Mwa othandizira omwe amasiyana mu hypoglycemic action, Maninil wa mankhwala amatchulidwa mu radar. Kuti odwala amvetsetse momwe mankhwalawo amathandizira komanso kuti adziwe zoopsa zomwe zingachitike, ndikofunikira kulingalira momwe zimakhudzira thupi, phunzirani za momwe mungagwiritsire ntchito, mankhwalawa komanso zotsatira zoyipa.
Zambiri, kapangidwe, mawonekedwe a kumasulidwa
M'mafakitala, mankhwalawa amagulitsidwa pansi pa dzina la malonda Maninil. Iwo akumasulidwa ku Germany. INN (dzina losavomerezeka padziko lonse lapansi) limatanthawuza Glibenclamide (kuchokera ku dzina lantchito).
Zapangidwa kuti zigwiritsidwe ntchito mkati. Ili ndi hypoglycemic effect, chifukwa chake gulu lalikulu la odwala lomwe limapangidwira ndi odwala matenda ashuga.
Kugawidwa kwa Maninil kuli ngati mapiritsi. Amakhala ndi mtundu wapinki komanso mawonekedwe a cylindrical. Mbali imodzi yamapiritsi iliyonse ili pachiwopsezo.
Maziko a mankhwalawa ndi Glibenclamide, omwe muyeso wake ndi 3.5 ndi 5 mg.
Kuphatikiza apo, zosakaniza zotsatirazi zimawonjezeredwa ku mankhwalawa:
- wowuma mbatata;
- stesiate ya magnesium;
- lactose monohydrate;
- gelatin;
- talc;
- utoto.
Chogulitsachi chimagulitsidwa m'mabotolo agalasi opanda rangi. Phukusili lili ndi miyala 120.
Pharmacology ndi pharmacokinetics
The yogwira pophika mankhwala ali m'gulu la sulfonylurea zotumphukira. Imakhala ndi hypoglycemic, imapangitsa kuti ikhale yosavuta kugwiritsa ntchito pochiza matenda ashuga. Glibenclamide imalumikizidwa ndi maselo a beta a kapamba, chifukwa chomwe thupi limakulitsa kupanga insulin.
Kuphatikiza apo, mukamamwa mapiritsiwa, chidwi cha insulin chimawonjezeka. Izi zimapangitsa kuyamwa kwa glucose mwachangu ndi minofu minofu. Chofunikira kwambiri cha Glibenclamide ndi kuthekera kwake kupumira pang'onopang'ono, komwe kumapewetsa chitukuko cha atherosulinosis. Komanso, mankhwalawa amalepheretsa kupangika kwa magazi.
Momwe mayamwidwe a glibenclamide amachokera ku chimbudzi. Vutoli limayamba kugwira ntchito patatha pafupifupi maola awiri. Mankhwalawa amalowa polumikizana ndi mapuloteni omwe amapezeka m'madzi a m'magazi. Metabolism imachitika m'chiwindi, ndikupanga ma metabolites awiri omwe amawonedwa kuti alibe ntchito. Chimodzi mwazo chimachotsa impso, chinacho chimachotsedwa ndi bile.
Kuchotsa theka la zinthu zomwe zili mthupi, zimatenga maola atatu mpaka 16 (izi zimatengera umunthu wa wodwalayo). Kutalika kwa mankhwalawa ndi pafupifupi maola 20, pomwe zotsatira zake zimadziwika ndi kufewa komanso physiology.
Zizindikiro ndi contraindication
Pogwiritsa ntchito mankhwalawa ndikofunikira kutsatira malangizo osagwiritsa ntchito mosayenerera. Zabwino koposa zonse, ngati mankhwala amalembedwa ndi dokotala, ndiye kuti mutha kutsimikiza kuti mankhwalawo amasankhidwa kuti akhale oyenera kwa wodwala wina.
Ndikofunikira kudziwitsa katswiri wazinthu zonse zokayikitsa, chifukwa zimatha kukhala zizindikiro za zotsutsana zomwe sizinachitike.
Maninil akulimbikitsidwa kuti agwiritse ntchito mtundu wachiwiri wa matenda ashuga. Chovomerezeka kugwiritsa ntchito mankhwalawa monga monotherapy, Kuphatikiza apo, angagwiritsidwe ntchito pophatikiza mankhwala. Nthawi zambiri, mankhwala ena omwe ali ndi hypoglycemic zotsatira amagwiritsidwa ntchito nawo.
Alinso ndi zotsutsana zomwe zimagwiritsidwa ntchito zoletsedwa kapena zofunika kusamala kwambiri.
Zovuta zotsutsana ndizophatikiza:
- tsankho limodzi kwa kapangidwe;
- mtundu woyamba wa matenda ashuga;
- chikomokere kapena mtundu wa odwala matenda ashuga;
- matenda ashuga ketoacidosis;
- opaleshoni yapanyumba yaposachedwa (resection);
- kulephera kwambiri kwa chiwindi;
- kulephera kwa aimpso;
- matumbo kutsekereza;
- kubereka mwana;
- kuyamwitsa;
- Zaka zodwala zimakhala zosakwana 18.
Kusamala ndikofunikira poyerekeza ndi odwala omwe ali ndi izi:
- febrile syndrome;
- uchidakwa wambiri;
- matenda a chithokomiro;
- poyizoni wa mowa;
- zaka zopitilira 70.
Milandu iyi, chithandizo ndi Maninil chololedwa, koma chimafuna kuyang'aniridwa kwachipatala.
Kanema pazizindikiro za matenda amtundu wa 2:
Malangizo ogwiritsira ntchito
Malangizo omwe amamwa maninil 5 amasankhidwa payekha kutengera kuchuluka kwa shuga m'magazi, zaka za wodwalayo, matenda oyanjana ndi zina. Nthawi zambiri, muyeso woyamba wa mankhwalawa ndi 2.5-5 mg wa patsiku (theka la piritsi kapena piritsi lonse). Ngati maphunzirowa sakubweretsani zomwe mukufunazo, muyezowo utha kuchuluka. Kutalika kovomerezeka kwa mankhwalawa ndi 15 mg.
Tengani mankhwalawo mkati musanadye. Simuyenera kutafuna mapiritsi, azitsukidwa ndi madzi. Ngati mlingo ndi wochepa, umagwiritsidwa ntchito nthawi (nthawi zambiri m'mawa). Zigawo zikuluzikulu za mankhwalawa ziyenera kugawidwa mu 2 Mlingo.
Ndikofunika kumwa mapiritsi nthawi yomweyo, izi zimakhalabe ndizambiri za mankhwalawa. Ngati phwando laphonyedwa, kuwonjezera mlingo sikuti ndikulimbikitsidwa.
Odwala Apadera ndi Mayendedwe
Kwa odwala ena, kusamala ndikofunikira pakugwiritsa ntchito Maninil.
Izi zikuphatikiza:
- Amayi oyembekezera. Pakubala kwa mwana, mankhwalawa amatsutsana. Chifukwa chake, azimayi oyembekezera amapatsidwa mankhwala ena.
- Amayi oyamwitsa. Palibe chidziwitso cha momwe mankhwalawo amagwira ntchito pa mkaka wa m'mawere, chifukwa chake madokotala samapereka mankhwala pa mkaka wa m'mawere.
- Ana ndi achinyamata. Chitetezo ndi kufunika kwa mankhwalawa m'gulu la odwala lino sikunafufuzidwe. Pokhudzana ndi izi, odwala matenda ashuga osakwana zaka zambiri, Maninil osavomerezeka.
- Anthu okalamba. Chifukwa cha kusintha komwe kumachitika mthupi la odwala, kusintha kwamphamvu kumatha kuchitika ku mankhwalawa, ndichifukwa chake zovuta zimakhalapo. Kugwiritsa ntchito mankhwalawa kuwagwirira ndikuloledwa, koma amafunikira mlingo wocheperako.
Kutsatira mosamala kumatsimikizira kutha kwa mankhwalawa komanso chitetezo cha odwala.
Matenda okhudzana ndi matenda a shuga amathandizanso kusankha mankhwala osokoneza bongo. Matenda ena ndi chifukwa chokana njira yosankhidwa.
Poyerekeza ndi Maninil, matenda ngati awa ndi:
- Kulephera kwa chiwindi. Ngati ilipo, mphamvu ya glibenclamide imatheka, chifukwa chomwe munthu amakhala ndi hypoglycemia.
- Kulephera kwina. Chifukwa chaichi, mawonekedwe a chinthu chogwira ntchito kuchokera mthupi amayamba kuchepa, zomwe zimawonjezera mwayi wa hypoglycemia. Komabe, ndi matenda awa, adokotala amatha kupatsa Maninil muyezo wochepetsedwa (ngati matendawa sapitirira mwamphamvu).
Mbali ina ya mankhwalawa ndikuti ingakhudze kuyendetsa bwino. Mkhalidwe wa hypoglycemic ukachitika, kuchuluka kwa zochita ndi chidwi zimachepa, zomwe zingakhudze chitetezo.
Zotsatira zoyipa ndi bongo
Mwa zina zoyipa zomwe zimachitika chifukwa cha mapiritsi awa amatchedwa:
- hypoglycemia
; - kusintha kwa thupi;
- nseru
- zotupa pakhungu;
- anaphylactic mantha;
- zosokoneza zowoneka;
- urticaria.
;Ndi mankhwala osokoneza bongo osokoneza bongo, kukula kwa hypoglycemia ndikotheka kwambiri. Sizimasankhidwa munjira zosiyanasiyana - kutengera mphamvu. Zomwezo zimachitidwa ndikupanga zotsatira zoyipa. Nthawi zina, kugwiritsa ntchito Maninil kuyenera kusiyidwa.
Kuyanjana Ndi Mankhwala Ndi Analogi
Kuchita bwino kwa mankhwalawa kumatithandizanso kudziwa kuphatikiza kwa mankhwala.
Manilin amakhumudwa ndi mankhwala monga:
- barbiturates;
- okodzetsa;
- sympathomimetics;
- estrogens
- njira zakulera za mahomoni.
Izi zikutanthauza kuti ngati mukufuna kumwa mankhwala a Maninil munthawi yomweyo, muyenera kuwonjezera.
Kuchita kwake kumathandizidwa ndi:
- mankhwala a hypoglycemic;
- othandizira antifungal;
- beta-blockers;
- ACE zoletsa;
- salicylates;
- manzeru.
Potengera zachilengedwe, mapiritsi omwe akufunsidwa ayenera kumwedwa.
Kufunika kwa mankhwala ofanana ndi omwewo kumatha kuchitika mwa wodwala aliyense.
Milandu iyi imagwiritsidwa ntchito
:
- Glyformin;
- Betanase;
- Amaryl;
- Siofor et al.
Wodwala sayenera kusintha mankhwalawo payekha, chifukwa muyenera kudziwa ngati mankhwalawo ndi oyenera.
Maganizo a akatswiri ndi odwala
Ndemanga za odwala ndi madokotala za Man Manil ndi zotsutsana. Sioyenera ambiri chifukwa cha zovuta zingapo. Izi zimatsimikiziranso kuti ndikofunikira kuyandikira kudya mankhwalawa mosamala komanso mosamala, kulabadira moyo wabwino ndikuyeza shuga m'magazi.
Sindimakonda kuperekera Maninil odwala anga. Nthawi zingapo panali milandu ya hypoglycemia chifukwa chake, motero ndimakonda kugwiritsa ntchito njira zina. Ngakhale ndinamva zambiri zabwino zokhudzana ndi mapiritsiwa kuchokera kwa ogwira nawo ntchito ndi omwe adawadziwa omwe adawalimbikitsa.
Lidia Mikhailovna, endocrinologist
Nthawi zambiri ndimayenera kugwiritsa ntchito mankhwalawa kuchiza matenda ashuga. Oyenera ena, ena amadandaula za zotsatira zoyipa. Ndikofunikira kuganizira mawonekedwe a wodwala aliyense kuti asankhe mankhwala oyenera.
Dmitry Sergeevich, endocrinologist
Sindimakonda Maninil. Zachidziwikire, adasunga shuga mwachizolowezi, koma chifukwa cha ichi ndidanenepa kwambiri, kupatula apo, ndimakhala ndikuzunzidwa nthawi zonse chifukwa cha mavuto am'mimba. Ndidafunsa adotolo kuti alowe m'malo.
Julia, wazaka 32
Ndakhala ndikugwiritsa ntchito Maninil kwa zaka ziwiri. Zimandikwanira kuposa mankhwala ena omwe ndimayenera kumwa. Palibe mavuto, shuga samachuluka. Chilichonse ndichabwino.
Andrey, wazaka 41
Mtengo wa mankhwalawa umatengera muyeso wa zomwe zimagwira ntchito momwemo. Pafupipafupi, Maninil 5 amawononga ma ruble 150, ngakhale pakhoza kukhala kusiyana pang'ono pamtengo.
