Mukafunikira kusankha Orlistat kapena Xenical, mankhwala amafanizidwa ndi mtundu wa chinthu chomwe chikugwira, mlingo wake. Ngati mugwiritsa ntchito mankhwalawa ndi ochepa kuchuluka kwa contraindication ndi zoyipa, chithandizo sichingakuyambitseni pakukula kwamavuto.
Khalidwe la Orlistat
Mankhwalawa amapangidwa ndi KRKA (Slovenia) ndipo ali m'gulu la mankhwala omwe mfundo zake zimayendera chifukwa cha kuletsa kwa lipases ya m'mimba. Orlistat imapezeka m'mapiritsi omwe amakhala ndi zopunthira. Gawo la dzina lomweli likuwonetsa ntchito (mlingo wa 120 mg mu kapisozi imodzi). Zomwe zimapangidwira zimaphatikizapo zinthu zopanda ntchito:
- ma cellcose a microcrystalline;
- sodium carboxymethyl wowuma;
- sodium lauryl sulfate;
- povidone;
- talcum ufa.
Kufunikira kwa chithandizo cha Orlistat zimaperekedwa ndikusokoneza ntchito ya michere ya m'mimba.
Orlistat ikuwoneka motsutsana ndi mankhwala ofanana chifukwa chogwira ntchito kwambiri pamilomo ya lipases (pancreatic, gastric). Izi zimapanga mgwirizano wolumikizana ndi ma serines awo. Chifukwa cha izi, njira yosinthira kwa triglycerides kuchokera m'mafuta, omwe amalowa m'thupi ndi chakudya, m'magawo omwe amakankhidwa ndi makoma am'mimba yamageji: monoglycerides, mafuta acids, ndi oletsedwa. Kufunikira kwa chithandizo cha Orlistat zimaperekedwa ndikusokoneza ntchito ya michere ya m'mimba.
Chifukwa cha njira zomwe zafotokozedwazi, mafuta amasinthidwa kukhala zinthu zomwe sizimayamwa ndi makoma amkati mwagaya ndipo amachotsedwedwa pakuyenda matumbo, njirayi imatenga masiku osapitilira 5.
Zotsatira zabwino za mankhwala zimaperekedwa chifukwa cha kuchepa kwa kalori chifukwa cha kuphwanya mafuta kagayidwe. Izi zimapangitsa kuti muchepetse kunenepa.
Mankhwalawa amaletsa kusintha kwa mafuta kupita ku mafuta acids ndi monoglycerides osati kwathunthu, koma ndi 30% yokha. Chifukwa cha izi, thupi limalandira chakudya chokwanira chofunikira kukhala ndi thanzi, koma limataya mtima wofuna kudziunjikira mafuta ochulukirapo.
Maphunziro ambiri a zotsatira za Orlistat pakugwira ntchito kwa ziwalo zamkati ndi machitidwe, zovuta zoyipa pakukula kwa kuchuluka kwa matumbo a m'matumbo ndi ntchito ya gallbladder sizinawonekere. Kapangidwe ka bile, komanso kuchuluka kwa kayendedwe ka matumbo, sikusintha. Mlingo wa acidity wa m'mimba ya m'mimba umagwiranso ntchito ndi choyambirira. Pa kafukufukuyu, maphunziro ena adawonetsa kuchepa pang'ono pazinthu zingapo zofunikira: calcium, magnesium, zinki, chitsulo, mkuwa, phosphorous.
Odwala onenepa kwambiri komanso ma pathologies ena angapo, kuwongolera kwathunthu kumadziwika. Ichi ndi chifukwa cha kuchepa kwa thupi, kusintha kwa zochita za michere. Pambuyo pa kutha kwa chithandizo chamankhwala ndi Orlistat, pali chiopsezo chobwezeretsa kulemera koyambirira. Komabe, kafukufuku wasonyeza kuti odwala ena okha ndi omwe amabwerera pang'onopang'ono magawo awo am'mbuyomu. Mankhwala tikulimbikitsidwa kwa nthawi yayitali. Nthawi yayitali ya maphunzirowa imachokera pa miyezi 6 mpaka 12.
Chizindikiro pakugwiritsa ntchito Orlistat ndikofunikira kwa kuchepa thupi (mwachitsanzo, kunenepa kwambiri). Chotsatira chabwino ndi kuchepa kwa minofu ya adipose pamitundu isanu ya 5-10% ya thupi lonse. Kuphatikiza apo, mankhwalawa amaperekedwa kuti achepetse chiopsezo cha kuchuluka kwa kulemera kwa choyambirira, ngati wodwalayo ali kale ndi vuto loti achepetse thupi. Zoyipa:
- zaka za ana (osakwana zaka 12);
- malabsorption syndrome;
- cholestasis;
- hyperoxaluria;
- nephrolithiasis;
- nthawi ya pakati, yoyamwitsa;
- kusalolera kwa thupi la zigawo za Orlistat.
Pa mankhwala, kunenepa kwambiri kumatha kuchepa, koma nthawi yomweyo, mavuto amawonekera:
- ndowe zimakhala mafuta;
- kulimbikitsa kunyoza kukuchulukirachulukira, zomwe zimachitika chifukwa cha kuchulukitsidwa kwa zinthu kuchokera mthupi zomwe sizisintha ndipo sizingatengeke ndimatumbo a matumbo chifukwa chotseka njira ya kagayidwe ka mafuta osakhazikika;
- kapangidwe ka gasi kumakulirakulira;
- fecal incinuence nthawi zina zimadziwika.
Kumayambiriro kwa mankhwala a Orlistat, kumakhala ndi nkhawa kumatha kuoneka.
Nthawi zambiri, poyambira maphunziro, mankhwalawa amapezeka chifukwa cha zotsatira zoyipa zamagetsi chapakati: kupweteka mutu, chizungulire, nkhawa, kusokonezeka kwa tulo. Izi zimachitikanso chifukwa chakuwonjezeka kwa moto wamafuta ndi kuwonjezeka kwa chiwopsezo cha thupi.
Makhalidwe a Xenical
Wopanga mankhwalawa ndi Hoffmann la Roche (Switzerland). Chida ichi chimawerengedwa ngati chiwongolero chachindunji cha Orlistat, chomwe chiri chifukwa cha kapangidwe kake (gawo lomwe limagwira ndi orlistat pamsasa wa 120 mg). Kuchita kwa Xenical, monga Orlisat, kumakhazikika pazoletsa za lipases ya m'mimba. Xenical imaperekedwa mu fomu 1 yotulutsira - mwa mawonekedwe a makapisozi.
Gawo lochita ntchito sililowa m'magazi, limatulutsidwa mosasunthika m'thupi (83% ya mlingo wonse).
Kuwongolera mkhalidwe wa wodwalayo kumadziwika m'masiku oyambira atangoyamba kumene maphunziro. Mankhwalawa amachotseredwa pakatha masiku atatu. Gawo lolimbikira limapangidwira mu khoma lamatumbo, ndipo mapangidwe awiri amamasulidwa. Poyerekeza ndi orlistat, ma metabolites awa amawonetsa ntchito zochepa, zomwe zikutanthauza kuti zimakhudza lipases ya m'mimba pang'ono.
Zisonyezero zosankhidwa:
- kunenepa kwambiri kapena kunenepa kwambiri pamaso pa zinthu zomwe zimapangitsa kuti munthu azichita kunenepa kwambiri;
- Chithandizo cha odwala omwe amadziwika ndi matenda a shuga 2 omwe amakonda kulemera (BMI kuchokera ku 27 kg / m² kapena kupitilira apo).
Mlandu wachiwiri, Xenical imalimbikitsidwa kuti igwiritsidwe ntchito ngati gawo la zovuta mankhwala pamodzi ndi othandizira a hypoglycemic. Pankhaniyi, Metformin, Insulin kapena kukonzekera kochokera ku sulfonylurea zotumphuka zimagwiritsidwa ntchito nthawi zambiri. Xenical sinafotokozeredwe zotere:
- cholestasis;
- malabsorption syndrome;
- tsankho kwa zigawo zikuluzikulu za mankhwala.
Zovuta zoyipa zimachitika kawirikawiri ngati mafuta ambiri amaphatikizidwa muzakudya za wodwalayo. Mtengo watsiku ndi tsiku umathanso kubweretsa mavuto. Pofuna kupewa kuyipa kwa mankhwalawa, tikulimbikitsidwa kutsatira zakudya zamafuta ochepa.
Odwala omwe ali ndi matenda ashuga, chiwopsezo chochepetsa shuga m'magazi chimawonjezeka - izi ndi zotsatira za kubwezeredwa kwabwino kwa kagayidwe kazakudya. Xenical imatha kuyambitsa magazi m'matumbo. Pa mankhwala, kuyamwa kwa mavitamini kumayipa. Pachifukwa ichi, mavitamini ovomerezekawo amapatsidwa 2 mawola atatha kumwa mankhwala.
Pofuna kupewa kuyipa kwa mankhwalawa, tikulimbikitsidwa kutsatira zakudya zamafuta ochepa.
Kuyerekezera kwa Orlistat ndi Xenical
Kufanana
Ndi mtundu wa ntchito, chifukwa cha kupangika kwa mankhwala, othandizira ali ofanana. Amagwiritsidwa ntchito pochiritsa kwa nthawi yayitali. Mlingo wa gawo yogwira ndi chimodzimodzi.
Mankhwalawa onse amapangitsa kuti pakhale zovuta zina.
Xenical ndi Orlistat zilipo mu mawonekedwe a kapisolo. Awa ndi mankhwala othandiza, amadziwika ndi kuthamanga komweko.
Kodi pali kusiyana kotani?
Mankhwala amasiyana mtengo.
Wopanga Xenical samalimbikitsa kuti atenge mankhwalawa motsutsana ndi maziko azikhalidwe zingapo za pathological, pomwe Orlistat imadziwika ndi zoletsa zochulukirapo zikagwiritsidwa ntchito.
Zomwe zimakhala zotsika mtengo
Xenical ingagulidwe kwa ma ruble 1740. (phukusi lili ndi makapisozi 42). Mtengo wa Orlistat ndi ma ruble 450. (chiwerengero chomwecho cha makapisozi). Popeza kuti ndalamazi zimayenera kutengedwa nthawi yayitali, chithandizo chotsika mtengo ndi Orlistat.
Zomwe zili bwino: Orlistat kapena Xenical
Mankhwalawa ali ndi chinthu chimodzi chomwe chikugwirira ntchito, mlingo wake sasintha. Chifukwa chake, nawonso amadzionetsera atachepetsa thupi. Palibe kusiyana pa kuchuluka kwa mankhwalawa. Kukhazikika kwa njira zochizira kumatengera kugwiritsa ntchito mankhwala ena (mwachitsanzo, mankhwala aliwonse omwe amagwiritsidwa ntchito mwachangu mu urology, hypoglycemic agents, etc.). Mankhwala onse awiriwa amalekeredwa. Mukamagwiritsidwa ntchito ngati gawo la zovuta mankhwala, palibe zotsatira zoyipa za mankhwala ena.
Pogula, chofunikira kwambiri ndi mtengo wa malonda. Ngati zikuwongoleredwa ndi gawo ili, kusankha kuyenera kuchitidwa mokomera Orlistat.
Madokotala amafufuza
Nazemtseva R.K., dokotala wazamankhwala, Samara
Xenical ndi mankhwala omwe amagwira ntchito moyenera. Mosiyana ndi zida zambirizi, ndi thandizo lake mutha kupeza zotsatira zomwe mukufuna mukamachepetsa thupi. Kuchepetsa thupi kumayamba pang'onopang'ono, chifukwa chake Xenical imalimbikitsidwa kuti izigwiritsidwa ntchito kwanthawi yayitali.
Belodedova A. A., wothandizira zakudya, Novomoskovsk
Ndikukhulupirira kuti njira zapadera zolemetsa sizofunika. Kwa izi, zakudya zopangidwa moyenera ndizokwanira. Kukula kochita zolimbitsa thupi kumathandizanso kwambiri. Njira monga Orlistat, ndimaona ngati ndizofunikira, pokhapokha ngati pali matenda oopsa, mwachitsanzo, matenda a shuga, pakakhala kulimba kwa thupi kosalamulirika. Kuphatikiza apo, mankhwalawa a gululi amapatsidwa mankhwala, bola kuchuluka kwa mafuta m'zakudya kumachepetsedwa.
Popeza kuti ndalamazi zimayenera kutengedwa nthawi yayitali, chithandizo chotsika mtengo ndi Orlistat.
Ndemanga za owonda ndi odwala za Orlistat ndi Xenical
Anna, wazaka 35, Krasnoyarsk
Kwa ine, mankhwalawa Xenical sanathandize, chifukwa kumapeto kwa maphunzirowa (adatenga makapisozi miyezi 1.5), kulemera kunawonjezeka. Sindizigwiritsanso ntchito.
Marina, wazaka 41, Vladimir
Choyamba adatenga Xenical, kenako adasinthira ku Orlistat. Njira yachiwiri ndiyotsika mtengo, koma amakhalanso chimodzimodzi. Kulemera kunachepa mwachangu ndikutenga kapisozi. Maphunzirowa atatha, mapaundi owonjezerawa anayamba kubwerera pang'onopang'ono, koma ndinatenga nthawi. Zotsatira zake, ndinawerengera 3 kg okha, zomwe sizokwanira ndi kulemera kwanga (90 kg).
