Atorvastatin kapena Simvastatin amalembedwa kuti muchepetse cholesterol ndikusintha njira za metabolic. Mankhwala onsewa akhala akugwiritsidwa ntchito kwa nthawi yayitali pochita zamankhwala, motero, adziwonetsa okha pochiza komanso kupewa matenda amtima.
Khalidwe la Atorvastatin
Atorvastatin amatanthauza mankhwala ochepetsa mphamvu ya lipid kuchokera pagulu la ma statins. Atorvastatin calcium calcium (10,84 mg) ndi chinthu chogwira ntchito chomwe chimakhudzidwa ndi kapangidwe ka cholesterol. Katunduyu amathandizira kuchepetsa kuchuluka kwa otsika osalimba lipoproteins (LDL) ndi kukachulukana kwambiri (HDL), potero amateteza mapangidwe a cholesterol plaques.
Atorvastatin kapena Simvastatin amalembedwa kuti muchepetse cholesterol ndikusintha njira za metabolic.
Pambuyo pakulowetsa, piritsi imalowa m'matumbo aang'ono, momwe imalowera mwachangu kufalikira kwa khoma. The bioavailability wa gawo yogwira ndi 60%. Hepatic michere imapanga gawo la mankhwala, ndipo zotsalazo zimachotsedwa m'thupi ndi ndowe, mkodzo ndi thukuta.
Cholesterol okwera mu atherossteosis, kupezeka kwa malo mu capillaries akuluakulu ndi ang'onoang'ono ndizomwe zikuwonetsa kwambiri pakugwiritsa ntchito Atorvastatin. Ndikofunika kuperekanso mankhwala othandizira kupewa matenda otsatirawa:
- mtundu 2 shuga;
- vuto la mtima;
- sitiroko;
- matenda oopsa
- angina pectoris;
- ischemia wamtima.
Atorvastatin amatanthauza mankhwala ochepetsa mphamvu ya lipid kuchokera pagulu la ma statins.
Atorvastatin amatha kudziunjikira m'thupi pogwiritsa ntchito nthawi yayitali komanso ma pathologies ena, mwachitsanzo, ngati ntchito ya chiwindi kapena impso ili ndi vuto. Pankhaniyi, poizoni wa mankhwala amawonedwa. Wodwala amatha kudandaula chifukwa cha kutentha thupi, kupweteka mutu, kufooka, komanso kugwira ntchito mwachangu. Ngati mumanyalanyaza zizindikiro zonsezi, ndiye kuti kuyamwa kwapoizoni wazambiri m'thupi ndikokwera.
Makhalidwe a simvastatin
Mankhwala Simvastatin nawonso ali m'gulu la ma statins. Yogwira pophika mankhwala ndi simvastatin. Opezekapo ndi monga:
- titanium dioxide;
- lactose;
- povidone;
- citric acid;
- ascorbic acid;
- magnesium wakuba, etc.
Simvastatin ili ndi mayamwidwe ambiri. Pazipita ndende yogwira ntchito m'magazi imakwaniritsidwa pambuyo maola 1-1,5 pambuyo pa kuperekedwa. Pambuyo maola 12, mulingo uwu umachepetsedwa ndi 90%. Njira yayikulu yakuzembera kudzera m'matumbo, kudzera mu impso, 10-15% yogwira ntchito imachotsedwa.
Cholinga chachikulu cha mankhwalawa ndikuchepetsa cholesterol pamavuto amtima. Mankhwalawa amalembedwa motere:
- chiopsezo chachikulu chotengera atherosulinosis;
- hypercholesterolemia yoyamba (mtundu II a ndi II b);
- hypercholesterolemia ndi hypertriglyceridemia;
- kupewa myocardial infarction, sitiroko, ischemic kuukira, atherosulinosis yamitsempha yama mtima.
Cholinga chachikulu chogwiritsira ntchito Simvastatin ndikuchepetsa cholesterol pamavuto amtima.
Kuyerekeza Atorvastatin ndi Simvastatin
Fotokozerani mankhwala ndikusankha mtundu wa mankhwalawa ayenera kungokhala katswiri yemwe samaganizira za matendawo, komanso machitidwe a thupi.
Kufanana
Mankhwala onse awiriwa amagwiritsidwa ntchito mwachangu matenda a mtima komanso mtima.
Onse a Atorvastatin ndi Simvastatin ndi mankhwala othandiza ndipo ali ndi cholinga chimodzi - kutsitsa cholesterol yamagazi.
Amagwirizananso ndi izi:
- Mankhwalawa ali ndi mitundu yosiyanasiyana yogwira, koma lactose ilipo mwa onse awiri. Chifukwa chake, ziyenera kufotokozedwa mosamala ndi kuzindikira kwa gawo lothandizali.
- Zotsatira zoyipa mu mawonekedwe a chizungulire zimadziwika ndi onse mankhwala. Pazifukwa izi, munthawi yamankhwala, muyenera kukana kuyendetsa galimoto ndikugwira ntchito moyenera.
- Mankhwala amatsutsana ndi mankhwala a lipid-otsitsa, chifukwa myopathy imayamba. Ngati, poyerekeza ndi zammbuyo zamankhwala ndi Atorvastatin kapena Simvastatin, kutentha kumawuka ndi kupweteka kwa minofu kuwoneka, ndiye kuti mankhwalawo ayenera kusiyidwa, ndikuwachotsa ndi analogues.
- Mimba ndi mkaka wa m'mawere ndizochita zina zotsutsana. Amayi munthawi ya chithandizo ayenera kugwiritsa ntchito njira zakulera.
- Pogwiritsa ntchito nthawi yayitali komanso mankhwala osokoneza bongo, mwayi wokhala ndi zotsatirapo zake ndi wokwera. Zikatero, impso ndi chiwindi zimavutika kwambiri. Chifukwa chake, ndizoletsedwa kwambiri kupitirira muyeso womwe dokotala watchulidwa.
Kodi pali kusiyana kotani?
Kusiyana kwakukulu ndikuti kapangidwe kazokonzekerako si chinthu chimodzi chogwira ntchito. Chifukwa chake, atorvastatin amatanthauza ma statin opangidwa, omwe ali ndi mphamvu yayitali yothandizira. Simvastatin ndi statin yachilengedwe yokhala ndi kanthawi kochepa.
The yogwira mankhwala a Atorvastatin ndi wamphamvu kwambiri, chifukwa chake, mankhwalawa ali ndi zotsutsana zambiri. Izi zikuphatikiza:
- mimba ndi mkaka wa m`mawere;
- zaka mpaka 10;
- uchidakwa wambiri;
- kuchuluka kwa transaminases m'magazi;
- thupi lawo siligwirizana;
- matenda opatsirana pachimake gawo.
Simvastatin siyikulimbikitsidwa kuti mugwiritse ntchito pazotsatirazi:
- Hypersensitivity zigawo zikuluzikulu za mankhwala;
- matenda a chiwindi
- zaka zazing'ono;
- mimba ndi mkaka wa m`mawere;
- mafupa minofu kuwonongeka.
Atorvastatin ndi osayenera kugwiritsidwa ntchito nthawi imodzi ndi antibacterial ndi antimicrobial agents. Simvastatin singathenso kuphatikizidwa ndi ma virus a HIV proteinase inhibitors ndi anticoagulants. Osamadya zipatso za mphesa kapena kumwa madzi a mphesa pochiritsa ndi mapiritsi. kuphatikiza kumeneku kumatha kupitilira kuchuluka kwa zinthu zomwe zimagwira m'magazi.
Zotsatira zoyipa izi zitha kuchitika mukamatenga Simvastatin:
- mavuto a chimbudzi;
- kusowa tulo
- mutu
- kuphwanya kukoma ndi kuwona (kawirikawiri);
- kuchuluka kwa ESR, kuchepa kwa maselo am'magazi ndi maselo ofiira amwazi.
Pochita mankhwala ndi Atorvastatin, odwala amatha kupeza tinnitus, mavuto a kukumbukira, komanso kumva kutopa kosalekeza.
Poyerekeza ndi kumbuyo kwa kutenga Simvastatin, kupweteka kwa mutu kumatha kuchitika.
Hemodialysis akuwonetsedwa milandu bongo wa simvastatin. Kuchita koteroko sikungakhale kwaphindu pamikhalidwe yofananayo ndi Atorvastatin.
Zomwe zimakhala zotsika mtengo
Mtengo wa mankhwala umatengera dziko lomwe amapanga komanso mlingo.
Simvastatin imapangidwa m'maiko ambiri, kuphatikizapo Russia, France, Serbia, Hungary, ndi Czech Republic. Mtengo wa phukusi la mapiritsi 30 a 20 mg udzakhala ma 50-100 rubles. Mtengo wokutira mankhwala (ma PC 20. Kwa 20 mg) wopangidwa ku Czech Republic ndi pafupifupi ma ruble 230-270.
Atorvastatin wopanga Russian angagulidwe muma pharmacies pamtengo uwu:
- 110 rub - 30 ma PC. 10 mg iliyonse;
- 190 rub - 30 ma PC. 20 mg iliyonse;
- 610 rub - 90 ma PC. 20 mg aliyense.
Zomwe zili bwino - atorvastatin kapena simvastatin
Dokotala wokhazikika ndi amene angadziwe za mankhwala omwe ali bwino mutapenda wodwalayo, koma pali zinthu zina zofunika kwambiri:
- Zotsatira zabwino zachangu zingatheke ndi Atorvastatin, monga ili ndi chinthu chogwira ndi mphamvu zambiri.
- Simvastatin imayambitsa mavuto ochepa, omwe ndi mwayi wa mankhwalawa. Ikagwiritsidwa ntchito moyenera, zinthu zapoizoni sizidziunjikira m'thupi.
- Zotsatira zofufuza zamankhwala zamankhwala, zimatsimikiziridwa kuti Simvastatin amachepetsa cholesterol yoyipa ndi 25%, ndi Atorvastatin - ndi 50%.
Chifukwa chake, pakuthandizira kwakanthaŵi kwa matenda a pathologies, Atorvastatin iyenera kukondedwa, komanso pofuna kupewa matenda amitsempha, ndibwino kugwiritsa ntchito Simvastatin.
Ndemanga za Odwala
Olga, wazaka 37, Veliky Novgorod
Pambuyo pa vuto la mtima, bambo adasankhidwa Simvastatin kuti achepetse cholesterol. Mankhwalawa adatha miyezi 4 ndipo munthawi imeneyi padalibe zotsatirapo zake. Kuphatikiza kosasinthika kwa mankhwalawo ndi mtengo, opanda - mphamvu zochepa. Kuwunikiranso mobwerezabwereza kunawonetsa kuti kuchuluka kwa cholesterol yoyipa kunachepa pang'ono. Abambo anakwiya, chifukwa anali ndi chiyembekezo chachikulu chamankhwala. Ndikhulupirira kuti simvastatin imathandizira pofatsa, osati mwa otsogola. Tsopano tikuthandizidwa ndi mankhwala ena.
Maria Vasilievna, wazaka 57, Murmansk
Potsatira mayeso otsatira, adotolo adati cholesterol idakwera pang'ono ndipo adalimbikitsa kutenga ma statins. Ndinkatenga Simvastatin, ndikamadya komanso kutsatira masewera olimbitsa thupi. Pambuyo pa miyezi iwiri ndidadutsa kuwunikanso kwachiwiri, komwe zizindikiro zonse zidabwereranso kwazonse. Sindikudandaula kuti ndinamwa mankhwalawa, ngakhale ambiri adachenjeza za kuvulaza kwake ndi kupanda pake m'magazi anga. Ndine wokondwa kuti zotsatira zake zakwaniritsidwa. Ndikupangira!
Galina, wazaka 50, Moscow
Ndidachita mantha nditamva kuchokera kwa dokotala kuti pali cholesterol yoposa 8. Ndimaganiza kuti mankhwalawa atenga nthawi yayitali komanso ovuta. Atorvastatin adalembedwa. Sindinatchule chiyembekezo chilichonse pamankhwala, koma osachita. Pambuyo pakuthandizidwa miyezi iwiri, cholesterol idatsikira ku 6. Sindimayembekezera kuti mankhwalawa athandiza. Ndikufuna kudziwa kuti ndimamwa mosamalitsa adokotala ndipo palibe zotsatira zoyipa.
Mankhwala onse awiriwa amagwiritsidwa ntchito mwachangu matenda a mtima komanso mtima.
Madokotala amawunika za Atorvastatin ndi Simvastatin
Egor Alexandrovich, wazaka 44, Moscow
Sindimakonda kulemba Simvastatin, chifukwa Ndimaona ngati mankhwala a m'zaka zapitazi. Tsopano pali ma statin amakono omwe ndi othandiza komanso otetezeka. Mwachitsanzo, atorvastatin. Mankhwalawa sangathe kutsitsa cholesterol yoyipa, komanso amachepetsa chiopsezo cha matenda a mtima ndi sitiroko. Fomu yabwino yotulutsidwa.
Lyubov Alekseevna, wazaka 50, Khabarovsk
Muzochita zamankhwala, ndimayesetsa kupereka Atorvastatin kwa odwala ngati palibe contraindication. Ndikukhulupirira kuti mankhwalawa amagwira ntchito modekha, osasokoneza kugwira ntchito kwamkati ndi ziwalo zamthupi. Odwala samakonda kudandaula za zoyipa, zomwe ndizofunikira. Kupatula apo, ambiri opuma pantchito amabwera ndi vuto lofananalo, omwe ali kale ndi matenda osachiritsika.
