Orlistat ndi mankhwala a gulu la zoletsa zomwe zimalepheretsa matumbo ndi m'mimba. Mankhwalawa amagwiritsidwa ntchito kukonza zolemetsa; amathandizanso matenda a shuga a 2.
Kwa Orlistat, malangizo ogwiritsira ntchito amalimbikitsa kutenga makapisozi kuti muchepetse kunenepa, kukhazikika pamiyendo, kuchepetsa mwayi woyimbanso. Zoletsa zomwe zimapanga mankhwalawa zimalepheretsa kuyamwa kwamafuta m'matumbo ndikuthandizira kuti zithetsedwe ndi ndowe.
Orlistat - kapangidwe ndi mawonekedwe a kumasulidwa
Kunja, makapisozi otsekemera a Orlistat amasiyanitsidwa ndi chipolopolo cha buluu chokhala ndi pelescent hue (phale lidzayera pokhomedwa), mzere wogawika komanso lolemba "f". M'maselo a mabulasitiki a pulasitiki, mankhwalawa amawaika mu zidutswa 10, m'bokosi mumatha kukhala timbale zingapo (kuchokera pa 1 mpaka 9).
Mankhwalawa akupezeka kuti mugulitsidwa, mutha kugula zonse mumafakitale wamba komanso pa intaneti. Ndizopindulitsa kwambiri kugula makapisozi pazonse zonse - kulongedza kwakukulu kumawononga ndalama zochepa. Mtengo wa Orlistrat udzadalira wopanga: mapiritsi apakhomo (21 ma PC. 120 mg iliyonse) muyenera kulipira ruble 1300, analogue ya Swiss wopanga, ofanana kulemera kwake, adzagula ruble 2300.
Alumali moyo wa mankhwalawa ulibenso zaka ziwiri. Kusunga zida zothandizira poyamba ndikwabwino kuti musankhe malo amdima osafikirika ndi ana.
Chofunikira chachikulu cha mankhwala okhala ndi zotumphukira ndi orlistat. The inhibitor imachepetsa kudya ndipo ili pafupi kuti isalowe mu kayendedwe ka magazi.
Zomwe zimapangidwira mu formula zimathandizira ndi ma excipients: magnesium stearate, acacia chingamu, sodium lauryl sulfate, crospovidone, mannitol.
Makhalidwe a Pharmacological a Orlistat
Ku Orlistat, limagwirira ntchito amatengera ndi zoletsa za lipases pamimba ndi matumbo. Zotsatira zake zimadziwikiratu m'mimba, komwe kumapangidwa mgwirizano ndi serase lipases. Ma Enzymes amataya mphamvu ya hydrolyze triglycerol kuchokera ku zakudya zamafuta kuti agwetse mamolekyulu kupita ku mafuta acids okhala ndi monoglycerides.
Ma mamolekyulu osadziwika omwe samatengedwa - kusowa kwa zopatsa mphamvu kumathandizira kuchepetsa kunenepa. Kuti mankhwalawa awone kuthekera kwake, safunikira njira yolekeramo magazi: muyezo wokwanira (120 mg / 3 p. / Day) amachepetsa kuyamwa kwamafuta ndi wachitatu.
Zinakhazikitsidwa poyesa kuti kusunthika kwa ndulu ndi kapangidwe kazomwe zili, momwe amasulidwe am'mimba komanso kuchuluka kwake kwa acidity sikusintha mukadzaza ndi orlistrist. Mwa 28 ophunzira omwe adatenga Orlistrat 120 mg / 3 p. / Day., Ndende ya ziwalo zamkuwa, phosphorous, iron, zinc, magnesium, calcium yachepa.
Kuthekera kwakutali kwa orlistat popewa matenda awa sikunaphunzire.
Orlystraat ndi ndani
Mankhwalawa amalimbikitsidwa kuti achepetse thupi, komanso kuti azitha kukhazikika, ngati abwerera kale. Kulandila kwa makapisozi kumafunikira kuphatikizidwa ndi minofu yogwira ntchito ndi chakudya chamafuta ochepa.
Aliyense amene ali pachiwopsezo (odwala matenda ashuga omwe ali ndi matenda amtundu wa 2, matenda oopsa oopsa ndi kuchuluka kwa thupi, anthu omwe ali ndi cholesterol yambiri "yoyipa") nthawi ndi nthawi amatha kumwa mankhwalawa pofuna kupewa.
Malangizo ogwiritsira ntchito
Kuchokera pazotsatira zimatsata kuti mphamvu ya mankhwalawo pazomwe zimapangidwa kale mafuta ndizochepa. Ntchito yake imapangidwa ndi ma calories atsopano omwe amalowa m'thupi limodzi ndi zakudya zamafuta. Poletsa kuyamwa kwamafuta, zoletsa zam'madzi zimachepetsa chakudya chama calorie ndikuthandizira kuchepetsa thupi.
Mu mtundu wanthawi zonse, mankhwalawa amawadyedwa 3 r. / Day. 1 kapisozi.
Nthawi yabwino yoyamwa orchidat ndikumwa mapiritsi ndi chakudya kapena mukangomaliza kudya. Njira ya chithandizo ndi miyezi itatu. Pofuna kupewa zovuta, musanayambe chithandizo, muyenera kufunsa dotolo kapena dokotala.
Zachuma ndi bongo wambiri
Ndipo, panthawi yosinthira, komanso kugwiritsa ntchito mankhwala kwa nthawi yayitali, zinthu zosafunikira ndizotheka:
- Kutulutsa kwamafuta kochokera kunthaka nthawi zina pomwe matumbo samatenga chakudya konse.
- Kuphwanya matumbo motility, kumadziwonetsera mu mawonekedwe a m'mimba.
- Fecal incontinence: rectum amasiya kutheka chifukwa kuphwanya malangizowo pakumwa mankhwalawo.
- Vuto lakuchuluka chifukwa chakudya chopanda mphamvu, kuchepa kwa mavitamini osungunuka a mafuta, kuchuluka kwazinthu zambiri zosaphatikizidwa zam'mimba.
Kugwiritsa ntchito kamodzi kwa 800 mg ya mankhwala kapena njira, nthawi zambiri 400 mg / 3r / tsiku. Kupitilira masabata awiri, zotsatira zosadziwika zomwe sizinachitike sizinaululidwe kwa anthu opanda kulemera kokwanira kapena mwa omwe ali ndi BMI yoposa 30.
Kwa omwe mankhwalawo amakwiriridwa
Zina mwa zotsutsana kwathunthu:
- Mimba ndi mkaka wa m`mawere;
- Matenda am'mimba;
- Zaka mpaka zaka 12;
- Vephrolithiasis;
- Cholestasis;
- Malabsorption syndrome;
- Hyperoxcaluria.
Ndi matumbo oyaka, makapisozi nawonso samapilira, ndikuwoneka ngati zizindikilo zotere, muyenera kusiya kumwa mankhwalawo ndikupita kwa katswiri.
Zotsatira za kuyanjana ndi mankhwala ena
Ndi kugwiritsidwa ntchito mosiyanasiyana kwa Orlistat ndi mowa, pravastin, digoxin (ngati amaperekedwa kamodzi) ndi phenytoin (300 mg imodzi), pharmacokinetics yamankhwala samasintha. Nifedipine yokhala ndi mphamvu yayitali imasunga magawo a bioavailability; mu njira zakulera zamkamwa, mphamvu ya zotupa m'mimba mwa m'mimba sizisintha.
Mowa, nawo, sukusintha mawonekedwe a Orlistrat komanso mawonekedwe a mafuta okhala ndi ndowe.
Osatengera Cyclosporin kuphatikiza ndi Orlistrat: zomwe zili kumapeto kwa magazi zidzachepetsedwa. Kutalikirana pakati pa kugwiritsa ntchito mankhwala ndi maola atatu.
Orlistat imatha kuchepetsa kuchepa kwa beta-carotene (mwachitsanzo, kuchokera pazakudya zowonjezera) ndi 30%, vitamini E - ndi 60%. Mphamvu ya mankhwalawa pakamwa mavitamini D ndi A sizinakhazikitsidwe, kuchepa kwa mayamwidwe a vitamini K kwalembedwa.
Kafukufuku wokhala ndi anthu khumi ndi awiri omwe sanatengepo kunenepa kwambiri akuwonetsa kuti Orlistrist samalepheretsa magawo a warfarin, koma magawo a coagulation amayang'aniridwa ndi chithandizo cha nthawi yayitali.
Momwe amagwiritsidwira ntchito pamodzi ndi Orlistat ndi levothyroxine sodium hypothyroidism sichili pambali. Muzochitika zotere, chithokomiro cha chithokomiro chikuyenera kuyang'aniridwa ndipo nthawi yayitali pakati pa mulingo uyenera kukulitsidwa mpaka maola 4.
Malangizo apadera
Ndikofunikira kumvetsetsa kuti Orlistat si panacea yolemetsa yonse. Ngati wodwalayo adayamba kale kupanga mafuta olimba ndikuyembekeza kuti athetse popanda zakudya ndi masewera olimbitsa thupi, kupanikizana ndi piritsi lina pabedi lomwe lili kutsogolo kwa TV, ndiye kuti simungathe kudalira zotsatira zomwe alengeza.
Mafuta akakhala 30% kapena ochulukirapo tsiku lililonse muzakudya, mphamvu ya machitidwe a makapisozi amachepa, ndipo chiwopsezo cha zochitika zoyipa chimawonjezeka. Zakudya za tsiku ndi tsiku za mafuta, chakudya komanso mapuloteni ayenera kugawidwa m'magawo atatu.
Kuti mukhale ndi mavitamini ndi michere yambiri, ndikofunikira kutenga zovuta za vitamini zomwe zimayenderana ndi Orlistat, popeza mankhwalawo amalepheretsa kuyamwa kwawo.
Popereka mankhwala, munthu ayenera kuganizira kuthekera kwa organic chifukwa choonjezera kunenepa, mwachitsanzo, hypothyroidism.
Popeza mankhwalawa amaletsa kuyamwa kwa mavitamini angapo osungunuka ndi mafuta, muyezo ungabwezeretsedwe mothandizidwa ndi maultivitamini, omwe amaphatikiza mavitamini osungunuka a mafuta. Amatengedwa mosinthana ndi maola a 2 asanachitike kapena atatha Orlistrat.
Ndi zovuta zamanjenje (bulimia, anorexia), kuwotcha mafuta ndikotheka. Kulandila kwa makapisozi mu mulingo woposa 120 mg / 3r / Day. sichimapereka zotsatira zowonjezereka. Mankhwala, maumino a oxalate nthawi zina amalowa mkodzo.
Zomwe zingalowe m'malo mwa Orlistat
Ndi kusalolera kwamunthu payekha, zovuta zoyipa kapena zotsutsana zina, dokotala amatha kusankha analogue ya Orlistrat. Ali ndi mitundu ingapo ya mankhwala omwe ali ndi kaphatikizidwe komwe kameneka ndi zinthu zina zothandizira popanga.
- Xenical. Pamtima pa mnzake waku Swiss ndi orlistat yomweyo. Amawonetsedwa kwa chithandizo cha nthawi yayitali odwala omwe ali ndi kunenepa kwambiri osakanikirana ndi zakudya za hypocaloric.
- Orsoten. Mankhwala ochepetsa lipid amathandizana ndi chapamimba komanso kapamba pamimba, motero ma enzymes satenga nawo mbali pakuwonongeka kwamafuta.
- Mndandanda. Chida chimagwiritsidwa ntchito kunenepa. Zotsatira zoyipa zimaphatikizapo mafuta opunthira mafuta, kupweteka kwa epigastric, kusokonezeka kwa phokoso.
- Allie Lipase inhibitor imalimbikitsa kuchepa thupi ndipo sikuti imalowa m'magazi. Ilibe mphamvu yothandizanso. Zizindikiro za bongo: kusokonezeka, kusakhazikika, kuthamanga kwapang'onopang'ono.
- Xenalten. Mankhwala okhazikika pa orlistrist amawonetsedwa kwa odwala matenda ashuga, matenda oopsa, ndi dyslipidemia. Kugwiritsidwa ntchito mosiyanasiyana kwa cyclosporine kumachepetsa kuyika kwake m'magazi.
Ndemanga za Orlistat
Pamabwalo azodzikongoletsa, zolemetsa zonse zimakhudzidwa ndikuwona zovuta zomwe zingachitike, koma kuyambitsa kuchepetsa thupi mothandizidwa ndi orlistat kumatha kukhala ndi zotsatira zabwino.
Pambuyo kuchepa thupi, kagayidwe kachakudya kamasintha, ndikuwongolera glycemic mu matenda ashuga amabwezeretsedwa. Zikatero, ndikofunikira kusintha mlingo wa mankhwala antidiabetesic ndi insulin.
Vutoli limachulukitsa anthu ambiri, timadziunjikira kwa zaka zambiri, ndipo timalakalaka titachichotsa pakatha masiku. Komabe, madokotala amagogomezera kuti kuchepetsa thupi ndi njira yayitali yomwe imafunikira njira yophatikizira. Ngati mungathe kuthana ndi vuto loyang'aniridwa ndi katswiri, mutha kusankha njira zabwino kwambiri zamankhwala ndikupeza zotsatira zotsimikizika popanda zodabwitsa.
Ndemanga ya othamanga pa kuthekera kwa owotchera mafuta Xenical ndi Orlistat, onani vidiyo:
