamtima kwambiri ndi mtima;
- aimpso mtima stenosis;
- matenda a mtima;
- ochepa hypotension;
- stenosis ya mitral ndi aortic valavu;
- hypertrophic cardiomyopathy;
- kutsika kwa kuchuluka kwa magazi;
- aldosteronism yoyamba;
- zosokoneza muyezo wamagetsi wamagetsi.
Kusamala makamaka pamene mukumwa mankhwalawa kuyenera kuonedwa kwa odwala omwe ali ndi vuto la ubongo.
Momwe mungatenge Lozap 50
Mapiritsi amatengedwa pakamwa, ngakhale nthawi yakudya. Kuphatikiza kwa mankhwalawa ndi mankhwala ena omwe amachepetsa kuthamanga kwa magazi ndizotheka.
Mlingo wokhazikika wa mankhwalawa kwa odwala omwe alibe concomitant pathologies ndi 50 mg. Mankhwala amatengedwa tsiku lililonse 1 pa tsiku. Kuchuluka kwa hypotensive kumawonedwa ndikugwiritsidwa ntchito kosalekeza kwa Lozap pafupifupi mwezi umodzi.
Ngati ndi kotheka, ndizotheka kuwonjezera mlingo wa tsiku ndi tsiku mpaka 100 mg. Anthu omwe amachepetsa magazi mozungulira amalandila theka la muyezo. Odwala ochepetsedwa aimpso ntchito amafunikanso kuchepetsa kuchepa.
Kulephera kwamtima kosalekeza, tikulimbikitsidwa kuti muyambitse mankhwala omwe ali ndi 12,5 mg. Popanda mphamvu yokwanira, amatha kuwonjezera milungu 7 iliyonse. Kuchuluka kwa mankhwala omwe amwedwa kuyenera kukhala kotero kuti kumatha kukhalabe pakati pa magwiridwe antchito a mankhwalawa komanso kusakhalapo poyipa.
Mapiritsi amatengedwa pakamwa, ngakhale nthawi yakudya.
Kumwa mankhwala a shuga
Odwala omwe ali ndi matenda osokoneza bongo omwe samadalira insulin amayamba mankhwala ndi muyezo wokwanira. Mwina kuchuluka kwake mpaka 100 mg / tsiku. Kuphatikizidwa ndi insulin ndi njira zina zowongolera shuga m'magazi, kukodzetsa thupi sikuwonjezera chiopsezo cha mavuto.
Zotsatira zoyipa
Matumbo
Mitsempha yamagayidwe ingayankhe chithandizo:
- mawonekedwe a kupweteka m'dera la epigastric;
- phokoso mokhumudwa;
- nseru
- kusanza
- kuchepa kwa chakudya;
- gastritis;
- kutulutsa;
- kuchuluka kwa aimpso michere.
Hematopoietic ziwalo
Nthawi zina amati:
- kuchepa magazi
- kuchepa kwa hemoglobin;
- thrombocytopenia;
- eosinophilia.
Pakati mantha dongosolo
Kuchokera wamanjenje amatha kuchitika:
- kutopa;
- Chizungulire
- mavuto atulo
- kulakwira;
- Kukhumudwa
- paresthesia;
- tinnitus;
- kulephera kudziwa;
- mutu.
Kuchokera kwamikodzo
Nthawi zina zotsatirazi zoyipa zimachitika:
- kulephera kwaimpso;
- matenda a kwamkodzo thirakiti
Kuchokera ku kupuma
Zitha kuchitika:
- kutupa kwa bronchi;
- pharyngitis;
- sinusitis
Pa khungu
Pali chiopsezo cha:
- erythema;
- dazi;
- kuzindikira kwa ma radiation a ultraviolet;
- khungu louma;
- zotupa;
- Hyperhidrosis.
Kuchokera ku genitourinary system
Zitha kuchitika:
- kukanika kwa erectile;
- kusabala.
Kuchokera pamtima
Zitha kuchitika:
- kuchuluka kwa mtima;
- kuchuluka kwa mtima;
- kugwa kwa orthostatic;
- bradycardia;
- kupweteka kumbuyo kwa sternum;
- vasculitis;
- mphuno.
Kuchokera ku minculoskeletal system
Kuchiza kumayendetsedwa ndi zotsatirazi zosavomerezeka:
- lumbalgia;
- kukokana
- kupweteka kwa minofu;
- kupweteka kwa molumikizana.
Kuchokera kumbali ya kagayidwe
Zotsatira zoyipa izi zitha kuchitika:
- milingo yayikulu ya potaziyamu m'madzi a m'magazi;
- kuchuluka kwa creatinine;
- hyperbilirubinemia.
Matupi omaliza
Zitha kuchitika:
- anaphylactic zimachitika;
- angioedema;
- bronchial chotchinga.
Malangizo apadera
Kuyenderana ndi mowa
Sikulimbikitsidwa kuphatikiza Lozap ndi mowa. Mowa ungapangitse kuchepa kwa chithandizo cha mankhwalawa.
Sikulimbikitsidwa kuphatikiza Lozap ndi mowa.
Zokhudza mphamvu pakuwongolera njira
Maphunziro apadera sanachitike. M'pofunika kukana kuchita zinthu zowopsa zomwe zimafuna kuti anthu azikhala ndi chidwi nthawi zonse chifukwa cha mavuto amthupi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Sikulimbikitsidwa kupereka mankhwala kwa amayi apakati. Palibe zambiri zodalirika ngati Lozap ili ndi mphamvu pa mwana wosabadwa, koma chifukwa cha chiwopsezo cha zotsatira zoyipa, sizikugwiritsidwa ntchito pagululi.
Amayi oyembekezera omwe adalandila zoletsa za ACE kale ayenera kusintha njira ina. Ndikofunikira kusintha mankhwalawa posachedwa mutazindikira kuti muli ndi pakati.
Palibe chidziwitso pakugawidwa kwazomwe zimagwira ndi mkaka. Kuperewera kwa data ndi chifukwa chokana kuyamwitsa pakumenyera amayi a Lozap. Mwanayo ayenera kusamutsidwira ku zakudya zakumaso.
Kusankhidwa kwa Lozap kwa ana 50
Sikulimbikitsidwa kupereka mankhwala ochizira ana osakwana zaka 18. Nthawi zina, n`zotheka kugwiritsa ntchito mankhwalawa mankhwalawa matenda oopsa kwa ana okulirapo kuposa zaka 6. Kukhazikitsidwa kwa Lozap kufikira m'badwo uno kumatsutsana kwambiri, chifukwa palibe chidziwitso chokhudza chitetezo cha mankhwalawa m'gululi.
Mukamalembera ana olemera 20-50 makilogalamu, muyezo wa tsiku ndi tsiku ndi ½ wa muyezo womwe munthu wamkulu amakhala nawo. Nthawi zina zimakhala zotheka kupereka 50 mg ya Lozap. Nthawi zambiri, Mlingo woterewu umaperekedwa kwa odwala omwe ali ndi thupi lolemera kuposa 50 kg.
Gwiritsani ntchito mu ukalamba
Kwa anthu opitirira zaka 75, ndikulimbikitsidwa kuti mulingo watsiku ndi tsiku muchepetse 25 mg. Kuwunikira kwambiri momwe mankhwalawa amathandizira. Ngati ndi kotheka, mlingo umasinthidwa ndi dokotala.
The ntchito aimpso kuwonongeka
Kutenga ma angiotensin-kutembenuza ma enzyme zoletsa kungakulitse zizindikiro za kusokonezeka kwa impso. Izi zikuwonetsedwa ndikuwonjezereka kwa ndende ya creatinine ndi urea m'magazi.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Ndi vuto la chiwindi pakubowola, kusintha kosungidwa kwa yogwira plasma ndikotheka.
Gwiritsani ntchito kulephera kwa mtima
Matenda a mtima omwe ali ndi vuto lalikulu amatha kuyambitsa matenda oopsa kwambiri kwa odwala omwe atenga Lozap. Chisamaliro chapadera chikuyenera kuthandizidwa popereka mankhwala kwa anthu omwe ali ndi vuto lofananalo.
Bongo
Ndi bongo wa Lozap, kuchepa kwakukulu kwa kuthamanga kwa magazi, kuwonjezeka kwa kugunda kwa mtima kumachitika. Zizindikiro zimathetsedwa ndikukhazikitsidwa kwa diuretics, dalili zochizira.
Kuchita ndi mankhwala ena
Kuphatikiza kwa mankhwalawa ndi mankhwala ena a antihypertensive ndikotheka. Kugwiritsa ntchito palimodzi ndi ma antipsychotic ndi ma antidepressants kumathandizira chidwi cha hypotensive.
Mankhwala omwe amakhudza ntchito ya CYP2C9 isoenzyme amatha kukulitsa kapena kuchepetsa mphamvu ya mankhwalawa. Sitikulimbikitsidwa kuphatikiza kayendedwe ka Lozap ndi mankhwala osokoneza bongo, omwe ali othandizira kwambiri omwe ndi mankhwala a potaziyamu.
Sitikulimbikitsidwa kuphatikiza kayendetsedwe ka angiotensin-kutembenuza ma enzyme inhibitors.
Kuphatikiza kwa mankhwalawa ndi mankhwala ena a antihypertensive ndikotheka.
Analogi
Otsatirawa amagwiritsidwa ntchito kusintha mankhwalawa:
- Angizap;
- Hyperzar;
- Closart;
- Cozaar;
- Xartan
- Losartan Sandoz;
- Achinyamata;
- Lozap Plus;
- Lozap AM;
- Lorista
- Presartan;
- Pulsar
- Centor;
- Tozaar;
- Rosan;
- Erinorm.
Analog ya ku Russia ya uchi wa Lozap 50 ikhoza kukhala mankhwala a Blocktran.
Mofananirana ndi mankhwala aku Russia:
- Blocktran;
- Losartan Canon;
- Lortenza.
Maholide opuma Lozapa 50 ochokera ku malo ogulitsa mankhwala
Amamasulidwa malinga ndi zomwe dokotala wanena.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo
Mtengo wake umadalira malo ogulira.
Zosungidwa zamankhwala
Iyenera kusungidwa pa kutentha osaposa + 30 ° C.
Tsiku lotha ntchito
Kutengera ndi momwe zimasungidwira, mankhwalawa angagwiritsidwe ntchito mkati mwa miyezi 24 kuyambira tsiku lotulutsidwa. Kugwiritsanso ntchito sikulimbikitsidwa.
M'malo mwa mankhwala Lozap 50 gwiritsani ntchito Presartan.
Wopanga Lozap 50
Izi zimapangidwa ndi kampani yaku Slovak Saneca Pharmaceuticals.
Ndemanga pa Lozap 50
Omvera zamtima
Oleg Kulagin, katswiri wa zamtima, Moscow
Lozap ndi mankhwala abwino ochizira matenda oopsa. Chifukwa chakuti zotsatira zake sizikugwirizana ndi kuponderezedwa kwa ntchito ya ACE, ili ndi zovuta zochepa. Chida chake chimafuna kusamala pakugwiritsa ntchito. Odwala omwe ali ndi vuto laimpso amayenera kuyesedwa nthawi ndi nthawi kuti awone momwe thupi liliri. Musagule mankhwalawa popanda kufunsa dokotala. Kuchita chithandizo popanda zovuta kumangothandiza kusankha kwakulondola kwa mlingo, womwe umayenera kuperekedwa kwa katswiri.
Ulyana Makarova, katswiri wa zamtima, St.
Chidachi chimangothandiza ndi kugwiritsa ntchito moyenera. Amakumana ndi milandu yosiyanasiyana machitidwe awo. Wodwala m'modzi wokhala ndi hypertrophy yamanzere adaganiza zokhala-yekhayekha. Mlingo wokhazikika sunathandize kuthana ndi mavuto, kotero adayamba kumwa mapiritsi atatu patsiku. Zonsezi zidatha ndikulimbana ndi mtima, kudzipulumutsa komanso kufa. Milandu ngati imeneyi ndiyosowa, koma mavuto azachipatala amatha kupewedwa ngati mutsatira malangizo ndi dokotala kuti mugwiritse ntchito.
Odwala
Ruslan, wazaka 57, Vologda
Ndakhala ndikumwa zakumwa kwa zaka zingapo. Zotsatira zoyipa sizinali zofunikira panthawi ya chithandizo. Kupsinjika kumasungidwa mkati mwa mtundu wamba, koma ndinayenera kuwonjezera kuchuluka kwake. Thupi limazolowera pang'onopang'ono mankhwala aliwonse, ndiye kuti posachedwa muyenera kufunafuna m'malo mwake.
Lyudmila, wazaka 63, Samara
Anamuthandiza matenda oopsa pogwiritsa ntchito njira zosiyanasiyana. Lozap adagwiritsa ntchito zaka ziwiri zapitazo. Kwakanthawi, kupanikizika kudakhala kokhazikika, koma kenako kudayambanso. Adotolo adasinthanitsa mankhwalawo ndi mtundu wina wa ACE inhibitor, womwe ndimamwa ndi okodzetsa. Mwina mankhwalawo sanakumane ndi ine chifukwa chakufooka kwa matendawa, koma sindingathe kuwalimbikitsa.
