Atomax amagwiritsidwa ntchito pochiza odwala omwe ali ndi matenda a hypercholesterolemia, cholowa cholowa hyperlipidemia, dysbetalipoproteinemia. Wothandizira pakamwa wa hypoglycemic amakulolani kukhazikika pamlingo wa lipids, zizindikiro za cholesterol yathunthu, triglycerides ndi kusalephera kwa mankhwala othandizira ndikuwonjezera zolimbitsa thupi. Kugwiritsa ntchito mankhwalawa kwakanthawi kumachepetsa mwayi wa kusintha kwa atherosulinotic mu mtima endothelium ndi cholesterol plaques.
Dzinalo Losayenerana
Atorvastatin.
ATX
C10AA05.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala amapangidwa mwa mawonekedwe a mapiritsi amkamwa. Chigawo chilichonse cha mankhwalawa chimakhala ndi 10 kapena 20 mg ya calcium ya calcium ya atorvastatin. Pakatikatiyi mulinso zosakaniza zina zofunika kukonzanso bioavailability ndi kuyamwa kwa chogwira ntchito m'matumbo:
- dehydrate silika dioxide;
- shuga mkaka;
- wowuma;
- triacetin;
- magnesium wakuba;
- povidone;
- croscarmellose sodium.
Mankhwala amapangidwa mwa mawonekedwe a mapiritsi ogwiritsira ntchito pakamwa, gawo lililonse la mankhwalawa limakhala ndi 10 kapena 20 mg ya atorvastatin calcium trihydrate.
Mapiritsi oyera oyera ozungulira ali ndi filimu ya enteric yopanga titanium dioxide, talc, crospovidone, hypromellose.
Zotsatira za pharmacological
Makina a zochita zamankhwala ochepetsa lipid amachokera pa atorvastatin, yemwe ndi blocker wa HMG-CoA reductase. Enzyme iyi ndiyofunikira kuti ipangidwe mevalonic acid, wolowera mafuta m'thupi. Ndi zoletsa za ntchito za HMG-CoA reductase, atorvastatin ikhoza kuletsa mapangidwe a cholesterol, otsika kachulukidwe lipoproteins (LDL) ndi triglycerides mu chiwindi.
Mankhwala amawonjezera kuchuluka kwa zolandila za LDL pamitsempha yama cell, zomwe zimapangitsa kuti pakhale zambiri komanso kagayidwe ka lipoproteins. Poyerekeza ndi kuchepa kwa ndende ya LDL, kuchuluka kwa lipoproteins yapamwamba kwambiri (HDL) kumawonedwa.
Pharmacokinetics
Ikalowa m'thupi, gawo lomwe limagwira limayamba kukhazikika mu khoma la matumbo ochepa. Bioavailability ndi 100%. Ikalowa m'magazi, atorvastatin imagwera beta-oxidation m'maselo a chiwindi ndikupanga zinthu za metabolic zokhala ndi lipid-kuchepetsa. Mankhwala ndi biotransformed pamaso pa P450 isoenzyme. The achire zotsatira zimatheka ndi 70% chifukwa yogwira metabolites.
Atomax amagwiritsidwa ntchito pochiza odwala omwe ali ndi matenda a hypercholesterolemia, cholowa cholowa hyperlipidemia, dysbetalipoproteinemia.
Atorvastatin ndi 95% womangidwa kumapuloteni a plasma. Ntchito yogwira ndi zinthu za metabolic zimasiya thupi makamaka kudzera munthawi yovomerezeka pambuyo pake. Pafupifupi 2% ya mankhwalawa amachokera mu mkodzo. Hafu ya moyo ndi maola 14.
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amagwiritsidwa ntchito kutsitsa cholesterol yayikulu, triglycerides ndi LDL. Mankhwala ndi othandizira odwala:
- cholowa kapena chachikulu hypercholesterolemia;
- dysbetalipoproteinemia ndi kulephera kudya;
- kuphatikiza Hyperlipidemia;
- mkulu seramu triglycerides.
Kukwaniritsa kwathunthu zotsatira za hypolipidemic ndizotheka pokhapokha pothandizidwa ndi zakudya zapadera kuti muchepetse cholesterol yayikulu.
Contraindication
Mankhwalawa adapangidwa pazochitika zotsatirazi:
- kuchuluka kwa zinthu zomwe zimapanga mankhwala;
- kuchuluka kwa hepatic transaminases mu seramu yopitilira muyeso ndi katatu pazifukwa zosadziwika;
- matenda oopsa a chiwindi;
- amayi apakati ndi oyamwitsa;
- muubwana ndi unyamata mpaka zaka 18.
Chenjezo liyenera kuchitika mukamamwa mapiritsi a anthu omwe ali ndi vuto la endocrine.
Chenjezo liyenera kuchitika mukamamwa mapiritsi a anthu omwe ali ndi:
- matenda a chiwindi ofatsa kapena zolimbitsa mwamphamvu:
- kusiya mowa matenda;
- kuphwanya kwakukulu kwamchere wamchere wamchere;
- matenda a endocrine;
- khunyu.
Momwe mungatenge atomax
Asanayambe mankhwala a Atomax, wodwalayo amapatsidwa zakudya zochepetsa lipid.
Mlingo wa akuluakulu pakadali koyambirira kwa chithandizo ndi 10 mg yogwiritsidwa ntchito kamodzi. Kuti muwonjezere zochizira, njira yotsatsira lipid, modekha, imatha kuwonjezeka mpaka 80 mg. Kuchulukitsa kuvomerezeka - 1 nthawi patsiku.
Masiku 14-28 aliwonse, muyenera kuyesa kuyesedwa kwa plasma ndende ya lipids. Kutengera ndi zomwe zapezeka, mlingo umasinthidwa ndi adokotala.
Pamodzi ndi hyperlipidemia ndi hypercholesterolemia, muyezo Mlingo 10 mg tsiku lililonse. The achire zotsatira zimawonedwa mkati 14 masiku, pazipita lipid-kutsitsa kumawonekera masabata 4 atayamba chithandizo. Pogwiritsa ntchito Atomax kwa nthawi yayitali, njira zochizira zimapitirira.
Ndi matenda ashuga
Mankhwala sangathe kukhudza kuchuluka kwa shuga m'thupi ndipo sikuti poizoni wama cell a kapamba. Munthawi yamankhwala, ndikofunikira kuyang'anitsitsa kuchuluka kwa shuga. Pakusintha kwakukulu, funsani kwa endocrinologist za kukonza kwa mankhwalawa a hypoglycemic.
Zotsatira zoyipa za Atomax
Zotsatira zoyipa zimayamba nthawi zambiri ngati osagwiritsa ntchito lipid-kuchepetsa.
Pa mbali ya gawo la masomphenyawo
Zouma conjunctiva, kukhathamiritsa m'maso, kuwonjezeka kwa kukakamira kwa mitsempha.
Kuchokera minofu ndi mafupa
Ndi kuphwanya kwamkati mwa masculoskeletal system, chitukuko cha nyamakazi, kukokana kwa minofu, kupweteka kwa mafupa ndi minofu ndikotheka. Mwapadera, rhabdomyolysis, myopathy imayamba.
Matumbo
Matumbo am'mimba amadziwika ndi kupezeka kwa:
- nseru
- kutentha kwa mtima;
- kutsegula m'mimba
- kusefukira, kudzimbidwa;
- stomatitis, glossitis;
- zilonda zam'mimba zotupa zam'mimba ndi duodenum;
- kutupa kwa kapamba;
- kuchuluka kwa hepatic aminotransferases;
- melena;
- magazi otupa.
Hematopoietic ziwalo
Pophwanya mapangidwe a mafupa a hematopoiesis, kuchuluka kwamitsempha yamagazi kumachepa.
Pakati mantha dongosolo
Kusokonezeka kwamanjenje kumayendetsedwa ndi kukula kwa chizungulire komanso kupweteka kwa mutu, vuto la kugona, kupumirana kwa mitsempha, kulephera kuyendetsa bwino, komanso mawonekedwe a dziko lokhumudwitsa.
Kuchokera kwamikodzo
Pali chiopsezo cha zotumphukira edema, matenda amkodzo thirakiti, dysuria, kutupa kwa impso, hematuria, magazi ndi urolithiasis.
Kuchokera ku kupuma
Mwina chitukuko cha zotupa mu bronchi, paranasal sinuses, kupuma kulephera.
Pa khungu
Mwa amuna, tsitsi limatha kutuluka. Pali kuwonjezeka kwa thukuta, mawonekedwe a dandruff, eczema.
Kuchokera ku genitourinary system
Ndi kuphwanya kwa njira yolerera, libido imachepa, kukomoka kwa erectile ndi vuto la umuna.
Kuchokera pamtima
Pali kupweteka pachifuwa, arrhythmia, vasodilation, phlebitis ndi ochepa hypotension.
Kuchokera kumbali ya kagayidwe
Ndi vuto la kagayidwe kazonse, kuwonjezeka kwa seramu ndende ya creatine phosphokinase ndikotheka. Kuwonongeka kwa chiwongolero cha glycemic, kukulitsa kwa albuminuria ndi ntchito yowonjezera ya ALT, AST sikuwonongedwa. Nthawi zina, kunenepa kwambiri, kuchuluka kwa zizindikiro za gout, hyperthermia zimawonedwa.
Matupi omaliza
Thupi lawo siligwirizana zimachitika mwa odwala omwe ali ndi tsankho pamagulu a Atomax. Thupi lawo siligwirizana ndi kukula kwa zotupa, kuyabwa ndi kukhudzana ndi dermatitis. Nthawi zina, angioedema, hypersensitivity to light, anaphylactic shock, Stevens-Johnson ndi matenda a Lyell angachitike.
Zokhudza mphamvu pakuwongolera njira
Mankhwalawa samakhudza zochitika za zotumphukira ndi mafupa am'mimba ndipo samatulutsa, chifukwa cha mankhwala ndi Atomax amaloledwa kuwongolera magwiridwe antchito ndi kuyendetsa galimoto.
Malangizo apadera
HMG-CoA reductase inhibitors imatsogolera kusintha kwa zochita zamankhwala am'thupi za hepatocytes. Chifukwa chake, musanayambe chithandizo, pakadutsa masabata 6 ndi 12 atasankhidwa Atomax, ndikofunikira kuyang'anira ntchito ya chiwindi. Ndi kulekerera kwabwino komanso michere yama chiwindi, chiwonetsero cha ntchito ya chiwindi chimachitika ndi kuwonjezeka kwa mlingo wa tsiku ndi tsiku komanso miyezi isanu ndi umodzi iliyonse.
Odwala onenepa ayenera kuyesa kuyimitsa cholesterol yawo asanayambe chithandizo.
Ndikofunika kukumbukira kuti kumwa atorvastatin kungayambitse myopathy. Ndikofunikira kudziwitsa dokotalayo za mawonekedwe a kupweteka ndi kufooka kwa minofu, makamaka ndi kukula kwa malungo ndi malaise wambiri. Ngati myalgia ichitika, ndikulimbikitsidwa kuti musiye kumwa Atomax. Ngati zotsatira za kuyezetsa magazi zikuwonetsa kuwonjezeka kwa ntchito ya creatine phosphokinase, kupitilira muyeso mwa nthawi 10 kapena kuposerapo, chithandizo cha atorvastatin chathetsedwa.
Munthawi yamankhwala osokoneza bongo, pamakhala chiopsezo cha myoglobinuria. Poyerekeza ndi momwe pathological process, rhabdomyolysis ndi vuto laimpso zingachitike. Ngati zizindikiro za myopathy kapena kulephera kwa impso zikuchitika, siyani chithandizo ndi Atomax.
Odwala onenepa musanayambe chithandizo ayenera kuyesetsa kuti azigwiritsa ntchito mafuta ena ake othandizira kudya, kuwonjezera masewera olimbitsa thupi komanso njira zina zochepetsera thupi.
Gwiritsani ntchito mu ukalamba
Mukafika zaka zopitilira 65, ndikulimbikitsidwa kutsatira njira yovomerezeka ndikutsatira malangizo a katswiri wazachipatala.
Kupatsa ana
Ndi zoletsedwa kumwa mankhwalawa kwa ana osakwana zaka 18. Palibe deta pazokhudza atorvastatin pa kukula ndi kukula kwa zimakhala za thupi.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amadzipaka pakati pa azimayi panthawi yoyembekezera chifukwa chosowa deta pa phytotoxicity ya Atomax. Atorvastatin samadziwika kuti amalowa mkaka wa m'mawere, chifukwa chake, tikulimbikitsidwa kuti musamutse mwana kuti adye ndi zosakaniza zosakanikirana panthawi yamankhwala.
The ntchito aimpso kuwonongeka
Zovuta za impso sizimakhudza kuchuluka kwa zotupa za atorvastatin ndi zomwe zili m'magazi, motero tikulimbikitsidwa kutenga mlingo woyenera wa matenda a impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Odwala omwe ali ndi matenda a chiwindi ayenera kumwa mankhwalawa moyang'aniridwa ndi dokotala. Kupatula kwawo ndi anthu omwe ali ndi zochita zambiri za hepatic aminotransferases, kupitirira nthawi zonse katatu kapena kuposerapo. Pankhaniyi, wothandizira kutsitsa lipid amuloledwa kugwiritsa ntchito.
Mankhwala osokoneza bongo a Atomax
Pochita malonda pambuyo pa malonda, sipanakhalepo ndi milandu ya bongo. Ngati mulingo wovomerezeka wa 80 mg upambana, ndizotheka kuwonjezera kapena kukulitsa mwayi wazotsatira zoyipa. Chifukwa chosowa deta, mankhwala enaake sanakhalepo. Chithandizo cha Syndrome chimagwiritsidwa ntchito pothana ndi zovuta zomwe zimachitika. Hemodialysis yochotsa mankhwalawa mofulumira.
Kuchita ndi mankhwala ena
Pali chiopsezo chotenga myopathy ndi makonzedwe ofanana a Atomax antifungal othandizira kuchokera ku gulu la azoles, ma cyclosporin maantibayotiki, Niacin, zotumphukira za fibroic acid, Erythromycin.
Pogwiritsa ntchito munthawi yomweyo ma suspensions okhala ndi mchere wa aluminium ndi magnesium, kuchuluka kwa plasma kwa atorvastatin kumachepetsedwa ndi 35%, pomwe gawo la LDL-cholesterol tata silisintha. Gawo logwira ntchito la Atomax silikuwakhudza pharmacokinetics a Antipyrine, Azithromycin. Mukamagwiritsa ntchito 80 mg ya Digoxin, ndizotheka kuwonjezera seramu yake ndi 20%. Odwala omwe adasintha izi mu ndende ya Digoxin amayang'aniridwa ndi achipatala.
Atorvastatin imakulitsa AUC ya ethylene estradiol yochokera pakubala mwa 20%.
Colestipol ikhoza kuyambitsa kuchepa kwa milingo ya plasma ya atorvastatin ndi 25%. Poterepa, pali kuwonjezeka kwa kutsitsa kwa lipid.
Kuyenderana ndi mowa
Munthawi yamankhwala, sikulimbikitsidwa kumwa zakumwa zoledzeretsa ndi mankhwala okhala ndi ethanol. Mowa wa Ethyl umayambitsa kuledzera, kupatsidwa zinthu za m'magazi komanso kuundana kwa maselo ofiira a m'magazi, zomwe zimakhudza mkhalidwe wamtima wamtima. Kuchepa mphamvu kwa achire zotsatira ndi kuwonongeka mu pathologies a kuzungulira dongosolo zimawonedwa.
Analogi
Pangokhala lipid-kutsitsa kwenikweni, mapiritsi a Atomax akhoza kutha ndi imodzi mwamankhwala otsatirawa:
- Liprimar;
- Atoris;
- Liptonorm;
- Tulip;
- Vazotor;
- Atorvastatin-SZ.
Kupita kwina mankhwala
Mankhwalawa amagulitsidwa ndi mankhwala azachipatala.
Kodi ndingagule popanda kulandira mankhwala?
Kugulitsa kwaulere kwa mankhwala ochepetsa lipid kumakhala kochepa chifukwa cha chiwopsezo chachikulu cha zotsatira zoyipa mukamagwiritsa ntchito molakwika.
Mtengo
Mtengo wapakati wa Atomax ndi ma ruble 400-500.
Zosungidwa zamankhwala
Sungani miyala pamapiritsi patali ndi dzuwa m'malo mwake ndi chinyezi chochepa. Ndikulimbikitsidwa kukhala ndi mankhwalawa pa kutentha kwa + 8 ... + 25 ° C.
Tsiku lotha ntchito
Zaka 2
Wopanga
CJSC MAKIZ-PHARMA, Russia.
Popanda kuchepa kwa lipid, mapiritsi a Atomax akhoza kutha ndi Liprimar.
Ndemanga
Eduard Petukhov, wazaka 38, Rostov-on-Don
Ndikuganiza kuti mankhwalawa ndi njira yothanirana ndi cholesterol. Miyezi 6 yapitayo, adayamwa kuti amwe mapiritsi ndi cholesterol ya 7.5 mmol. Kuyesa magazi komaliza milungu iwiri yapitayo kunaulula kutsika mpaka 6 mmol. Ndikupitiliza chithandizo. Panalibe zovuta zomwe zimachitika panthawi yonse ya chithandizo.
Vasily Zafiraki, katswiri wa zamtima, St.
M'kati mwa maphunziro pazofanana ndi achire a Atomax ndi Lipirimar, milingo ya triglyceride ndi ntchito yogwira mtima ya endothelium ya mtima umayerekeza ndi kugwiritsa ntchito mankhwala kwa nthawi yayitali. Kafukufuku wasonyeza zabwino za Atomax. Opanga ena a atorvastatin sachitanso mayeso ofananawo ndipo amapereka mtengo wotsika kwa mapiritsi, zomwe zimatipangitsa kuganiza za momwe mankhwalawo amathandizira. Ndimakonda kuti Atomax ili ndi mitundu yambiri.
