Ibertan ndi wa gulu la antihypertensive mankhwala. Mankhwalawa ali ndi zochepa zotsutsana, zomwe zimapangitsa kuti ntchito yake ikhale yambiri. Chiwopsezo cha zotsatira zoyipa panthawi ya chithandizo chochepa. Ubwino wa mankhwalawa ndi kuthekera kosunga zotsatira zomwe zimapezeka panthawi ya 1 pakumwa mapiritsi.
Dzinalo Losayenerana
Irbesartan
Dzinalo losavomerezeka padziko lonse la Ibertan ndi Irbesartan.
ATX
C09CA04
Kutulutsa mafomu ndi kapangidwe kake
Mutha kugula othandizira antihypertensive m'mapiritsi okhala ndi filimu. Ntchito yogwira ntchito ndi irbesartan. Chipangizocho ndi chimodzi chimodzi, zomwe zikutanthauza kuti zida zotsalira sizikuwonetsa ntchito za antihypertensive. The kuchuluka kwa irbesartan piritsi 1: 75, 150 ndi 300 mg. Mutha kugula mankhwalawo m'matumba (14 ma PC.). Bokosi lamatoni lili ndi mapaketi awiri amnyumba.
Zotsatira za pharmacological
Mankhwala amapereka hypotensive kwenikweni. Chopanga chachikulu pakuphatikizika kwake chimagwira ngati wogwirizira wa receptor. Izi zikutanthauza kuti irbesartan imasokoneza machitidwe a angiotensin II receptors, omwe amathandizira kukhazikika kwa makoma am'kati mwa kamvekedwe (kuchepetsa lumen ya mitsempha, mitsempha). Zotsatira zake, kuchuluka kwa magazi kumatsika pang'ono.
Ntchito ya mtundu 2 angiotensin sikuti kuchepa kwamitsempha yamagazi kokha komanso kuwonjezereka kwa kukakamiza, komanso malamulo a kuphatikiza kwa maselo ndi kutsatira kwawo. Kugwirizana kwa ma receptor ndi timadzi timeneti kumalepheretsa kupanga kwa nitric oxide, yomwe ndi chinthu chowonjezera. Mothandizidwa ndi Ibertan, njira zomwe zafotokozedwazo zimachepetsa.
Kuphatikiza apo, pali kuchepa kwa kuchuluka kwa aldosterone. Awa ndi mahomoni a gulu la mineralocorticoid. Zimapangidwa ndi adrenal cortex. Ntchito yake yayikulu ndikuwongolera mayendedwe a sodium ndi potaziyamu cations ndi anyezi a chlorine. Hormoni iyi imathandizira katundu wamtunduwu monga hydrophilicity. Aldosterone imapangidwa ndi kutenga mtundu wa angiotensin wa 2. Chifukwa chake, ndi kuchepa kwa ntchito yotsirizira, kugwira ntchito kwa mahomoni oyambilira kumachepetsa.
Mankhwala amapereka hypotensive kwenikweni.
Komabe, palibe zotsatira zoyipa za kinase II, zomwe zimakhudzidwa ndikuwonongeka kwa bradykinin ndikuthandizira kupanga mtundu wa 2 angiotensin. Irbesartan ilibe gawo lalikulu pamlingo wamtima. Zotsatira zake, chiopsezo cha zovuta kuchokera ku mtima sichikukula. Zadziwika kuti chida chomwe chikufunsidwa sichikhudza kupanga kwa triglycerides, cholesterol.
Pharmacokinetics
Mankhwala samayamba kuchitapo kanthu mwachangu. Kusintha koyenera kumatha kuonekera pambuyo pa maola 3-6 mutatha kumwa mankhwalawa. Chifukwa cha izi, palibe mafunde akuthwa. Kutsitsa magazi kumachitika bwino. Zotsatira zokhazikika sizimachitika mwachangu, koma pambuyo pa masabata awiri oyambira mutangoyamba chithandizo. Kuchita bwino kumatsimikizika kwakanthawi. Zotsatira zabwino kwambiri ndi mankhwala a antihypertensive zimawonedwa pambuyo pa miyezi 1-1.5.
Mutatenga mlingo umodzi wa irbesartan, ndende ya plasma ndende imafikiridwa pambuyo 2 maola. The bioavailability wa ichi sichikuposa 80%. Mankhwala amatha kumwedwa nthawi iliyonse yabwino. Kudya sikuchepetsa mayamwidwe ndipo sikukhudza kukula kwa chidziwitso cha mankhwala.
Ndi mankhwala, irbesartan siziunjikira kwambiri mu seramu yamagazi. Izi zimasinthidwa ndikumasulidwa kwa 1 metabolite - glucuronide. Izi zimachitika chifukwa cha makutidwe ndi okosijeni. Njira zazikulu zoperekera mankhwala: pamodzi ndi ndulu, pokodza. Pankhani ya kuwonongeka kwa chiwindi ndi impso, palibe kusintha kwakukulu pamachitidwe a pharmacokinetic.
Mankhwalawa ndi mankhwala ochizira matenda a nephropathy, omwe amayamba chifukwa cha matenda a shuga a mtundu 2.
Zizindikiro zogwiritsidwa ntchito
Njira yayikulu yogwiritsira ntchito mankhwalawa ndi ochepa matenda oopsa. Kuphatikiza apo, mankhwalawa amatha kugwiritsidwa ntchito ngati matenda a nephropathy (kuwonongeka kwa aimpso parenchyma). Amagwiritsidwa ntchito ngati matendawa amakula motsutsana ndi maziko a matenda a shuga 2 kapena matenda oopsa.
Contraindication
Pali zoletsa zochepa pa kuperekedwa kwa mankhwalawa: kusagwirizana ndi gawo lomwe limapangitsa, kuperewera kwa lactase, kuyamwa kwa galactose, shuga.
Ndi chisamaliro
Zowerengeka zingapo zawonedwa, momwe ndikofunikira kuwonetsa chidwi, kuphatikiza:
- kuphwanya kayendedwe ka sodium cato;
- Zakudya zopanda mchere;
- aimpso kuwonongeka ntchito, makamaka, kuchepetsa kwa lumen mtsempha wamagazi;
- kuthamangitsa kwamadzi kuchokera mthupi, kuphatikiza matenda, limodzi ndi kusanza, kutsekula m'mimba;
- kugwiritsa ntchito kwaposachedwa kwa thiazide diuretics;
- kuchira nthawi pambuyo kumuika impso;
- Kuchepetsa kupyola magazi kudzera mu ma mitral, mavairasi aortic, omwe amatha chifukwa cha stenosis;
- kugwiritsa ntchito munthawi yomweyo kukonzekera komwe kumakhala ndi lithiamu;
- matenda endocrine amagwirizana ndi kuwonongeka kwa aldosterone kaphatikizidwe;
- kusintha kwa atherosulinotic mu ziwiya zamafuta;
- matenda a mtima dongosolo: ischemia, kuchepa kwa ntchito ya thupilo.
Mochenjera, mankhwalawa amapatsidwa matenda a mtima.
Kutenga Ibertan?
Pa gawo loyambirira la mankhwalawa, mlingo wa irbesartan ndi wocheperako (150 mg). Kuchulukitsa kuvomerezeka - 1 nthawi patsiku. Mankhwalawa amatha kumwa pamimba yopanda kanthu, nthawi yakudya kapena itatha. Komabe, nthawi zina, kuchepetsa wamphamvu kwamphamvu kwa mlingo kumafunikira - mpaka 75 mg patsiku. Chizindikiro cha izi ndi kusowa kwamadzi, kuchepa kwa kuchuluka kwa magazi oyendayenda, kumwa mankhwala omwe amalimbikitsa kutulutsa kwa madzi, ndi chakudya chopanda mchere.
Ngati thupi limayankha mofooka pazigawo zochepa, ndiye kuti kuchuluka kwa irbesartan kumakulitsidwa mpaka 300 mg patsiku. Amadziwika kuti kumwa Mlingo wowonjezera wa 300 mg sikukula mphamvu ya antihypertensive. Mukamasintha kuchuluka kwa mankhwalawo mbali yayikulu, nthawi yopuma iyenera kukhalabe (mpaka milungu iwiri).
Chithandizo cha nephropathy: mankhwalawa mankhwala 150 mg tsiku. Ngati ndi kotheka, muyeso wa zomwe zimagwiritsidwa ntchito umakulitsidwa mpaka 300 mg (osapitilira 1 nthawi patsiku).
Ndi matenda ashuga
Mankhwala amavomerezedwa kuti azigwiritsidwa ntchito. Njira ya chithandizo iyenera kuyamba ndi mlingo wochepa (150 mg). Ngati mankhwalawa amalekeredwa bwino, kuchuluka kwa yogwira pophika kumatha kuwonjezeka.
Kutalika kwa chithandizo kumatsimikiziridwa payekhapayekha.
Zotsatira zoyipa za Ibertan
Pa mankhwala, zovuta zingapo zamankhwala zimadziwika, kufupika kwa zomwe zimatengera momwe wodwalayo alili, kupezeka kwa matenda ena.
Pa mbali ya gawo la masomphenyawo
Zosawonedwa.
Kuchokera minofu ndi mafupa
Ululu pachifuwa, minofu, ndi mafupa.
Matumbo
Mseru, kusanza, mapando otayirira, kutentha kwa mtima, kudzimbidwa.
Hematopoietic ziwalo
Kuwonjezeka kwa zoleinine phosphokinase, potaziyamu, ndi kuchepa kwa hemoglobin.
Pakati mantha dongosolo
Chizungulire, kupweteka mutu, kusokonezeka kwa malingaliro, limodzi ndi kutopa kwambiri, kusachedwa, nkhawa.
Kuchokera kwamikodzo
Matenda a impso.
Kuchokera ku kupuma
Kukhosakhota kouma kumawonekera.
Mukamwa mankhwalawa, kutsokomola kumayamba.
Kuchokera ku genitourinary system
Kusagonana.
Kuchokera pamtima
Kusintha kwa kugunda kwa mtima, kumverera kwa kugundika pakhungu la nkhope.
Matupi omaliza
Urticaria, vasculitis.
Zokhudza mphamvu pakuwongolera njira
Chifukwa cha chiwopsezo chowonjezereka cha zotsatira zoyipa kuchokera ku dongosolo lamkati lamanjenje, kusamala kuyenera kuchitidwa poyendetsa magalimoto. Maphunziro a chitetezo cha mankhwalawa panthawi yomwe ikufunika chidwi sichinachitike.
Malangizo apadera
Pa mankhwala motsutsana maziko a madzi am'madzi, kuphwanya kwamadzi kwamagetsi kumadziwika. Potere, kutenga Ibertan kumatha kupangitsa kuchepa kwamphamvu kwa mavuto.
Pankhani ya osakwanira aimpso ntchito, tikulimbikitsidwa kuwongolera zomwe zili potaziyamu, creatinine.
Poyerekeza ndi maziko a aimpso a stenosis, njira yoopsa kwambiri imayamba.
Pankhani ya osakwanira aimpso ntchito, tikulimbikitsidwa kuwongolera zomwe zili potaziyamu, creatinine.
Kuchepetsa kwa Ibertan pothandiza odwala omwe apezeka ndi hyperaldosteronism kumadziwika.
Ngati pali zovuta zamavuto amkati mwa mtima, muyenera kuyang'anira kuchuluka kwa kuthamanga kwa magazi mukamalandira chithandizo, chifukwa izi zimawonjezera chiopsezo chokhala ndi myocardial infarction.
Gwiritsani ntchito mu ukalamba
Odwala opitirira zaka 75 amalimbikitsidwa kumwa mankhwalawa ochepa - 75 mg patsiku.
Kupatsa ana
Zosagwiritsidwa ntchito.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Zosavomerezeka.
The ntchito aimpso kuwonongeka
Kulephera kwamkati si chifukwa chosiya chithandizo. Ngakhale kumwa mankhwalawa motsutsana ndi matendawa, tiyenera kusamala.
Kukula kwa pathologies ofiira a chiwindi si chifukwa chosiya mankhwala.
Gwiritsani ntchito ntchito yolakwika ya chiwindi
Kukula kwa ma metabolic ofatsa a chiwalochi sikuti chifukwa chosiya mankhwala. Chitetezo chomwa mankhwalawo kuchokera pachiwopsezo chachikulu cha chiwindi sichinafufuzidwe. Chifukwa chake, ndibwino kukana chithandizo ndi mankhwalawa omwe ali munjira imeneyi.
Ibertan Overdose
Nthawi zambiri, odwala amachepetsa kuthamanga kwa magazi, nthawi zambiri kumachepetsa tachycardia. Nthawi zina, zizindikiro za bradycardia zimachitika. Kuchepetsa kukula kwa mawonekedwe owoneka bwino kungathandize kupuma kwamatumbo, kuyika kwa sorbents (bola mankhwala atangotengedwa). Pofuna kuthetsa zizindikiro za munthu aliyense, mankhwala opatsidwa mankhwala apadera amalembedwa, mwachitsanzo, kusintha mtundu wa mtima, kuthamanga kwa mavuto.
Kuchita ndi mankhwala ena
Hydrochlorothiazide sichimathandizira kuti kusintha kwa pharmacodynamics ndi pharmacokinetics ku Ibertan. Zotsatira zofananazo zimawonedwa ndikuyanjana kwa mankhwalawo mufunso ndi Warfarin.
Kuphatikiza kophatikizidwa
Pamodzi ndi Ibertan, mankhwala ena omwe amathandizira kuchepetsa kukakamiza sanatchulidwe.
Osagwiritsa ntchito zokonzekera zomwe zili ndi lithiamu. Pankhaniyi, kawopsedwe wa mankhwala omwe amafunsidwa akuwonjezeka.
Hydrochlorothiazide yokhala ndi Ibertan sichiphatikizidwa bwino ndi colestiramine.
Osavomerezeka kuphatikiza
NSAIDs zimayambitsa chitukuko cha aimpso kulephera, hyperkalemia.
Hydrochlorothiazide yokhala ndi Ibertan sichiphatikizidwa bwino ndi colestiramine.
Fluconazole amalepheretsa kusintha kwa mankhwalawa.
Kuphatikiza komwe kumafunikira kusamala
Amaloledwa kugwiritsa ntchito beta-blockers, okodzetsa gulu la thiazide, calcium block blockers limodzi ndi Ibertan.
Muyenera kusamala mukamagwiritsa ntchito mankhwala omwe amafunsidwa ndi mankhwala okhala ndi potaziyamu.
Kuyenderana ndi mowa
Popeza ethanol imathandizira kukulitsa mitsempha yamagazi, sikulimbikitsidwa kumwa zakumwa zoledzeretsa zam'kati pochita ndi Ibertan. Pankhaniyi, ntchito ya antihypertgency ya mankhwala imawonjezeka.
Popeza ethanol imathandizira kukulitsa mitsempha yamagazi, sikulimbikitsidwa kumwa zakumwa zoledzeretsa zam'kati pochita ndi Ibertan.
Analogi
Zosankha zovomerezeka zosinthira mankhwalawa:
- Irbesartan
- Irsar;
- Aprovel;
- Telmisartan.
Njira yoyamba ndiyotengera malo a Iberta. Chida ichi chili ndi chophatikizira chimodzi chomwechi. Mlingo wake ndi 150 ndi 300 mg piritsi limodzi. Malinga ndi zigawo zazikulu, Irbesartan siwosiyana ndi Ibertan.
Irsar ndi analogue ina yamankhwala omwe amafunsidwa. Sizisintha pakupanga, kuchuluka kwa yogwira mankhwala, zikuwonetsa ndi zotsutsana. Ndalama izi zili m'gulu lomwelo. Wina wogwirizira (Aprovel) amawononga ndalama zochepa (600-800 rubles). Kutulutsa mawonekedwe - mapiritsi. Mu 1 pc ili ndi 150 ndi 300 mg ya irbesartan. Momwemo, mankhwalawo amathanso kuikidwa m'malo mwa mankhwalawo omwe mukufunsidwa.
Telmisartan ili ndi gawo la dzina lomweli. Kuchuluka kwake ndi 40 ndi 80 mg piritsi limodzi. Mfundo zoyenera kuchitira mankhwalawa zimakhazikika pakuletsa ntchito ya ma receptors omwe amalumikizana ndi angiotensin II. Zotsatira zake, kuchepa kwa kukakamiza kumadziwika. Chifukwa chake, malinga ndi momwe amagwirira ntchito, Telmisartan ndi mankhwala omwe amafunsidwawa ndi ofanana. Zisonyezero ntchito: matenda oopsa, kupewa kukula kwa zovuta (kuphatikizapo imfa) matenda a mtima dongosolo.
Telmisartan imakhala ndi zotsutsana zambiri. Kuletsa kugwiritsa ntchito mankhwalawa panthawi yapakati, kuyamwa, muubwana, ndikuphwanya khunyu, kumadziwika kuti chiwindi chimadziwika. Sitikulimbikitsidwa kuti muziphatikiza ndi mankhwala ochokera ku gulu la angiotensin-kutembenuza ma enzyme inhibitors. Mwa ndalama zomwe zaganiziridwa, Telmisartan ndi okhawo omwe angagwiritsidwe ntchito m'malo mwa Ibertan, malinga ngati tsankho la gawo lomwe likugwira, irbesartan, limakula.
Kupita kwina mankhwala
Mankhwala ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi, muyenera kulandira chithandizo cha dokotala kuti mugule mankhwalawo.
Mtengo wa Ibertan
Mtengo wapakati ndi ma ruble 350.
Zosungidwa zamankhwala
Kutentha kotsimikizika - kosaposa + 25 ° ะก.
Tsiku lotha ntchito
Mankhwala omwe amafunsidwawo amasunga miyezi 36 kuchokera tsiku lotulutsidwa.
Wopanga
Polpharma (Poland).
Mankhwala ndi mankhwala.
Ndemanga za Ibertan
Daria, wazaka 45, Saratov
Takhala tikupezeka ndi matenda oopsa kwa nthawi yayitali. Kuyambira pamenepo ndakhala ndikuyang'ana mankhwala omwe angamachite zinthu mwankhanza komanso othandiza. Ndidayesera zakudya zingapo zophatikiza ndi zakudya zamankhwala. Ndimakonda momwe Ibertan alili. Ngakhale ndikuvomereza, ndikumva bwino.
Veronika, wazaka 39, Krasnodar
Adayamba maphunziro akudya zamankhwala osokoneza bongo. Pazifukwa izi, adotolo sanalimbikitse kumwa muyezo, koma anamwetsa 75 mg patsiku. Sindinawone zotsatira zambiri. Adokotala ataloleza kuchuluka kwa mankhwalawa katatu, kukakamira kunatsika kwambiri, ndikubwerera kwakhazikika. Izi zisanachitike, panali kulumikizana kosalekeza mu kuthamanga kwa magazi, ndi kupita m'mwamba.
