Clopidogrel-Teva mankhwala: malangizo ntchito

Clopidogrel-Teva ndi mankhwala omwe amapondereza kuphatikizira kwa maselo ambiri komanso amachepetsa ziwiya zamagetsi. Chida chimagwiritsidwa ntchito pochiza matenda ndi mtima.

Dzinalo Losayenerana

INN - Clopidogrel.

Clopidogrel-Teva ndi mankhwala omwe amapondereza kuphatikizira kwa maselo ambiri komanso amachepetsa ziwiya zamagetsi.

ATX

Code ya ATX: B01AC04.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwalawa ali ngati mapiritsi ataliitali amtundu wopepuka wa pinki. The yogwira thunthu ndi clopidogrel hydrosulfate (kuchuluka kwa 75 mg).

Othandizira:

• lactose monohydrate;
• ma cellcose a microcrystalline;
• hyprolosis;
• crospovidone;
• hydrogenated masamba mafuta a mtundu I;
• sodium lauryl sulfate.

Khola la mafilimu lili ndi zinthu izi:

• lactose monohydrate;
• hypromellose 15 cP;
• titanium dioxide;
• macrogol;
• ma oxide ofiira ndi achikasu (utoto wachitsulo);
• indigo carmine.

Mankhwala amapezeka monga mapiritsi.

Zotsatira za pharmacological

Yogwira pophika mankhwala amachepetsa kuphatikizika kwa masamba. Ma ADP nucleotides (adenosine diphosphates) amakonda kuchititsa glycoprotein inhibitors ndipo amamangirira ku mapulateleti. Mothandizidwa ndi clopidogrel, njira izi zimasokonekera ndipo potero kuphatikiza kwa ma cellulin kumachepetsedwa. Zochita (PDE) za phosphodiesterase sizisintha zinthu.

Mphamvu ya antiplatelet ya mankhwalawa imatenga nthawi yonse ya moyo wama mapulateleti (pafupifupi masiku 7).

Pharmacokinetics

Mukamamwa pakamwa, mapiritsiwo amatengedwa mwachangu m'mimba. Clopidogrel imakhala ndi bioavailability yayikulu, koma yosasinthika siyothandiza (ichi ndi mankhwala osokoneza bongo). Imakhala m'magazi kwakanthawi ndipo imaphatikizidwa mwachangu m'chiwindi ndikupanga metabolites yogwira komanso yolimba. Kenako clopidogrel ndi metabolite yogwira imamangiratu pafupifupi mapuloteni amwazi.

Patatha ola limodzi mutamwa mankhwalawa m'magazi, pazotheka kugwiritsidwa ntchito kwa magazi kosagwiritsidwa ntchito mu plasma - kutuluka kwa carboxylic acid.

Mankhwalawa amuchotsa mkodzo ndi ndowe mkati mwa masiku asanu. Yogwira metabolite imachotsedwa mkati mwa maola 16.

Clopidogrel-Teva amalembedwa chifukwa cha kulowetsedwa kwa myocardial.

Ischemic stroke ndi chisonyezo chogwiritsira ntchito mankhwalawa.

Clopidogrel-Teva amagwiritsidwa ntchito pochiza matenda atria.

Zisonyezo zogwiritsa ntchito mankhwalawa ndi thrombosis.

Zizindikiro zogwiritsidwa ntchito

Mankhwala amathandizidwa kupewa matenda a mtima mu milandu yotsatirayi:

1. Myocardial infaration.
2. Ischemic stroke.
3. Acute coronary syndrome popanda kuwonjezeka gawo la ST.
4. Thrombosis (yogwiritsidwa ntchito limodzi ndi acetylsalicylic acid).
5. Supomboembolism.
6. Fibrillation yoyeserera.
7. Pamaso pa contraindications kugwiritsa ntchito anticoagulants yosalunjika kanthu.

Contraindication

Mapiritsi amaletsedwa kutenga odwala omwe ali ndi vuto la chiwindi (kwambiri maphunziro), hypersensitivity kwa mankhwala kapena magazi owopsa.

Contraindication amakhalanso ndi pakati, kuyamwa ndi ana osakwana zaka 18.

Ndi chisamaliro

Mochenjera, mankhwalawa amapatsidwa mankhwala aimpso (osakwanira ndi creatinine chilolezo cha 5-15 ml / min), magazi ochulukirapo (hematuria, menorrhagia), komanso pambuyo pa opareshoni, kuvulala ndi kulephera mu heentatic system.

Pochiza odwala omwe ali ndi matenda a chiwindi, coagulogram imachitika kawirikawiri ndipo kugwira ntchito kwa chiwindi kumayang'aniridwa.

Mosamala, mankhwalawa amatchulidwa kuti ayambe kugwira ntchito impso.

Kodi kutenga clopidogrel-teva?

Odwala omwe adakumana ndi myocardial infarction amapatsidwa 75 mg ya mankhwala (piritsi 1) tsiku lililonse kwa masiku 7 mpaka 35. Pambuyo pa stroke, mankhwalawa amamwa mlingo womwewo, koma chithandizo chamankhwala chimatha mpaka miyezi isanu ndi umodzi.

Odwala omwe ali ndi pachimake coronary syndrome popanda kuwonjezeka gawo la ST akulimbikitsidwa kuti atenge 300 mg tsiku lililonse ngati mlingo woyambirira. Kenako, mankhwalawo amachepetsedwa mpaka 75 mg patsiku, koma kuphatikiza kwa antiplatelet ndi acetylsalicylic acid kumaphatikizidwa. Mankhwalawa amachitika chaka chimodzi.

Ndi matenda ashuga

Odwala omwe ali ndi matenda a shuga, kuchuluka kwa mapulogalamu am'magazi nthawi zambiri kumawonedwa. Pofuna kupewa matenda a coronary syndrome ndi matenda a coronary, 75 mg ya clopidogrel-Teva ndi tsiku.

Kutalika kwa makonzedwe ndi mlingo wa Insulin uyenera kutsimikiziridwa ndi dokotala, kutengera mtundu wa wodwalayo.

Zotsatira zoyipa za clopidogrel-Teva

Pa mbali ya ziwalo zamasomphenya

Kumbuyo kumwa mankhwalawa, zotupa za m'mimba (zotupa ndi zamkati) zimatha kuchitika.

Kuchokera minofu ndi mafupa

Zotsatira zoyipa za musculoskeletal system ndizosowa. Nyamakazi, arthralgia ndi myalgia ndizotheka.

Mankhwala angayambitse kukula kwa colitis.

Matumbo

Zomwe zimachitika m'matumbo am'mimba zimawonetsedwa motere:

• kupweteka m'mimba;
• magazi m'mimba;
• kusanza ndi kusanza
• kutsegula m'mimba
• zilonda zam'mimba;
• gastritis;
• mitengo;
• hepatitis;
• kapamba
• stomatitis
• kulephera kwa chiwindi.

Hematopoietic ziwalo

Kuchokera mbali ya dongosololi:

• thrombocytopenia;
• leukocytopenia;
• eosinophilia.

Pakati mantha dongosolo

Mankhwalawa kwenikweni samakhudza dongosolo lamanjenje. Nthawi zina, mutu, chizungulire, ndi chisokonezo zimachitika.

Kuchokera kwamikodzo

Zotsatira zoyipa za mkodzo:

• hematuria;
• glomerulonephritis;
• kuchuluka kwa creatinine m'magazi.

Kutengera komwe kumamwa mankhwalawa, zotupa za m'maso zimatha kuchitika.

Clopidogrel-Teva angayambitse nyamakazi.

Nthawi zina, mankhwala amatha kuyambitsa gastritis.

Nthawi zina, clopidogrel-Teva amachititsa kupweteka mutu komanso chizungulire.

Kumwa mankhwalawa kumatha kutsegula m'mimba.

Kusanza ndi kusanza ndizotsatira zoyipa za mankhwalawa.

Clopidogrel-Teva imatha kuyambitsa mphuno.

Kuchokera ku kupuma

Zokhudza kupuma kwamatumbo:

• nosebleeds;
• hemorrhage m'mapapo;
• bronchospasm;
• interstitial pneumonitis.

Kuchokera ku genitourinary system

Zotsatira zoyipa sizinakhazikitsidwe.

Kuchokera pamtima

Kuchokera pamtima zimawonedwa:

• magazi
• ochepa hypotension;
• vasculitis.

Matupi omaliza

Zotsatira zotsatirazi zimachitika:

• Edema ya Quincke;
• matenda a seramu;
• urticaria;
• kuyabwa

Poyerekeza ndi momwe mankhwalawo amatsatirira, mankhwalawa angayambike.

Zokhudza mphamvu pakuwongolera njira

Odwala ena amakhala ndi mutu komanso chizungulire akamamwa Clopidogrel-Teva. Chenjezo liyenera kugwiritsidwa ntchito poyang'anira makina kapena kugwira ntchito yofunika chidwi kwambiri.

Malangizo apadera

Asanachitidwe opareshoni, mankhwalawo ayenera kusiyidwa (masiku 5-7 asanafike pochita opareshoni) chifukwa cha chiwopsezo chotaya magazi.

Gwiritsani ntchito mu ukalamba

Mankhwalawa amagwiritsidwa ntchito pochiza odwala okalamba. Koma pankhaniyi, mankhwalawa amachitika popanda kuwerengetsa mlingo (limodzi mlingo wofanana ndi 300 mg) kumayambiriro kwa mankhwalawa.

Kulemba Clopidogrel-Teva kwa ana

Mankhwalawa amaletsedwa kwa ana osakwana zaka 18.

Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere

Mimba komanso kuyamwitsa ndi contraindication kugwiritsa ntchito mankhwalawa.

Simungathe kugwiritsa ntchito mankhwalawa panthawi yapakati.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Odwala omwe ali ndi matenda a chiwindi (cirrhosis, chiwindi kulephera) amapatsidwa mankhwala mosamala. Pofuna kupewa kutaya magazi, mankhwalawa amayenera kutsatiridwa ndikuwunika momwe chiwindi chikugwirira ntchito.

Clopidogrel-Teva bongo

Ndi pakamwa limodzi lokha waukulu Mlingo wa mankhwalawa (mpaka 1050 mg), kunalibe zotsatirapo zoyipa za thupi.

Kugwiritsa ntchito nthawi yayitali mu Mlingo waukulu kungayambitse magazi.

Kuchita ndi mankhwala ena

Chifukwa chowopsa kukhetsa magazi, ndizoletsedwa kumwa mankhwalawa limodzi ndi mankhwalawa monga:

1. Ma Anticoagulants.
2. Glycoprotein IIa / IIIb zoletsa.
3. NSAIDs.

Njira zopewera kusamala ziyenera kuphatikizidwa ndi heparin.

Njira zopewera kuyenera kuphatikizidwa ndi thrombolytics ndi heparin. Pogwiritsa ntchito munthawi yomweyo ndi omeprazole, esomeprazole ndi ma proton pump zoletsa, kuchepa kwa mphamvu ya antiplatelet kumachitika.

Kuyenderana ndi mowa

Mankhwala samalimbikitsidwa kuti aphatikizidwe ndi zakumwa zoledzeretsa. Kuledzera kwamthupi komwe kumatheka, kuwonetseredwa ndi kusanza, kutsegula m'mimba, kupweteka, kutentha thupi, kulephera kupuma komanso palpitations.

Analogi

Mankhwala otchuka omwe ali ndi vuto lofananalo ndi awa:

1. Lopirel.
2. Plavix.
3. Sylt.
4. Piragril.
5. Aggregal.
6. Muthana.

Zomwe zimagwiritsidwa ntchito pazofanizira izi ndi clopidogrel.

Kupita kwina mankhwala

Kodi ndingagule popanda kulandira mankhwala?

Malinga ndi malangizo, mankhwalawa amayenera kupatsidwa mankhwala.

Mtengo wa Clopidogrel-Teva

Mtengo wa phukusi la mapiritsi 14 umachokera ku ruble 290 mpaka 340, mapiritsi 28 - ma ruble 600-700.

Zosungidwa zamankhwala

Kusungirako kuyenera kuchitika pamalo amdima pa kutentha osaposa + 25 ° C.

Tsiku lotha ntchito

Mankhwalawa ndi oyenera kwa zaka ziwiri.

Wopanga

Wopanga - Teva (Israel).

Mankhwala amaperekedwa ndi mankhwala.

Ndemanga ya clopidogrel-Teva

Irina, wazaka 42, ku Moscow.

Nditayezetsa magazi, ndidapeza magulu ambiri am'mapulogalamu. Dotolo adayikira Clopidogrel. Ndidamwa mankhwalawa kwa milungu itatu, ndipo kuchuluka kwa maplateni m'magazi kunayamba kukhala kwabwinobwino.

Alexander, wazaka 56, Izhevsk.

Ndinayamba kumwa mankhwalawa motsutsana ndi dokotala pambuyo poti adwala. Ndakhala ndikuwatenga kwa miyezi iwiri ndipo sindikudandaula kuti ndili bwino. Palibe mavuto omwe adachitika. Mankhwala ndiofunika ndalama.

Leonid, wazaka 63, Volgograd.

Ndinagwiritsa ntchito mapiritsiwa kupewa zovuta pambuyo pa opaleshoni ya msana. Mu nthawi ya ntchito, mankhwalawa adathandizira kupewa magazi. Ndinalekerera kuvomereza kwake; sindinakumane ndi zoyipa zilizonse.