Kuti mudziwe chomwe chiri bwino: Phasostabil kapena Cardiomagnyl, muyenera kuyerekezera mankhwalawa ndi mikhalidwe yofunika. Chifukwa chake, choyamba zingapo zotsutsana, zikuwonetsa, zoyipa, momwe zimagwirira ntchito za mankhwalawo ndi magawo awo omwe amaphunziridwa. Mukamasankha, Mlingo wa zomwe zimagwira ndi mawonekedwe a kumasulidwa umagwira nawo ntchito.
Phasostabil wakhalidwe
Zomwe zimagwira ndi acetylsalicylic acid (ASA) ndi magnesium hydroxide. Mankhwala amapezeka monga mapiritsi. Ndi gawo la gulu la antiplatelet agents. Piritsi limodzi lili ndi 75 mg ya ASA ndi 15.2 mg ya magnesium hydroxide. Kuphatikizikako kumaphatikizanso zinthu zina zomwe sizikuwonetsa ntchito ya antiplatelet:
- ma cellcose a microcrystalline;
- croscarmellose sodium;
- povidone-K25;
- magnesium wakuba.
Kuti mudziwe chomwe chiri bwino: Phasostabil kapena Cardiomagnyl, muyenera kuyerekezera mankhwalawa ndi mikhalidwe yofunika.
Mapiritsiwo amakhala atakutidwa ndi mafilimu, omwe amathandiza kuchepetsa kutulutsa kwa ASA komanso kuteteza mucous membrane m'mimba, komanso duodenum kuchokera kuzovuta zamankhwala. Acetylsalicylic acid ndi salicylic ester wa acetic acid. Katunduyu ndi wa NSAIDs (mankhwala omwe si a antiidal. Amadziwika ndi kuphatikiza: ASA imadziwonetsa ngati analgesic, imachotsa zizindikiro za kutupa, komanso imasintha kutentha kwa thupi.
Mfundo zoyeserera pa chigawochi ndizokhazikitsidwa ndi choletsa ntchito za COX isoenzymes zomwe zimakhudzidwa ndikupanga prostaglandin kuchokera ku arachidonic acid ndi thromboxane. Zotsatira zake, kuchuluka kwa zovuta zawo pamthupi kumachepa. Chifukwa chake, ma prostaglandins amatenga nawo gawo limodzi pantchito yotupa. Zimakhudza makina owonjezera chidwi cha ma receptors, potero zimathandizira kuwonjezeka kwa kupweteka kwambiri.
Mothandizidwa ndi ma prostaglandins, kukana kwa malo a hypothalamic omwe amachititsa kuti magazi awonjezere mphamvu ya zinthu zoperewera kuchepa. ASA nthawi yomweyo imapanikiza njira zonse zomwe zafotokozedwazo, chifukwa chomwe kuchepa kwamphamvu kwa kutupa, kupweteka komanso kuchepa kwa kutentha kwa thupi zimadziwika nthawi yomweyo.
Zomwe zimagwira ndi acetylsalicylic acid (ASA) ndi magnesium hydroxide.
Kuphatikiza apo, gawo ili limakhudzanso ndondomeko ya kuphatikiza kwa mapulateleti. Izi ndichifukwa choti ASA ikulepheretsa zochitika za proogurantant endogenous thromboxane proaggregant. ASA ndi othandizira othandizira kwambiri othandizira kuchokera ku ma analogu angapo, chifukwa amakhudza mwachindunji ntchito ya thromboxane.
Komabe, acetylsalicylic acid imapereka odana ndi kutupa. Izi ndichifukwa choti zinthuzi zimalepheretsa COX-1 kukula kwakukulu. Ma Isoenzymes a gululi amagwira nawo ntchito zosiyanasiyana: amakhudza mbali ya kupukusa kwam'mimba, magazi a impso.
Acetylsalicylic acid imakhudzanso ma enzymes a cycloo oxygenase COX-2, zomwe zikutanthauza kuti amatsika mu ma analogu angapo pakugwiritsa ntchito anti-yotupa, zotsatira za analgesic. Kuphatikiza apo, munthawi ya mankhwala omwe ali ndi mankhwala omwe ali ndi chinthu ichi, mavuto ambiri amadziwika.
Phazostabil ili ndi chinthu china chogwira - magnesium hydroxide. Izi zimachokera ku gulu la ma antacid. Zimadziwika ndi zotsatira zabwino mthupi. Chifukwa chake, mukumwa mankhwala acetylsalicylic acid ndi magnesium hydroxide, mankhwala a magnesium chloride amamasulidwa, chifukwa chomwe zotsatira zoyipa za hydrochloric acid zimapangidwa pa metabolism ya ASA sizitenga mbali.
Pamene magnesium chloride ilowa m'matumbo, imadziwonetsa ngati mankhwala ofewetsa thukuta.
Kuphatikiza apo, pamene magnesium chloride ilowa m'matumbo, imadziwonetsa ngati mankhwala ofewetsa thukuta. Izi ndichifukwa choti chinthu ichi sichimamwa. Kuphatikiza apo, kuwonjezeka kwa kuthamanga kwa osmotic m'matumbo amadziwika. Komanso, mankhwala enaake a chloride opangidwa pakusintha kwa magnesium hydroxide magnesium chloride activates peristalsis. Izi zikuchitika chifukwa cha kuchuluka kwamkati mwa matumbo ndikuwonjezera kukakamiza kwa makoma ake.
Chifukwa cha magnesium hydroxide, chithandizo cha ASA sichimathandizira pamavuto. Zoopsa kwambiri, mukalandira chithandizo, zotsatira zoyipa sizitchulidwa kawirikawiri poyerekeza ndi zomwe zimachitika ngati aspirin woyenera agwiritsidwa ntchito.
Pharmacokinetics of Phasostabil
Mankhwala omwe akufunsidwa amasinthidwa kwakanthawi kochepa. Komanso, kagayidwe amapezeka mkati mwa mayamwidwe.
Acetylsalicylic acid imasinthidwa kwambiri m'chiwindi, komwe ma metabolites amasulidwa, omwe amagawidwa minofu ndi ziwalo zonse. Pambuyo pa mphindi 20, gawo lalikulu kwambiri la ndende ya ASA limakwaniritsidwa. Kutha kumangiriza mapuloteni a plasma kumatengera mlingo wa mankhwalawa.
Mukuchotsa acetylsalicylic acid, impso zimaphatikizidwa. Izi zikutanthauza kuti zinthu zambiri zimachotsedwa pokodza. Popeza aimpso kuwonongeka, mankhwalawa kwathunthu pambuyo masiku atatu. Ngati matenda a chiwalochi apezeka, ASA imadziunjikira pang'onopang'ono mu media media (zamadzimadzi ndi zimakhala). Zotsatira zakuchulukitsa kwazinthu izi ndikupanga zovuta, popeza metabolites ya acetylsalicylic acid imakhala ndi mphamvu yokhudza thupi.
Mukuchotsa acetylsalicylic acid, impso zimaphatikizidwa.
Zizindikiro ndi contraindication, mavuto
Phasostabil zotchulidwa zotere:
- kupewa chitukuko cha matenda a mtima dongosolo, makamaka, mtima kulephera, thrombosis pamaso pangozi, pakati pawo matenda a shuga, hyperlipidemia, matenda oopsa;
- kupewa zizindikiro zobwereza myocardial infaration;
- kupweteka pachifuwa;
- kuchepa kwakukulu kwa venous lumen pambuyo pakuchita opaleshoni ya mtima.
Mankhwala omwe amafunsidwa amaphatikizidwa milandu ingapo:
- tsankho kwa magawo omwe amagwira ntchito a phasostabil kapena mankhwala ena osapweteka a antiidal;
- matenda am'mimba;
- kusowa kwa vitamini K, chomwe ndicho chimapangitsa kwambiri kuti magazi azituluka;
- kulephera kwa mtima;
- kuukira kwa mphumu;
- kuphatikiza kwa njira zingapo za pathological zomwe zimathandizira kupuma ntchito: bronchial mphumu, mphuno ya polyposis, tsankho la acetylsalicylic acid;
- pachimake nthawi ya chitukuko cha zilonda zam'mimba;
- kutulutsa magazi m'mimba;
- kugwiritsa ntchito phasostabil ndi methotrexate;
- kusowa kwa shuga-6-phosphate dehydrogenase;
- kwambiri mkhutu aimpso ndi kwa chiwindi ntchito;
- mkaka wa m'mawere ndi pakati (I ndi III trimesters);
- ana ochepera zaka 18.
Phasostabil ali ndi zovuta zambiri, zomwe zimawonetsedwa ndi zizindikiro zotsatirazi:
- kukokoloka kwa mucous nembanemba zam'mimba ndi matumbo;
- kupweteka pamimba;
- nseru
- kuthawa;
- kutentha kwa mtima;
- kukonzanso kwa makoma am'mimba;
- kutupa ndi kufalikira kwa zotupa m'mimba;
- bronchospasm;
- kutsika kwa hemoglobin wambiri ndi magazi m'thupi;
- kusintha kwa kapangidwe kake ndi zinthu zamagazi zomwe zimagwirizana ndi zinthu monga thrombocytopenia, leukopenia, etc;
- magazi
- chisokonezo cha kugona;
- matenda am'mimba;
- kumva kuwonongeka.
Mbali ya Cardiomagnyl
Mutha kugula chida ichi ngati mapiritsi. Kuphatikizikako kumaphatikizapo magawo omwe amagwira ntchito monga momwe zimaganizirira kale: acetylsalicylic acid, magnesium hydroxide. Komabe, mankhwalawa amaperekedwa m'mitundu yosiyanasiyana ndi mitundu yosiyanasiyana ya zinthu zomwe zimagwira. Piritsi limodzi lili: 75 kapena 150 mg ya ASA; 15.2 kapena 30.39 mg wa magnesium hydroxide. Chifukwa chake, Cardiomagnyl amadziwika ndi makina amachitidwe ofanana ndi Phasostubil.
Cardiomagnyl ingagulidwe mu mawonekedwe a piritsi. Kuphatikizikako kumaphatikizapo zinthu monga yogwira asidi monga acetylsalicylic acid, magnesium hydroxide.
Kuyerekezera Mankhwala
Kufanana
Chofunikira kuphatikiza ndalamazi ndikufunsanso mawonekedwe ake. Kugwiritsa ntchito zinthu zomwezi pakuchita kumakupatsani mwayi wopeza ndalama zomwe zimagwirira ntchito limodzi. Chifukwa cha izi, Cardiomagnyl ndi Phasostabil amakhumudwitsa zomwezo. Zolepheretsa pakusankhidwa kwa mankhwalawa ndizofanana. Gwiritsani ntchito mankhwala omwe mankhwalawa amagwiritsidwa ntchito pothandizira matenda amtundu womwewo.
Kodi pali kusiyana kotani?
Cardiomagnyl imayimiriridwa ndi mitundu iwiri yomwe imasiyana muyezo. Chimodzi mwazosankha ndi analogue mwachindunji ya Phazostabil (wokhala ndi mlingo wotsika wa ASA ndi magnesium hydroxide). Chifukwa chake, polemba Cardiomagnyl yomwe ili ndi zosakaniza zokhala ndi 150 ndi 30.39 mg (piritsi limodzi), munthu akhoza kudalira mphamvu zowonjezera. Zotsatira zabwino zimakwaniritsidwa mwachangu. Komabe, zovuta zoyambira zimakula kwambiri. Izi zikutanthauza kuti chiopsezo cha zovuta zimachuluka, makamaka kuchokera kumimba.
Chotsika mtengo ndi chiyani?
Phasostabil ndi mankhwala otsika mtengo. Itha kugulidwa ma ruble 130. (paketi yokhala ndi mapiritsi 100). Cardiomagnyl yokhala ndi mlingo womwewo (75 mg ndi 15.2 mg) umagula ma ruble 130, koma mu nkhani iyi mtengo wa phukusi lokhala ndi mapiritsi 30 akuwonetsedwa.
Cardiomagnyl imayimiriridwa ndi mitundu iwiri yomwe imasiyana muyezo.
Zomwe zili bwino: Phasostabil kapena Cardiomagnyl?
Ngati tingayerekeze kukonzekera ndi muyeso womwewo wa zosakaniza zomwe zimapangidwa, amadziwika ndi kugwira ntchito komweko. Nthawi yomweyo, kuchuluka kwa zinthu zomwe mankhwala osokoneza bongo amakhalapo sikungasinthe, monga theka la moyo wa zigawo zomwe zimagwira. Malinga ndi kuchuluka kwakukwaniritsa bwino kwambiri, mankhwalawa nawonso ndi ofanana.
Kodi Cardiomagnyl akhoza m'malo mwa Phasostabil?
Izi ndi zida zosinthika. Komabe, pokhapokha ngati wodwala wayamba kuvuta pazinthu zilizonse za Cardiomagnyl, Phazostabil sangathe kugwiritsidwa ntchito, chifukwa mankhwalawa onse ali ndi zinthu zomwezo.
Madokotala amafufuza
Kartashova S.V., katswiri wazamtima, wazaka 37, Tambov
Cardiomagnyl nthawi zambiri amagwiritsidwa ntchito kwa odwala okulirapo kuposa zaka 40. Chida chimagwira bwino: chimagwira nthawi yomweyo, kuwonjezera apo, zovuta zoyipa sizimakula. Ngati mutsatira njira yomwe munapatsidwa pa mankhwala, zovuta sizingabuke.
Maryasov A.S., dokotala wa opaleshoni, wazaka 38, Krasnodar
Phasostabil ndi wotsika mtengo kuposa Cardiomagnyl, koma mfundo yogwirira ntchito ndi yomweyo. Mankhwala onse awiriwa ndi othandiza. Komabe, ngati kugwiritsidwa ntchito nthawi yayitali ndikofunikira (mwachitsanzo, kuti muchepetse kuphatikizana kwa maselo othandiza magazi kuundana), ndimakonda Phasostabilus chifukwa cha mtengo wotsika.
Ndemanga za Odwala za Phasostable ndi Cardiomagnyl
Galina, wazaka 46, Saratov
Mtengo wa Cardiomagnyl ndiwambiri, koma ndine wokhutira kwathunthu ndi chida ichi mothandizidwa ndi kuchuluka kwaukali pamimba. Ndimalekerera mankhwalawa bwino mpaka panali zovuta zina. Pachifukwa ichi, sindimaganizira ma analogu ena, kuphatikiza ma enics, ngakhale atakhala otsika mtengo.
Eugenia, wazaka 38, St. Petersburg
Kwa ine, Phasostabil ndiye chida chabwino kwambiri m'gululi, chifukwa ndi chothandiza, amathandizira kuthetseratu zizindikiro zoopsa za mtima.
