Novomix Flekspen 30 ndi ndalama zomwe zimakhala ndi insulin. Ubwino wake ndi magawo awiri a zochita. Chida ichi chimadziwika ndi gawo lochepa, malire ochepera mukamagwiritsa ntchito.
Dzinalo Losayenerana
Insulin aspart magawo awiri
Novomix Flexspen 30 imadziwika ndi gawo lochepa, zoletsa zochepa mukamagwiritsa ntchito.
ATX
A10AD05
Kutulutsa mafomu ndi kapangidwe kake
Mutha kugula mankhwalawa mwa kuyimitsidwa komwe kumapangidwira kulowetsedwa kwa insulin. Chogulacho chimamasulidwa mu cholembera cha 3 ml. The kuchuluka kwa yogwira mankhwala 1 ml ya mankhwala ndi 100 IU. Chiwerengero chonse cha wothandizira mu cholembera ndi 300 IU.
Gawo lochita ndi insulin aspart. Izi zimapezeka m'mitundu iwiri: sungunuka, mwa mawonekedwe a makristali. Zowunika zawo ali 30 ndi 70%. Mutha kugula malonda mumaphukusi okhala ndi zolembera 5.
Zotsatira za pharmacological
Kuphatikizika kwa mankhwalawa kumaphatikizapo analog ya insulin ya munthu. Izi ndi zinthu za magawo awiri. Insulin imawonetsa mwachidule komanso kwakanthawi. Munthawi zonsezi, magawo osiyanasiyana a kuyimitsidwa amakhudzidwa. Amayendedwe a zomwe zimachitika pazochitikazo zimatengera luso lotukula shuga. Zotsatira zomwe zimafunidwa zimakwaniritsidwa pamene mahomoni amakhudzana ndi ma receptors a minofu yambiri (mafuta, minofu). Nthawi yomweyo, pamakhala kuchepa kwa kapangidwe ka shuga m'chiwindi. Kachitidwe ka ndondomeko ya lipo- ndi glycogenogenesis amadziwikanso.
Mankhwala amamasulidwa mu mawonekedwe a kuyimitsidwa mu cholembera cha 3 ml.
Ponena za molarity, insulin aspart imafanana ndi insulin ya anthu. Komabe, chifukwa cha kukhalapo kwa zinthu zosungunuka m'mapangidwe ake, zotsatira zabwino zimathandizira. Gawo lokangalika limakupatsani mwayi kuti mupeze zotsatira zofunika pakadutsa mphindi 10 mpaka 10 mutabaya jekeseni wa subcutaneous. Komabe, chifukwa cha tizigawo tating'onoting'ono, timatha kulimbikira. Pankhaniyi, kuchuluka kwa insulini kumafikiridwa panthawi yoyamba ya 4 jakisoni.
Zotsatira zake zimasungidwa kwa maola 24. Kutengera zotsatira za kafukufukuyu, zitha kuchitika kuti kumwa mankhwalawa kawiri patsiku (mutatha kudya) kumakupatsani mwayi wambiri wolamulira shuga m'magazi. Amadziwika kuti kugwiritsa ntchito insulin aspart sikuti kumabweretsa kuchepa kwakukulu kwa hemoglobin ya glycated.
Kuphatikiza apo, zidapezeka kuti chifukwa chogwiritsa ntchito insulini kwa nthawi yayitali, chiopsezo chokhala ndi hypoglycemia usiku, komanso mtundu wovuta kwambiri wa pathological mkhalidwewu, umachepetsedwa. Direct pharmacodynamics pochiza odwala okalamba sizinaphunzire. Komabe, zidakhazikitsidwa mosadziwika kuti zizindikiritso zazikulu zimakhalabe pamlingo wofanana ndi wa achinyamata.
Pharmacokinetics
Njira ya mayamwidwe yosungunulira insulini yomwe ili mu mankhwala omwe akuwunikira imayamba msanga poyerekeza katundu wa pharmacokinetic ndi insulin ya munthu wosungunuka. Chifukwa cha izi, mutha kupeza zotsatira zabwino ndi hypoglycemia kwakanthawi kochepa. Ngati tilingalira za zomwe zidutswa zamafuta a kristalo, ndiye kukula kwa mayeso awo sikusiyana ndi kagwiritsidwe ntchito ka insulin ya NPH.
Kugwiritsa ntchito kwa Novomix Flekspen kwa matenda a chiwindi ndi impso sikuti kumawunikira mawonekedwe owoneka bwino.
Mulingo woyenera kwambiri wa mankhwala a hypoglycemic amafikira mwachangu poyerekeza ndi insulin ya anthu. Mwa odwala ambiri, insulin aspart imafika pachimake mu 60-95 mphindi. Hafu ya moyo wake imasiyanasiyana kuyambira maola 8 mpaka 18, omwe amakhudzidwa ndi boma, kupezeka kwa ma pathologies ena. Kutalika kwa mankhwalawa kumatengera kuchuluka kwa magazi, kuchuluka kwa insulin.
Kugwiritsa ntchito mankhwalawa kwa matenda aimpso ndi kwa chiwindi sikunaphunzire. Komabe, pochita (mankhwalawa odwala omwe ali ndi matenda oterewa) zidapezeka kuti kusintha pang'ono kwa kuchuluka kwa mankhwalawa m'matenda a ziwalo izi sizitengera kuwonekera.
Zizindikiro zogwiritsidwa ntchito
Mankhwala amatchulidwa ngati mankhwala odziyimira pawokha kapena, pamodzi ndi ena a hypoglycemic mankhwala a matenda otere:
- mtundu 1 shuga mellitus (amadalira insulin);
- lembani matenda ashuga a 2 a shuga (nawonso ndi insulin-pawokha).
Insulin imayikidwa hyperglycemia.
Contraindication
Zoletsa kugwiritsa ntchito mankhwalawa ndizochepa. Siligwiritsidwa ntchito ngati mukupanga vuto lililonse pazomwe zimapangidwa pakupanga mankhwala. Chinsinsi china ndi hypoglycemia. Poterepa, kuyambitsa mtundu wa insulin kudzapangitsa kuchepa kwa shuga.
Ndi chisamaliro
Gulu la contraindication wachibale limaphatikizapo kusokonezeka kwa impso, pakati, wodwala wokalamba.
Momwe mungatengere Novomix Flekspen?
Popewa kukula kwamavuto, makamaka kuphwanya kwamphamvu kagayidwe kachakudya, mankhwalawa amaperekedwa pokhapokha. Kuchuluka kwa ndalama kumatengera zaka, wodwala komanso matenda ena. Mankhwalawa amaperekedwa kumapeto kwa tsiku (nthawi imodzi) kapena kuchuluka kwake kumagawidwa pawiri. Mayunitsi 12 amatchulidwa patsiku (ngati wodwalayo sanalandire chithandizo cha insulin kale).
Njira Yophatikiza ndi Insulin
Popeza chida chomwe chikufunsachi chili magawo awiri, kukonzekera kuyenera kuchitidwa musanagwiritse ntchito. Malinga ndi malangizo, cartridge imayikidwa mu cholembera, ndikutanthauza kuti yankho limadziwika ndi kutentha kwa chipinda. Amayikidwa mu ndege yopingasa, kenako ndikugudika pakati pa kanjedza mpaka maulendo 10 mbali zosiyanasiyana (kumbuyo ndi kutsogolo). Pa gawo lotsatira, cartridge imasunthidwa mu ndege yoyima: mu arc, ndi mpira wamkati ukugudubuza kuchokera kumapeto kwonyamula kwina kupita kwina.
Njira zomwe zalongosoledwazo zimabwerezedwanso mpaka yankho litakhala mitambo ndikusintha kukhala loyera. Iyenera kudziwika ndi kusasinthasintha. Pamapeto pa zosintha zonse, kutentha kwa wothandizirayo kumakwera pang'ono (kutentha kwa chipinda) ndipo mutha kuyitanitsa nthawi yomweyo.
Momwe mungagwiritsire ntchito cholembera?
Njira yogwiritsira ntchito mankhwalawa imafotokozedwa ndi dokotala. Pambuyo kuyikika, singano ikhale m'misempha masekondi 6 otsatira. Ikachotsedwa, mutha kuchotsa dzanja kuchokera kubatani pa syringe cholembera. Singano ndiyotaya, motero timayikidwa watsopano. Ndikofunikira kuchichotsa mu cholembera pambuyo pa jakisoni. Katoniyo sanapangidwe kuti adzazidwe ndi insulin.
Malamulo ena ogwiritsa ntchito cholembera:
- mukakhazikitsa singano yatsopano, kapu yodzitetezera sayenera kutumizidwa mwachangu kumtunda, imathandizira pambuyo pake;
- Musanagwiritse ntchito syringe, imayang'aniridwa kuti ikhale yogwira ntchito: pogwiritsa ntchito chosankha cha mlingo, kufunika komwe kumayikidwa (osachepera, mwachitsanzo, mayunitsi 2), ndiye kuti chipangizocho chimatembenuzidwa ndi singano ndikuyesa inulin ikuchitika, kuti muchite izi, kanikizani batani;
- ngati pakuyang'ana kunapezeka kuti insulini siyikuwoneka kuchokera singano, cholembera cha syringe ndiyenera kulowamo;
- asanayambitse chinthu, mlingo wosankha umayang'anizana ndi 0;
- mulingo wotsalira sungagwiritsidwe ntchito kusintha kuchuluka kwa insulin;
- mutagwiritsa ntchito cholembera, muyenera kuchotsa singano, ndipo chifukwa, capuyo imayikidwa koyamba, kenako singano siyotsegulidwa.
Zotsatira zoyipa za Novomix Flekspen
Retinopathy, yopangidwa maziko a matenda osokoneza bongo a shuga, lipodystrophy.
Kuchokera ku chitetezo chamthupi
Anaphylactoid zimachitika.
Pakati mantha dongosolo
Neuropathy (munthawi yovuta kwambiri), yotsatana ndi zowawa.
Kuchokera ku kupuma
Kulephera kupuma, chomwe ndi zotsatira za mawonekedwe a anaphylactoid (amakumana ndi maziko a kutupa kwa m'mimba).
Pa khungu
Zowawa pakhungu pakubaya jakisoni wa insulin, kutupa pang'ono, hematoma, redness, kuyabwa, kutupa.
Kuchokera ku genitourinary system
Poyerekeza ndi maziko a hypoglycemia, kupatsirana kwamikodzo kumachitika (pafupipafupi kukakamiza kukodza kumachulukitsa).
Kuchokera kumbali ya kagayidwe
Hypoglycemia.
Matupi omaliza
Urticaria.
Malangizo apadera
Kutsekedwa kwa mankhwalawa kapena kumwa molakwika mlingo wa insulin 1 matendawa kumatha kuyambitsa hypoglycemia, nthawi zina ketoacidosis imawoneka pamwambapa.
Kukhazikitsidwa kwa kuchuluka kwa mankhwalawo kumathandizanso kukulitsa hypoglycemia. Zotsatira zinanso zofananira zimachitika chifukwa cha kuchuluka kwa zolimbitsa thupi m'thupi, komanso ngati wodwalayo amadumphira chakudya.
Gwiritsani ntchito mu ukalamba
Mankhwala angagwiritsidwe ntchito, koma mosamala. Palibe chifukwa chofotokozera mlingo wa insulin aspart.
Kulemba a Novomix Flekspen kwa Ana
Palibe chidziwitso chokhudzana ndi chitetezo cha mankhwalawa chomwe chikufunsidwa pochiza odwala osakwana zaka 18. Komabe, motsogozedwa ndi zotsatira za kafukufuku wazokhudza zotsatira za insulini kwa ana amisinkhu yosiyanasiyana, zimadziwika kuti zizindikiro zina zimasintha (mwachitsanzo, nthawi yofika kwambiri. Izi zikusonyeza kufunika kwa kutsimikiza kwa munthu payekha pa mlingo wa insulin. Mankhwala amaloledwa kugwiritsidwa ntchito pochiza odwala omwe ali ndi zaka zopitilira 6.
Gwiritsani ntchito pa nthawi yoyembekezera komanso mkaka wa m`mawere
Chenjezo liyenera kuchitika pakubala kwa mwana. Palibe chidziwitso chokwanira pa mankhwalawa. Komabe, machitidwe adapezeka kuti pakati pa mankhwala omwe akufotokozedwayo samakupangitsani kukula kwa zovuta. Mu 1 trimester, kufunikira kwa insulin kumachepa, ndiye pang'onopang'ono kumawonjezeka. Pambuyo pobadwa, mahormoni amafikira pamlingo womwe anali asanakhale ndi pakati.
Pa mkaka wa m`mawere, mankhwala omwe amawaganizira ndi ovomerezeka kugwiritsa ntchito.
Mankhwala ochulukirapo a Novomix Flekspen
Sichikukhazikitsidwa pazomwe matendawo amakumana. Munthawi zonsezi, kuchuluka kwa mankhwalawa ndi kosiyana, zomwe zimatengera zinthu zokhudzana. Hypoglycemia imayamba pang'onopang'ono, yomwe imathandizidwa ndi kugwiritsa ntchito mankhwala pafupipafupi.
Zizindikiro zofatsa za matenda amtunduwu zimathetsedwa ndikutenga chinthu chomwe chili ndi shuga. Ngati mawonetseredwe akuchulukirapo, glucose wolumikizira umalimbikitsidwa. Njira ina ndiyo jakisoni wa glucagon (intramuscularly). Ngati izi sizikupereka zotsatira zoyenera, chitani jakisoni wa dextrose.
Kuchita ndi mankhwala ena
Zinthu zotsatirazi ndi othandizira amathandizira kutsitsa shuga:
- mankhwala ena opangidwa kuti athetse matenda a glycemia;
- mankhwala omwe amalepheretsa kugwira ntchito kwa ACE;
- beta-blockers omwe sadziwika ndi kusankha kosankha;
- anabolics;
- tetracycline mankhwala;
- Ketoconazole;
- Mebendazole;
- Theophylline;
- Pyridoxine;
- salicylates;
- malonda omwe ali ndi lithiamu.
Mankhwala omwe amafunsidwawo amakhala ndi mphamvu yocheperako kuphatikiza ndi heparin, mahomoni a dongosolo la endocrine, thiazide gulu diuretics, ma tridclic antidepressants, Danazol, Morphine, etc.
Mothandizidwa ndi beta-blockers, zizindikiro zakuchepa kwa shuga m'magazi sizimatchulidwanso.
Kuyenderana ndi mowa
Zakumwa zokhala ndi zakumwa zoledzeretsa zimagwira thupi posadzisamalira poyambira kugwiritsa ntchito insulin. Mlingo wa glycemia ukhoza kukwera ndikuchepa, zomwe zimakhudzidwa ndi momwe wodwalayo alili komanso kupezeka kwa ma pathologies ena.
Analogi
Zofananira mwachindunji za mankhwala omwe amafunsidwa ndi:
- Novomiks Penfill Flekspen 30;
- Novorapid Flekspen.
Mankhwalawa amapezeka mu mawonekedwe a yankho, muli ndi insulin. Mutha kuzigula pogwiritsa ntchito syringe. Njira zimakhudzana ndi mtundu wa chinthu chomwe chikugwirira ntchito. Chifukwa chake, amatsatira mfundo imodzi. Poika ayenera kuganizira zomwe zikuwonetsa, contraindication. Poganizira momwe mankhwalawo amafananira, zitha kuyembekezeredwa kuti nawonso achitapo kanthu mwachangu. Awo ena ma pharmacokinetic katundu nawonso ndi ofanana.
Kupita kwina mankhwala
Chida ichi ndi mankhwala.
Kodi ndingagule popanda kulandira mankhwala?
Ayi, muyenera kupangana ndi adotolo kuti mugule mankhwalawo.
Mtengo wa Novomix Flexspen
Mtengo wapakati ndi ma ruble 1850.
Zosungidwa zamankhwala
Mtengo wolimbikitsidwa + 2 ... + 8 ° ะก. Malo abwino kwambiri ndi firiji, koma osati pafupi ndi mufiriji. Cholembera chomwe amagwiritsidwa ntchito chimayenera kusungidwa kutentha, koma osapitirira milungu 4. Malo ogulitsiramo nyumba ayenera kukhala okutidwa ndi chipewa choteteza.
Tsiku lotha ntchito
Mankhwalawa sayenera kugwiritsidwa ntchito patatha zaka ziwiri kuchokera tsiku lotulutsidwa.
Wopanga
Novo Nordisk (Denmark).
Cholembera chomwe amagwiritsidwa ntchito chimayenera kusungidwa kutentha, koma osapitirira milungu 4.
Ndemanga za Novomix Flekspen
Vera, wazaka 39, Moscow
Mankhwala mwachangu amathandizira kubwezeretsa shuga. Kwa ine, kuwonetsa zolakwika sizinachitike. Ndimamwa mankhwalawa kwa nthawi yayitali. Chokhacho chomwe sindimakonda ndi mtengo.
Vladlena, wazaka 34, Saratov
Ndimadwala matenda a shuga a insulin. Nthawi zina ndimasintha njira, ndimayeserera mankhwala osiyanasiyana monga adokotala adanenera. Sindinganene choyipa chilichonse pa Novomix Flekspen: imagwira ntchito molondola, monga fanizo lake, mtengo ukhoza kutsika, apo ayi ndi chida chabwino.
