Momwe mungagwiritsire ntchito mankhwala Janumet 50?

Pa mndandanda wa mankhwala othandiza kwambiri a hypoglycemic, a Janumet ayenera kutchulidwa. Gawo lake ndi kuphatikiza, komwe kumalola kukwaniritsa zotsatira zapamwamba pamtengo wotsika.

Dzinalo Losayenerana

Mankhwala a INN - Metformin + Sitagliptin.

Pa mndandanda wa mankhwala othandiza kwambiri a hypoglycemic, a Janumet ayenera kutchulidwa.

ATX

Khodi ya ATX ndi A10BD07.

Kutulutsa mafomu ndi kapangidwe kake

Mtundu wokhawo wa Janumet 50 ndi mapiritsi, komabe, atha kukhala ndi mlingo wina.

Kupanga kwakukulu kwa mankhwalawa kuli ndi zinthu zotsatirazi:

• sitagliptin phosphate monohydrate - mu kuchuluka kwa 64.25 mg (izi ndi zofanana ndi 50 mg ya sitagliptin);
• metformin hydrochloride - kuchuluka kwa gawo lino kumatha kufika 500, 850 kapena 1000 mg (kutengera mtundu wa mankhwalawo).

Zinthu zothandiza ndi:

• sodium fumarate;
• povidone;
• madzi oyeretsedwa;
• sodium lauryl sulfate.

Mapiritsi a Biconvex, ophatikizidwa ndi filimu, osalala mbali imodzi ndi ena kumbuyo. Mtundu umasiyanasiyana kutengera mlingo: pinki yowala (50/500 mg), pinki (50/8 mg mg) ndi wofiyira (50/1000 mg).

Mapiritsi amayikidwa m'matumba a 14 ma PC. Bokosi la makatoni limatha kukhala ndi mbale 1 mpaka 7.

Zotsatira za pharmacological

Mapiritsi a Yanumet - mankhwala ophatikiza. Muli ndi mankhwala 2 a hypoglycemic omwe amathandizira zomwe wina akuchita. Kumwa mapiritsi kumathandizira kukwaniritsa kuwongolera kwa hypoglycemia mwa odwala matenda a shuga II.

Kumwa mapiritsi kumathandizira kukwaniritsa kuwongolera kwa hypoglycemia mwa odwala matenda a shuga II.

Sitagliptin

Chipangizochi chili ndi mphamvu ya inhibitor yosankha kwambiri (DPP-4). Nthawi zambiri amagwiritsidwa ntchito pa zovuta chithandizo cha mtundu II matenda a shuga.

DPP-4 zoletsa zimagwira mwa kuyambitsa ma insretin. Mukaletsa ntchito ya DPP-4, sitagliptin imachulukitsa kuchuluka kwa glucose-insulinotropic polypeptide (HIP) komanso glucagon-peptide 1 (GLP-1). Zinthu izi ndi mahomoni othandizira ochokera kubanja la incretin. Ntchito yawo ndikuchita nawo gawo la glucose homeostasis.

Ndi shuga wabwinobwino kapena wapamwamba, HIP ndi GLP-1 imathandizira kapangidwe ka insulin ndi maselo a kapamba. GLP-1 imathandizanso kuletsa kupangika kwa glucagon mu kapamba, komwe kumachepetsa kaphatikizidwe ka shuga m'chiwindi.

Chachilendo cha sitagliptin ndikuti pamankhwala othandizira othandizira, izi sizimalepheretsa ntchito za ma enzymes okhudzana, kuphatikizapo DPP-8 ndi DPP-9.

Metformin

Gawoli lilinso ndi katundu wa hypoglycemic. Mothandizidwa ndi iwo, anthu omwe ali ndi matenda a shuga a mtundu II amawonjezera kulolera kwa glucose. Izi zikufotokozedwa ndi kuchepa kwa gluprose wa postprandial and basal plasma glucose.

Mankhwala a metformin a zochita za metformin amasiyana kwambiri ndi zochita za othandizira pakamwa, omwe ali m'magulu ena a pharmacological. Kugwiritsa ntchito mankhwalawa kumathandizira kukwaniritsa izi:

• kupanga shuga m'magazi kumachepa;
• kuchuluka kwa mayamwidwe a shuga m'matumbo amachepa;
• inapitilira kufinya kwamkati ndi kuwononga shuga m'magazi kumawonjezera chidwi chovulaza insulin.

Ubwino wa chinthuchi (poyerekeza ndi sulfonylurea) ndikuchepa kwa kukula kwa hypoglycemia ndi hyperinsulinemia.

Pharmacokinetics

Mlingo wa mankhwalawa Yanumet amafanana ndi dongosolo la metformin ndi sitagliptin payokha. Bioavailability wa metformin ali ndi chizindikiro cha 87%, sitagliptin - 60%.

Zogwira pophatikizika zimapukusidwa kudzera mu impso.

Kuchuluka kwa ntchito kwa sitagliptin kumatheka patadutsa maola 1-4 kuchokera pakamwa. Zakudya zomwe sizimakhudzidwa sizikhudza kuchuluka ndi kuchuluka kwa mayamwidwe. Zochita za Metformin zimayamba kuwonekera patatha maola awiri. Ndi chakudya chochuluka, kuchuluka kwa mayamwidwe kumachepetsedwa.

Zogwira pophatikizika zimapukusidwa kudzera mu impso.

Zizindikiro zogwiritsidwa ntchito

Yanumet idapangidwa kuti ikhazikitse kuwongolera kwa hypoglycemia mwa odwala matenda a shuga a 2. Madokotala amalembera mapiritsi angapo:

1. Popeza zotsatira zoyenera kuchokera ku mankhwala ndi Metformin. Pankhaniyi, kukonzekera kosakanikirana kumawongolera mbiri ya glycemic komanso moyo wa odwala matenda ashuga.
2. Kuphatikiza ndi masewera a gamma receptor antagonists.
3. Ndi shuga yokwanira osapumira jakisoni wa insulin.

Contraindication

Ndi osavomerezeka kumwa mankhwalawa ndi:

• chidwi chamunthu pazinthu zomwe zili pamapiritsi;
• mtundu I shuga;
• matenda a shuga;
• matenda osiyanasiyana opatsirana;
• chikhalidwe chododometsa;
• kwambiri aimpso kuwonongeka;
• mtsempha wa magazi makonzedwe a ayodini;
• kukanika kwambiri kwa chiwindi;
• matenda limodzi ndi kuperewera kwa oxygen;
• poyizoni, uchidakwa;
• mimba ndi kuyamwitsa;
• wosakwana zaka 18.

Iwo ali osavomerezeka kuti amwe mankhwalawa panthawi yapakati.

Iwo ali osavomerezeka kumwa mankhwala osakwana zaka 18.

Ndi osavomerezeka kumwa mankhwalawa nthawi yoyamwitsa.

Ndi osavomerezeka kumwa mankhwalawa uchidakwa.

Ndi bwino kuti musamwe mankhwalawa ngati chiwindi chayamba kuperewera.

Iwo ali osavomerezeka kumwa mankhwalawa chifukwa aimpso.

Malinga ndi malangizo, mankhwalawa amaperekedwa kwa odwala okalamba mosamala kwambiri.

Ndi chisamaliro

Malinga ndi malangizo, mankhwalawa amaperekedwa kwa odwala okalamba mosamala kwambiri.

Mungamutenge bwanji Janumet 50?

Mapiritsi amatengedwa m'mawa pamimba yopanda chakudya. Ndi kudya kwa nthawi ziwiri, mankhwalawa amatengedwa m'mawa ndi madzulo. Dokotala amamulembera aliyense payekha, ngakhale kuti akuganizira za momwe wodwalayo alili, msinkhu wake komanso njira zake zamankhwala zomwe zilipo:

1. Ngati palibe glycemic control ndi metformin pazipita kololera. Odwala zotchulidwa Janumet 2 kawiri pa tsiku. Kuchuluka kwa sitagliptin sikuyenera kupitirira 100 mg patsiku, Mlingo wa metformin umasankhidwa masiku ano.
2. Ngati pali kusintha kwa mankhwala ndi metformin + sitagliptin zovuta. Mlingo woyamba wa Yanumet pamilandu iyi amasankhidwa kale.
3. Popeza pakufunika zotsatira za kuphatikiza kwa metformin ndi sulfonylurea. Mlingo wa Yanumet uyenera kuphatikiza mlingo waukulu wa tsiku ndi tsiku wa sitagliptin (100 mg) ndi mlingo waposachedwa wa metformin. Nthawi zina, mankhwalawa amaphatikizidwa kuti aphatikizidwe ndi sulfonylurea, ndiye kuti mlingo wotsiriza uyenera kuchepetsedwa. Kupanda kutero, pamakhala chiopsezo cha hypoglycemia.
4. Pakusowa zotsatira zoyenera kutenga metformin ndi agonist wa PPAR-y. Madokotala amalembera mapiritsi a Yanumet omwe ali ndi mlingo waposachedwa wa metformin ndi 100 mg ya sitagliptin.
5. Sinthani zovuta za metmorphine ndi insulin ndi mapiritsi a tsiku lililonse a 100 mg a sitagliptin ndi mlingo wa metformin. Kuchuluka kwa insulini kuyenera kuchepetsedwa.

Ndi matenda ashuga

Mapiritsiwo adapangira odwala omwe ali ndi matenda a shuga a mtundu wachiwiri. Anthu omwe ali ndi matenda amtundu woyamba amatsutsana.

Zotsatira zoyipa za Yanumet 50

Wothandizira wa hypoglycemic ali ndi zovuta zingapo. Dokotala ayenera kudziwa wodwalayo, chifukwa ngati chizindikiro chimodzi kapena zingapo zadziwika, muyenera kukana kumwa mankhwalawo. Zitangochitika izi, muyenera kufunsa dokotala, kuti akamayeze magazi komanso kuwayika.

Matumbo

Kuchokera m'mimba, kakomedwe ka zitsulo mkamwa kamakonda kuonedwa. Zochepa zomwe zimachitika ndi mseru komanso kusanza. Vutoli ndikukhazikika kwa matenda otsekula m'mimba ndizotheka kumayambiriro kwamankhwala. Odwala ena amati amapweteka m'mimba.

Vomiting ndi imodzi mwazotsatira zamankhwala.

Kuchokera kumbali ya kagayidwe

Odwala ambiri amakhala ndi vuto la metabolic m'thupi. Izi zimaphatikizidwa ndi hypoglycemia. Nthawi zina, hypothermia, kukula kwa vuto la kupuma, mawonekedwe a kugona, kupweteka kwam'mimba, ndi hypotension amapezeka.

Pa khungu

Khungu limakhudzidwa nthawi zambiri limasonyeza kusalolera pazinthu zomwe zimapanga mapiritsi. Pankhaniyi, dermatitis, zidzolo ndi kuyabwa kungaoneke. Zomwe zimakonda kwambiri ndi matenda a Stevens-Johnson komanso cutculous vasculitis.

Kuchokera pamtima

Nthawi zina, vuto la kuchepa kwa magazi m'thupi limatha chifukwa cha malabsorption a vitamini B12 ndi folic acid.

Matupi omaliza

Ziwengo zimawonekera poyeserera khungu ndi zotupa.

Zokhudza mphamvu pakuwongolera njira

Mankhwala alibe mwachindunji kuthamanga kwa psychomotor zochita ndi ndende. Pakadali pano, kutenga sitagliptin kungayambitse kugona komanso kufooka. Pachifukwa ichi, kuyendetsa galimoto ndi njira zina zovuta kuyenera kuchitidwa mosamala kwambiri.

Malangizo apadera

Kutenga mapiritsi nthawi yayitali kumafunikira kuwonetsetsa impso.

Ngati wodwalayo ali ndi njira yodziwira kapena yothandizila pogwiritsa ntchito mankhwala okhala ndi ayodini, Janumet sayenera kugwiritsidwa ntchito maola 48 isanachitike komanso itatha.

Odwala omwe ali ndi pancreatitis ndi matenda a impso, mapiritsi amatha kuwonjezera zizindikiro za matendawa. Pofuna kupewa izi, dokotala amayenera kusintha mlingo wake ndikuwonetsetsa momwe wodwalayo alili.

Odwala omwe ali ndi kapamba, mapiritsi amatha kuwonjezera zizindikiro za matenda.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Amayi pa nthawi yoyembekezera komanso mkaka wa m'mawere saloledwa kumwa mankhwala a hypoglycemic. Zikatero, chithandizo chimachokera pakumwa insulini.

Kuikidwa kwa Yanumea kwa ana 50

Palibe zambiri zamankhwala pazotsatira za mankhwala ophatikizidwa pamthupi la ana. Pachifukwachi, Janumet sanalembedwe kwa odwala osakwana zaka 18.

Gwiritsani ntchito mu ukalamba

Anthu okalamba amapatsidwa mankhwala awa, koma izi zisanachitike, kuwunika kwa impso kumafunika.

The ntchito aimpso kuwonongeka

Mankhwalawa ali osavomerezeka kwa anthu omwe ali ndi matenda owopsa a impso (kuphatikizanso omwe ali ndi vuto lowu la impso).

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Ngati vuto la chiwindi likusokonekera, kutenga Janumet sikulimbikitsidwa. Izi ndichifukwa cha chiwopsezo cha lactic acidosis.

Overdose wa Yanumet 50

Ngati wodwalayo aposa achire mlingo wa mankhwalawa, izi zimakhudza kukula kwa lactic acidosis. Kuti khazikitse vutoli, phokoso lam'mimba limachitika ndipo hemodialysis imayikidwa.

Chizindikiro china cha bongo ndi hypoglycemia. Ndi chiwonetsero chofatsa, wodwalayo amalimbikitsidwa kudya zakudya zamafuta ambiri. Hypoglycemia yapakati kapena yozama iyenera kutsatiridwa ndi jakisoni wa Glucagon kapena njira ya Dextrose. Wodwala akayambanso kuzindikira, amapatsidwa zakudya zamafuta ambiri.

Kuti khazikitse vutoli ngati pakhale mankhwala osokoneza bongo, hemodialysis ndi mankhwala.

Kuchita ndi mankhwala ena

Ndi chithandizo chovuta cha wodwalayo, adokotala ayenera kuganizira momwe mapiritsi amaphatikizira ndi mankhwala ena.

Kuchita kwa Yanumet kumafooketsa pamaso pa mankhwala otsatirawa:

• Phenothiazine;
• Glucagon;
• thiazide okodzetsa;
• nicotinic acid;
• corticosteroids;
• mahomoni a chithokomiro;
• Isoniazid;
• estrogens;
• sympathomimetics;
• odana ndi calcium;
• Phenytoin.

Mphamvu ya hypoglycemic imalimbikitsidwa ikagwiritsidwa ntchito limodzi ndi mankhwala otsatirawa:

• mankhwala osapweteka a antiidal;
• Insulin
• beta-blockers;
• zotumphukira sulfonylurea;
• Oxetetracycline;
• Acarbose;
• Cyclophosphamide;
• ACE ndi Mao zoletsa;
• zotumphukira za clofibrate.

Ndi cimetidine, pali chiopsezo cha acidosis.

Ndi sulfonylurea zotumphukira kapena insulin. Nthawi zambiri pamakhala hypoglycemia pakalibe kusintha kwa mlingo.

Kuyenderana ndi mowa

Kuphatikiza ndi mowa, chiwopsezo cha zotsatira zoyipa chikukula.

Analogi

Mwa anifanizo amatchedwa:

• Amaryl M;
• Yanumet Long;
• Douglimax;
• Velmetia;
• Avandamet;
• Glucovans;
• Glibomet;
• Galvus Met;
• Gluconorm;
• Tripride.

Kupita kwina mankhwala

M'mafakitala, mumalandira mankhwala.

Kodi ndingagule popanda kulandira mankhwala?

Mankhwala ali mgululi sangathe kugula popanda mankhwala a dokotala.

Mtengo wa Yanumet 50

Mtengo wa mankhwalawa ku Ukraine, Russia ndi mayiko ena zimatengera kuchuluka kwa mankhwalawa omwe amaperekedwa m'mapiritsi ndi kuchuluka kwa zingati zomwe zimaperekedwa phukusi. Mumafakisi ku Moscow, mitengo ya Yanumet ndi iyi:

• 500 mg + 50 mg (56 ma PC.) - 2780-2820 rubles;
• 850 mg + 50 mg (ma 56 ma PC.) - 2780-2820 rubles;
• 1000 mg + 50 mg (28 ma PC.) - 1750-1810 rubles;
• 1000 mg + 50 mg (56 ma PC.) - 2780-2830 rubles.

Zosungidwa zamankhwala

Mankhwalawa amayenera kusungidwa m'malo otetezeka ku dzuwa ndi chinyezi mwachindunji. Kutentha kofunikira mpaka + 25 ° C.

Tsiku lotha ntchito

Mankhwalawa amatha kugwiritsidwa ntchito kwa zaka ziwiri.

Wopanga

Mapiritsiwo amapangidwa ndi kampani yopanga mankhwala Patheon Puerto Rico Inc. ku Puerto Rico. Kuyika mankhwala kumachitika ndi makampani osiyanasiyana:

• Merck Sharp & Dohme B.V, yomwe ili ku Netherlands;
• OJSC "Chomera cha mankhwala opangira mankhwala" AKRIKHIN "ku Russia;
• Frosst Iberica ku Spain.

Mankhwalawa amachotsedwa pamafakisoni mosiyanasiyana malinga ndi mankhwala.

Ndemanga za Yanumet 50

Alexandra, endocrinologist, wodziwa zachipatala kwa zaka 9, Yaroslavl.

Mankhwalawa adatha kutsimikizira kugwira ntchito kwake poyesedwa kuchipatala ndikuchita. Nthawi zambiri ndimapereka mankhwalawa kwa odwala anga omwe amadalira insulin. Zotsatira zoyipa ndizochepa. Chofunikira chachikulu ndi mlingo woyenera.

Valery, endocrinologist, odziwa zachipatala kwa zaka 16, ku Moscow.

Yanumet imakulolani kuti mukwaniritse zomwe mukufuna nthawi zambiri pamene shuga sangathe kuyendetsedwa ndi Metformin. Odwala ena amawopa kuti asinthane ndi chithandizo chamtunduwu chifukwa cha zovuta zoyambira komanso chiopsezo cha hypoglycemia. Pakalipano, pochita, milandu yotere imatha kutchedwa kuti raric, makamaka ngati mlingo woyenera ndi malingaliro ena a dokotala amawonedwa.