Tegretol CR - mankhwala ochepetsa mphamvu ya antiepileptic yomwe imakweza poyambira kutsimikiza, potero popewa kuchitika mwadzidzidzi.
Dzinalo Losayenerana
Carbamazepine.
Tegretol CR - mankhwala othandizira antiepileptic omwe amakweza poyambira kutsimikiza.
ATX
Khodi ya ATX ndi N03AF01.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapezeka mu mawonekedwe a mapiritsi okhala ndi mafupa. Mapiritsiwo ali ndi mawonekedwe a biconvex.
Zomwe zimagwiritsidwa ntchito popanga mapiritsi zitha kukhala 200 mg kapena 400 mg. Zomwe zimagwira ndi carbamazepine.
Mapiritsi a 200 mg amapezeka m'matakatoni a 50 zidutswa. Mkati mwathumba la matuza 5 azinthu 10.
Mapiritsi a 400 mg amapezeka m'matumba a zidutswa 30. Mkati mwa paketi 3 matuza a zidutswa 10.
Zotsatira za pharmacological
Carbamazepine akuwonetsedwa kuti apulumutsidwa mwamphamvu. Chofunikira chachikulu cha mankhwalawa ndi mtundu wa dibenzoazepine. Imakhala ndi antiepileptic makamaka pamodzi ndi neurotropic komanso psychotropic.
Zochita zamankhwala zamankhwala sizinaphunzire konse. Pali chidziwitso kuti gawo lomwe limagwira limakhudza ma membrane am'mimba a ma neurons, kuwakhazikika ndikuletsa kuthana kwambiri. Izi zimachitikanso chifukwa cha kuponderezana kwakakamizidwa mwachangu, chifukwa pamakhala kukhudzidwa kwa mitsempha.
Kugwiritsa ntchito kwa Tegretol kwa odwala omwe ali ndi khunyu kumayendera limodzi ndi kuponderezana kwa malingaliro amisala.
Gawo lalikulu la ntchito ya mankhwalawa likuletsa kukonzanso kwa ma neurons pambuyo pakutsekeka. Izi ndichifukwa chachuma cha ion njira zomwe zimapereka mayendedwe a sodium.
Kafukufuku awonetsa kuti kugwiritsa ntchito Tegretol kwa odwala omwe ali ndi khunyu kumayendera limodzi ndi kuponderezedwa kwa malingaliro amisala othandiza kukumbukira: kukhumudwa, kukwiya komanso kuchuluka kwa nkhawa.
Palibe umboni wotsimikiza kuti carbamazepine imakhudzanso kuchuluka kwa zochitika zama psychomotor komanso luso la kuzindikira la odwala. M'maphunziro ena, zambiri zotsutsana zimapezeka, ena adawonetsa kuti mankhwalawa amathandizira luso lozindikira.
Mphamvu ya neurotropic ya Tegretol imakuthandizani kuti mugwiritse ntchito pochizira ma neurological pathologies. Amalembera odwala neuralgia n. trigeminus mpumulo wa kuukira kwa zokha zomwe zimabweretsa ululu.
Odwala omwe amamwa mowa amathandizidwa kuti achepetse kugwa.
Odwala omwe amamwa mowa amathandizidwa kuti achepetse kugwa. Amachepetsa kuuma kwa mawonetseredwe a pathological a zopweteka.
Kwa anthu omwe ali ndi matenda a shuga, kugwiritsa ntchito mankhwalawa kumawonjezera matendawa.
Mphamvu ya tegretol imagwiritsidwa ntchito pochiza matenda amisala. Itha kugwiritsidwa ntchito palokha komanso kuphatikiza ndi ma antipsychotic ena, antidepressants. Kuponderezedwa kwa zizindikiro zamankhwala kumafotokozedwa ndi choletsa cha ntchito ya dopamine ndi norepinephrine.
Pharmacokinetics
Mafuta a gawo yogwira amapezeka m'matumbo mucosa. Kutulutsidwa kwake pamapiritsi kumayenda pang'onopang'ono, komwe kumapangitsa kuti pakhale nthawi yayitali. Kuchuluka kwazinthu zambiri m'magazi kumafikira pafupifupi maola 24. Ndi yotsika poyerekeza ndi kuchuluka kwa mankhwalawa.
Chifukwa chakumasulidwa pang'onopang'ono kwa chinthu chogwira ntchito, kusinthasintha kwakukhudzika kwa plasma ndikosathandiza. The bioavailability wa carbamazepine mukamatenga mapiritsi otulutsa otulutsa amachepetsedwa ndi 15%.
Ikalowa m'magazi, chinthu chogwira ntchito chimamangilira kuti chizinyamula ma 70-80%. Imawoloka chikhodzodzo ndikuyamwa mkaka wa m'mawere. Kugwiritsidwa ntchito kwa mankhwalawa kumapeto kumatha kukhala kuposa 50% ya chizindikiro chomwecho m'magazi.
The bioavailability wa carbamazepine mukamatenga mapiritsi otulutsa otulutsa amachepetsedwa ndi 15%.
Kagayidwe kachakudya komwe kamagwira zimachitika mchikakamizo cha michere ya chiwindi. Chifukwa cha kusinthika kwa mankhwala, metabolite yogwira ya carbamazepine ndi pawiri wake wokhala ndi glucuronic acid amapangidwa. Kuphatikiza apo, kagayidwe kochepa ka metabolite kamapangidwa.
Pali njira ya metabolic yosagwirizanitsidwa ndi cytochrome P450. Chifukwa chake mankhwala ophatikizika a carohamroepine amapangidwa.
Hafu ya moyo wa chinthu chogwira ndi maola 16-36. Zimatengera nthawi yamankhwala. Ndi kutsegula kwa michere ya chiwindi ndi mankhwala ena, theka la moyo lingathe kuchepetsedwa.
2/3 ya mankhwalawa imachotsedwa kudzera mu impso, 1/3 - kudzera m'matumbo. Mankhwala pafupifupi amachotsedwa kwathunthu ngati ma metabolites.
Zizindikiro zogwiritsidwa ntchito
Zizindikiro zakugwiritsa ntchito chida ichi ndi:
- khunyu (yolamulidwa kugwidwa kosavuta komanso kosakanikirana komanso kwachiwiri);
- matenda ochititsa munthu kupuma;
- pachimake manic psychosis;
- trigeminal neuralgia;
- diabetesic neuropathy, limodzi ndi ululu;
- shuga insipidus ndi kuchuluka kwa diuresis ndi polydipsia.
Contraindication
Kugwiritsidwa ntchito kwa Tegretol kumatsutsana pazochitika zotsatirazi:
- Hypersensitivity munthu yogwira mankhwala kapena zinthu zina za mankhwala;
- atrioventricular block;
- kusiya mowa;
- kuphwanya hematopoietic ntchito mafupa;
- pachimake porphyria;
- kuphatikiza kwa mankhwala ndi monoamine oxidase zoletsa.
Momwe mungatengere Tegretol CR
Chakudya sichimakhudza mphamvu ya mankhwalawa. Piritsi imatengedwa yonse ndikutsukidwa ndi kuchuluka kwa madzi.
Monotherapy ndi Tegretol ndizotheka, komanso kuphatikiza kwake ndi othandizira ena.
Ma regimen omwe amagwiritsidwa ntchito ngati mankhwalawa amaphatikizapo kuwongolera kwa mapiritsi kawiri. Chifukwa cha mankhwalawa chifukwa chomwa mankhwalawa chifukwa cha kuchuluka kwa nthawi yayitali, kuwonjezereka kwa tsiku ndi tsiku kungafunike.
Piritsi imatengedwa yonse ndikutsukidwa ndi kuchuluka kwa madzi.
Anthu omwe ali ndi khunyu amalimbikitsidwa tegretol monotherapy. Choyamba, Mlingo wotsika umayikidwa, womwe umayamba kukula. Mlingo woyambirira wa mankhwalawa ndi 100 mg 1 kapena 2 pa tsiku. Mulingo woyenera umodzi ndi 400 mg katatu patsiku. Nthawi zina, mungafunikire kuwonjezera kuchuluka kwa tsiku lililonse mpaka 2000 mg.
Ndi neuralgia n. trigeminus koyamba Mlingo watsiku ndi tsiku mpaka 400 mg. Zowonjezereka zikufika ku 600-800 mg. Okalamba odwala amalandira 200 mg ya mankhwalawa patsiku.
Anthu omwe amamwa mowa amathandizidwa kuchoka pa 600 mpaka 1200 mg / tsiku. Zizindikiro zazikulu zochotsera, mankhwalawa amaphatikizidwa ndi mankhwala osokoneza bongo.
Odwala omwe ali ndi pachimake manic psychosis amapatsidwa 400 mpaka 1600 mg wa Tegretol patsiku. Chithandizochi chimayamba ndi milingo yotsika, yomwe imayamba kuwonjezeka.
Ndi matenda ashuga
Carbamazepine akuwonetsedwa kwa odwala omwe ali ndi matenda ashuga. Mankhwala amaletsa kupweteka komwe kumachitika chifukwa cha kusintha kwa kagayidwe kachakudya mu minyewa yamanjenje. Mlingo wovomerezeka wa tsiku ndi tsiku wa anthu odwala matenda ashuga ndi 400 mpaka 800 mg.
Carbamazepine akuwonetsedwa kwa odwala omwe ali ndi matenda ashuga.
Zotsatira zoyipa za Tegretol CR
Pa mbali ya gawo la masomphenyawo
Zitha kuchitika:
- zosokoneza kukoma kwamaso;
- kutupa kwa conjunctival;
- tinnitus;
- hypo-hyperacusia;
- kuthina kwa mandala.
Kuchokera minofu ndi mafupa
Zotsatira zotsatirazi zingachitike:
- kupweteka kwa minofu
- kupweteka kwa molumikizana.
Matumbo
Kumachitika kwa zosayenera zoterezi ndizotheka:
- nseru
- kusanza
- kutupa kwa mucous nembanemba mkamwa;
- kusintha kwa mpando;
- kutupa kwa kapamba;
- kusintha kwa ntchito ya chiwindi michere.
Hematopoietic ziwalo
Amatha kuyankha chithandizo pogwiritsa ntchito:
- leukopenia;
- thrombocytopenia;
- agranulocytosis;
- kuchepa magazi
- kuchepetsa folic acid wambiri.
Hematopoietic ziwalo atha kuyankha mankhwalawa ndi thrombocytopenia.
Pakati mantha dongosolo
Atha kuyankha pamankhwala omwe ali ndi zotsatirazi:
- Chizungulire
- mutu
- zotumphukira neuropathy;
- paresis;
- kusokonekera kwa mawu;
- kufooka kwa minofu;
- kugona
- hallucinatory syndrome;
- kuchuluka kukwiya;
- mavuto okhumudwitsa;
- masomphenya apawiri
- kusokonezeka kwa kayendedwe;
- zovuta zamaganizidwe;
- kutopa.
Mitsempha yapakati imatha kuyankha mankhwalawa ndikuwona kawiri.
Kuchokera kwamikodzo
Zingaoneke:
- yade;
- polakiuria;
- kusungika kwamikodzo.
Kuchokera ku kupuma
Zotheka:
- kupuma movutikira
- chibayo.
Pa khungu
Zingaoneke:
- zithunzi;
- dermatitis;
- kuyabwa
- erythema;
- hirsutism;
- utoto;
- zotupa;
- Hyperhidrosis.
Kuchokera ku genitourinary system
Kutha kusakhalitsa kwakanthawi kumatha kuchitika.
Kuchokera ku genitourinary system, kusabereka kwakanthawi kumatha kuchitika.
Kuchokera pamtima
Zitha kuchitika:
- atrioventricular block;
- arrhythmia;
- kutsika kwa mtima;
- kuchuluka kwa zizindikiro za matenda a mtima.
Dongosolo la Endocrine
Mawonekedwe otheka:
- kutupa;
- gynecomastia;
- hyperprolactinemia;
- hypothyroidism.
Kuchokera kumbali ya kagayidwe
Zitha kuchitika:
- hyponatremia;
- okwera triglycerides;
- kuchuluka kwa mafuta m'thupi.
Matupi omaliza
Mawonekedwe otheka:
- Hypersensitivity zimachitikira;
- lymphadenopathy;
- malungo
- angioedema;
- matenda aseptic meningitis.
Kutenga Tegretol CR ngati zotsatira zoyipa, wodwalayo amatha kuona kutentha thupi.
Zokhudza mphamvu pakuwongolera njira
Zoopsa zomwe zingakhale ndi chiopsezo chowonjezereka ziyenera kupewedwa ndikumwa carbamazepine. Izi ndichifukwa cha mwayi wazotsatira zoyipa zamagetsi.
Malangizo apadera
Gwiritsani ntchito mu ukalamba
Nthawi zina, kusintha kwa tsiku ndi tsiku kwa mankhwala kungafunike.
Kupatsa ana
Mankhwala amatha kuperekedwa kwa ana. Mlingo watsiku ndi tsiku umachokera ku 200-1000 mg, kutengera zaka komanso kulemera kwa wodwala. Popereka mankhwala, ana osaposa zaka 3 amalimbikitsidwa kusankha mankhwalawa ngati madzi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Chithandizo cha carbamazepine panthawi yoyembekezera ziyenera kuchitika mosamala kwambiri. Kumbukirani kuti tegretol imatha kuwonjezera kuchepa kwa vitamini B12 mwa amayi apakati.
Pochiza mayi woyamwitsa ndi carbamazepine, ayenera kuthekera kusamutsa mwanayo ku zakudya zopanda ntchito. Kudyetsa kosatha kumatha kuchitika ndikuwunika kwa ana pafupipafupi. Mwana akakumana ndi vuto lililonse, kudyetsa kuyenera kusiyidwa.
The ntchito aimpso kuwonongeka
Gawani Tagretol ndikofunikira poyesa impso. Iwo ali osavomerezeka ntchito mankhwalawa odwala kwambiri aimpso kukanika.
Gawani Tagretol ndikofunikira poyesa impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Mbiri yodwala matenda a chiwindi ndi chifukwa chosamala mukamamwa mankhwalawa. Kuwunika kwa chiwindi pafupipafupi ndikofunikira kuti kupewa kufalikira kwa matenda a chiwindi.
Mankhwala osokoneza bongo a Tegretol CR
Chifukwa cha bongo wa carbamazepine, zizindikiro za pathological zimachitika kumbali yamanjenje, kupuma kwamatenda ndi ntchito ya mtima. Vomiting, anuria, zoletsa zambiri zimawonekeranso.
Zizindikiro zopitirira muyeso zimayimitsidwa ndikutsuka m'mimba ndikugwiritsira ntchito ufiti. Chithandizo chikuyenera kuchitika kuchipatala. Syndrome dalili, kuwunika ntchito zamtima kumasonyezedwa.
Kuchita ndi mankhwala ena
Tegretol ikaphatikizidwa ndi othandizira ena omwe amasintha kuchuluka kwa zochitika za CYP3A4 isoenzyme, kuchuluka kwa carbamazepine m'magazi amasintha. Izi zitha kuchititsa kuchepa kwa chithandizo cha mankhwala. Kuphatikiza kwa mankhwalawa kungafune kusintha kwa mlingo.
Kuchepetsa chidwi cha yogwira pophika ndi phenobarbital.
Macrolides, azoles, histamine receptor blockers, mankhwala othandizira odwala amatha kukulitsa kuchuluka kwa zinthu zogwira ntchito m'magazi.
Kuphatikiza kwa phenobarbital, valproic acid, rifampicin, felbamate, clonazepam, theophylline, ndi zina zotere, kuchepetsa kuchepa kwa ntchito yogwira.
The munthawi yomweyo mankhwala ena amafuna kusintha awo Mlingo: tricyclic antidepressants, corticosteroids, proteinase inhibitors, calcium njira blockers, estrogens, antiviral agents, antifungal mankhwala.
Kuphatikizidwa ndi ma diuretics ena kumapangitsa kutsika kwa plasma ndende ya sodium. Carbamazepine itha kuchepa mphamvu ya mankhwalawa osapatsirana minofu.
Kugwiritsa ntchito limodzi ndi njira zakulera zam'mlomo zimatha kutulutsa magazi mu maliseche.
Kuyenderana ndi mowa
Sitikulimbikitsidwa kumwa mowa wamtundu uliwonse pogwiritsa ntchito Tegretol.
Analogi
Ma Analogs a chida ichi ndi:
- Finlepsin retard;
- Finlepsin;
- Carbamazepine.
Chimodzi mwazifanizo za mankhwalawa ndi Finlepsin retard.
Kusiyana pakati pa Tegretol ndi Tegretol CR
Mankhwalawa amasiyana ndi Tegretol wokhazikika pakumasulidwa kwa carbamazepine. Mapiritsi amakhala ndi mphamvu yayitali.
Kupita kwina mankhwala
Mankhwala omwe mumalandira.
Kodi ndingagule popanda kulandira mankhwala?
Ayi.
Mtengo
Zimatengera malo ogula.
Zosungidwa zamankhwala
Iyenera kusungidwa m'malo owuma pa kutentha osaposa + 25 ° C.
Tsiku lotha ntchito
Kutengera ndi malo osungirako, moyo wa alumali ndi zaka 3 kuyambira tsiku lotuluka.
Wopanga
Mankhwalawa amapangidwa ndi Novartis Pharma.
Ndemanga
Artem, wazaka 32, Kislovodsk
Tegretol ndi mankhwala abwino omwe amathandiza kuthana ndi kukomoka. Kuyamba kumwa mankhwalawa, ndidapezanso mwayi wokhala ndi moyo wabwino. Mapiritsi amatha kuthana ndi kugwidwa kakang'ono ndi kwakukulu. Sindinazindikire zoyipa zilizonse pakugwiritsa ntchito. Ndimalangiza aliyense amene ali ndi matenda a khunyu.
Nina, wazaka 45, Moscow
Ntchito chida ichi chaka chatha. Mankhwala akale okonda kugwiritsa ntchito mankhwala osokoneza bongo adayamba kukhala osokoneza bongo, adokotala adalemba Tegretol kuti alowe m'malo mwake. Ndinkamwa mapiritsiwo pafupifupi milungu iwiri. Kenako zovuta zidawonekera. Kusanza ndi kusanza kunawonekera. Thanzi langa linaipiraipira, ndinali kuda nkhawa ndi chizungulire. Ndinayeneranso kupita kwa dokotala. Adatero. Mankhwala anachititsa hematological zimachitika: kuchepa magazi ndi thrombocytopenia. Ndinafunika kusintha mankhwalawo mwachangu.
Cyril, wazaka 28, Kursk
Dokotala adalemba mankhwalawa limodzi ndi ena pochiza matenda a neongia ya trigeminal. Sindikudziwa ngati Tegretol kapena mankhwala ena atathandizapo, koma zizindikirizo zinazimiririka. Mavuto owawa atayamba kudandaula. Apanso ndinatha kugona ndikudya mwachizolowezi. Nditha kupangira mankhwalawa kwa aliyense amene wakumanapo ndi mavuto ngati omwewo.
