Aprovel 150 ndi mankhwala omwe ali ndi hypotensive zotsatira (kuchepetsa kuthamanga). Amagwiritsidwa ntchito kwambiri pochiza matenda osiyanasiyana oopsa.
Dzinalo Losayenerana
INN yamankhwala ndi Irbesartan.
Aprovel 150 ndi mankhwala omwe ali ndi hypotensive zotsatira (kuchepetsa kuthamanga).
ATX
Code ya ATX: C09CA04.
Kutulutsa mafomu ndi kapangidwe kake
Mankhwala ali ngati mapiritsi oyera okhala ndi mafilimu. Pazikhadakhodi zamankhwala pali mapiritsi 14 kapena 28 m'matumba.
Mapiritsi, ntchito yogwira (irbesartan) ili ndi kuchuluka kwa 150 mg. Zinthu zothandiza ndi:
- lactose monohydrate;
- ma cellcose a microcrystalline;
- croscarmellose sodium;
- hypromellose;
- magnesium wakuba;
- silika.
Zinthu zomwe zimapanga filimuyo:
- Opadra yoyera;
- sera ya carnauba.
Aprovel 150 imapangidwa ngati mapiritsi oyera okhala ndi filimu.
Zotsatira za pharmacological
Zochita za pharmacological - antihypertgency (kutsitsa magazi).
Mphamvu yogwira ya mankhwala ndi angiotensin II receptor antagonist (oligopeptide hormone). Thupi limapangitsa zochita za mahomoni. Zotsatira zake, mulingo wa renin m'magazi umakwera ndipo zomwe aldosterone zimachepa.
Mphamvu ya antihypertensive imachitika mu maola 3-5 ndipo imatha tsiku lonse. Kuti mukhale ndi mphamvu yayitali, ndikofunika kumwa mankhwalawa kwa masabata awiri. Pambuyo pochotsa mapiritsi, palibe lakuthwa kuchotsera matenda (kupanikizika kumakula pang'onopang'ono).
Pharmacokinetics
Mankhwala amadziwika ndi kuyamwa msanga m'mimba. Kudya sikusintha kuchuluka kwa mayamwidwe. Ibersartan imakhala ndi bioavailability yayikulu (mpaka 80%) komanso yomanga kumapuloteni amwazi (mpaka 96%). Zinthu zapamwamba kwambiri zomwe zimapezeka m'magazi zimawonedwa pambuyo pa maola awiri.
Mankhwala amachotsedwa mu mkodzo makamaka mu mawonekedwe a metabolites.
Kusintha kwa zinthu mwa metabolism kumachitika m'chiwindi. Nthawi yochotsa ndi maola 22-30. Mankhwala amachotsedwa mu ndulu, mkodzo ndi ndowe makamaka mu mawonekedwe a metabolites. Ndi chithandizo cha nthawi yayitali ndi irbesartan, kuchuluka kwake pang'ono m'magazi kumawonedwa (mpaka 20%).
Zizindikiro zogwiritsidwa ntchito
Mankhwalawa amagwiritsidwa ntchito pochiza:
- Matenda oopsa a arterial (mitundu yosiyanasiyana ya maphunziro). Mapiritsi atha kukhala gawo la kuphatikiza antihypertensive therapy.
- Matenda a impso chifukwa cha matenda oopsa kapena mtundu II matenda a shuga.
Contraindication
Aprovel ndi yoletsedwa kwa amayi apakati komanso oyembekezera, komanso ana osaposa zaka 18. Zotsutsana zina ndi:
- Matenda akulu a chiwindi (kulephera kwa chiwindi).
- Lactase akusowa.
- Lactose kapena galactose tsankho (malabsorption).
- Kusalolera payekha kwa irbesartan kapena Excipients.
Ndi chisamaliro
Madokotala amapereka mankhwala mosamala ndi osachepera sodium mu plasma, aortic ndi mitral stenosis, kulephera kwa impso, hypovolemia, atherosranceotic pathologies ndi matenda a mtima (matenda a mtima, mtima). Ndi ma pathologies awa, kuchepa kwambiri kwa kupanikizika ndikotheka, limodzi ndi zizindikiro zamankhwala.
Simungathe kumwa mankhwalawa matenda a chiwindi.
Momwe mungatenge Aprovel 150?
Mankhwalawa adapangira pakamwa.
Pa gawo loyambirira la chithandizo, wodwalayo amapatsidwa 150 mg ya irbesartan (piritsi 1 la Aprovel). Antihypertensive zotsatira zimapitirira kwa tsiku limodzi. Ngati kuthamanga kwa magazi sikuchepa, ndiye kuti mlingowo umakwezedwa mpaka 300 mg.
Odwala omwe ali ndi nephropathy amalangizidwa kuti atenge 300 mg ya irbesartan kuti ikhale yothandiza. Dokotala amatha kuchepetsa mlingo woyambirira wa 75 mg pa mankhwalawa okalamba (opitilira 65) ndi odwala pa hemodialysis.
Ndi matenda ashuga
Odwala omwe ali ndi mtundu wachiwiri wa shuga amakhala ndi piritsi limodzi patsiku kumayambiriro kwa mankhwalawa. Ngati ndi kotheka, tsiku lililonse mlingo uyenera kuchuluka kwa mapiritsi 2. Mankhwala amayenera kuperekedwa moyang'aniridwa ndi dokotala.
Zotsatira zoyipa za Aprovel 150
Chibale chomwe chimachitika pakachitika zinthu zina zoyipa ndi kugwiritsa ntchito mankhwalawa sichinatsimikizidwe. Izi zimachitika chifukwa cha kafukufuku yemwe amayang'aniridwa ndi placebo, momwe zotsatira zoyipa zimachitikira mwa anthu omwe akuchitika.
Pa mankhwalawa, zizindikiro za kupindika kwambiri zimatha:
- kutopa kwambiri;
- kupweteka kwa minofu;
- asthenia.
Matenda a metabolism (hyperkalemia) amathanso kutha.
Matumbo
Zotsatira zoyipa zomwe zimachitika kuchokera m'matumbo am'mimba ndizovuta zam'mimba komanso kusanza. Zizindikiro za Dyspeptic ndi kutsegula m'mimba sizimachitika kawirikawiri.
Mukamamwa Aprovel, zotsatira zoyipa zam'mimba zimayambitsa mseru komanso kusanza.
Pakati mantha dongosolo
Odwala ena amakhala ndi migraines ndi chizungulire.
Kuchokera ku kupuma
Kutsokomola kumachitika.
Kuchokera ku genitourinary system
Odwala ena amakhala ndi vuto la kugona.
Kuchokera pamtima
Zotsatira zoyipa pa ntchito ya mtima zimawonekera ndikuphwanya kwa mtima (tachycardia), orthostatic hypotension, ndi hyperemia ya khungu.
Matupi omaliza
Mukamamwa mankhwalawa, zimakhala zotheka kukhala ndi zovuta monga Quincke's edema, urticaria, ndi kuyabwa.
Zokhudza mphamvu pakuwongolera njira
Zotsatira za mankhwalawa pamsasa sizimamveka bwino. Koma munthawi yamankhwala, mavuto am'thupi am'thupi amatha kuwonekera. Odwala omwe amakhala ndi chizungulire komanso asthenia samalimbikitsidwa kuyendetsa magalimoto kapena njira zina.
Malangizo apadera
Ndi aldosteronism yayikulu, pali kuchepa kwa zotsatira kuchokera ku RAAS inhibitors (retin-angiotensin-aldosterone system), kuphatikizapo Aprovel.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Mankhwalawa amaletsedwa azimayi oyembekezera komanso akumayamwa chifukwa chosowa maphunziro odalirika azachipatala.
Kusankhidwa kwa Aprovel kwa ana 150
Mankhwalawa amangogwiritsidwa ntchito pochiza akuluakulu.
Gwiritsani ntchito mu ukalamba
Okalamba odwala, mankhwala ndi mankhwala muyezo. Potsatira malangizo a dokotala, mlingo woyambirira ungachepetse 75 mg. Pa mankhwala, ndikofunikira kuwunika momwe chiwindi, impso ndi potaziyamu zili mthupi.
The ntchito aimpso kuwonongeka
Kwa anthu omwe ali ndi vuto la impso (m'magawo oyambawo), mankhwalawa amayikidwa mosamala. Kulandila kwa Aprovel kuyenera kutsagana ndi kuwunika mulingo wa creatinine ndi potaziyamu m'magazi.
Sitikulimbikitsidwa kupereka mankhwala ngati magwiridwe antchito a impso amatengera RAAS. Zochita zake mukamamwa Aprovel ndizolepheretsa, zomwe zimatsogolera ku matenda a impso.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kulephera kwamphamvu kwa chiwindi ndikuphwanya kugwiritsa ntchito mankhwalawa. M'magawo oyamba a matenda, mankhwalawa amagwiritsidwa ntchito moyang'aniridwa ndi dokotala.
Zosokoneza bongo za Aprovel 150
Pogwiritsa ntchito mankhwala kwa nthawi yayitali, mankhwalawa amayambitsidwa kukhala osatetezeka kwambiri. Mwina chitukuko cha ochepa hypotension ndi kuledzera thupi (kusanza, kutsegula m'mimba).
Ngati pali mankhwala osokoneza bongo, ndikofunikira kuti muzitsuka m'mimba ndikutenga adsorbent (makala opangidwa, makala a Polysorb MP kapena Enterosgel). Hemodialysis yochotsa zinthu mthupi sikuchitika. Chithandizo cha Zizindikiro chingafunike.
Kuchita ndi mankhwala ena
Mankhwalawa amatha kuphatikizidwa ndi mankhwala ena a antihypertensive, monga thiazide diuretics, calcium blockers blockers ndi β-blockers. Kuphatikiza uku kumabweretsa kuwonjezeka kwa hypotensive zotsatira. Ndi milingo yosankhidwa bwino, hypotension imatha.
Kufooka kwa hypotensive zotsatira za Aprovel mankhwala Ibuprofen.
Mosamala, Aprovel iyenera kutengedwa ndi heparin, potaziyamu-yosalekerera okodzetsa komanso zinthu zina zomwe zili ndi potaziyamu. Kugwiritsa ntchito mogwirizana ndi ACE zoletsa kapena Aliskiren ndi nephropathy ndikosayenera.
Mankhwala ochokera ku gulu la NSAID amafooketsa mphamvu ya hypotensive (Paracetamol, Nurofen, Ibuprofen, etc.). Kugwiritsa ntchito mankhwalawa kuphatikizana kumayambitsa kulephera kwa impso ndi hyperkalemia.
Kuyenderana ndi mowa
Kumwa mowa panthawi ya chithandizo cha Aprovel ndizoletsedwa. Mowa umawonjezera mwayi wokhala ndi zovuta zoyipa.
Analogi
Mafanizo otchuka a mankhwalawa: Irbesartan ndi Ibertan. Ndalamazi zimakhala ndi chinthu chimodzi - irbesartan.
Ma analogu aku Russia ndi Irsar ndi Blocktran.
Kupita kwina mankhwala
Aprovel ikupezeka pamankhwala.
Mtengo wa Aprovel 150
Mtengo wa phukusi la mapiritsi 14 umachokera ku 280 mpaka 350 rubles. Paketi ya mapiritsi 28 imadya ma ruble 500-600.
Zosungidwa zamankhwala
Mankhwalawa amayenera kusungidwa kuti ana asawatenthe mpaka kutentha 30 mpaka C.
Tsiku lotha ntchito
Moyo wa alumali ndi zaka zitatu.
Wopanga
Wopanga - Sanofi Winthrop Viwanda (France).
Ndemanga za Aprovel 150
Omvera zamtima
Vladimir, wazaka 36, mzinda wa St.
Pochita, ndimakonda kupereka mankhwala awa kwa odwala omwe ali ndi matenda oopsa. Imalekeredwa bwino ndipo imachitika mwachangu. Ubwino ndi mwayi wolandirira ndikusunga zotsatira kwa maola 24. Zotsatira zoyipa ndizochepa.
Svetlana, wazaka 43, Vladivostok
Ichi ndi mankhwala othandizira kuti magazi azithamanga. Itha kuperekedwa kwa odwala okalamba komanso odwala matenda a shuga. Chiwopsezo cha zotsatira zoyipa ndizochepa. Choyipa chokha cha chida ichi ndi mtengo.
Analogue ya Aprovel ndi mankhwala Irbesartan, omwe amaperekedwa ndi mankhwala.
Odwala
Diana, wazaka 52, Izhevsk
Ndakhala ndikuvutika ndi matenda oopsa kwa nthawi yayitali. Ndayesa mankhwala ambiri, koma ndimalandila kuchokera kwa Aprovel kokha. Kupanikizika kumasungidwa mwachizolowezi. Sindimawona zoyipa.
Alexandra, wazaka 42, Krasnodar
Ndinayamba kumwa mapiritsiwo monga adanenera dokotala. Ndimamwa mankhwalawa m'mawa. Izi zimachitika tsiku lonse. Kuyambira koyamba ndidayamba kumva bwino.
Dmitry, wazaka 66, Moscow
Poganizira za matenda a shuga, kuthamanga kwanga kwa magazi kunayamba kukwera. Dotolo adalangiza mankhwalawa. Sabata yoyamba kuvomereza inali kufooka pang'ono, koma kenako ndidamva bwino. Ndakhala ndikumwa mankhwalawa kwa miyezi itatu, ndipo mavuto ake sanawonjezeke.
