Mwa kuchuluka kwamankhwala osiyanasiyana omwe amagwiritsidwa ntchito pochiza matenda osokoneza bongo omwe amadalira shuga, Gliclazide ikhoza kusiyanitsidwa.
Malondawa adalandira dzina loterolo mu INN system. Kugwiritsa ntchito kwake kumatheka pokhapokha kuyang'aniridwa ndi adokotala ndikutsatira malangizo onse.
Potere, kugwiritsa ntchito Gliclazide kudzachita bwino.
Kuwonetsedwa kwa matendawa ndi chithandizo chake?
Type 2 shuga mellitus angatchulidwe ndi zazikulu za m'zaka za zana la makumi awiri ndi limodzi. Njira yamakono yamoyo, kuthamanga kosalekeza komanso kupsinjika, ntchito yogwira ntchito limodzi ndi zakudya zopanda thanzi imakhala zifukwa zazikulu zachitukuko chake.
Chithandizo cha matenda a kagayidwe kachakudya zimagwiritsidwa ntchito zovuta, zomwe mankhwala apadera ndi kudya kwambiri amakhala. Dziwani kuti munthu amatha kumwa mankhwalawa momwe angafunikire, koma popanda chithandizo cha zakudya, sizingatheke kuchita zabwino.
Mankhwala osankhidwa bwino amathandiza wodwala matenda ashuga kukhala ndi moyo wabwino komanso kupewa zovuta.
Mankhwala onse omwe amagwiritsidwa ntchito popanga mankhwala amatha kugawidwa m'magulu otsatirawa:
- Mapiritsi omwe amathandizira kapamba.
- Mankhwala omwe amachotsa kukokana kwa insulin. Matenda oterewa nthawi zambiri amapezeka mwa anthu omwe ali ndi mtundu wachiwiri wa matenda osokoneza bongo ndipo ndi chiwonetsero cha kusazindikira mtima kwa minyewa yomwe imapangidwa ndi kapamba.
- Mankhwala okhala ndi acarbose. Chifukwa cha gawo ili, pali cholepheretsa mayamwidwe m'matumbo.
Mwa mankhwala omwe ali ndi phindu pa masanjidwewo a kapamba ndi mapiritsi ochokera ku gulu la sulfonylureas ndi glinides.
Zosakanikirana zimachitika mothandizidwa ndi ma insretins. Mankhwala omwe amalepheretsa mawonetseredwe a insulin kukokana ndi mapiritsi otengera metformin kapena thiazolinedione.
Zomwe zili bwino kwa wodwala aliyense zitha kutsimikiziridwa ndi adotolo pamaziko a chithunzi chazachipatala ndi mawonekedwe a wodwalayo.
Pharmacological katundu wa mankhwala
Mankhwala Gliclazide anayamba kugwiritsidwa ntchito ngati mankhwala a matenda a shuga 2 molumikizana ndi mankhwala omwe adokotala adya.
Mankhwala samangoleketsa kuchuluka kwa shuga m'magazi, komanso amathandizira kuchepetsa kuchepa kwa thupi, zomwe ndizofunikira kwambiri kwa anthu omwe ali ndi vutoli.
Mpaka pano, mawonekedwe ena a mankhwalawo adadziwika.
Zakhazikitsidwa zasayansi kuti munthu atha kutenga Glyclazide 80 mg kuti akwaniritse zolinga izi:
- Zimathandizira kuteteza ubongo ku obsolescence, womwe umakulolani kugwiritsa ntchito zolinga zake za prophylactic za matenda a Alzheimer's.
- Mosangalatsa zimakhudza chikhalidwe cha zotengera ndi mitsempha. Chifukwa chake, mothandizidwa ndi mankhwala, kukhazikika kwa atherosclerosis, kuchepa kwa mtima, matenda oopsa, komanso mtima wamankhwala kumatha kupewedwa.
- Amachepetsa mwayi wokhala ndi khansa
- Amagwira ntchito kuti athandize kukonza mwayi wa abambo omwe asokonezeka chifukwa cha matenda osiyanasiyana okalamba.
- Zimalepheretsa kukula kwa mafupa ndi matenda ashuga. Makamaka mafupa owundana nthawi zambiri amakhudza azimayi atayamba kusamba, popeza pali kuchepa kwakukulu kwamahomoni - estrogen.
- Chimakonda bwino chithokomiro cha chithokomiro.
- Imawonetsa ntchito yoteteza mokhudzana ndi dongosolo la kupuma.
Mankhwala Glyclazide amagwiritsidwa ntchito mwachangu kuchepetsa magazi. Nthawi yomweyo, kuchepa kwa zizindikiro kumachitika osati pambuyo pa chakudya chachikulu, komanso kumakupatsani mwayi kuti muchepetse maziko. Gawo lalikulu la mapiritsi limakupatsirani mwayi wopanga insulin ndi kapamba, yemwe amakhudza thupi ndipo samapangitsa kuti hypoglycemia itukuke. Kuphatikiza apo, zina mwazabwino ndi izi:
- kulowetsedwa kwa hyperinsulinomy;
- zabwino zimapangitsa kuti muchepetse kunenepa;
- amachepetsa chiopsezo cha matenda opatsirana ndi mtima;
- bwino zimakhudza kagayidwe kachakudya matenda lipid;
- amachepetsa njira mafuta oxidation;
- amachepetsa kwambiri kuchuluka kwa cholesterol;
- amachepetsa chiwopsezo cha matenda a shuga;
Zimathandizira kuchepetsa triglycerides.
Malangizo ogwiritsira ntchito mankhwalawa
Gliclazide ya mankhwala imayikidwa pokhapokha ngati anthu achikulire ndi piritsi losinthika.
Ndikofunika kumwa mankhwala oterowo motsogozedwa ndi kuyang'aniridwa ndi adokotala. Malangizo a Gliclazide ogwiritsa ntchito amakhalanso ndi chidziwitso chofunikira chokhudza kumwa mosamala.
Mankhwalawa atha kugulidwa ku malo azamankhwala azigawo munthawi zotsatirazi:
- 30 mg yogwira mankhwala piritsi limodzi;
- 60 mg ya yogwira pophika;
- 80 mg
Kutengera mlingo wake, malamulo omwera mankhwalawa amadalira. Njira ya mankhwalawa imafotokozedwa mu Mlingo womwe umachokera ku chithunzithunzi chachikulu cha matenda ndi mthupi la wodwalayo.
Chizindikiro chachikulu chomwe muyenera kulabadira posankha mlingo ndi kuchuluka kwa glucose m'magazi ndi gawo la kulemera kwa wodwala. Mlingo wa tsiku ndi tsiku sayenera kupitirira 120 mg ya chinthu chachikulu.
Pankhaniyi, njira yoyambira yovomerezeka iyenera kuyamba ndi Mlingo wa 30 kapena 60 mg. Mapiritsi amayenera kuledzera kamodzi patsiku, makamaka m'mawa. Ngati, pazinthu zina, mankhwala adasowa, palibe chifukwa chowonjezera mlingo wotsatira. Kuphatikiza apo, malangizo a boma akuti kuwonjezera kuchuluka kwa mankhwalawa ndikofunikira patatha mwezi umodzi atangoyamba kumene mankhwalawa.
Chosiyana ndi odwala omwe, atatha maphunziro a masabata awiri, osawona momwe zinthu zilili komanso kuchuluka kwa shuga m'magazi nthawi zonse kumakhala kosangalatsa kwambiri. Kenako, kuti mupeze zotsatira zabwino, adokotala angasankhe kuwonjezera kuchuluka kwake.
Mukamamwa mankhwalawa, ndikofunikira kukhazikitsa kuyang'anira shuga wamagazi pafupipafupi kuti hypoglycemia isachitike. Pofuna kupeza phindu kuchokera pakumwa mankhwalawo, nthawi zambiri njira yochizira imathandizidwa ndimankhwala otsatirawa:
- zotumphukira sulfonylurea;
- Gliclazide metformin;
- insulin;
- zoletsa;
- zotengera thiazolidione.
Kutengera kampani yomwe ikupanga mankhwala, mtengo wa Gliclazide ungasiyane pang'ono. Mtengo wawo amathanso kukhudzidwa ndi kuchuluka kwa mankhwalawa (30 mg, 60 mg kapena 80 mg).
Ndemanga zambiri za odwala zikuwonetsa kupezeka komanso kuchuluka kwa mapiritsi.
Ndi zovuta zoyipa ziti zomwe zingachitike mutamwa mankhwalawa?
Chithandizo ndi chithandizo cha mankhwala ndi Glyclazide ziyenera kuchitika moyang'aniridwa ndi achipatala.
Sizovomerezeka kumwa mankhwalawa mu Mlingo wopitilira malangizo a dokotala, kapena molumikizana ndi mapiritsi ena osankhidwa ndi wodwalayo.
Njira yakugwiritsira ntchito ndi mulingo womwewo akuwonetsedwa mu malangizo ochokera kwa wopanga.
Kusagwiritsa ntchito mankhwalawa mosayenerera kungayambitse mavuto ambiri, mankhwala owopsa a thupi la munthu atseguka.
Zowonetsa zazikulu za mankhwalawa zimaphatikizapo izi:
- Mavuto ogaya, omwe amatha kutsagana ndi kubala, kupweteka m'mimba kapena m'mimba.
- Zotsatira zosasangalatsa zachitsulo mkamwa zitha kuwoneka pambuyo povulala.
- Kumva kwamphamvu njala.
- Kusanza ndi kusanza.
- Kuwonetsedwa kwa thupi lawo siligwirizana ndi chimodzi kapena zingapo za mankhwalawa.
- Chizungulire ndi mutu.
- Kutupa kosiyanasiyana pakhungu, mawanga kapena kutupira kwa minofu kumachitika.
- Kuphwanya ziwalo zamasomphenya.
- Maonekedwe a hypoglycemia.
- Kukula kwa lactic acidosis.
- Megaloblastic anemia.
Monga lamulo, Zizindikiro zotere zimazimiririka atasiya kumwa mankhwalawo. Tiyeneranso kudziwa kuti njira yolakwika ndi kuchuluka kwa mankhwalawa kungayambitse kwambiri hypoglycemia.
Kodi mankhwala amaletsedwa liti?
Mankhwala ali ndi mndandanda wofunikira wa contraindication chifukwa chogwiritsa ntchito. Ndiye chifukwa chake, musanayambe maphunziro, muyenera kuwerenga malangizo mosamala.
Zotsatira zoyipa zilizonse zikachitika, muyenera kulumikizana ndi dokotala ndikufotokozeranso zina zomwe mungachite pomwa mankhwalawo.
Ndi zoletsedwa kugwiritsa ntchito mankhwalawa pamaso pa zinthu ndi matenda:
- Zochizira matenda amtundu 1 a shuga, odalira insulin.
- Kukula kwa ketoacidosis, chikomokere kapena kholo la mtundu wa matenda ashuga.
- Njira zazikulu za pathological mu impso kapena chiwindi, komanso pamaso pa kusakwanira kwawo.
- Matenda ena a kupuma thirakiti, komanso ngati mukuvuta ndi kupuma.
- Matenda a mtima ndi mtima, kulephera kwa mtima, kapena kulowerera kwamitsempha.
- Kukula kwa matendawa chifukwa cha matenda osiyanasiyana.
- Opaleshoni yaposachedwa komanso kuvulala.
- Madzulo komanso pambuyo poyeserera. Izi zikuphatikiza ma radiology, chifukwa wothandizira wosiyana ndi ayodini amagwiritsidwa ntchito.
- Lactic acidosis;
- Kusalolera kapena hypersensitivity ku chimodzi kapena zingapo za mankhwalawa;
- Pamaso pa kusowa kwamadzi;
- Kugwiritsa ntchito miconazole mosangalatsa.
Atsikana ndi amayi oyembekezera panthawi yoyembekezera amaletsedwa kutenga metformin, chifukwa mavuto osiyanasiyana ndi kukhazikika kwa mwana wosabadwayo angachitike. Ndi kufunikira kwakanthawi kwamankhwala, mkazi ayenera kusiya kuyamwitsa.
Kuphatikiza apo, ana osakwana zaka khumi ndi zisanu ndi zitatu ali pachiwopsezo.
Kodi ndizotheka kusintha mankhwalawa ndimankhwala ena?
Mankhwala Gliclazide, monga momwe akuwonera pakuwunikira wodwala, amaloledwa mosavuta ndipo amakhala ndi kuchepetsa shuga.
Mtengo wapakati ndi pafupifupi ma ruble 135.
Nthawi zina pamakhala chithandizo chamankhwala ena. Mwanjira iyi, mutha kusankha ma analogi a Gliclazide kapena maimelo omwe msika wa pharmacological umapereka.
Mpaka pano, pali malo ena otere:
- Diabetes;
- Metformin;
- Glidiab;
- Diabefarm;
- Glidiazinamide.
A diabetes ali m'gulu la sulfonylureas la m'badwo wachiwiri. Ndemanga yakuchipatala ikuwonetsa kuti ngati mutenga Diabeteson kwa zaka ziwiri, palibe chitukuko cha kukana insulin.
M'mapangidwe ake, Diabetes ndi chithunzi chonse cha mapiritsi a Gliclazide. Njira makonzedwe a mankhwala zimatengera umunthu wodwala. Monga lamulo, ndi piritsi limodzi kapena awiri patsiku. Mtengo wapakati pa Diabeteson ndi ma ruble 330 pamapiritsi 30.
Metformin - ndi mankhwala ochokera ku kalasi ya biguanides, yomwe imagwiritsidwa ntchito mwachangu pochiza matenda amtundu wa 2 shuga. Chofunikira chachikulu cha mankhwalawa ndi metformin hydrochloride. Mtengo wamba mumafakisi ndi ma ruble 250.
Glidiab ndi mankhwala a hypoglycemic omwe ali ndi 80 mg yogwira ntchito. Mtengo wapakati wamsika ndi ma ruble 140 pa paketi (mapiritsi 60).
Diabefarm ndi piritsi lomwe limagwiritsidwa ntchito mosamala pochiza matenda amtundu wa 2 shuga. Mtengo wa mankhwalawa umakhala ma ruble 120. Kanemayo munkhaniyi akufotokoza za momwe angachiritsire matenda ashuga ndi mankhwala osokoneza bongo.
