Glucophage Long 500, 750, 1000 - malangizo ndi kuwunika kwa wodwala

Metformin ndi amodzi mwa mankhwala omwe amagwiritsidwa ntchito kwambiri pa matenda ashuga. Amachepetsa glycated hemoglobin komanso chiopsezo cha macro- ndi microvascular zovuta, komabe, kotala la odwala omwe ali ndi vuto la m'mimba, mpaka 10% ya odwala matenda ashuga amakana chithandizo pazifukwa izi. Mankhwala atsopano okhala ndi metformin Glucofage Long adapangidwa ndi Merck Sante makamaka kuti athetse mavuto awa. Amasintha bwino kulolerana kwa mapiritsi, kumawonjezera kutsatira kwa odwala omwe ali ndi matenda ashuga kwa omwe amalandira.

Izi zimatheka pogwiritsa ntchito mtundu wapadera wa Glucofage Long, womwe umakuthandizani kuti muchepetse kuyenda kwa metformin kupita m'magazi, kukwaniritsa kuyang'anira ndende, chifukwa chake kuchepetsa chiopsezo cha mavuto. Poterepa, zotsatira za mankhwalawa sizikuwonongeka konse. Kafukufuku wosiyanasiyana wowerengeka awonetsa kuti ntchito yotsitsa glucose ya Glucophage ndi Glucophage Long ndi yofanana.

Kodi Glucophage Kutalika Bwanji

Metformin tsopano ikulimbikitsidwa ndi anthu onse ammagulu a endocrinologist kuti ayambe kulandira chithandizo cha odwala matenda ashuga amtundu wa 2. Simayambitsa hypoglycemia, yomwe imakhala yoopsa kwambiri kwa okalamba, siyambitsa kulemera, koma imathandizira kuchepetsa thupi.

Glucophage mapiritsi aatali amachepetsa glycemia ya postprandial komanso kusala, osalimbikitsa kutulutsa insulin. Malangizo ogwiritsira ntchito akuwonetsa zinthu zitatu zomwe zimapangitsa kutsitsa kwake:

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

1. Kuchepetsa kutulutsidwa kwa glucose ku chiwindi kumatheka chifukwa chopondereza kupanga kwa glucose kuchokera pazinthu zopanda mafuta ndi glycogen.
2. Kusintha minofu ya m'magazi ndikugwiritsira ntchito pochepetsa minyewa ya insulin.
3. Kuchepetsa mayamwidwe a glucose m'mimba, ndikusintha kutembenuka kwake kukhala lactate. Mukamamwa mankhwalawa, kutuluka kwa chakudya kuchokera m'mimba, komwe nthawi zambiri kumathandizira odwala matenda ashuga, kumachepetsa. Ndemanga zingapo zikuwonetsa kuti izi zimapangitsa odwala kusintha mawonekedwe akudya, ndikuthandizira kunenepa.

Ndi ntchito tsiku lililonse, mankhwalawa amachepetsa pafupipafupi komanso kuopsa kwa zovuta za matenda ashuga. Chiwopsezo cha zovuta zam'mitsempha, kugunda kwa mtima, kufa kwathunthu kwa odwala onenepa kwambiri kumachepetsedwa ndi wachitatu, kufa chifukwa cha matenda ashuga - ndi 42%. Zotsatira zabwino zotere sizingafotokozedwe pokhapokha pobweza shuga. Zotsatira zamaphunziro, zidapezeka kuti metformin yatchula katundu wa angioprotective yemwe sagwirizana ndi zotsatira za mankhwala pa glycemia. Mwa mankhwala omwe amagwiritsidwa ntchito pa matenda a shuga, mankhwalawa ndi apadera.

Zowonjezera za mapiritsi a Glucophage Long, zothandiza kwa matenda ashuga:

Poyerekeza ndi ndemanga, chidwi cha anthu odwala matenda ashuga onenepa kwambiri komanso odwala omwe ali ndi metabolic syndrome ndiwothandiza kwa Metformin kuti achepetse thupi. Amatha kukhala ndi chidwi ndi zotsatira za kafukufuku wina pogwiritsa ntchito metformin, orlistat (Xenical) ndi sibutramine (Reduxin). Odwala sanasinthe kuchuluka kwa zochita zawo zolimbitsa thupi, koma adalangizidwa kuti azichepetsa kudya kwawo kwa chakudya madzulo. Metformin idayambitsidwa ndi mapiritsi a Glucofage Long 500 malinga ndi malangizo, pang'onopang'ono idakwera mpaka 1500 mg mwa odwala BMI <30, mpaka 2000 mg kwa BMI <35, ndi mlingo waukulu wa BMI ≥35.

Zizindikiro zamankhwala

Mu "Zowonetsa" gawo la malangizo ogwiritsira ntchito Glucophage Long - mtundu wachiwiri wa shuga. Mankhwalawa ayenera kuyikidwa pamodzi ndi zakudya komanso maphunziro akuthupi, kuphatikiza kwake ndi mapiritsi ena ochepetsa shuga ndi insulin ndikovomerezeka.

Mu zenizeni, mitundu yamagwiritsidwe a Glucofage Long ndi yotakata kwambiri. Itha kuperekedwa:

1. Zochizira prediabetes. Metformin imachepetsa kwambiri vuto la matenda osokoneza bongo omwe ali ndi vuto lozindikira panthawi yake.
2. Monga chimodzi mwazinthu zothandizira pa matenda a metabolic, limodzi ndi mankhwala osokoneza bongo a lipid popanga magazi, antihypertensive mankhwala.
3. Odwala onenepa kwambiri, omwe nthawi zambiri amakhala ndi insulin. Mapiritsi amtundu wa Glucofage amathandizira kuchepetsa insulini, zomwe zimatanthawuza kuti ntchito yothamangitsa mafuta ikhale "ndikuyamba" kuwonda.
4. Amayi okhala ndi PCOS. Zinapezeka kuti metformin imakhala ndi mphamvu yolimbikitsira ovulation. Malinga ndi ndemanga, mankhwalawa amawonjezera mwayi wokhala ndi pakati ndi polycystic.
5. Lembani odwala matenda ashuga 1 okhala ndi kulemera kwakukulu ndi insulin yayikulu tsiku ndi tsiku kuti amalimbikitse kuchepetsa komanso kuchepetsa kufunika kwa mahomoni opanga.

Pali umboni kuti Glucofage Long imatha kuchepetsa chiwopsezo cha mitundu ina ya khansa, koma mothandizidwa ndi zamankhwala izi sizinayambe ntchito.

Pharmacokinetics

Kusiyana kwakukulu pakati pa Glucofage Long ndi omwe adatsogola ndi pharmacokinetics apadera a mankhwala atsopano. Maziko piritsi la metformin yotalikilapo ndi njira yosanjikiza ziwiri. Danga lamkati lili ndi metformin, lakunja ndi loteteza. Mutatha kumwa mapiritsi, kumtunda kumadutsa madzi, kutupira kwamkati, ndikusandulika gel. Chifukwa cha izi, nthawi yomwe piritsi limakhala m'mimba limawonjezeka. Mankhwalawa amamasulidwa pang'onopang'ono kuchokera kumkati, amaponda kudzera pakatikati ndipo amalowetsedwa m'magazi. Potere, 90% ya chinthu chomwe chimagwira chimatulutsidwa mkati mwa maola 10. Poyerekeza, metformin yochokera ku Glucofage yokhazikika imagwiranso ntchito chimodzimodzi mphindi 30.

Zambiri kuchokera pa malangizo a pharmacokinetics a Glucofage Long:

Mtundu watsopano wamankhwala umakupatsani mwayi:

1. Imwani mapiritsi kamodzi patsiku, chifukwa zotsatira zake zimakhudza maola 24 kapena kupitilira. Malinga ndi ndemanga ya odwala matenda ashuga omwe adatenga nawo mbali m'maphunzirowa, mtundu woterewu umachepetsa mwayi wopezeka piritsi lina.
2. Chepetsani chiopsezo cha mavuto obwera chifukwa cha metformin yokhazikika. Mwayi uwu ndi chifukwa cha kutulutsa pang'onopang'ono kwa chinthucho m'magazi, komwe kumachepetsa kuchuluka kwake pochita ndi 25%.
3. Tsatirani kusankha kwa odwala. Kutulutsa kwa metformin kuchokera pagome sikudalira mphamvu ya munthu wodwala matenda ashuga, kapangidwe ka chakudya.

Kafukufuku akuwonetsa kuti palibe kusiyana pakumveka kwa Glucofage Long ndi Glucofage, pomwe Glucophage imataya molingana ndi kulolerana kwa metformin komanso kutsatira kwa odwala omwe ali ndi matenda ashuga.

Mtengo wa chithandizo ndi Glucophagem Long ndi 2-2,5 nthawi zambiri kuposa Glucofagem:

Njira zotsika mtengo zotsalira pa Glucofage Long

Metformin wokhala ndi nthawi yayitali akuyamba kutchuka. Kuphatikiza pa kampani ya Merck, ena opanga adayamba kupanga. Mankhwalawa amadziwika kuti ndi fanizo la Glucophage Long; akalembetsedwe, ayenera kutsimikizira kufanana kwawo ndi koyambirira. Komabe, mu lipoti la madotolo ndikuwunika kwa anthu odwala matenda ashuga, pamakhala zonena za apo ndi apo kuti ma analogu amayambitsa zotsatira zoyipa kwambiri kuposa zoyambilira za Glucofage Long, koma zoperewera kuposa metformin yokhazikika. Mtengo wa analogu ndi wotsika, popeza wopanga safunikira kuchita maphunziro otetezeka ndikuzindikira zovuta za mankhwala.

Mwa mankhwala omwe adalembedwa ku Russian Federation, metformin yowonjezera imakhala ndi Russian Metformin Long Canon (yopangidwa ndi Canonpharma), Metformin MV (Izvarino), Formmetin Long (Pharmstandart, Biosynthesis), Gliformin Prolong (Akrikhin), Israeli Metformin MV-Teva, Indian Diaformin OD.

Mtengo wa mapiritsi 60 a 750 mg a Metformin Canon ndi Formetin Long ndi ma ruble 310, omwe amakhala otsika mtengo kuposa 1.5 Gulcofage Long la mlingo womwewo.

Momwe mungatengere ndi kumwa

Mapiritsi a Glucofage atali okha amaledzera ndi chakudya, chosambitsidwa ndi madzi. Malangizowa akutsimikiza kuti kumwa kumwa wonse pa chakudya chamadzulo, kapena kugawa chakudya cham'mawa komanso m'mawa. Kuti musunge kutulutsidwa kwa nthawi yayitali kwa metformin, piritsi imayenera kuledzera yonse popanda kuphwanya. Glucophage Long 1000 imatha kuthyoledwa pakati.

Mu shuga mellitus, mlingo umasankhidwa malinga ndi lamulo lofanana ndi metformin wokhazikika: timayamba ndi mlingo woyambira ndikuwonjezera pang'onopang'ono mpaka glycemia atasintha.

Glucophage Kutalika 500 mg

Mlingo woyambira - 500 mg. Ngati palibe zoyipa, zitha kuwonjezeka pambuyo pa masabata awiri kuyambira chiyambi cha chithandizo. Mlingo uyenera kuchulukitsidwa ndi 500 mg milungu iwiri iliyonse mpaka shuga atafika pokhazikika. Choyipa chake chikamaloledwa, pang'onopang'ono kuchuluka kwake kuyenera kukhala. Mulingo wovomerezeka wa metformin mukamamwa Glucofage Long 500 ndi mapiritsi 4. Ngati salipira matenda ashuga, mankhwala ena ochepetsera shuga amawonjezeredwa ku regimen.

Glucofage Long 500 ya zakumwa zolemetsa pamiyeso ya 1500 mg, yokhala ndi kulemera kwakukulu komanso kusowa kwa contraindication, mlingo ungathe kukwezedwa pang'onopang'ono mpaka wokwanira.

Glucophage Kutalika 750 mg

Glucophage Long 750 imapangidwira odwala omwe ali ndi matenda a shuga omwe anali ndi glycemia yoyambirira. Ndi chithandizo chake, mutha kufikira chithandizo chamankhwala mwachangu. Mlingo woyambira wa mankhwalawa ndi piritsi limodzi, amamwa pa chakudya chamadzulo. Mlingo ukuwonjezeka kawiri pamwezi ndi 750 mg. Malinga ndi endocrinologists, mlingo wothandiza kwambiri kwa odwala ambiri ndi mapiritsi awiri. Malangizo ogwiritsira ntchito amakhazikitsa mlingo wovomerezeka - 2250 mg. Metformin yokhazikika imaloledwa 3,000 mg, kotero, odwala omwe ali ndi insulin yambiri sangathe kusintha kuchokera ku Glucophage kupita ku Glucophage Long.

Zotsatira zoyipa

Odwala ambiri omwe amatha kulipira bwino matenda a shuga omwe ali ndi metformin amakakamizidwa kukana kumwa mankhwalawa milungu yoyamba. Kwa izi amakakamizidwa ndi kupukusa m'mimba, zomwe zimakhala zotsatira zoyipa za mankhwalawo. Chiwopsezo chawo chimatha kuchepetsedwa ndikuwonjezera pang'onopang'ono mlingo, kumwa metformin nthawi yomweyo ndi chakudya komanso madzulo okha. Malinga ndi ndemanga, Zizindikiro zosasangalatsa pang'onopang'ono zimafooka ndipo pofika kumapeto kwa mwezi woyamba wamankhwala nthawi zambiri zimatha.

Ngati zotupa zimasokoneza moyo wabwinobwino kapena kupitiliza kwa nthawi yayitali, akatswiri a ma endocrinologists amalimbikitsa kutenga glucophage yayitali kapena mawonekedwe ake. Mu theka la milandu, kusintha kwa mankhwala kumayendera limodzi ndi kutha kapena kufooka kwa zotsatira zoyipa.

Mndandanda ndi pafupipafupi (%%) zamatumbo zomwe zingachitike:

Malangizo ena amatcha zotsalira zoyipa za Glucofage ndizosowa kwambiri, malinga ndi wopanga, osakwana 0.01% odwala amakumana nawo:

• Thupi lawo siligwirizana nthawi zambiri limafotokozedwa mu mawonekedwe a kuyabwa ndi urticaria;
• kusokonezeka kwa chiwindi, kukula kwa michere ya chiwindi. Mbali yotsatirayi nthawi zambiri imasowa chithandizo ndipo imazimiririka yokha ukachoka kwa Glucophage Long;
• kusowa kwa vitamini B12 ndi chithandizo cha nthawi yayitali;
• lactic acidosis imachitika nthawi zambiri ndi kulephera kwa aimpso, komwe kumayambitsa kukodza kwa metformin. Kuopsa kwa lactic acidosis kumachulukitsidwa ndi hypoxia, mowa, kusala kudya kwanthawi yayitali.

Kwa omwe mankhwalawo amatsutsana

Lactic acidosis ndi owopsa kwambiri. Chiwopsezo cha kufa kwa odwala matenda a shuga omwe ali ndi lactic acidosis ndi okwera kwambiri poyerekeza ndi zovuta zina za matenda ashuga. Metformin imachulukitsa kuchuluka kwa lactate m'thupi, chifukwa chake, mu contraindication kuti igwiritsidwe ntchito, malangizowa akuphatikizapo zochitika zonse momwe chiopsezo cha lactic acidosis chikuwonjezeka. Awa ndimatenda aliwonse omwe amayambitsa hypoxia: mtima, impso ndi kupuma, kuchepa magazi, kusowa kwam'mimba chifukwa cha kusanza kapena kutsegula m'mimba, matenda opatsirana, makamaka matenda am'mapapo ndi kwamkodzo. Simungathe kutenga Glucophage Long ndi calorie osakwanira (osakwana 1000 patsiku), uchidakwa, uchidakwa. Chonde dziwani kuti zochita za metformin zimatha kuposa tsiku, chifukwa chake simungathe kumwa piritsi m'mawa ndikumwa mowa madzulo.

Contraindication imaphatikizapo vuto lililonse la anthu odwala matenda ashuga, pomwe sizingatheke kuyendetsa glycemia ndi mapiritsi, ndipo insulin yofunikira ndiyofunikira. Izi zonse ndi zovuta za matenda ashuga, osatengera gawo lawo, kuvulala kwambiri, kuwotcha, kukonzekera ndi njira zothandizira opaleshoni yodzidzimutsa yomwe ikufuna opaleshoni yayikulu.

Kugwiritsa Ntchito Mimba

Metformin imatha kulowa m'magazi a amayi kulowa m'magazi a mwana wosabadwayo. Komabe, sizimayambitsa kubadwa mwatsopano, sizimachulukitsa kufa kwa intrauterine. Pali malingaliro omwe mankhwalawa angayambitse kuyipa kwa mwana, koma sanapezeke mu maphunziro omwe alipo. Ku Russia, kubereka ndi kutsutsana kwathunthu kwa metformin. Poyerekeza ndi ndemanga, ngakhale mankhwalawo sanagwiritse ntchito molingana ndi mawonekedwe (kukonza ntchito yamchiberekero), amathetsedwa ndi isanayambike mimba. Ku Europe, metformin imavomerezeka chifukwa cha matenda ashuga.

Thupi limatha kudutsa mkaka wa m'mawere, ndipo kuchokera pamenepo limalowa m'magazi am'mimba ndi magazi a mwana. Ndi mkaka wa m'mawere, malangizowo amakupatsani mwayi kuti mutenge mankhwala a Glucofage Long ndi fanizo pokhapokha ngati phindu lake limakhala lokwera kwambiri kuposa zomwe zingavulaze mwana. Izi zitha kukhala kukana kwambiri kwa insulini kuphatikiza kunenepa kwambiri, ndipo mogwirizana ndi kufunikira kwa milingo yayikulu ya insulin. Kuchepetsa thupi pambuyo pobereka kapena kuchepetsa pang'ono glycemia, metformin nthawi zambiri sagwiritsidwa ntchito pa mkaka wa m`mawere.

Kuphatikiza ndi mankhwala ena

Zinthu zina zimatha kukhudza ma pharmacokinetics a Glucophage Long, ndikuchulukitsa chiopsezo cha mavuto:

Zomwe akunena za Glucophage Long