Zowonetsa ntchito ndi katundu wa insulin Detemir

Kukonzekera kwa insulin kumasiyana. Izi ndichifukwa chakufunika kugwiritsa ntchito mankhwala omwe ali oyenera kwa anthu omwe ali ndi mawonekedwe osiyanasiyana.

Ngati mukutsutsana ndi zigawo za mankhwala amodzi, muyenera kugwiritsa ntchito ina, ndichifukwa chake akatswiri azamankhwala akupanga zinthu zatsopano ndi mankhwala omwe angagwiritsidwe ntchito kupondereza zizindikiro za matenda ashuga. Chimodzi mwa izo ndi Detemir insulin.

Zambiri ndi mankhwala a pharmacological

Mankhwala ndi a gulu la insulin. Imakhala ndi chochitika chachitali. Dongosolo la malonda la mankhwalawa ndi Levemir, ngakhale pali mankhwala omwe amatchedwa Insulin Detemir.

Fomu yomwe wothandizirayo amagawidwira ndi yankho la kayendetsedwe ka subcutaneous. Maziko ake ndi chinthu chomwe chimapezeka pogwiritsa ntchito ukadaulo wa maumboni a DNA - Detemir.

Ichi ndi chimodzi mwazinthu zosungunuka za insulin yamunthu. Cholinga cha machitidwe ake ndikuchepetsa kuchuluka kwa shuga m'thupi la odwala matenda ashuga.

Gwiritsani ntchito mankhwalawa molingana ndi malangizo. Mlingo ndi mawonekedwe a jekeseni amasankhidwa ndi dokotala. Kusintha koyimira kwa mlingo kapena kusatsatira malangizo kumatha kuyambitsa bongo, komwe kumayambitsa hypoglycemia. Komanso, simuyenera kusiya kumwa mankhwala osadziwa dokotala, chifukwa izi ndizowopsa ndi zovuta za matendawa.

Chithandizo chogwira ntchito cha mankhwala ndi analogue ya insulin ya anthu. Zochita zake ndizitali. Chidacho chimakumana ndi ma receptor a membrane wam'maselo, kotero kuti kuyamwa kwake kuthamanga.

Kuongolera kuchuluka kwa shuga ndi chithandizo chake kumakwaniritsidwa pakuwonjezera kuchuluka kwa kudya kwake ndi minofu ya minofu. Mankhwala amathandizanso kupanga shuga m'magazi. Mothandizidwa ndi iye, ntchito ya lipolysis ndi mapuloteni imachepa, pomwe mitundu yambiri yama protein imagwira.

Kuchuluka kwakukulu kwa Detemir m'magazi ndi maola 6-8 atatha kupanga jakisoni. Kutsimikiziridwa kwa chinthuchi kumachitika pafupifupi mu odwala onse (ndikusinthasintha pang'ono), umagawidwa m'chigawo cha 0,1 l / kg.

Zikalowa m'mapuloteni a plasma, metabolites omwe sanapangidwe amapangidwa. Kuchiritsa kumadalira kuchuluka kwa mankhwalawo omwe amaperekedwa kwa wodwala komanso momwe mayamwidwe amachitikira mwachangu. Hafu ya zinthu zomwe zimaperekedwa zimachotsedwa m'thupi pambuyo pa maola 5-7.

Zizindikiro, njira ya makonzedwe

Pokhudzana ndi kukonzekera kwa insulin, malangizo ogwiritsira ntchito akuyenera kuwonedwa bwino. Iyenera kuphunziridwa mosamala, koma ndikofunikanso kuganizira malingaliro a dokotala.

Kuchita bwino kwa mankhwala ndi mankhwalawa zimatengera momwe chithunzi cha matendawa chawunikira. Pokhudzana ndi izi, mlingo wa mankhwalawa komanso ndandanda ya jekeseni imatsimikiziridwa.

Kugwiritsa ntchito chida ichi kukuwonetsedwa pakupeza matenda ashuga. Matendawa atha kukhala a mtundu woyamba ndi wachiwiri. Kusiyanako ndikuti ndi matenda amtundu woyamba, Detemir amagwiritsidwa ntchito ngati monotherapy, ndipo ndi mtundu wachiwiri wa matenda, mankhwalawo amaphatikizidwa ndi njira zina. Koma zitha kupezeka zina chifukwa cha zomwe munthu ali nazo payekha.

Mlingowo umatsimikiziridwa ndi adotolo, poganizira zovuta zamatenda, moyo wa wodwalayo, mfundo zake za zakudya komanso kuchuluka kwa zochita zolimbitsa thupi. Kusintha kwazinthu zonsezi kumafuna kusintha masinthidwewo komanso maperekedwe ake.

Zilonda zitha kuchitika nthawi iliyonse, ngati zili zoyenera kwa wodwalayo. Koma ndikofunikira kuti jakisoni wobwereza umachitika nthawi yomweyo yomwe yoyamba idamalizidwa. Amaloledwa kubaya mankhwala mu ntchafu, phewa, khomo lamkati, matako. Saloledwa kupereka jakisoni m'dera lomwelo - izi zimayambitsa lipodystrophy. Chifukwa chake, akuyenera kusuntha mkati mwa malo ovomerezeka.

Phunziro la kanema pa njira yothandizira kuperekera insulin pogwiritsa ntchito cholembera:

Contraindators ndi malire

Muyenera kudziwa komwe nthawi zina kugwiritsa ntchito mankhwalawa kumatsutsana. Ngati sizingaganiziridwe, wodwala amatha kukhudzidwa kwambiri.

Malinga ndi malangizo, insulin ili ndi zotsutsana zochepa.

Izi zikuphatikiza:

1. Hypersensitivity pamagawo a mankhwala. Chifukwa chaichi, odwala ali ndi zovuta zonse pamankhwala awa. Zina mwazomwezi zimadzetsa chiwopsezo chachikulu pamoyo.
2. Zaka za ana (osakwana zaka 6). Onani kuyenera kwa mankhwalawa kwa ana a m'badwo uno kwalephera. Kuphatikiza apo, palibe deta pa chitetezo chogwiritsidwa ntchito pakadali pano.

Palinso mikhalidwe ina yomwe kugwiritsa ntchito mankhwalawa kumaloledwa, koma amafunika kuwongolera mwapadera.

Zina mwa izo ndi:

1. Matenda a chiwindi. Ngati alipo, momwe gawo la yogwira lingasokonekera, chifukwa chake, mlingo uyenera kusintha.
2. Kuphwanya impso. Pankhaniyi, kusintha pamalingaliro a mankhwalawa ndizothekanso - kumatha kuwonjezeka kapena kuchepa. Kuwongolera okhazikika pamachitidwe othandizira kumathandizira kuthetsa vutoli.
3. Ukalamba. Thupi la anthu opitilira zaka 65 likukusintha kwambiri. Kuphatikiza pa matenda ashuga, odwala oterewa ali ndi matenda ena, kuphatikizapo matenda a chiwindi ndi impso. Koma ngakhale atasowa, ziwalozi sizigwira ntchito komanso ngati mwa achinyamata. Chifukwa chake, kwa odwala awa, mlingo woyenera wa mankhwalawa ndiwofunikanso.

Zinthu zonsezi zikamaganiziridwa, chiwopsezo cha zotsatira zoyipa kuchokera ku Detemir insulin chitha kuchepetsedwa.

Malinga ndi kafukufuku waposachedwa pamutuwu, mankhwalawa alibe zotsatira zoyipa pakukula kwa mimbayo komanso kukulira kwa mluza. Koma izi sizimamupangitsa kukhala wotetezeka kwathunthu, chifukwa chake madokotala amawunika zoopsa asanasankhe mayi ake amtsogolo.

Mukamagwiritsa ntchito mankhwalawa, muyenera kuyang'anitsitsa momwe chithandizo chikuyendera, ndikuwona kuchuluka kwa shuga. Munthawi yamatumbo, zizindikiro za shuga zimatha kusintha, motero, kuwongolera ndikuwongolera kwakanthawi Mlingo wa insulin ndikofunikira.

Palibe chidziwitso chokwanira pokhudzana ndi kulowa kwa chinthucho pakaka mkaka wa m'mawere. Koma amakhulupirira kuti ngakhale zikafika kwa mwana, zotsatira zoyipa siziyenera kuchitika.

Dongosolo la Detemir limachokera ku mapuloteni, motero limatha kutengeka mosavuta. Izi zikusonyeza kuti kuthandizira mayi pogwiritsa ntchito mankhwalawa sikungavulaze mwana. Komabe, azimayi pakadali pano ayenera kutsatira zakudya, komanso kuyang'ana kuchuluka kwa shuga.

Zotsatira zoyipa ndi bongo

Mankhwala aliwonse, kuphatikiza insulin, amatha kuyambitsa mavuto. Nthawi zina zimawonekera kwakanthawi kochepa, mpaka thupi lizolowera zomwe zimagwira.

Nthawi zina, mawonetseredwe a pathological amachitika chifukwa cha contraindication osadziwika kapena kuchuluka kwa mlingo. Izi zimabweretsa zovuta zazikulu, zomwe nthawi zina zimatha kupangitsa kuti wodwalayo afe. Chifukwa chake, zovuta zilizonse zokhudzana ndi mankhwalawa ziyenera kudziwitsidwa kwa dokotala.

Zina mwazotsatira zake ndi izi:

1. Hypoglycemia. Vutoli limaphatikizidwa ndi kuchepa kwakukulu kwa shuga m'magazi, amenenso limapangitsa thanzi labwino la odwala matenda ashuga. Odwala amakumana ndi mavuto monga kupweteka mutu, kunjenjemera, mseru, tachycardia, kusazindikira. Mu hypoglycemia yayikulu, wodwalayo amafunika kuthandizidwa mwachangu, popeza nkusintha komwe kumagwirizana ndi ubongo kumachitika.
2. Zowonongeka. Chodziwika kwambiri ndi matenda ashuga retinopathy.
3. Ziwengo. Imatha kudziwoneka ngati mitundu yaying'ono (zotupa, kufooka kwa khungu), komanso ndi zizindikiro zotchulidwa (anaphylactic shock). Chifukwa chake, popewa zochitika zotere, kuyesa kumvetsetsa kumachitika musanayambe kugwiritsa ntchito Detemir.
4. Mawonetsero apafupi. Amakhala chifukwa cha zomwe khungu limayendetsa pakumwa mankhwala. Amapezeka pamalo a jakisoni - malowa amathanso kukhala ofiira, nthawi zina pamakhala kutupa pang'ono. Maganizo ofananawa nthawi zambiri amapezeka koyamba kwa mankhwalawa.

Ndizosatheka kunena kuti ndi gawo liti la mankhwalawa lomwe lingayambitse bongo wambiri, chifukwa izi zimatengera umunthu wake. Chifukwa chake, wodwala aliyense ayenera kutsatira malangizo omwe adalandira kuchokera kwa dokotala.

Chiwerengero cha odwala omwe adakumana ndi gawo loposa limodzi la hypoglycemia panthawi ya mankhwala ndi Detemir insulin kapena Glargin insulin

Malangizo apadera ndi kugwiritsa ntchito mankhwala osokoneza bongo

Kugwiritsa ntchito mankhwalawa kumafuna kusamala.

Kuti mankhwalawa akhale othandiza komanso otetezeka, malamulo awa akuyenera kuonedwa:

1. Osagwiritsa ntchito mankhwalawa kuchiza ana osakwana zaka 6.
2. Osadumpha chakudya (pamakhala chiopsezo cha hypoglycemia).
3. Osachulukitsa ndi zochitika zolimbitsa thupi (izi zimabweretsa kuchitika kwa dziko la hypoglycemic).
4. Kumbukirani kuti chifukwa cha matenda opatsirana, kufunikira kwa insulin kumakulirakulira.
5. Osamapereka mankhwalawa kudzera m'mitsempha, pamenepa, hypoglycemia imayamba).
6. Kumbukirani kuthekera kwa kusokonezeka kwa chidwi ndi momwe angapangire hypo- ndi hyperglycemia.

Wodwala ayenera kudziwa za zonsezi kuti achite bwino mankhwalawo.

Chifukwa chogwiritsa ntchito mankhwala ochokera m'magulu ena, zotsatira za insulin Detemir zimasokonekera.

Nthawi zambiri, madokotala amakonda kusiya kuphatikiza koteroko, koma nthawi zina izi sizingatheke. Zikatero, muyezo wa mankhwalawo umaperekedwa.

Ndikofunika kuwonjezera mlingo pamene mukumwa mankhwala monga:

• sympathomimetics;
• glucocorticosteroids;
• okodzetsa;
• Kukonzekera kwa kulera;
• gawo la antidepressants, etc.

Mankhwalawa amachepetsa mphamvu ya chinthu chomwe chili ndi insulin.

Kuchepetsa Mlingo Nthawi zambiri kumagwiritsidwa ntchito limodzi ndi mankhwala otsatirawa:

• tetracyclines;
• carbonic anhydrase, ACE, Mao zoletsa;
• othandizira a hypoglycemic;
• anabolic steroids;
• beta-blockers;
• mankhwala okhala ndi mowa.

Ngati simukusintha muyeso wa insulin, kumwa mankhwalawa kungayambitse hypoglycemia.

Nthawi zina wodwala amakakamizika kuwona dokotala kuti athetse wina ndi mnzake. Zifukwa za izi zimatha kukhala zosiyana (kupezeka kwa zovuta, mtengo wokwera, zovuta zosagwiritsidwa ntchito, ndi zina). Pali mankhwala ambiri omwe ali fanizo la Detemir insulin.

Izi zikuphatikiza:

• Pensulin;
• Insuran;
• Rinsulin;
• Protafan, etc.

Mankhwalawa ali ndi vuto lofananalo, nthawi zambiri amagwiritsidwa ntchito ngati m'malo. Koma munthu amene ali ndi chidziwitso chofunikira komanso chidziwitso ayenera kusankha kuchokera pamndandandawu kuti mankhwalawo asavulaze.

Mtengo wa Levemir Flexpen (dzina lamalonda la Detemir) wopanga Danish kuchokera ku 1 390 mpaka 2 950 rubles.