Viktoza: malongosoledwe, malangizo ogwiritsira ntchito, chithunzi

Mankhwala Victoza akuwonetsedwa kuti agwiritsidwe ntchito kwa odwala omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo monga chothandiza. Imagwiritsidwa ntchito nthawi yomweyo ndi chakudya ndikuwonjezera zolimbitsa thupi kuti muchepetse shuga.

Liraglutide yomwe ndi gawo la mankhwalawa imakhudza kulemera kwa thupi ndi mafuta m'thupi. Imagwira mbali zina zamanjenje zapakati zomwe zimayambitsa njala. Wovutitsayo amathandiza wodwalayo kuti azimva kutalika kwa nthawi yayitali pochepetsa kugwiritsa ntchito mphamvu.

Mankhwalawa amatha kugwiritsidwa ntchito ngati mankhwala odziimira pawokha, kapena osakanikirana ndi mankhwala ena. Ngati mankhwalawa ali ndi mankhwala okhala ndi metformin, sulfonylureas kapena thiazolidatediones, komanso kukonzekera kwa insulini kulibe vuto, ndiye kuti Victoza angalembedwe mankhwala omwe adamwa kale.

Contraindication kugwiritsa ntchito mankhwalawa

Zotsatirazi zitha kukhala zotsutsana pakugwiritsa ntchito mankhwalawa:

• kuchuluka kwa chidwi cha odwala pazinthu zomwe zimagwiritsidwa ntchito ndi mankhwala kapena zigawo zake;
• nthawi ya pakati kapena yoyamwitsa;
• mtundu 1 shuga
• ketoacidosis, yopangidwa motsutsana maziko a shuga;
• kwambiri aimpso kuwonongeka;
• chiwindi ntchito;
• matenda a mtima, kulephera kwa mtima;
• matenda am'mimba ndi matumbo. Njira zotupa m'matumbo;
• paresis am'mimba;
• zaka odwala.

Mankhwala ndikugwiritsa ntchito mankhwalawa amayi apakati kapena oyembekezera

Mankhwala okhala ndi liraglutide ali osavomerezeka kuti mugwiritse ntchito pa nthawi yoyembekezera komanso pakukonzekera. Munthawi imeneyi, kukhalabe ndi shuga wokwanira ayenera kukhala mankhwala okhala ndi insulin. Ngati wodwalayo adagwiritsa ntchito Victoza, ndiye pambuyo pathupi, phwando lake liyenera kuyimitsidwa nthawi yomweyo.

Zotsatira za mankhwalawa paubwino wa mkaka wa m'mawere sizikudziwika. Mukadyetsa, kutenga Viktoza osavomerezeka.

Zotsatira zoyipa

Poyesa Victoza, odwala nthawi zambiri amadandaula za mavuto am'mimba. Adanenanso kusanza, kutsegula m'mimba, kudzimbidwa, kupweteka pamimba. Izi zimawonedwa mwa odwala kumayambiriro kwa makonzedwe kumayambiriro kwa kayendetsedwe ka mankhwala. M'tsogolomu, pafupipafupi zotsatirapo zoyipa zotere zidachepetsedwa kwambiri, ndipo mkhalidwe wa wodwalayo umakhala wokhazikika.

Zotsatira zoyipa za kupuma zimawonedwa nthawi zambiri, pafupifupi 10% ya odwala. Amayamba kudwala matenda am'mapapo. Mukamamwa mankhwalawa, odwala ena amadandaula chifukwa cha mutu wopitilira.

Ndi zovuta mankhwala othandizira omwe ali ndi mankhwala angapo, kukulitsa kwa hypoclycemia ndikotheka. Kwenikweni, izi zimadziwika ndi chithandizo chanthawi imodzi ndi Viktoza komanso mankhwala osokoneza bongo omwe amapezeka kuchokera ku sulfonylurea.

Zotsatira zoyipa zilizonse zomwe zimachitika mukamamwa mankhwalawa ndi chidule.

Zotsatira zonse zomwe zidafotokozedwa mwachidule patebulopo zidadziwika nthawi yayitali ya gawo lachitatu la mankhwalawa Victoza, komanso kutengera mauthenga obwera nawo. Zotsatira zoyipa zomwe zidapezeka pofufuza kwakanthawi zidapezeka muoposa 5% ya odwala omwe amatenga Victoza, poyerekeza ndi odwala omwe akuchita mankhwala ena.

Komanso mu tebulo ili mndandanda wazotsatira zomwe zimapezeka mwaoposa 1% ya odwala ndipo pafupipafupi kukula kwawoko kumakulirakawiri kawiri kuposa pafupipafupi wa chitukuko mukamamwa mankhwala ena. Zotsatira zonse zoyipa patebulopo zimagawika m'magulu potengera ziwalo komanso pafupipafupi zomwe zimachitika.

Kufotokozera kwamomwe munthu amachitikira mosiyanasiyana

Hypoglycemia

Zotsatira zoyipa izi mwa odwala omwe akutenga Victoza adadziwonetsa pang'ono. Pankhani ya matenda a shuga a mellitus kokha ndi mankhwalawa, kupezeka kwa hypoglycemia sikunenedwe.

Zotsatira zoyipa, zomwe zimafotokozedwa ndi kuchuluka kwa hypoglycemia, zimawonedwa panthawi yovuta ya mankhwala a Viktoza pokonzekera okhala ndi zinthu zina zochokera ku sulfonylurea.

Mankhwala osokoneza bongo omwe ali ndi liraglutide ndi mankhwala omwe alibe sulfonylurea samapereka zotsatira zoyipa za hypoglycemia.

Matumbo

Njira zoyipa zoyambira kuchokera m'matumbo am'mimba zambiri zimasonyezedwa ndikusanza, mseru ndi m'mimba. Iwo anali opepuka mwachilengedwe ndipo anali ofanana ndi gawo loyamba la chithandizo. Pambuyo pake panali kuchepa kwa zomwe zinapangitsa chifukwa cha zovuta izi. Milandu yakuchotsedwa kwa mankhwalawa chifukwa cha zovuta zomwe zimachitika m'matumbo am'mimba sizinalembedwe.

Pakufufuzidwa kwanthawi yayitali kwa odwala omwe amatenga Victoza osakanikirana ndi metformin, 20% yokha idadandaula za vuto limodzi la nseru panthawi ya chithandizo, pafupifupi 12% ya matenda otsegula m'mimba.

Kuchiza mokwanira ndi mankhwala omwe ali ndi liraglutide ndi zotumphukira za sulfonylurea kunabweretsa zotsatirapo zotsatirazi: 9% ya odwala amadandaula ndi mseru akumwa mankhwala, ndipo pafupifupi 8% amadandaula ndi matenda otsegula m'mimba.

Poyerekeza zomwe zimachitika mukamamwa mankhwala a Viktoza ndi mankhwala ena omwe ali ofanana ndi mankhwala omwe amapezeka, zotsatira zoyipa zimadziwika mu 8% ya odwala omwe amatenga Victoza ndi 3.5 - akumamwa mankhwala ena.

Chiwerengero cha zoyipa za anthu okalamba chinali zapamwamba pang'ono. Matenda okhala ndi vuto limodzi, monga kulephera kwa impso, amakhudzanso zomwe zimachitika.

Pancreatitis

Muzochita zachipatala, milandu ingapo yonyansa yamankhwala imapangidwa ndikukula ndikuchulukirachulukira kwa kapamba akuti. Komabe, kuchuluka kwa odwala omwe matendawa adapezeka chifukwa chotenga Victoza ndi ochepera 0.2%.

Chifukwa cha kuchepa kwakukulu kwa mbali iyi komanso chifukwa chakuti kapamba ndi zovuta za shuga, sizingatheke kutsimikizira kapena kutsutsa izi.

Chithokomiro

Chifukwa chophunzira momwe mankhwalawa amathandizira odwala, zomwe zimapangitsa kuti chithokomiro chizigwira. Zowunikira zinapangidwa kumayambiriro kwa maphunzirowa ndikugwiritsa ntchito liraglutide kwa nthawi yayitali, placebo ndi mankhwala ena.

Kuchuluka kwa zoyipa zomwe zinali motere:

• liraglutide - 33.5;
• placebo - 30;
• mankhwala ena - 21.7

Kuchulukitsa kwa kuchuluka kumeneku ndi kuchuluka kwa zovuta zomwe zimachitika zaka chikwi zakubadwa zogwiritsa ntchito ndalama. Mukamamwa mankhwalawa, pamakhala chiopsezo chokhala ndi vuto lalikulu la chithokomiro.

Zina mwazotsatira zoyipa kwambiri, madotolo amawona kuchuluka kwa magazi a calcitonin, goiter komanso ma neoplasms osiyanasiyana a chithokomiro.

Ziwengo

Mukamamwa Victoza, odwala adanenanso kuti thupi siligwirizana. Pakati pawo, khungu loyenda, urticaria, mitundu yosiyanasiyana ya totupa imatha kusiyanitsidwa. Mwa milandu yayikulu, milandu ingapo ya anaphylactic imadziwika ndi izi:

1. kutsika kwa kuthamanga kwa magazi;
2. kutupa
3. kuvutika kupuma
4. kuchuluka kwa mtima.

Tachycardia

Osati kawirikawiri, pogwiritsa ntchito Viktoz, kuwonjezeka kwa kugunda kwa mtima kunadziwika. Komabe, malinga ndi zotsatira za kafukufukuyu, kuwonjezeka kwapakati pa kugunda kwa mtima kunali kumenyedwa katatu pamphindi poyerekeza ndi zotsatira zisanachitike chithandizo. Maphunziro a nthawi yayitali sapezeka.

Mankhwala osokoneza bongo

Malinga ndi malipoti pa kafukufuku wa mankhwalawa, milandu imodzi ya mankhwala osokoneza bongo idalembedwa. Mlingo wake umaposa 40 nthawi yoyenera. Mphamvu ya bongo anali kwambiri mseru komanso kusanza. Zodabwitsa monga hypoglycemia sizinadziwike.

Pambuyo pa chithandizo choyenera, kuchira kwathunthu kwa wodwalayo komanso kusapezeka kwathunthu kwa mankhwala osokoneza bongo adadziwika. Pankhani ya bongo, ndikofunikira kutsatira malangizo a madokotala ndikugwiritsa ntchito mankhwala oyenerera.

Kugwirizana kwa Victoza ndi Mankhwala Ena

Pounika mphamvu ya liraglutide pochiza matenda ashuga, kuchepa kwake ndi zochitika zina zomwe amapanga mankhwalawo kunadziwika. Zinadziwikanso kuti liraglutide imakhudzanso kupopera kwa mankhwala ena chifukwa chovuta kutulutsa m'mimba.

Kugwiritsa ntchito pamodzi kwa paracetamol ndi Victoza sikufuna kusintha kwa mankhwalawa. Zomwezi zimagwiranso ntchito pa mankhwalawa: atorvastatin, griseofulvin, lisinopril, njira zakulera pakamwa. Panthawi yogwiritsidwa ntchito molumikizana ndi mankhwala amtunduwu, kuchepa kwa mphamvu yawo sikunawonedwenso.

Kuti muthandizike kwambiri, nthawi zina, kupatsidwa insulin ndi Viktoza ndi mankhwala. Kuyanjana kwa mankhwalawa sikunaphunzirepo kale.

Popeza kafukufuku wokhudzana ndi Victoza ndi mankhwala ena sanatengedwe, madokotala salimbikitsidwa kumwa mankhwalawa nthawi imodzi.

Kugwiritsa ntchito mankhwala ndi mlingo

Mankhwalawa amalowetsedwa mwachangu mu ntchafu, mkono wapamwamba, kapena pamimba. Mankhwala, jakisoni wa nthawi 1 patsiku ndikokwanira nthawi iliyonse, mosasamala kanthu za kudya. Nthawi ndi malo a jakisoni ndi jakisoni wake amatha kusinthidwa ndi wodwalayo payokha. Pankhaniyi, ndikofunikira kutsatira mlingo wa mankhwalawo.

Ngakhale kuti nthawi yopanda jekeseni siyofunika, timalimbikitsidwabe kuperekera mankhwalawa nthawi yomweyo, yomwe ili yoyenera kwa wodwalayo.

Zofunika! Victoza sagwiritsidwa ntchito kudzera m'mitsempha kapena m'mitsempha.

Madokotala amalimbikitsa kuyambitsa chithandizo ndi 0,6 mg ya liraglutide patsiku. Pang'onopang'ono, mlingo wa mankhwalawa uyenera kuchuluka. Pambuyo pa sabata la mankhwala, mlingo wake uyenera kuwonjezeka ndi 2 times. Ngati pakufunika, wodwalayo atha kuwonjezera mlingo wa 1.8 mg mlungu wamawa kuti akwaniritse zotsatira zabwino zamankhwala. Kuwonjezeka kwina kwa mankhwalawa osavomerezeka sikulimbikitsidwa.

Victoza angagwiritsidwe ntchito ngati kuwonjezera kwa mankhwala omwe ali ndi metformin kapena chithandizo chovuta ndi metformin ndi thiazolidinedione. Pankhaniyi, mlingo wa mankhwalawa ukhoza kusiidwa pamlingo womwewo popanda kusintha.

Kugwiritsa ntchito Viktoza monga mankhwala osokoneza bongo okhala ndi sulfonylurea kapena njira yovuta yokhala ndi mankhwalawa, ndikofunikira kuti muchepetse kuchuluka kwa sulfonylurea, popeza kugwiritsidwa ntchito kwa mankhwalawa m'miyeso yapitayi kungayambitse hypoglycemia.

Pofuna kusintha mlingo wa Viktoza tsiku ndi tsiku, sikofunikira kuchita mayeso kuti mupeze kuchuluka kwa shuga. Komabe, kupewa hypoglycemia m'magawo oyamba a zovuta mankhwala okhala ndi sulfonylurea, ndikofunikira kuyang'anira kuchuluka kwa shuga m'magazi.

Kugwiritsa ntchito mankhwalawa m'magulu apadera a odwala

Mankhwalawa amatha kugwiritsidwa ntchito mosasamala zaka za wodwalayo. Odwala achikulire osaposa zaka 70 safuna kusintha kwapadera kwa mankhwala tsiku lililonse. Mwachidziwitso, zotsatira za mankhwalawa kwa odwala ochepera zaka 18 sizinakhazikitsidwe. Komabe, pofuna kupewa kupezeka kwa zovuta ndi zovuta, mankhwalawa ali osavomerezeka kwa odwala omwe ali ndi zaka 18.

Kusanthula kwa kafukufuku kumawonetsa zomwe zimachitika mthupi la munthu, mosaganizira jenda ndi mtundu. Izi zikutanthauza kuti zovuta zamankhwala zokhala liraglutide sizimayenderana ndi wodwala komanso mtundu.

Komanso, sizinakhudze zovuta zamatenda a liraglutide thupi zinapezeka. Kafukufuku akuwonetsa kuti index yamasamba a thupi alibe gawo lalikulu pazotsatira za mankhwalawa.

Ndi matenda a ziwalo zamkati ndi kuchepa kwa ntchito zawo, mwachitsanzo, kulephera kwa chiwindi kapena aimpso, kuchepa kwa mphamvu yogwira ntchito ya mankhwala. Kwa odwala omwe ali ndi matenda osakhazikika, kusintha kwa mankhwalawa sikofunikira.

Odwala omwe ali ndi vuto lochepa kwambiri kwa hepatic, mphamvu ya liraglutide inachepetsedwa ndi pafupifupi 13-23%. Kulephera kwambiri kwa chiwindi, ntchito yake idatsala pang'ono kutha. Kuyerekeza kunapangidwa ndi odwala omwe ali ndi ntchito yofanana ndi chiwindi.

Pakulephera kwa impso, kutengera kuwuma kwa matendawa, mphamvu ya Viktoza idatsika ndi 14-33%. Ngati matenda a impso akuwonongeka, mwachitsanzo, ngati kulephera kwaimpso kumatha, mankhwalawa ndi osavomerezeka.

Zomwe zimatengedwa kuchokera kuzomwe zimayankhidwa zamafuta.