Glimecomb - mankhwala ophatikizira awiri a matenda a shuga a 2

Glimecomb ndi m'gulu la mankhwala ophatikiza matenda antidiabetes. Amasiyanitsidwa ndi mawonekedwe apadera, osayerekezeka mu Russia kuphatikiza pazogwira ntchito. Mankhwalawa ali ndi metformin ndi gliclazide. Kuchuluka kwa zinthuzi kumathandiza kuchepetsa kusala kudya ndi 3prolial glycemia ndi 3 mmol / l, osakhudza kulemera kwa odwala matenda ashuga

Ubwino wofunika wa Glimecomb pazophatikizira zomwe zimadziwika kwambiri zomwe zimakhala ndi metformin ndi glibenclamide ndizochepetsera chiopsezo cha hypoglycemia. Glimecomb imapangidwa ndi bizinesi ya Akrikhin pafupi ndi Moscow.

Zisonyezero zakudikirira

Sulfonylurea derivatives (PSM) ndi mitundu yodziwika bwino kwambiri yamankhwala 2 a odwala matenda ashuga pambuyo pa metformin. Kuphatikizidwa kwa PSM ndi metformin ndikofunikira kwa odwala omwe omwe amadya ochepa wama carb, masewera, ndi metformin samapereka kuchepetsedwa kwa shuga. Zinthu izi zimagwira pazolumikizira zazikulu za matenda amtundu wa 2 shuga: kukana kwambiri kwa insulini komanso kuchepa kwa insulin, chifukwa chake zimapereka zotsatira zabwino kuphatikiza. Glyclazide, yomwe ndi gawo la mankhwala Glimecomb, ndi PSM wa mibadwo iwiri ndipo imawerengedwa kuti ndi imodzi mwazinthu zotetezeka kwambiri mgulu lake.

Mapiritsi a Glimecomb angalembedwe:

1. Pamene chithandizo cham'mbuyomu chidasiya kupereka chindapusa chabwino cha matenda ashuga.
2. Atangozindikira matenda ashuga, ngati mulingo wa glycemia ndiwokwera kwambiri.
3. Ngati wodwalayo salola kuti metformin ikhale yayikulu.
4. Kuchepetsa kuchuluka kwa mapiritsi odwala omwe amatenga gliclazide ndi metformin.
5. Anthu odwala matenda ashuga omwe glibenclamide (Maninil ndi analogues) kapena kuphatikiza kwake ndi metformin (Glibomet et al.) Amayambitsa kufooka pafupipafupi kapena kosatsimikizika kwa hypoglycemia.
6. Odwala omwe amalephera aimpso omwe glibenclamide amaletsedwa.
7. Ndi matenda a shuga ophatikizidwa ndi matenda a mtima. Zatsimikiziridwa kuti gliclazide sichikukhudza myocardium.

Malinga ndi kafukufuku, kale mwezi umodzi wowerengeka ndi Glimecomb, shuga yofulumira imachepa ndi pafupifupi 1.8 mmol / L. Pogwiritsa ntchito mankhwalawa, mphamvu zake zimakulirakulira, miyezi itatu itachepa kale 2.9. Matenda a miyezi itatu amasinthidwe a shuga mu theka la odwala omwe ali ndi matenda osokoneza bongo a shuga, pomwe mankhwalawa sanali oposa mapiritsi 4 patsiku. Kulemera kwambiri komanso hypoglycemia yayikulu, yofunikira kuchipatala, sinalembedwe ndi mankhwalawa.

Matenda a shuga ndi kupsinjika kudzakhala chinthu chakale

• Matenda a shuga -95%
• Kuthetsa kwa mitsempha thrombosis - 70%
• Kuthetsa kwa kugunda kwamtima kwamphamvu -90%
• Kuthana ndi kuthamanga kwa magazi - 92%
• Kuwonjezeka kwa mphamvu masana, kukonza kugona usiku -97%

Pharmacology Glimecomb

Kuphatikiza kwa PSM ndi metformin kumawonedwa ngati kwachikhalidwe. Ngakhale pakubwera othandizira atsopano a hypoglycemic, mabungwe apadziko lonse a shuga ndi Unduna wa Zaumoyo ku Russian Federation akupitilizabe kuphatikiza kuphatikiza uku monga koyenera kwambiri. Glimecomb ndi yosavuta kugwiritsa ntchito komanso yotsika mtengo. Zigawo zake ndizothandiza komanso zotetezeka.

Glyclazide yokhala ndi matenda a shuga a 2 amathandizira kupanga insulin yake, ndikuyamba kugwira ntchito gawo lake loyamba, pomwe shuga yangolowa kumene m'magazi. Kuchita izi kumakupatsani mwayi wochepetsera glycemia mutatha kudya, kutumiza shuga ku zotumphukira. Glyclazide imalepheretsa kukhazikika kwa angiopathy: imalepheretsa thrombosis, imasintha kukoka kwam'mimba komanso mkhalidwe wamakoma amitsempha yamagazi. Zotsatira zabwino za gliclazide pamapeto a retinopathy ndi nephropathy zatsimikiziridwa. Mapiritsi a Glimecomb kwenikweni samatsogolera ku insulin yochuluka m'magazi, chifukwa sayambitsa kulemera. Malangizowo adanenanso kuthekera kwa gliclazide kusintha kukhudzika kwa insulin, koma mwanjira iyi ali kutali ndi metformin, mtsogoleri wodziwika polimbana ndi insulin.

Metformin ndi mankhwala okhawo omwe amalimbikitsidwa kwa anthu amitundu mitundu iwiri ya matenda ashuga kupatula. Zimathandizira kusintha kwa glucose kuchokera m'mitsempha kupita m'maselo, kumalepheretsa kupanga kwa chiwindi ndi chiwindi, kuchedwa kuyamwa kwake m'matumbo. Mankhwala amalimbana bwino ndi matenda a lipid metabolism, omwe amadziwika ndi mtundu 2 wamatendawa. Chifukwa cha ndemanga zambiri za odwala matenda ashuga, metformin imagwiritsidwa ntchito kuchepa thupi. Sichimayambitsa hypoglycemia, akagwiritsidwa ntchito molingana ndi malangizo amakhala otetezeka kwathunthu. Zoyipa zamtunduwu wa Glimecomb ndizowonjezereka pazosafunikira pazakudya zam'mimba.

Pharmacokinetics yamagulu a mankhwala:

Mlingo

Glimecomb wa mankhwala ali ndi njira imodzi - 40 + 500, piritsi 40 mg la glyclazide, 500 mg ya metformin. Kuti mupeze theka la theka, piritsi likhoza kugawidwa, pali chiwopsezo.

Ngati wodwalayo sanalandire metformin m'mbuyomu, piritsi limodzi limayesedwa ngati mankhwala oyambira. Masabata awiri otsatira ndikosayenera kuichulukitsa, kotero mutha kuchepetsa chiwopsezo cha kusapeza bwino m'mimba. Odwala omwe amadziwa metformin ndipo amalekerera bwino amatha kutumizidwa mapiritsi atatu a Glimecomb. Mlingo wofunikira umatsimikiziridwa ndi dokotala, poganizira kuchuluka kwa glycemia wodwala komanso mankhwala ena omwe amamwa.

Ngati kumwa koyambira sikupereka zotsatira zomwe zimafunikira, zimayamba kuwonjezeka pang'onopang'ono. Popewa hypoglycemia, gawo pakati pakusintha kwa mankhwala liyenera kukhala osachepera sabata. Kutalika kololedwa ndi mapiritsi 5. Ngati pa kumwa motere, Glimecomb sapereka chindapusa cha matenda a shuga, ndiye kuti mankhwala ena ochepetsa shuga amaperekedwa kwa wodwala.

Ngati wodwala amakhala ndi insulin yambiri, Glimecomb mu shuga amatha kumwa ndi metformin. Chiwerengero cha mapiritsi pamenepa amawerengedwa kuti kuchuluka kwa metformin sikupitirira 3000 mg.

Malangizo a kumwa Glimecomb

Kupititsa patsogolo kulekerera kwa metformin ndikutchingira dontho lakuthwa la shuga, mapiritsi a Glimecomb amamwa nthawi yomweyo ndi chakudya kapena atangochita. Chakudya chizikhala chabwino komanso chizikhala ndi chakudya, makamaka chovuta kugaya. Poyerekeza ndemanga, mpaka 15% ya anthu odwala matenda ashuga amakhulupirira kuti kumwa Glimecomb ndi mankhwala ena omwe amachepetsa shuga kumatha kufunika kotsatira zakudya. Zotsatira zake, amamwa mankhwala okwanira, omwe amawonjezera zovuta zake komanso mtengo wa chithandizo, akudandaula za shuga, komanso m'mbuyomu amakumana ndi zovuta za matenda ashuga.

Tsopano palibe piritsi limodzi la shuga lomwe lingalowe m'malo mwa zakudya. Ndi nthenda yachiwiri ya 2, zakudya zimawonetsedwa popanda chakudya chambiri, zoletsa pang'ono pang'onopang'ono, ndipo nthawi zambiri zimakhala ndi zopatsa mphamvu za calorie - chakudya cha matenda a shuga a 2. Njira ya mankhwalawa imaphatikizapo kuvomerezeka kwachulukidwe ka kulemera ndi kuchuluka kwa ntchito.

Kuonetsetsa kuti mayendedwe amtundu wa Glimecomb masana, mlingo womwe waperekedwa umagawidwa pawiri - Mlingo ndi madzulo. Malinga ndi ndemanga, zotsatira zabwino kwambiri za chithandizo zimawonedwa mwa odwala omwe amamwa mankhwalawa katatu (mutatha kudya chilichonse), ngakhale kuti malangizo omwe angagwiritsidwe ntchito samapereka mwanjira imeneyi.

Zotsatira zoyipa

Zotsatira zoyipa zambiri zimatha kufooka ngati mutsatira malamulo oti mutenge ndikuwonjezera mlingo kuchokera pamalangizo. Kuletsa kwa Glimecomb chifukwa cha tsankho sikufunika kwenikweni.

Contraindication

Mukapanda kumwa Glimecomb:

• mtundu 1 shuga;
• hypoglycemia. Mankhwalawa sangakhale oledzera mpaka shuga atayamba kuchuluka;
• zovuta za matenda a shuga, matenda oopsa komanso kuvulala komwe kumafunikira mankhwala a insulin. Mlandu wa lactic acidosis m'mbuyomu;
• mimba, yoyamwitsa;
• X-ray yokhala ndi ma ayodini okhala ndi ayodini;
• tsankho ku zilizonse za mankhwala;
• aimpso, kulephera kwa chiwindi, hypoxia, ndi matenda omwe amayambitsa zovuta izi;
• uchidakwa, kumwa kwambiri kamodzi.

Odwala omwe ali ndi matenda a mahomoni. okalamba odwala matenda ashuga pogwiritsa ntchito nthawi yayitali, chiwopsezo cha mavuto amabwera, chifukwa chake akamamwa Glimecomb, ayenera kusamala makamaka ndi thanzi lawo.

Kugwirizana kwina ndi mankhwala ena

Zotsatira za Glimecomb zitha kupitilizidwa kapena kufooka mukamamwa mankhwala ena. Mndandanda wamachitidwe ogwiritsira ntchito mankhwalawa ndiwokulirapo, koma nthawi zambiri kusintha kwa magwiridwe antchito sikofunikira kwambiri ndipo kungasinthidwe mosavuta posintha mlingo.

Zofananira

Glimecomb alibe ma analoge athunthu omwe adalembetsedwa ku Russian Federation. Ngati mankhwalawo mulibe mankhwala, mankhwala awiri omwe ali ndi zinthu zomwezo angathe kusintha:

1. Metformin ili mu Glucofage yoyambilira yomwe idapangidwa ku France, Siofor yaku Germany, Metformin yaku Russia, Merifatin, Glformin. Onse ali ndi mlingo wa 500 mg. Kwa odwala matenda ashuga osalekerera bwino a metformin, mtundu wosinthika wa mankhwalawa ndi wabwino, womwe umatsimikizira kuti kulowa kwa zinthu zomwe zili m'magazi ndikuchepetsa kwambiri mavuto. Awa ndi mankhwala Metformin Long Canon, Metformin MV, Formin Long ndi ena.
2. Gliclazide ndiwodziwikanso kwambiri wa hypoglycemic. Katunduyu ndi gawo la Russian Glidiab ndi Diabefarm. Gliclazide yosinthidwa pano amawona ngati mawonekedwe omwe amakonda. Kugwiritsidwa ntchito kwake kumachepetsa kuchepa komanso kuopsa kwa hypoglycemia. Gliclazide yosinthidwa imakhala mu kukonzekera Diabefarm MV, Diabeteson MV, Gliclazide MV, Diabetalong, etc. Mukamagula, muyenera kuyang'anira chidwi ndi mankhwalawa, mungafunike kugawa piritsi pakati.

Pali mitundu yambiri yamagulu a Glimecomb pamsika waku Russia. Ambiri a iwo ndi ophatikiza a metformin okhala ndi glibenclamide. Mankhwalawa sakhala otetezeka kuposa glimecomb, chifukwa nthawi zambiri amayambitsa hypoglycemia. M'malo abwino a Glimecomb ndi Amaril (metformin + glimepiride). Pakadali pano, uyu ndiye mankhwala apamwamba kwambiri ophatikizidwa ndi PSM.

Mtengo

Mtengo wa paketi ya mapiritsi 60 a Glimecomb ndi wochokera pa 459 mpaka 543 rubles. Gliclazide ndi metformin kuchokera kwa wopanga yemweyo adzagula ma ruble 187. pa mlingo womwewo (mapiritsi 60 a Glidiab 80 mg amatenga ma ruble 130, mapiritsi 60. Gliformin 500 mg - 122 rubles). Mtengo wa kuphatikiza koyambirira kwa gliclazide ndi metformin (Glucofage + Diabeteson) ndi ma ruble pafupifupi 750, onse omwe ali mu mawonekedwe osinthika.

Ndemanga za Matenda a shuga