Mankhwala Irmed: malangizo ntchito

Irume ndi mankhwala ogwiritsidwa ntchito pochotsa matenda oopsa komanso zina za mtima ndi mitsempha yamagazi yokhudzana ndi kuchuluka kwa mitsempha. Ngati itagwiritsidwa ntchito molakwika, imatha kukupweteketsani ku moyo, chifukwa chake mutha kuyamba kumwa mankhwalawo mwachilolezo cha dokotala.

Dzinalo Losayenerana

Lisinopril - dzina la yogwira mankhwala.

Irume ndi mankhwala ogwiritsidwa ntchito pochotsa matenda oopsa komanso zina mwa mtima ndi m'mitsempha yamagazi.

ATX

С09АА03 - code for anatomical-achire mankhwala-mankhwala.

Kutulutsa mafomu ndi kapangidwe kake

Mankhwala ali ndi mawonekedwe apiritsi yotulutsidwa. Piritsi lililonse limaphatikizapo:

• lisinopril dihydrate (10 kapena 20 mg);
• mannitol;
• wowuma mbatata;
• calcium phosphate dihydrate;
• chitsulo oxide chikasu;
• silicon dioksidi madzi;
• mbatata wowuma pregelatinized;
• magnesium wakuba.

Mapiritsi amaperekedwa m'maselo a ma polymeric 30, omwe amawaika m'makatoni ndikunyamula malangizo.

Zotsatira za pharmacological

Lisinopril ndi zoletsa za ACE zomwe zimakhala ndi izi:

• amachulukitsa kuchuluka kwa vasodilator prostaglandins;
• Imachepetsa mayendedwe azomwe zimachitika panthawi yomwe mtundu 1 angiotensin umasinthidwa kukhala mtundu wa angiotensin, womwe umapangitsa kuchuluka kwa magazi;
• amachepetsa vasopressin ndi endothelin, omwe ali ndi katundu wa vasoconstrictor;
• amachepetsa kukana kwa capillary ndi mtima;
• normalization wa contractile ntchito ya mtima minofu, kumawonjezera kulolerana kwa mtima kupsinjika mwa anthu ndi mtima kulephera;
• Ili ndi tanthauzo lotsogolera, lomwe limakhala pafupifupi tsiku limodzi;
• linalake ndipo tikulephera ntchito ya renin-angiotensin dongosolo la myocardium, amalepheretsa makulidwe a minofu ya minofu ndi kukulira kwa mbali yamanzere;
• amachepetsa kupanikizika kwa mapapu;
• amachepetsa chiwerengero chaimfa pakati pa odwala omwe adadwala matenda amitsempha yotupa, kusokonezeka kwakukulu kwa magazi m'mitsempha yayikulu kapena matenda a mtima.

Amaganizira matenda a minofu ya mtima.

Pharmacokinetics

Mukamagwiritsa ntchito piritsi la Irume, chinthu chogwira ntchito chimalowa mkatimu. Kudya sikusintha magawo a pharmacokinetic a lisinopril. Kuzungulira kwazinthu zambiri m'magazi kumatsimikiziridwa pambuyo maola 6. Lisinopril samalumikizana ndi zigawo za plasma ndipo samapangidwira. Mankhwala omwe ali ndi mkodzo sasintha. Hafu ya mlingo wotumizidwa umachoka m'thupi mkati mwa maola 12.

Zomwe zimayikidwa

Zisonyezo zakusankhidwa kwa Irume ndi:

• matenda oopsa (monga othandizira okhawo othandizira kapena osakaniza mankhwala ena);
• Kulephera kwamtima kosalekeza (kuphatikiza ndi diuretics kapena mtima glycosides);
• kupewa ndi kuchiza infarction ya myocardial (tsiku loyamba, mankhwalawa amaperekedwa kuti azikhala ndi hemodynamic magawo ndi kupewa kugunda kwa mtima;
• kuwonongeka kwa matenda ashuga a m'matumbo (kuchepetsa kuchuluka kwa albumin komwe kumachitika mu mkodzo mwa anthu omwe ali ndi matenda amtundu wa 2 ndi mtundu wa 2).

Irume akuwonetsedwa chifukwa cha kulephera kwamtima.

Iramed imayikidwa kuti iwononge matenda a shuga.

Edema ya Quincke yomwe idasamutsidwa kale ndi yotsutsana ndikusankhidwa kwa Irume.

Contraindication

Mankhwala sakhazikitsidwa:

• thupi lawo siligwirizana ndi lisinopril ndi zoletsa zina za ACE;
• edema ya Quincke yapita chifukwa chotenga mankhwala a antihypertensive;
• majini angioedema;
• munthawi yomweyo mankhwala osokoneza bongo aliskiren.

Ndi chisamaliro

Zotsatira zokhudzana ndi kugwiritsa ntchito mankhwala a antihypertensive ndi:

• kutchukitsa zotupa za impso;
• kupatsidwa impso kwaposachedwa;
• milingo yokwera ya nayitrogeni ndi potaziyamu m'magazi;
• coronary artery stenosis;
• mtima wowononga;
• ochepa hypotension;
• kusokonezeka kwa magazi muubongo;
• sitiroko;
• kuwonongeka kwa ischemic kwa minofu ya mtima;
• wosakhazikika mtima kulephera;
• autoimmune zotumphukira zotupa;
• kutsatira zakudya zopanda mchere;
• kuchepa kwa thupi;
• kusokonezeka kwa hematopoietic dongosolo;
• kukhala pa hemodialysis;
• anakonza kapena kuchedwetsa njira zochitira opaleshoni.

Kuphwanya wachibale pakugwiritsa ntchito mankhwalawa ndikutopa madzi.

Kukhala pa hemodialysis ndikosemphana ndi kukhazikitsidwa kwa Irume.

Mankhwala sinafotokozedwe zotupa za ischemic pamisempha ya mtima.

Stroke ndi contraindication pakugwiritsa ntchito Irume.

Ndi ochepa hypotension, mankhwala si mankhwala.

Mapiritsi okhala ndi ayimidwe amagwiritsidwa ntchito nthawi imodzi patsiku, kuwunikira njira yovomerezeka.

Momwe mungatore Irreg

Mapiritsi amagwiritsidwa ntchito 1 nthawi patsiku, kuwunikira njira yovomerezeka. Mlingo umatengera mtundu wa matenda:

1. Matenda oopsa - mu milungu yoyambirira yamankhwala kutenga 10 mg pa tsiku. Kuyambira milungu itatu, mankhwalawa amayamba kukula pang'onopang'ono kukhala mlingo wokonzanso (20 mg). Zitha kutenga osachepera mwezi umodzi kuti mukhale ndi zotsatira zoyipa. Ngati munthawi imeneyi zotsatira zabwino sizinachitike, mankhwalawo ayenera kuikidwa m'malo mwake.
2. Matenda oopsa a renovascular - yambani mankhwalawa ndi 2,5-5 mg patsiku. Chithandizo chimaphatikizidwa ndikuwunika magwiridwe antchito.
3. Kulephera kwa mtima - asanamwe ndi Irume, amachepetsa mlingo wa omwe adamwa kale mankhwala. Chithandizo chimayamba ndi kuyambitsa 2,5 mg wa lisinopril patsiku. M'tsogolomu, tsiku lililonse mlingo umakulitsidwa mpaka 10 mg.
4. Pachimake m`mnyewa wamtima infarction - kutenga 5 mg tsiku loyamba, yemweyo mlingo kutumikiridwa 48 mawola ntchito koyamba. M'tsogolomu, mankhwalawa amatengedwa pa 10 mg patsiku kwa masiku 45.

Ndi matenda ashuga

Odwala a Type 1 ndi 2 a shuga amatenga 10 mg a lisinopril patsiku.

Zotsatira zoyipa za Irume

Matumbo

Matenda am'mimba omwe amachitika mukatenga Irume, amawonetsedwa:

• kamwa yowuma
• kupumirana mseru ndi kusanza;
• kuchepa kwa chakudya;
• kuwonongeka kwa kapamba;
• mavuto a dyspeptic;
• cholestatic jaundice;
• kutupa kwa chiwindi;
• kupweteka m'mimba.

Zizindikiro pafupipafupi mutamwa mapiritsiwa zimawerengedwa ngati ululu wam'mimba.

Kumwa mankhwalawa kumatha kuyenda limodzi ndi kutupa kwa chiwindi.

Kutengera komwe kumamwa mankhwalawa, kugwidwa ndi mseru komanso kusanza kungachitike.

Mukamamwa Irreg, kuchepa kwa chidwi cha chidwi kungaoneke.

Irmed imathandizira kuti magazi m'thupi athe.

Zotsatira za mankhwalawa ku ubongo zimawonetsedwa ndi mavuto ogona.

Pa mankhwala, kupezeka kwa zoyipa ngati kukokana kwa minofu ya ng'ombe kumadziwika.

Hematopoietic ziwalo

Mankhwalawa angathandizire kuti magazi asamayende bwino komanso kuti achulukane. Ndi kugwiritsa ntchito nthawi yayitali, kuchepa kwa magazi m'thupi kumayamba ndipo magazi amayamba kuchepa.

Pakati mantha dongosolo

Mphamvu ya lisinopril pa ubongo imawonetsedwa:

• masinthidwe;
• kuchepa mphamvu kwa miyendo;
• kugona movutikira;
• kupindika kwa minofu ya ng'ombe;
• kufooka kwa minofu.

Kuchokera ku kupuma

Kutengera komwe kumamwa mankhwalawa, matenda a mphumu ya bronchial komanso kupuma movutikirapo kumatha kuchitika.

Kuchokera pamtima

Zizindikiro zowonongeka pamtima ndi m'mitsempha yamagazi yomwe imachitika mukamayamwa:

• kukanikiza kupweteka pachifuwa;
• kuchepa kwa magazi magazi;
• kuchepa kwakukulu kwa kuthamanga kwa magazi;
• kugwa kwa orthostatic;
• bradycardia;
• tachycardia;
• kuphwanya atrioventricular conduction;
• myocardial infaration.

Poyerekeza ndi kumbuyo kwa kutenga Irady, bradycardia imachitika.

Kutenga Irume kumayambitsa tachycardia.

Atatha kumwa mankhwalawa, odwala ena amakhala ndi vuto loyambitsa khungu.

Zoyipa kwa mankhwalawa zimasonyezedwa ndi totupa mu mawonekedwe a urticaria.

Kumwa mankhwalawa kumatha limodzi ndi anaphylactic.

Mukamagwiritsa ntchito mankhwalawa, mutha kukumana ndi mawonekedwe oyipa ngati chizungulire.

Kutengera komwe kumamwa mankhwalawa, matenda a mphumu ya bronchial angachitike.

Kuchokera kumbali ya kagayidwe

Mukatenga Irume, kuchuluka kwa magazi, sodium, potaziyamu, ndi bilirubin kumatha kuchuluka. Ntchito za hepatic transaminases sizisintha kwenikweni.

Matupi omaliza

Zoyipa kwa mankhwala zikuwonetsedwa:

• kutupa kwa nkhope ndi khosi;
• kuyabwa ndi redness khungu;
• totupa mu mawonekedwe a urticaria;
• anaphylactic mantha.

Zokhudza mphamvu pakuwongolera njira

Mankhwalawa amatha kuyambitsa chizungulire, chomwe chimachepetsa ndende. Chifukwa chake, munthawi yamankhwala, muyenera kupewa kugwira ntchito ndi zida zovuta.

Malangizo apadera

Gwiritsani ntchito mu ukalamba

Pochiza matenda oopsa mwa anthu opitilira 65, mapiritsi amagwiritsidwa ntchito mosamala.

Kupatsa ana

Cholepheretsa kugwiritsidwa ntchito kwa Irume ndi zaka za ana (mpaka zaka 18).

Mimba ikachitika, chithandizo ndi Irume chimayimitsidwa nthawi yomweyo.

Kukongoletsa kumakhudza kwambiri mkhalidwe wa mwana, chifukwa chake simungathe kumwa mapiritsi pa nthawi yokumwitsa.

Cholepheretsa kugwiritsidwa ntchito kwa Irume ndi zaka za ana (mpaka zaka 18).

Pochiza matenda oopsa mwa anthu opitilira 65, mapiritsi amagwiritsidwa ntchito mosamala.

Mukamagwiritsa ntchito mlingo waukulu wa lisinopril, magazi amatsika kwambiri.

Chithandizo cha mankhwala osokoneza bongo amakhudzanso mtsempha wa magazi.

Gwiritsani ntchito panthawi yoyembekezera komanso mkaka wa m`mawere

Mimba ikachitika, mankhwalawa ndi lisinopril amasiya pomwepo. Pulogalamuyi imayikidwa mkaka ndipo imatha kusokoneza mwana, choncho simuyenera kumwa mapiritsi nthawi yotsekemera.

The ntchito aimpso kuwonongeka

Ndi aimpso kuwonongeka, kumwa mankhwalawa kumafuna kuwunika pafupipafupi magawo.

Gwiritsani ntchito ntchito yolakwika ya chiwindi

Mu matenda owopsa a chiwindi, mankhwalawa saikidwa mankhwala.

Mankhwala osokoneza bongo a Irume

Mukamagwiritsa ntchito mlingo waukulu wa lisinopril, kuthamanga kwa magazi kumatsika kwambiri, kugwa kwa orthostatic kumayamba. Pali posungira mkodzo ndi ndowe, ludzu lalikulu. Palibe chinthu chomwe chimachepetsa zotsatira za lisinopril. Chithandizo chimaphatikizapo kugwiritsa ntchito ma sorbents ndi mankhwala ofewetsa tuvi tolimba, kuphatikizira kwamchere kwa mchere.

Mankhwala amatha kuchotsedwa ndi hemodialysis.

Kuchita ndi mankhwala ena

Ndi munthawi yomweyo kugwiritsa ntchito Irume ndi:

• potaziyamu kuteteza okodzetsa ndi cyclosporine kumawonjezera mwayi kuwonongeka kwa impso;
• beta-blockers imawonjezera hypotensive zotsatira za lisinopril;
• Kukonzekera kwa lifiyamu, chimbudzi chakumapeto chimachepetsa;
• Maantacid, kuyamwa kwa mankhwala a antihypertensive kumayipa;
• kuchepetsa matenda a shuga kumawonjezera chiopsezo cha hypoglycemia;
• non-hormonal anti-yotupa mankhwala hypotensive mphamvu ya lisinopril yafupika.

Kuyenderana ndi mowa

Zakumwa zoledzeretsa pakumwa mankhwalawo zimakhudza mkhalidwe wam'mimba, genitourinary ndi mantha system.

Analogi

Mankhwala ofanana ndi a Irume ndi awa:

• Lisinopril;
• Diroton;
• Lisinotone;
• Lysiprex;
• Lysigamm.

Kupita kwina mankhwala

Kodi ndingagule popanda kulandira mankhwala?

Sizotheka kugula mapiritsi popanda mankhwala.

Mtengo

Mtengo wapakati wamapiritsi 30 ndi ma ruble 220.

Zosungidwa zamankhwala

Mapiritsi amasungidwa pamalo abwino, owuma, otetezedwa kuti asayerekezedwe ndi kuwala.

Tsiku lotha ntchito

Itha kugwiritsidwa ntchito mkati mwa miyezi 36 kuyambira tsiku lopangira.

Wopanga

Mankhwalawa amapangidwa ndi kampani yopanga mankhwala ku Belupo ku Croatia.

Analogue yaumbidwe ya Irume ndi mankhwala a Lisinopril.

Omwe ali ndi magwiridwe ofanana ndi mankhwala Lysinoton.

Diroton amathandizanso thupi.

Mutha kusintha mankhwalawa ndi mankhwala monga Lysigamm.

Ndemanga

Sofia, wazaka 55, ku Moscow: "Ndakhala ndikudwala matenda oopsa kwa nthawi yayitali. Kupanikizika kumawuka nthawi zambiri, komwe kumayambitsa kupweteka m'mutu komanso kufooka. Sindikufuna kumwa mankhwala aliwonse, chifukwa chake ndinayesa zakudya zingapo zomwe sizinapatse kanthu. Kwa mwezi umodzi. Kwa theka la chaka mavuto akhala akusungidwa munthawi yoyenera. "

Tamara, wazaka 59, Narofominsk: "Amayi akhala akudwala matenda a shuga kwa nthawi yayitali, ndipo chifukwa cha ukalamba wawo, matendawa adayamba kusokonekera mitsempha yamagazi ndi impso. Kupanikizika kudakulirakulira, chifukwa amayi ake amapititsidwa kuchipatala. "Kamodzi patsiku - izi ndizokwanira kupitiliza kupanikizika nthawi zonse. Mankhwala okwera mtengo samayambitsa mavuto."